Maya Sieber-Blum

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. pmc Epidermal neural crest stem cell (EPI-NCSC)--mediated recovery of sensory function in a mouse model of spinal cord injury
    Yao Fei Hu
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Stem Cell Rev 6:186-98. 2010
  2. doi request reprint Epidermal neural crest stem cells (EPI-NCSC) and pluripotency
    Maya Sieber-Blum
    Institute of Human Genetics and North East England Stem Cell Institute, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne NE13BZ, UK
    Stem Cell Rev 4:256-60. 2008
  3. pmc Epidermal stem cell dynamics
    Maya Sieber-Blum
    Institute of Genetic Medicine and Northeast England Stem Cell Institute, Newcastle University, Centre for Life, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
    Stem Cell Res Ther 2:29. 2011
  4. doi request reprint Epidermal neural crest stem cells and their use in mouse models of spinal cord injury
    Maya Sieber-Blum
    Institute of Human Genetics and North East England Stem Cell Institute, Newcastle University, Centre for Life, Newcastle upon Tyne, UK
    Brain Res Bull 83:189-93. 2010
  5. ncbi request reprint Neurotrophin-3 signaling in mammalian Merkel cell development
    Viktor Szeder
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Dev Dyn 228:623-9. 2003
  6. ncbi request reprint Characterization of epidermal neural crest stem cell (EPI-NCSC) grafts in the lesioned spinal cord
    Maya Sieber-Blum
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Mol Cell Neurosci 32:67-81. 2006
  7. ncbi request reprint Neural crest origin of mammalian Merkel cells
    Viktor Szeder
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Dev Biol 253:258-63. 2003
  8. ncbi request reprint Ontogeny and plasticity of adult hippocampal neural stem cells
    Maya Sieber-Blum
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisc 53226, USA
    Dev Neurosci 25:273-8. 2003
  9. pmc Norepinephrine transport-mediated gene expression in noradrenergic neurogenesis
    Yao Fei Hu
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    BMC Genomics 10:151. 2009
  10. ncbi request reprint An epidermal neural crest stem cell (EPI-NCSC) molecular signature
    Yao Fei Hu
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Stem Cells 24:2692-702. 2006

Collaborators

  • Yao Fei Hu
  • Zdenek Halata
  • Martin E Schwab
  • Marc G Caron
  • Alla Narytnyk
  • Oliver Clewes
  • Viktor Szeder
  • Zhi Jian Zhang
  • Benjamin M Ellington
  • Milos Grim
  • Kevin Gillinder
  • Bernard Verdon
  • Kevin R Gillinder
  • Andrew D Loughney
  • Alison P Murdoch
  • Kathleen M Schmainda
  • Brian D Schmit
  • Krishnaj Gourab
  • Jan Kucera

Detail Information

Publications17

  1. pmc Epidermal neural crest stem cell (EPI-NCSC)--mediated recovery of sensory function in a mouse model of spinal cord injury
    Yao Fei Hu
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Stem Cell Rev 6:186-98. 2010
    ..EPI-NCSC are uniquely qualified for cell-based therapy in spinal cord injury, as neural crest cells and neural tube stem cells share a higher order stem cell and are thus ontologically closely related...
  2. doi request reprint Epidermal neural crest stem cells (EPI-NCSC) and pluripotency
    Maya Sieber-Blum
    Institute of Human Genetics and North East England Stem Cell Institute, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne NE13BZ, UK
    Stem Cell Rev 4:256-60. 2008
    ..Since the patients' own EPI-NCSC could be used for autologous transplantation, this would avoid graft rejection...
  3. pmc Epidermal stem cell dynamics
    Maya Sieber-Blum
    Institute of Genetic Medicine and Northeast England Stem Cell Institute, Newcastle University, Centre for Life, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
    Stem Cell Res Ther 2:29. 2011
    ..While this is a provocative result and the authors' conclusion may well be correct, there are alternative explanations...
  4. doi request reprint Epidermal neural crest stem cells and their use in mouse models of spinal cord injury
    Maya Sieber-Blum
    Institute of Human Genetics and North East England Stem Cell Institute, Newcastle University, Centre for Life, Newcastle upon Tyne, UK
    Brain Res Bull 83:189-93. 2010
    ..Intraspinal EPI-NCSC thus have multiple effects in the contused spinal cord, the sum of which can explain the observed functional improvements...
  5. ncbi request reprint Neurotrophin-3 signaling in mammalian Merkel cell development
    Viktor Szeder
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Dev Dyn 228:623-9. 2003
    ..These results show that NT-3 signaling is not required for the differentiation of Merkel cells, but that it is essential for their postnatal survival...
  6. ncbi request reprint Characterization of epidermal neural crest stem cell (EPI-NCSC) grafts in the lesioned spinal cord
    Maya Sieber-Blum
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Mol Cell Neurosci 32:67-81. 2006
    ..Collectively, our data indicate that intraspinal EPI-NCSC demonstrate several desirable characteristics that may include local neural replacement and re-myelination...
  7. ncbi request reprint Neural crest origin of mammalian Merkel cells
    Viktor Szeder
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Dev Biol 253:258-63. 2003
    ..Merkel cells in whiskers and interfollicular locations express the transgene, beta-galactosidase, identifying them as neural crest descendants. We thus conclude that murine Merkel cells originate from the neural crest...
  8. ncbi request reprint Ontogeny and plasticity of adult hippocampal neural stem cells
    Maya Sieber-Blum
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisc 53226, USA
    Dev Neurosci 25:273-8. 2003
    ..Furthermore, they show plasticity and a remarkably wide range of developmental options of adult hippocampal stem cells...
  9. pmc Norepinephrine transport-mediated gene expression in noradrenergic neurogenesis
    Yao Fei Hu
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    BMC Genomics 10:151. 2009
    ..While the structure of NET und the regulation of NET function are well described, little is known about downstream target genes of norepinephrine (NE) transport...
  10. ncbi request reprint An epidermal neural crest stem cell (EPI-NCSC) molecular signature
    Yao Fei Hu
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Stem Cells 24:2692-702. 2006
    ..Multipotent adult mammalian stem cells are of great interest because of their potential value in future cell replacement therapy by autologous transplantation, which avoids graft rejection...
  11. ncbi request reprint The role of NT-3 signaling in Merkel cell development
    Maya Sieber-Blum
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Prog Brain Res 146:63-72. 2004
    ....
  12. ncbi request reprint The adult hair follicle: cradle for pluripotent neural crest stem cells
    Maya Sieber-Blum
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee 53226, USA
    Birth Defects Res C Embryo Today 72:162-72. 2004
    ..The intrinsic high degree of plasticity of eNCSCs and the fact that they are easily accessible in the skin make them attractive candidates for diverse autologous cell therapy strategies...
  13. doi request reprint Essential role of stem cell factor signaling in primary sensory neuron development
    Zhi Jian Zhang
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, USA
    Dev Neurosci 31:202-11. 2009
    ..We thus conclude that, in the absence of SCF signaling, neural crest-derived progenitors do not differentiate into c-kit-expressing visceral and somatic afferent neurons...
  14. doi request reprint Neural Crest Stem Cell-specific Deletion of the Pygopus2 Gene Modulates Hair Follicle Development
    Alla Narytnyk
    Institute of Genetic Medicine, Newcastle University, Centre for Life, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
    Stem Cell Rev 10:60-8. 2014
    ..Taken together, our data support the novel notion that neural crest cells are involved in the earliest stages of hair follicle development. ..
  15. pmc Human epidermal neural crest stem cells (hEPI-NCSC)--characterization and directed differentiation into osteocytes and melanocytes
    Oliver Clewes
    Institute of Genetic Medicine, and North East England Stem Cell Institute, Centre for Life, Newcastle University, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    Stem Cell Rev 7:799-814. 2011
    ..As somatic stem cells, hEPI-NCSC are conducive to autologous transplantation, which avoids graft rejection. Together, these traits make hEPI-NCSC novel and attractive candidates for future cell-based therapies and regenerative medicine...
  16. ncbi request reprint Diffusion heterogeneity tensor MRI (?-Dti): mathematics and initial applications in spinal cord regeneration after trauma - biomed 2009
    Benjamin M Ellington
    Medical College of Wisconsin, Milwaukee, WI
    Biomed Sci Instrum 45:167-72. 2009
    ..This study develops the mathematics of this new technique along with an initial application in quantifying spinal cord regeneration following acute injection of epidermal neural crest stem cell (EPI-NCSC) grafts...
  17. ncbi request reprint Cardiac neural crest stem cells
    Maya Sieber-Blum
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anat Rec A Discov Mol Cell Evol Biol 276:34-42. 2004
    ..Surprisingly, many diverse nonneuronal embryonic tissues, in particular in the cardiovascular system, express NET also. It will be of interest to determine whether norepinephrine transport plays a role also in cardiovascular development...