James A M Shaw

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Cushing's syndrome during pregnancy: curative adrenalectomy at 31 weeks gestation
    James A M Shaw
    Department of Medicine, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
    Eur J Obstet Gynecol Reprod Biol 105:189-91. 2002
  2. ncbi request reprint Secretion of bioactive human insulin following plasmid-mediated gene transfer to non-neuroendocrine cell lines, primary cultures and rat skeletal muscle in vivo
    J A M Shaw
    Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    J Endocrinol 172:653-72. 2002
  3. pmc Expression of mesenchymal and α-cell phenotypic markers in islet β-cells in recently diagnosed diabetes
    Michael G White
    Corresponding author James A M Shaw
    Diabetes Care 36:3818-20. 2013
  4. pmc Comparison of Optimised MDI versus Pumps with or without Sensors in Severe Hypoglycaemia (the Hypo COMPaSS trial)
    Stuart Little
    Institute of Cellular Medicine, The Medical School, Newcastle University, 4th Floor William Leech Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    BMC Endocr Disord 12:33. 2012
  5. ncbi request reprint Tetracycline-regulated secretion of human (pro)insulin following plasmid-mediated transfection of human muscle
    Magdalene O Wilson
    Diabetes Research Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    J Mol Endocrinol 34:391-403. 2005
  6. ncbi request reprint A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells
    Catherine Arden
    Institute of Cellular Medicine, The Medical School, Leech Bld Level 4, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Biochem J 411:41-51. 2008
  7. doi request reprint Transgene expression in mononuclear muscle cells not infiltrating inflammatory cells following intramuscular plasmid gene electrotransfer
    Jarupa Ratanamart
    Institute of Cellular Medicine, University of Newcastle, Newcastle upon Tyne, UK
    J Gene Med 12:377-84. 2010
  8. doi request reprint Pluripotency-associated stem cell marker expression in proliferative cell cultures derived from adult human pancreas
    Michael G White
    Diabetes Research Group, Medical School, Institute of Cellular Medicine, North East Stem Cell Institute, Newcastle University, UK
    J Endocrinol 211:169-76. 2011
  9. ncbi request reprint In vitro and in vivo evaluation of intrinsic immunogenicity of reporter and insulin gene therapy plasmids
    Jarupa Ratanamart
    Diabetes Research Group, Institute of Cell and Molecular Biosciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    J Gene Med 9:703-14. 2007
  10. ncbi request reprint Tetracycline-regulated secretion of human insulin in transfected primary myoblasts
    Kathleen T Scougall
    Diabetes Research Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, Framlington Place, NE2 4HH, Newcastle upon Tyne, UK
    Biochem Biophys Res Commun 304:167-75. 2003

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Cushing's syndrome during pregnancy: curative adrenalectomy at 31 weeks gestation
    James A M Shaw
    Department of Medicine, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
    Eur J Obstet Gynecol Reprod Biol 105:189-91. 2002
    ..Curative adrenalectomy was performed via a posterior approach in the third trimester with subsequent uncomplicated delivery of a healthy infant...
  2. ncbi request reprint Secretion of bioactive human insulin following plasmid-mediated gene transfer to non-neuroendocrine cell lines, primary cultures and rat skeletal muscle in vivo
    J A M Shaw
    Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    J Endocrinol 172:653-72. 2002
    ..4 mmol/l). In conclusion, prolonged constitutive systemic secretion of bioactive human (pro)insulin has been attained in non-neuroendocrine cells in vitro and in growing and mature rats following intramuscular plasmid injection...
  3. pmc Expression of mesenchymal and α-cell phenotypic markers in islet β-cells in recently diagnosed diabetes
    Michael G White
    Corresponding author James A M Shaw
    Diabetes Care 36:3818-20. 2013
    ..The aim was to determine whether phenotypes of β-cell dedifferentiation and plasticity are present in human diabetes...
  4. pmc Comparison of Optimised MDI versus Pumps with or without Sensors in Severe Hypoglycaemia (the Hypo COMPaSS trial)
    Stuart Little
    Institute of Cellular Medicine, The Medical School, Newcastle University, 4th Floor William Leech Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    BMC Endocr Disord 12:33. 2012
    ..abstract:..
  5. ncbi request reprint Tetracycline-regulated secretion of human (pro)insulin following plasmid-mediated transfection of human muscle
    Magdalene O Wilson
    Diabetes Research Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    J Mol Endocrinol 34:391-403. 2005
    ....
  6. ncbi request reprint A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells
    Catherine Arden
    Institute of Cellular Medicine, The Medical School, Leech Bld Level 4, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Biochem J 411:41-51. 2008
    ..It is concluded that PFK-2/FBPase-2 protein rather than its product fructose 2,6-P(2) is the over-riding determinant of glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting...
  7. doi request reprint Transgene expression in mononuclear muscle cells not infiltrating inflammatory cells following intramuscular plasmid gene electrotransfer
    Jarupa Ratanamart
    Institute of Cellular Medicine, University of Newcastle, Newcastle upon Tyne, UK
    J Gene Med 12:377-84. 2010
    ..Gene transfer efficiency and phenotypic identification of intramuscular transgene-expressing mononuclear cells was studied following electroporation-mediated plasmid delivery...
  8. doi request reprint Pluripotency-associated stem cell marker expression in proliferative cell cultures derived from adult human pancreas
    Michael G White
    Diabetes Research Group, Medical School, Institute of Cellular Medicine, North East Stem Cell Institute, Newcastle University, UK
    J Endocrinol 211:169-76. 2011
    ..Further studies are required to elucidate whether these cells possess functional stem cell characteristics and assess potential for differentiation into pancreatic cell lineages including new β-cells...
  9. ncbi request reprint In vitro and in vivo evaluation of intrinsic immunogenicity of reporter and insulin gene therapy plasmids
    Jarupa Ratanamart
    Diabetes Research Group, Institute of Cell and Molecular Biosciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    J Gene Med 9:703-14. 2007
    ..As plasmid DNA is bacterial in origin, presence of bacterial lipopolysaccharide (LPS) or unmethylated CpG dinucleotides may stimulate host innate immunity...
  10. ncbi request reprint Tetracycline-regulated secretion of human insulin in transfected primary myoblasts
    Kathleen T Scougall
    Diabetes Research Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, Framlington Place, NE2 4HH, Newcastle upon Tyne, UK
    Biochem Biophys Res Commun 304:167-75. 2003
    ..Conversion of proinsulin to insulin in transfected myoblasts was <1% for hppI1 and >45% for hppI4. In conclusion, regulated insulin secretion has been achieved in a dose-dependent and reversible manner in primary myoblasts...
  11. ncbi request reprint Cell biology assessment of glucokinase mutations V62M and G72R in pancreatic beta-cells: evidence for cellular instability of catalytic activity
    Catherine Arden
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Diabetes 56:1773-82. 2007
    ..These results suggest that cellular loss of GK catalytic activity rather than impaired translation or enhanced protein degradation may account for the hyperglycemia in subjects with V62M and G72R mutations...
  12. ncbi request reprint Tetracycline-regulated secretion of human insulin in a transfected non-endocrine cell line
    K T Scougall
    Department of Medicine and Therapeutics, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, Scotland, UK
    J Mol Endocrinol 30:331-46. 2003
    ..In conclusion, regulation of fully processed human insulin secretion has been achieved in a transiently transfected non-endocrine cell line...
  13. ncbi request reprint Plasmid-mediated muscle-targeted gene therapy for circulating therapeutic protein replacement: a tale of the tortoise and the hare?
    Jarupa Ratanamart
    Diabetes Research Group, Institute of Cell and Molecular Biosciences, University of Newcastle upon Tyne, NE2 4HH, UK
    Curr Gene Ther 6:93-110. 2006
    ..Translation of advances in all of these areas to clinical success will enable muscle-targeted gene therapy to capitalise on its inherent strengths and realise its long-standing promise...