Tyson V Sharp
Affiliation: University College London
- LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcriptionTyson V Sharp
Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, University College London, London WC1E 6BT, United Kingdom
Proc Natl Acad Sci U S A 101:16531-6. 2004..Our data indicate that LIMD1 is a tumor-suppressor gene, the protein product of which functionally interacts with pRB and the loss of which promotes lung carcinogenesis...
- Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivinHsei Wei Wang
The Cancer Research UK Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, University College London, London WC1E 6BT, UK
EMBO J 21:2602-15. 2002..These data also suggest that survivin-DeltaEx3 might function by a similar mechanism to that of K7. We denote K7 as vIAP (viral inhibitor-of-apoptosis protein)...
- K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic functionTyson V Sharp
The CRC Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, London, United Kingdom WC1E 6BT
J Virol 76:802-16. 2002..The putative functions of K15 with respect to its interaction with HAX-1 are discussed...
- Differential subcellular localisation of the tumour suppressor protein LIMD1 in breast cancer correlates with patient survivalIan Spendlove
Academic and Clinical Department of Oncology, University of Nottingham, Nottingham, United Kingdom
Int J Cancer 123:2247-53. 2008..The possible functions of LIMD1 localisation within the nucleus and cytoplasm and its relationship to tumour prognosis are discussed...