Paul M Sharp

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. pmc The origins of acquired immune deficiency syndrome viruses: where and when?
    P M Sharp
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Philos Trans R Soc Lond B Biol Sci 356:867-76. 2001
  2. ncbi request reprint Origins of human virus diversity
    Paul M Sharp
    Institute of Genetics, University of Nottingham, Queens Medical Centre, NG7 2UH, Nottingham, United Kingdom
    Cell 108:305-12. 2002
  3. pmc Variation in the strength of selected codon usage bias among bacteria
    Paul M Sharp
    Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
    Nucleic Acids Res 33:1141-53. 2005
  4. pmc Adaptation of HIV-1 to its human host
    Louise V Wain
    Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham, UK
    Mol Biol Evol 24:1853-60. 2007
  5. pmc Simian immunodeficiency virus infection of chimpanzees
    Paul M Sharp
    Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham, United Kingdom
    J Virol 79:3891-902. 2005
  6. pmc Helicobacter pylori FlhB function: the FlhB C-terminal homologue HP1575 acts as a "spare part" to permit flagellar export when the HP0770 FlhBCC domain is deleted
    Matthew E Wand
    Institute of Infection, Immunity, and Inflammation, Queen s Medical Centre, Nottingham, United Kingdom
    J Bacteriol 188:7531-41. 2006
  7. ncbi request reprint Hybrid origin of SIV in chimpanzees
    Elizabeth Bailes
    University of Nottingham, Nottingham NG72UH, UK
    Science 300:1713. 2003
  8. ncbi request reprint Enterobacterial repetitive intergenic consensus (ERIC) sequences in Escherichia coli: Evolution and implications for ERIC-PCR
    Lindsay A Wilson
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham, United Kingdom
    Mol Biol Evol 23:1156-68. 2006
  9. ncbi request reprint Synonymous codon usage in Pseudomonas aeruginosa PA01
    Russell J Grocock
    Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
    Gene 289:131-9. 2002
  10. pmc Full-length sequence analysis of SIVmus in wild populations of mustached monkeys (Cercopithecus cephus) from Cameroon provides evidence for two co-circulating SIVmus lineages
    Avelin F Aghokeng
    Laboratoire Retrovirus, UMR 145, IRD and the Department of International Health, University of Montpellier I, Montpellier, France
    Virology 360:407-18. 2007

Collaborators

  • George M Shaw
  • Renee Elizabeth Sockett
  • Brandon F Keele
  • Feng Gao
  • Klaus Winzer
  • M Peeters
  • Michael Worobey
  • John Fy Brookfield
  • Jonathan P Clewley
  • Andrew Rambaut
  • Beatrice H Hahn
  • Elizabeth Bailes
  • Frederic Bibollet-Ruche
  • Mario L Santiago
  • Yingying Li
  • Jun Takehisa
  • Eric Delaporte
  • Fran Van Heuverswyn
  • Shadrack Kamenya
  • Anne E Pusey
  • Valerie Courgnaud
  • Weimin Liu
  • Jesus F Salazar-Gonzalez
  • Michael L Wilson
  • Cecile Neel
  • Ian Henry
  • Severin Loul
  • Julie M Decker
  • Avelin F Aghokeng
  • Louise V Wain
  • Matthias H Kraus
  • Michael Schindler
  • Benjamin Dewals
  • Matthew E Wand
  • Lindsay A Wilson
  • Nicole Gross-Camp
  • Michaela C Muller-Trutwin
  • Eitel Mpoudi-Ngole
  • Eric Nerrienet
  • YiPing Chen
  • Russell J Grocock
  • Bette T M Korber
  • Stephen L Clifford
  • Jean Bosco N Ndjango
  • Christophe Boesch
  • Koichiro Zamma
  • Paul Farmer
  • Cynthia A Derdeyn
  • Olivier Manigart
  • Yuanyuan Guo
  • Gayathri S Athreya
  • Paul A Goepfert
  • John C Mitani
  • Susan Allen
  • Michael A Huffman
  • David P Watts
  • Crickette Sanz
  • Eric Hunter
  • Maria G Salazar
  • Kimmy T Pham
  • Jeffrey A Anderson
  • Barton F Haynes
  • Vince Smith
  • Ronald Swanstrom
  • William M Switzer
  • Joseph Mulenga
  • M Brad Guffey
  • Bienvenue Yangda
  • Eitel Mpoudi-Ngolle
  • Katharina S Shaw
  • Kenneth P Zammit
  • Christelle Butel
  • Zhiping Weng
  • Benedicte Lafay
  • Florian Liegeois
  • Eitel Mpoudi Ngole
  • Francis J Novembre
  • Pierre Roques
  • Nicolas Markine-Goriaynoff
  • Katy J Evans
  • Alain Vanderplasschen
  • Katalin de Fays
  • Olaf Kutsch
  • Donald L Sodora
  • Kim R Hardie
  • Hui Li
  • Muriel Thirion
  • Laurent Gillet
  • Frank Kirchhoff
  • Frédéric Minner

Detail Information

Publications27

  1. pmc The origins of acquired immune deficiency syndrome viruses: where and when?
    P M Sharp
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Philos Trans R Soc Lond B Biol Sci 356:867-76. 2001
    ....
  2. ncbi request reprint Origins of human virus diversity
    Paul M Sharp
    Institute of Genetics, University of Nottingham, Queens Medical Centre, NG7 2UH, Nottingham, United Kingdom
    Cell 108:305-12. 2002
    ..Advances in the ease of finding and characterizing viral genome sequences are having a major impact on our understanding of the diversity of human viruses and of their relatives infecting other species...
  3. pmc Variation in the strength of selected codon usage bias among bacteria
    Paul M Sharp
    Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
    Nucleic Acids Res 33:1141-53. 2005
    ..For example, Clostridium perfringens, the species with the highest value of S, can have a generation time as short as 7 min...
  4. pmc Adaptation of HIV-1 to its human host
    Louise V Wain
    Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham, UK
    Mol Biol Evol 24:1853-60. 2007
    ..Taken together, these observations provide compelling evidence for host-specific adaptation during the emergence of HIV-1 and identify the viral matrix protein as a modulator of viral fitness following transmission to the new human host...
  5. pmc Simian immunodeficiency virus infection of chimpanzees
    Paul M Sharp
    Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham, United Kingdom
    J Virol 79:3891-902. 2005
  6. pmc Helicobacter pylori FlhB function: the FlhB C-terminal homologue HP1575 acts as a "spare part" to permit flagellar export when the HP0770 FlhBCC domain is deleted
    Matthew E Wand
    Institute of Infection, Immunity, and Inflammation, Queen s Medical Centre, Nottingham, United Kingdom
    J Bacteriol 188:7531-41. 2006
    ..However, mutation of the proline contained within the NPTH site of HP0770 did not affect motility and flagellar assembly, although it clearly interfered with processing when the protein was heterologously produced in Escherichia coli...
  7. ncbi request reprint Hybrid origin of SIV in chimpanzees
    Elizabeth Bailes
    University of Nottingham, Nottingham NG72UH, UK
    Science 300:1713. 2003
  8. ncbi request reprint Enterobacterial repetitive intergenic consensus (ERIC) sequences in Escherichia coli: Evolution and implications for ERIC-PCR
    Lindsay A Wilson
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham, United Kingdom
    Mol Biol Evol 23:1156-68. 2006
    ..The small number of ERIC sequences in E. coli genomes indicates that a widely used bacterial fingerprinting method using primers based on ERIC sequences (ERIC-PCR) does not rely on the presence of ERIC sequences...
  9. ncbi request reprint Synonymous codon usage in Pseudomonas aeruginosa PA01
    Russell J Grocock
    Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
    Gene 289:131-9. 2002
    ..In addition, genes on the leading strand of replication were on average more G+T-rich. Our findings contradict the results of two previous analyses, and the reasons for the discrepancies are discussed...
  10. pmc Full-length sequence analysis of SIVmus in wild populations of mustached monkeys (Cercopithecus cephus) from Cameroon provides evidence for two co-circulating SIVmus lineages
    Avelin F Aghokeng
    Laboratoire Retrovirus, UMR 145, IRD and the Department of International Health, University of Montpellier I, Montpellier, France
    Virology 360:407-18. 2007
    ..These results indicate that cross-species transmission and recombination play a major role in the evolution of primate lentiviruses among sympatric primate species...
  11. ncbi request reprint Predicting gene expression level from codon usage bias
    Ian Henry
    Mol Biol Evol 24:10-2. 2007
    ....
  12. pmc Generation of infectious molecular clones of simian immunodeficiency virus from fecal consensus sequences of wild chimpanzees
    Jun Takehisa
    Department of Medicine, University of Alabama at Birmingham, 720 20th Street South, Kaul 816, Birmingham, AL 35294, USA
    J Virol 81:7463-75. 2007
    ..Such isolates are needed to identify viral determinants that contribute to cross-species transmission and host adaptation...
  13. ncbi request reprint Genetic diversity and phylogeographic clustering of SIVcpzPtt in wild chimpanzees in Cameroon
    Fran Van Heuverswyn
    UMR145, Institut de Recherche pour le Developpement, Department of International Health, University of Montpellier 1, 911, Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
    Virology 368:155-71. 2007
    ....
  14. pmc Deciphering human immunodeficiency virus type 1 transmission and early envelope diversification by single-genome amplification and sequencing
    Jesus F Salazar-Gonzalez
    Department of Medicine, University of Alabama at Birmingham, 720 20th Street South, Kaul 816, Birmingham, AL 35294, USA
    J Virol 82:3952-70. 2008
    ....
  15. pmc Molecular ecology and natural history of simian foamy virus infection in wild-living chimpanzees
    Weimin Liu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS Pathog 4:e1000097. 2008
    ....
  16. ncbi request reprint Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1
    Michael Schindler
    Department of Virology, University of Ulm, 89081 Ulm, Germany
    Cell 125:1055-67. 2006
    ..This function was lost during viral evolution in a lineage that gave rise to HIV-1 and may have predisposed the simian precursor of HIV-1 for greater pathogenicity in humans...
  17. pmc Chimpanzee reservoirs of pandemic and nonpandemic HIV-1
    Brandon F Keele
    Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Science 313:523-6. 2006
    ..These findings establish P. t. troglodytes as a natural reservoir of HIV-1...
  18. ncbi request reprint Evolution of Bovine herpesvirus 4: recombination and transmission between African buffalo and cattle
    Benjamin Dewals
    Immunology Vaccinology B43b, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, University of Liege, B 4000 Liege, Belgium
    J Gen Virol 87:1509-19. 2006
    ....
  19. pmc Amplification of a complete simian immunodeficiency virus genome from fecal RNA of a wild chimpanzee
    Mario L Santiago
    Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Virol 77:2233-42. 2003
    ....
  20. ncbi request reprint Noninvasive detection of Simian immunodeficiency virus infection in a wild-living L'Hoest's monkey (Cercopithecus Ihoesti)
    Mario L Santiago
    Department of Medicine and Microbiology, University of Alabama at Birmingham, Alabama 35294, USA
    AIDS Res Hum Retroviruses 19:1163-6. 2003
    ..L'Hoest's monkeys represent the third primate species for which the utility of noninvasive SIV testing has been documented...
  21. ncbi request reprint Origin of AIDS: contaminated polio vaccine theory refuted
    Michael Worobey
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Nature 428:820. 2004
    ....
  22. pmc New simian immunodeficiency virus infecting De Brazza's monkeys (Cercopithecus neglectus): evidence for a cercopithecus monkey virus clade
    Frederic Bibollet-Ruche
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Virol 78:7748-62. 2004
    ..The vpu gene appears to have been acquired by a subset of these Cercopithecus viruses after the divergence of SIVdeb and SIVsyk...
  23. ncbi request reprint Analysis of 15 novel full-length BK virus sequences from three individuals: evidence of a high intra-strain genetic diversity
    YiPing Chen
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, RE 213B, 330 Brookline Avenue, Boston, MA 02215, USA
    J Gen Virol 85:2651-63. 2004
    ..55 % of sites, implying a rate of nucleotide substitution of approximately 5 x 10(-5) substitutions per site per year, which is two orders of magnitude faster than estimated for the other human polyomavirus, JC virus...
  24. pmc Simian immunodeficiency virus infection in wild-caught chimpanzees from cameroon
    Eric Nerrienet
    Laboratoire de Virologie, Centre Pasteur du Cameroun, Yaounde, Cameroon
    J Virol 79:1312-9. 2005
    ..Whether P. t. vellerosus apes are naturally infected with SIVcpz requires further study...
  25. pmc Complete genome analysis of one of the earliest SIVcpzPtt strains from Gabon (SIVcpzGAB2)
    Frederic Bibollet-Ruche
    Department of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    AIDS Res Hum Retroviruses 20:1377-81. 2004
    ..These data indicate extensive diversity among naturally occurring SIVcpzPtt strains and provide new insight into the origin of HIV-1 group O...
  26. pmc Simian immunodeficiency virus infection in free-ranging sooty mangabeys (Cercocebus atys atys) from the Taï Forest, Côte d'Ivoire: implications for the origin of epidemic human immunodeficiency virus type 2
    Mario L Santiago
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Virol 79:12515-27. 2005
    ....
  27. doi request reprint AIDS: prehistory of HIV-1
    Paul M Sharp
    Nature 455:605-6. 2008