Research Topics
Species | Paul M SharpSummaryAffiliation: University of Nottingham Country: UK Publications
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Detail Information
Publications
The origins of acquired immune deficiency syndrome viruses: where and when?P M Sharp
Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
Philos Trans R Soc Lond B Biol Sci 356:867-76. 2001....
Origins of human virus diversityPaul M Sharp
Institute of Genetics, University of Nottingham, Queens Medical Centre, NG7 2UH, Nottingham, United Kingdom
Cell 108:305-12. 2002..Advances in the ease of finding and characterizing viral genome sequences are having a major impact on our understanding of the diversity of human viruses and of their relatives infecting other species...
Variation in the strength of selected codon usage bias among bacteriaPaul M Sharp
Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
Nucleic Acids Res 33:1141-53. 2005..For example, Clostridium perfringens, the species with the highest value of S, can have a generation time as short as 7 min...- Adaptation of HIV-1 to its human hostLouise V Wain
Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham, UK
Mol Biol Evol 24:1853-60. 2007..Taken together, these observations provide compelling evidence for host-specific adaptation during the emergence of HIV-1 and identify the viral matrix protein as a modulator of viral fitness following transmission to the new human host... - Simian immunodeficiency virus infection of chimpanzeesPaul M Sharp
Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham, United Kingdom
J Virol 79:3891-902. 2005 - Helicobacter pylori FlhB function: the FlhB C-terminal homologue HP1575 acts as a "spare part" to permit flagellar export when the HP0770 FlhBCC domain is deletedMatthew E Wand
Institute of Infection, Immunity, and Inflammation, Queen s Medical Centre, Nottingham, United Kingdom
J Bacteriol 188:7531-41. 2006..However, mutation of the proline contained within the NPTH site of HP0770 did not affect motility and flagellar assembly, although it clearly interfered with processing when the protein was heterologously produced in Escherichia coli... - Hybrid origin of SIV in chimpanzeesElizabeth Bailes
University of Nottingham, Nottingham NG72UH, UK
Science 300:1713. 2003 - Enterobacterial repetitive intergenic consensus (ERIC) sequences in Escherichia coli: Evolution and implications for ERIC-PCRLindsay A Wilson
Institute of Genetics, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom
Mol Biol Evol 23:1156-68. 2006..The small number of ERIC sequences in E. coli genomes indicates that a widely used bacterial fingerprinting method using primers based on ERIC sequences (ERIC-PCR) does not rely on the presence of ERIC sequences... - Synonymous codon usage in Pseudomonas aeruginosa PA01Russell J Grocock
Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
Gene 289:131-9. 2002..In addition, genes on the leading strand of replication were on average more G+T-rich. Our findings contradict the results of two previous analyses, and the reasons for the discrepancies are discussed... - Full-length sequence analysis of SIVmus in wild populations of mustached monkeys (Cercopithecus cephus) from Cameroon provides evidence for two co-circulating SIVmus lineagesAvelin F Aghokeng
Laboratoire Retrovirus, UMR 145, IRD and the Department of International Health, University of Montpellier I, Montpellier, France
Virology 360:407-18. 2007..These results indicate that cross-species transmission and recombination play a major role in the evolution of primate lentiviruses among sympatric primate species... - Predicting gene expression level from codon usage biasIan Henry
Mol Biol Evol 24:10-2. 2007.... - Generation of infectious molecular clones of simian immunodeficiency virus from fecal consensus sequences of wild chimpanzeesJun Takehisa
Department of Medicine, University of Alabama at Birmingham, 720 20th Street South, Kaul 816, Birmingham, AL 35294, USA
J Virol 81:7463-75. 2007..Such isolates are needed to identify viral determinants that contribute to cross-species transmission and host adaptation... - Genetic diversity and phylogeographic clustering of SIVcpzPtt in wild chimpanzees in CameroonFran Van Heuverswyn
UMR145, Institut de Recherche pour le Developpement, Department of International Health, University of Montpellier 1, 911, Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
Virology 368:155-71. 2007.... - Deciphering human immunodeficiency virus type 1 transmission and early envelope diversification by single-genome amplification and sequencingJesus F Salazar-Gonzalez
Department of Medicine, University of Alabama at Birmingham, 720 20th Street South, Kaul 816, Birmingham, AL 35294, USA
J Virol 82:3952-70. 2008.... - Molecular ecology and natural history of simian foamy virus infection in wild-living chimpanzeesWeimin Liu
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS Pathog 4:e1000097. 2008.... - Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1Michael Schindler
Department of Virology, University of Ulm, 89081 Ulm, Germany
Cell 125:1055-67. 2006..This function was lost during viral evolution in a lineage that gave rise to HIV-1 and may have predisposed the simian precursor of HIV-1 for greater pathogenicity in humans... - Chimpanzee reservoirs of pandemic and nonpandemic HIV-1Brandon F Keele
Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
Science 313:523-6. 2006..These findings establish P. t. troglodytes as a natural reservoir of HIV-1... - Evolution of Bovine herpesvirus 4: recombination and transmission between African buffalo and cattleBenjamin Dewals
Immunology-Vaccinology (B43b, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, , , Belgium
J Gen Virol 87:1509-19. 2006.... - Amplification of a complete simian immunodeficiency virus genome from fecal RNA of a wild chimpanzeeMario L Santiago
Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Virol 77:2233-42. 2003.... - Noninvasive detection of Simian immunodeficiency virus infection in a wild-living L'Hoest's monkey (Cercopithecus Ihoesti)Mario L Santiago
Department of Medicine and Microbiology, University of Alabama at Birmingham, Alabama 35294, USA
AIDS Res Hum Retroviruses 19:1163-6. 2003..L'Hoest's monkeys represent the third primate species for which the utility of noninvasive SIV testing has been documented... - Origin of AIDS: contaminated polio vaccine theory refutedMichael Worobey
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
Nature 428:820. 2004.... - New simian immunodeficiency virus infecting De Brazza's monkeys (Cercopithecus neglectus): evidence for a cercopithecus monkey virus cladeFrederic Bibollet-Ruche
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Virol 78:7748-62. 2004..The vpu gene appears to have been acquired by a subset of these Cercopithecus viruses after the divergence of SIVdeb and SIVsyk... - Analysis of 15 novel full-length BK virus sequences from three individuals: evidence of a high intra-strain genetic diversityYiPing Chen
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, RE 213B, 330 Brookline Avenue, Boston, MA 02215, USA
J Gen Virol 85:2651-63. 2004..55 % of sites, implying a rate of nucleotide substitution of approximately 5 x 10(-5) substitutions per site per year, which is two orders of magnitude faster than estimated for the other human polyomavirus, JC virus... - Simian immunodeficiency virus infection in wild-caught chimpanzees from cameroonEric Nerrienet
Laboratoire de Virologie, Centre Pasteur du Cameroun, Yaound, Cameroon
J Virol 79:1312-9. 2005..Whether P. t. vellerosus apes are naturally infected with SIVcpz requires further study... - Complete genome analysis of one of the earliest SIVcpzPtt strains from Gabon (SIVcpzGAB2)Frederic Bibollet-Ruche
Department of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
AIDS Res Hum Retroviruses 20:1377-81. 2004..These data indicate extensive diversity among naturally occurring SIVcpzPtt strains and provide new insight into the origin of HIV-1 group O... - Simian immunodeficiency virus infection in free-ranging sooty mangabeys (Cercocebus atys atys) from the Taï Forest, Côte d'Ivoire: implications for the origin of epidemic human immunodeficiency virus type 2Mario L Santiago
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Virol 79:12515-27. 2005.... - AIDS: prehistory of HIV-1Paul M Sharp
Nature 455:605-6. 2008