Genomes and Genes
Affiliation: University of Aberdeen
- Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE reviewLinda Sharp
Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Scotland, UK
Am J Epidemiol 159:423-43. 2004..Overall, the roles of folate-pathway genes, folate, and related dietary factors in colorectal neoplasia are complex. Research priorities are suggested...
- Dietary flavonoid intake and colorectal cancer: a case-control studyJanet A M Kyle
Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB21 9SB, UK
Br J Nutr 103:429-36. 2010..5; 95 % CI 0.3, 0.8; P(trend) < 0.01). We concluded that flavonols, specifically quercetin, obtained from non-tea components of the diet may be linked with reduced risk of developing colon cancer...
- Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR)L Sharp
Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill House Annex, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
Cancer Lett 181:65-71. 2002..Patterns in risk with regard to genotype and folate combinations are broadly similar those reported for colorectal neoplasia. The roles of MTHFR and folate in breast cancer aetiology are likely to be complex...
- Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intakeLinda Sharp
Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, UK
Br J Nutr 99:379-89. 2008..Investigation of particular folate vitamers (for example, tetrahydrofolate, 5,10-methylenetetrahydrofolate) may help clarify carcinogenesis pathways...
- Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: a case-control study in the Grampian region of ScotlandJulian Little
Epidemiology Group, Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, UK
Int J Cancer 119:2155-64. 2006..There was no evidence of interaction between CYP1A1 and smoking, and no evidence of interaction between the GSTM1 or GSTT1 polymorphisms and smoking, meat intake, green leafy vegetable intake, CYP1A1 variants or each other...
- Length and somatic mosaicism of CAG and GGN repeats in the androgen receptor gene and the risk of prostate cancer in men with benign prostatic hyperplasiaMohammed T Tayeb
Departments of Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
Ann Saudi Med 24:21-6. 2004..We analysed the polymorphic CAG and GGN repeats sequence in exon 1 of the AR gene to determine if the number of repeats might be an indicator of PRCa risk in patients with BPH...
- After-effects reported by women having follow-up cervical cytology tests in primary care: a cohort study within the TOMBOLA trialSeonaidh Cotton
Institute of Applied Health Sciences, University of Aberdeen, Scotland, UK
Br J Gen Pract 61:e333-9. 2011..Although it is recognised that some women experience pain or bleeding during a cervical cytology test, few studies have quantified physical after-effects of these tests...
- The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of ScotlandMairi Macarthur
Department of Medicine and Therapeutics, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
Cancer Epidemiol Biomarkers Prev 14:1613-8. 2005..These results suggest that host genetics may play a role in predicting response to chemopreventive strategies. Confirmation of these findings in other populations is required...
- Trial of management of borderline and other low-grade abnormal smears (TOMBOLA): Trial designSeonaidh C Cotton
Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UK
Contemp Clin Trials 27:449-71. 2006..This paper describes the design of the trial, and discusses the rationale underlying aspects of the design and the challenges faced in designing and implementing the trial...
- The unintended consequences of cervical screening: distress in women undergoing cytologic surveillanceLinda Sharp
1National Cancer Registry Ireland, Cork Airport Business Park, Cork, Ireland 2Obstetrics and Gynaecology and 3Centre of Academic Primary Care, University of Aberdeen, Foresterhill, Aberdeen, Scotland 4Medical Statistics Team, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, Scotland 5Department of Pathology, Aberdeen Royal Infirmary, Aberdeen, Scotland 6University of Hull, Hull, England and 7Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
J Low Genit Tract Dis 18:142-50. 2014..Less is known about the impact of follow-up by repeat cytology tests. We quantified prevalence, and identified predictors, of distress after repeat cytologic testing in women with a single low-grade test...
- Is there evidence for aetiologically distinct subgroups of idiopathic congenital talipes equinovarus? A case-only study and pedigree analysisAmanda H Cardy
Clubfoot Research Group, University of Aberdeen, Aberdeen, Scotland
PLoS ONE 6:e17895. 2011..Previous studies consider CTEV as a homogenous entity which may conceal risk factors in particular subgroups. We investigate evidence for aetiologically distinct subgroups of CTEV...
- Enclosing a pen with a postal questionnaire can significantly increase the response rateLinda Sharp
Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, Scotland
J Clin Epidemiol 59:747-54. 2006..It is important to maximize response rates to postal questionnaires. We compared the impact of three low-cost interventions on response rates...
- Persistent infection with human papillomavirus following the successful treatment of high grade cervical intraepithelial neoplasiaMargaret E Cruickshank
Wellbeing Centre for the Prevention of Cervical Cancer, University of Aberdeen, UK
BJOG 109:579-81. 2002..0 (95% CI 2.13-30.37). The persistence of HPV 16/18 infection following the confirmed eradication of CIN is a highly significant risk factor for recurrence...
- Variation in WNT7A is unlikely to be a cause of familial congenital talipes equinovarusGuoqing Liu
Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, UK
BMC Med Genet 9:50. 2008..WNT7A is a plausible candidate gene for CTEV as it provides a signal for pattern formation during limb development, and mutation in WNT7A has been reported in a number of limb malformation syndromes...
- Colon cancer and genetic variation in folate metabolism: the clinical bottom lineJulian Little
Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, UK
J Nutr 133:3758S-3766S. 2003....
- CYP3A4 promoter variant is associated with prostate cancer risk in men with benign prostate hyperplasiaMohammed T Tayeb
Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, Aberdeen, UK
Oncol Rep 9:653-5. 2002..The CYP3A4 variant allele identified men with BPH who are at increased risk of progressing to PRCa (odds ratio 6.3, 95% CI 2.3-17.3), providing a potential tool to assist prediction strategies for this disease...
- United Kingdom cervical cancer screening and the costs of time and travelClaire Woolley
University of Nottingham, UK
Int J Technol Assess Health Care 23:232-9. 2007....
- The C677T polymorphism in the methylenetetrahydrofolate reductase gene (MTHFR), maternal use of folic acid supplements, and risk of isolated clubfoot: A case-parent-triad analysisLinda Sharp
National Cancer Registry Ireland, Cork, Ireland
Am J Epidemiol 164:852-61. 2006..However, clubfoot mechanisms are poorly understood, and the folate metabolism pathway is complex. Further research is needed to elucidate these relations...
- Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivoSabrina Narayanan
Division of Cellular Integrity, Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom
Cancer Epidemiol Biomarkers Prev 13:1436-43. 2004....
- Vitamin D receptor, HER-2 polymorphisms and risk of prostate cancer in men with benign prostate hyperplasiaMohammed T Tayeb
Department of Medical Sciences, Faculty of Medicine and Medical Sciences, Umm Al Qura University, Makkah, Kingdom of Saudi Arabia
Saudi Med J 25:447-51. 2004..This study used a case-control design to assess the predictive value of 3 polymorphisms in VDR (TaqI and FokI) and HER-2 (Val655Ile) to determine the risk of developing PRCa in patients with BPH...
- Folate, DNA stability and colo-rectal neoplasiaSusan J Duthie
Division of Cellular Integrity, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Proc Nutr Soc 63:571-8. 2004..Evidence from animal and human studies is presented here in support of folate acting to maintain genomic stability through both these mechanisms...
- Refining the management of low-grade cervical abnormalities in the UK National Health Service and defining the potential for human papillomavirus testing: a commentary on emerging evidenceElaine Bentley
University of Nottingham Medical School at Derby, Derby City General Hospital, UK
J Low Genit Tract Dis 10:26-38. 2006
- The epidemiologic approach to pharmacogenomicsJulian Little
Department of Epidemiology and Community Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, Ontario K1H 8M5, Canada
Am J Pharmacogenomics 5:1-20. 2005....
- Evidence for an age-related influence of microsatellite instability on colorectal cancer survivalSusan M Farrington
Colon Cancer Genetics Group, University of Edinburgh, Edinburgh, United Kingdom
Int J Cancer 98:844-50. 2002..These findings underscore the rationale for surveillance and early identification of tumours in MMR gene carriers as well as refining understanding of the influence of MSI on cancer progression...