Linda Sharp

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. ncbi Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review
    Linda Sharp
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Scotland, UK
    Am J Epidemiol 159:423-43. 2004
  2. doi Dietary flavonoid intake and colorectal cancer: a case-control study
    Janet A M Kyle
    Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB21 9SB, UK
    Br J Nutr 103:429-36. 2010
  3. ncbi Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR)
    L Sharp
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill House Annex, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Cancer Lett 181:65-71. 2002
  4. ncbi Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake
    Linda Sharp
    Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Br J Nutr 99:379-89. 2008
  5. ncbi Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: a case-control study in the Grampian region of Scotland
    Julian Little
    Epidemiology Group, Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, UK
    Int J Cancer 119:2155-64. 2006
  6. ncbi Length and somatic mosaicism of CAG and GGN repeats in the androgen receptor gene and the risk of prostate cancer in men with benign prostatic hyperplasia
    Mohammed T Tayeb
    Departments of Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Ann Saudi Med 24:21-6. 2004
  7. pmc After-effects reported by women having follow-up cervical cytology tests in primary care: a cohort study within the TOMBOLA trial
    Seonaidh Cotton
    Institute of Applied Health Sciences, University of Aberdeen, Scotland, UK
    Br J Gen Pract 61:e333-9. 2011
  8. ncbi The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of Scotland
    Mairi Macarthur
    Department of Medicine and Therapeutics, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:1613-8. 2005
  9. ncbi Trial of management of borderline and other low-grade abnormal smears (TOMBOLA): Trial design
    Seonaidh C Cotton
    Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UK
    Contemp Clin Trials 27:449-71. 2006
  10. ncbi The unintended consequences of cervical screening: distress in women undergoing cytologic surveillance
    Linda Sharp
    1National Cancer Registry Ireland, Cork Airport Business Park, Cork, Ireland 2Obstetrics and Gynaecology and 3Centre of Academic Primary Care, University of Aberdeen, Foresterhill, Aberdeen, Scotland 4Medical Statistics Team, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, Scotland 5Department of Pathology, Aberdeen Royal Infirmary, Aberdeen, Scotland 6University of Hull, Hull, England and 7Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Low Genit Tract Dis 18:142-50. 2014

Collaborators

Detail Information

Publications24

  1. ncbi Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review
    Linda Sharp
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Scotland, UK
    Am J Epidemiol 159:423-43. 2004
    ..Overall, the roles of folate-pathway genes, folate, and related dietary factors in colorectal neoplasia are complex. Research priorities are suggested...
  2. doi Dietary flavonoid intake and colorectal cancer: a case-control study
    Janet A M Kyle
    Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB21 9SB, UK
    Br J Nutr 103:429-36. 2010
    ..5; 95 % CI 0.3, 0.8; P(trend) < 0.01). We concluded that flavonols, specifically quercetin, obtained from non-tea components of the diet may be linked with reduced risk of developing colon cancer...
  3. ncbi Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR)
    L Sharp
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill House Annex, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Cancer Lett 181:65-71. 2002
    ..Patterns in risk with regard to genotype and folate combinations are broadly similar those reported for colorectal neoplasia. The roles of MTHFR and folate in breast cancer aetiology are likely to be complex...
  4. ncbi Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake
    Linda Sharp
    Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Br J Nutr 99:379-89. 2008
    ..Investigation of particular folate vitamers (for example, tetrahydrofolate, 5,10-methylenetetrahydrofolate) may help clarify carcinogenesis pathways...
  5. ncbi Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: a case-control study in the Grampian region of Scotland
    Julian Little
    Epidemiology Group, Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, UK
    Int J Cancer 119:2155-64. 2006
    ..There was no evidence of interaction between CYP1A1 and smoking, and no evidence of interaction between the GSTM1 or GSTT1 polymorphisms and smoking, meat intake, green leafy vegetable intake, CYP1A1 variants or each other...
  6. ncbi Length and somatic mosaicism of CAG and GGN repeats in the androgen receptor gene and the risk of prostate cancer in men with benign prostatic hyperplasia
    Mohammed T Tayeb
    Departments of Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Ann Saudi Med 24:21-6. 2004
    ..We analysed the polymorphic CAG and GGN repeats sequence in exon 1 of the AR gene to determine if the number of repeats might be an indicator of PRCa risk in patients with BPH...
  7. pmc After-effects reported by women having follow-up cervical cytology tests in primary care: a cohort study within the TOMBOLA trial
    Seonaidh Cotton
    Institute of Applied Health Sciences, University of Aberdeen, Scotland, UK
    Br J Gen Pract 61:e333-9. 2011
    ..Although it is recognised that some women experience pain or bleeding during a cervical cytology test, few studies have quantified physical after-effects of these tests...
  8. ncbi The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of Scotland
    Mairi Macarthur
    Department of Medicine and Therapeutics, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:1613-8. 2005
    ..These results suggest that host genetics may play a role in predicting response to chemopreventive strategies. Confirmation of these findings in other populations is required...
  9. ncbi Trial of management of borderline and other low-grade abnormal smears (TOMBOLA): Trial design
    Seonaidh C Cotton
    Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UK
    Contemp Clin Trials 27:449-71. 2006
    ..This paper describes the design of the trial, and discusses the rationale underlying aspects of the design and the challenges faced in designing and implementing the trial...
  10. ncbi The unintended consequences of cervical screening: distress in women undergoing cytologic surveillance
    Linda Sharp
    1National Cancer Registry Ireland, Cork Airport Business Park, Cork, Ireland 2Obstetrics and Gynaecology and 3Centre of Academic Primary Care, University of Aberdeen, Foresterhill, Aberdeen, Scotland 4Medical Statistics Team, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, Scotland 5Department of Pathology, Aberdeen Royal Infirmary, Aberdeen, Scotland 6University of Hull, Hull, England and 7Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Low Genit Tract Dis 18:142-50. 2014
    ..Less is known about the impact of follow-up by repeat cytology tests. We quantified prevalence, and identified predictors, of distress after repeat cytologic testing in women with a single low-grade test...
  11. pmc Is there evidence for aetiologically distinct subgroups of idiopathic congenital talipes equinovarus? A case-only study and pedigree analysis
    Amanda H Cardy
    Clubfoot Research Group, University of Aberdeen, Aberdeen, Scotland
    PLoS ONE 6:e17895. 2011
    ..Previous studies consider CTEV as a homogenous entity which may conceal risk factors in particular subgroups. We investigate evidence for aetiologically distinct subgroups of CTEV...
  12. ncbi Enclosing a pen with a postal questionnaire can significantly increase the response rate
    Linda Sharp
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, Scotland
    J Clin Epidemiol 59:747-54. 2006
    ..It is important to maximize response rates to postal questionnaires. We compared the impact of three low-cost interventions on response rates...
  13. ncbi Persistent infection with human papillomavirus following the successful treatment of high grade cervical intraepithelial neoplasia
    Margaret E Cruickshank
    Wellbeing Centre for the Prevention of Cervical Cancer, University of Aberdeen, UK
    BJOG 109:579-81. 2002
    ..0 (95% CI 2.13-30.37). The persistence of HPV 16/18 infection following the confirmed eradication of CIN is a highly significant risk factor for recurrence...
  14. pmc Variation in WNT7A is unlikely to be a cause of familial congenital talipes equinovarus
    Guoqing Liu
    Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, UK
    BMC Med Genet 9:50. 2008
    ..WNT7A is a plausible candidate gene for CTEV as it provides a signal for pattern formation during limb development, and mutation in WNT7A has been reported in a number of limb malformation syndromes...
  15. ncbi Colon cancer and genetic variation in folate metabolism: the clinical bottom line
    Julian Little
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, UK
    J Nutr 133:3758S-3766S. 2003
    ....
  16. ncbi CYP3A4 promoter variant is associated with prostate cancer risk in men with benign prostate hyperplasia
    Mohammed T Tayeb
    Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, Aberdeen, UK
    Oncol Rep 9:653-5. 2002
    ..The CYP3A4 variant allele identified men with BPH who are at increased risk of progressing to PRCa (odds ratio 6.3, 95% CI 2.3-17.3), providing a potential tool to assist prediction strategies for this disease...
  17. ncbi United Kingdom cervical cancer screening and the costs of time and travel
    Claire Woolley
    University of Nottingham, UK
    Int J Technol Assess Health Care 23:232-9. 2007
    ....
  18. ncbi The C677T polymorphism in the methylenetetrahydrofolate reductase gene (MTHFR), maternal use of folic acid supplements, and risk of isolated clubfoot: A case-parent-triad analysis
    Linda Sharp
    National Cancer Registry Ireland, Cork, Ireland
    Am J Epidemiol 164:852-61. 2006
    ..However, clubfoot mechanisms are poorly understood, and the folate metabolism pathway is complex. Further research is needed to elucidate these relations...
  19. ncbi Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo
    Sabrina Narayanan
    Division of Cellular Integrity, Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom
    Cancer Epidemiol Biomarkers Prev 13:1436-43. 2004
    ....
  20. ncbi Vitamin D receptor, HER-2 polymorphisms and risk of prostate cancer in men with benign prostate hyperplasia
    Mohammed T Tayeb
    Department of Medical Sciences, Faculty of Medicine and Medical Sciences, Umm Al Qura University, Makkah, Kingdom of Saudi Arabia
    Saudi Med J 25:447-51. 2004
    ..This study used a case-control design to assess the predictive value of 3 polymorphisms in VDR (TaqI and FokI) and HER-2 (Val655Ile) to determine the risk of developing PRCa in patients with BPH...
  21. ncbi Folate, DNA stability and colo-rectal neoplasia
    Susan J Duthie
    Division of Cellular Integrity, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Proc Nutr Soc 63:571-8. 2004
    ..Evidence from animal and human studies is presented here in support of folate acting to maintain genomic stability through both these mechanisms...
  22. ncbi Refining the management of low-grade cervical abnormalities in the UK National Health Service and defining the potential for human papillomavirus testing: a commentary on emerging evidence
    Elaine Bentley
    University of Nottingham Medical School at Derby, Derby City General Hospital, UK
    J Low Genit Tract Dis 10:26-38. 2006
  23. ncbi The epidemiologic approach to pharmacogenomics
    Julian Little
    Department of Epidemiology and Community Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, Ontario K1H 8M5, Canada
    Am J Pharmacogenomics 5:1-20. 2005
    ....
  24. ncbi Evidence for an age-related influence of microsatellite instability on colorectal cancer survival
    Susan M Farrington
    Colon Cancer Genetics Group, University of Edinburgh, Edinburgh, United Kingdom
    Int J Cancer 98:844-50. 2002
    ..These findings underscore the rationale for surveillance and early identification of tumours in MMR gene carriers as well as refining understanding of the influence of MSI on cancer progression...