Kevin M Shakesheff
Affiliation: University of Nottingham
Dixon J, Osman G, Morris G, Markides H, Rotherham M, Bayoussef Z, et al
. Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides. Proc Natl Acad Sci U S A. 2016;113:E291-9 pubmed publisher
..This technology represents an efficient strategy for controlling cell labeling and directing cell fate or behavior that has broad applicability for basic research, disease modeling, and clinical application. ..
Amer M, Rose F, White L, Shakesheff K. A Detailed Assessment of Varying Ejection Rate on Delivery Efficiency of Mesenchymal Stem Cells Using Narrow-Bore Needles. Stem Cells Transl Med. 2016;5:366-78 pubmed publisher
..The findings of this study demonstrate that ejection rate has substantial impact on the percentage of cell dose delivered and cellular health postejection. ..
Eltaher H, Yang J, Shakesheff K, Dixon J. Highly efficient intracellular transduction in three-dimensional gradients for programming cell fate. Acta Biomater. 2016;41:181-92 pubmed publisher
..We believe that GET could provide a powerful tool to program cell behaviour using gradients of recombinant proteins that allow tissue generation directly by programming gene expression with TFs. ..
Xue X, Thiagarajan L, Dixon J, Saunders B, Shakesheff K, Alexander C. Post-Modified Polypeptides with UCST-Type Behavior for Control of Cell Attachment in Physiological Conditions. Materials (Basel). 2018;11: pubmed publisher
..These new TRP coatings provide an additional means to mediate cell attachment for application in cell-based tissue regeneration and therapies. ..
Baki A, Rahman C, White L, Scurr D, Qutachi O, Shakesheff K. Surface modification of PdlLGA microspheres with gelatine methacrylate: Evaluation of adsorption, entrapment, and oxygen plasma treatment approaches. Acta Biomater. 2017;53:450-459 pubmed publisher
Kirby G, White L, Steck R, Berner A, Bogoevski K, Qutachi O, et al
. Microparticles for Sustained Growth Factor Delivery in the Regeneration of Critically-Sized Segmental Tibial Bone Defects. Materials (Basel). 2016;9: pubmed publisher
..However, regions treated with VEGF and PDGF showed increased vascularity. This study demonstrates an effective method for the controlled delivery of therapeutic growth factors in vivo, using microparticles. ..