Mala M Shah

Summary

Affiliation: University of London
Country: UK

Publications

  1. ncbi HCN and KV7 (M-) channels as targets for epilepsy treatment
    Mala M Shah
    Department of Pharmacology, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
    Neuropharmacology 69:75-81. 2013
  2. ncbi Differential effects of Kv7 (M-) channels on synaptic integration in distinct subcellular compartments of rat hippocampal pyramidal neurons
    Mala M Shah
    Department of Pharmacology, School of Pharmacy, University of London, London, UK
    J Physiol 589:6029-38. 2011
  3. ncbi Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons
    Mala M Shah
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 105:7869-74. 2008
  4. ncbi Dendritic ion channel trafficking and plasticity
    Mala M Shah
    Department of Pharmacology, The School of Pharmacy, University of London, London, WC1N 1AX, UK
    Trends Neurosci 33:307-16. 2010
  5. ncbi TRIP8b-Independent Trafficking and Plasticity of Adult Cortical Presynaptic HCN1 Channels
    Zhuo Huang
    Department of Pharmacology, UCL School of Pharmacy, University College London, London, WC1N 1AX, United Kingdom, Departamento Ciencias Medicas, Centro de Investigación en Discapacidades Neurológicas IDINE, Universidad de Castilla La Mancha, 02006 Albacete, Spain, Davee Department of Neurology and Clinical Neurosciences and Department of Physiology, Northwestern Feinberg School of Medicine, Chicago, Illinois 60611 3078
    J Neurosci 32:14835-48. 2012
  6. ncbi Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077)
    Mala M Shah
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT UK
    Mol Pharmacol 70:1494-502. 2006
  7. ncbi Tritylamino aromatic heterocycles and related carbinols as blockers of ca 2+-activated potassium ion channels underlying neuronal hyperpolarization
    Patricia A Zunszain
    Department of Chemistry, University College London, 20 Gordon Street, UK
    Arch Pharm (Weinheim) 335:159-66. 2002
  8. ncbi Loss of dendritic HCN1 subunits enhances cortical excitability and epileptogenesis
    Zhuo Huang
    Department of Pharmacology, The School of Pharmacy, University of London, London WC1N 1AX, United Kingdom
    J Neurosci 29:10979-88. 2009
  9. ncbi Presynaptic HCN1 channels regulate Cav3.2 activity and neurotransmission at select cortical synapses
    Zhuo Huang
    Department of Pharmacology, The School of Pharmacy, University of London, London, UK
    Nat Neurosci 14:478-86. 2011
  10. ncbi Hippocalcin: a new solution to an old puzzle
    David A Brown
    Department of Pharmacology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
    Neuron 53:467-8. 2007

Collaborators

Detail Information

Publications13

  1. ncbi HCN and KV7 (M-) channels as targets for epilepsy treatment
    Mala M Shah
    Department of Pharmacology, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
    Neuropharmacology 69:75-81. 2013
    ..This article is part of the Special Issue entitled 'New Targets and Approaches to the Treatment of Epilepsy'...
  2. ncbi Differential effects of Kv7 (M-) channels on synaptic integration in distinct subcellular compartments of rat hippocampal pyramidal neurons
    Mala M Shah
    Department of Pharmacology, School of Pharmacy, University of London, London, UK
    J Physiol 589:6029-38. 2011
    ..This may be important for their relative contributions to physiological processes such as synaptic plasticity as well as patho-physiological conditions such as epilepsy...
  3. ncbi Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons
    Mala M Shah
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 105:7869-74. 2008
    ..These results indicate that axonal Kv7 channels, by controlling axonal RMP and action potential threshold, are fundamental for regulating the inherent firing properties of CA1 hippocampal neurons...
  4. ncbi Dendritic ion channel trafficking and plasticity
    Mala M Shah
    Department of Pharmacology, The School of Pharmacy, University of London, London, WC1N 1AX, UK
    Trends Neurosci 33:307-16. 2010
    ..We also consider the implications for neuronal function. We argue that to gain an insight into neuronal information processing it is essential to understand the regulation of dendritic ion channel expression and properties...
  5. ncbi TRIP8b-Independent Trafficking and Plasticity of Adult Cortical Presynaptic HCN1 Channels
    Zhuo Huang
    Department of Pharmacology, UCL School of Pharmacy, University College London, London, WC1N 1AX, United Kingdom, Departamento Ciencias Medicas, Centro de Investigación en Discapacidades Neurológicas IDINE, Universidad de Castilla La Mancha, 02006 Albacete, Spain, Davee Department of Neurology and Clinical Neurosciences and Department of Physiology, Northwestern Feinberg School of Medicine, Chicago, Illinois 60611 3078
    J Neurosci 32:14835-48. 2012
    ....
  6. ncbi Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077)
    Mala M Shah
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT UK
    Mol Pharmacol 70:1494-502. 2006
    ....
  7. ncbi Tritylamino aromatic heterocycles and related carbinols as blockers of ca 2+-activated potassium ion channels underlying neuronal hyperpolarization
    Patricia A Zunszain
    Department of Chemistry, University College London, 20 Gordon Street, UK
    Arch Pharm (Weinheim) 335:159-66. 2002
    ..1-1.2 microM) and are much more selective than clotrimazole since they have less effect on the high voltage-activated Ca2+ current...
  8. ncbi Loss of dendritic HCN1 subunits enhances cortical excitability and epileptogenesis
    Zhuo Huang
    Department of Pharmacology, The School of Pharmacy, University of London, London WC1N 1AX, United Kingdom
    J Neurosci 29:10979-88. 2009
    ..Furthermore, these findings suggest that the reduction in dendritic HCN1 subunit expression during epileptogenesis is likely to facilitate the disorder...
  9. ncbi Presynaptic HCN1 channels regulate Cav3.2 activity and neurotransmission at select cortical synapses
    Zhuo Huang
    Department of Pharmacology, The School of Pharmacy, University of London, London, UK
    Nat Neurosci 14:478-86. 2011
    ..2 subunit. This represents a previously unknown mechanism by which HCN channels regulate synaptic strength and thereby neural information processing and network excitability...
  10. ncbi Hippocalcin: a new solution to an old puzzle
    David A Brown
    Department of Pharmacology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
    Neuron 53:467-8. 2007
    ..In this issue of Neuron, Tzingounis et al. now show that calcium binding to hippocalcin, a member of the NCS family, is one of the necessary steps involved in production of the sAHP...
  11. ncbi HCN1 channels: a new therapeutic target for depressive disorders?
    Mala M Shah
    UCL School of Pharmacy, University College, London WC1N 1AX, UK
    Sci Signal 5:pe44. 2012
    ..Recent evidence suggests that these channels may also be therapeutic targets for treatment of depressive disorders...
  12. ncbi K+ currents generated by NMDA receptor activation in rat hippocampal pyramidal neurons
    Mala M Shah
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurophysiol 87:2983-9. 2002
    ..The activation of these channels may, however, depend on their location relative to NMDA receptors as well as on the spatial Ca2+ buffering within individual neurons...
  13. ncbi Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons
    Mala M Shah
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 44:495-508. 2004
    ..Our results suggest that dendritic I(h) plays an important role in determining the excitability of EC layer III neurons and their associated neural networks...