Mala M Shah

Summary

Affiliation: University of London
Country: UK

Publications

  1. pmc Presynaptic HCN1 channels regulate Cav3.2 activity and neurotransmission at select cortical synapses
    Zhuo Huang
    Department of Pharmacology, The School of Pharmacy, University of London, London, UK
    Nat Neurosci 14:478-86. 2011
  2. doi request reprint HCN and KV7 (M-) channels as targets for epilepsy treatment
    Mala M Shah
    Department of Pharmacology, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
    Neuropharmacology 69:75-81. 2013
  3. pmc Dendritic ion channel trafficking and plasticity
    Mala M Shah
    Department of Pharmacology, The School of Pharmacy, University of London, London, WC1N 1AX, UK
    Trends Neurosci 33:307-16. 2010
  4. pmc Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons
    Mala M Shah
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 105:7869-74. 2008
  5. pmc Differential effects of Kv7 (M-) channels on synaptic integration in distinct subcellular compartments of rat hippocampal pyramidal neurons
    Mala M Shah
    Department of Pharmacology, School of Pharmacy, University of London, London, UK
    J Physiol 589:6029-38. 2011
  6. pmc Loss of dendritic HCN1 subunits enhances cortical excitability and epileptogenesis
    Zhuo Huang
    Department of Pharmacology, The School of Pharmacy, University of London, London WC1N 1AX, United Kingdom
    J Neurosci 29:10979-88. 2009
  7. doi request reprint TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels
    Zhuo Huang
    Department of Pharmacology, UCL School of Pharmacy, University College London, London, WC1N 1AX, United Kingdom
    J Neurosci 32:14835-48. 2012
  8. pmc Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077)
    Mala M Shah
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT UK
    Mol Pharmacol 70:1494-502. 2006
  9. ncbi request reprint Tritylamino aromatic heterocycles and related carbinols as blockers of ca 2+-activated potassium ion channels underlying neuronal hyperpolarization
    Patricia A Zunszain
    Department of Chemistry, University College London, 20 Gordon Street, UK
    Arch Pharm (Weinheim) 335:159-66. 2002
  10. pmc Hippocalcin: a new solution to an old puzzle
    David A Brown
    Department of Pharmacology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
    Neuron 53:467-8. 2007

Collaborators

Detail Information

Publications15

  1. pmc Presynaptic HCN1 channels regulate Cav3.2 activity and neurotransmission at select cortical synapses
    Zhuo Huang
    Department of Pharmacology, The School of Pharmacy, University of London, London, UK
    Nat Neurosci 14:478-86. 2011
    ..2 subunit. This represents a previously unknown mechanism by which HCN channels regulate synaptic strength and thereby neural information processing and network excitability...
  2. doi request reprint HCN and KV7 (M-) channels as targets for epilepsy treatment
    Mala M Shah
    Department of Pharmacology, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
    Neuropharmacology 69:75-81. 2013
    ..This article is part of the Special Issue entitled 'New Targets and Approaches to the Treatment of Epilepsy'...
  3. pmc Dendritic ion channel trafficking and plasticity
    Mala M Shah
    Department of Pharmacology, The School of Pharmacy, University of London, London, WC1N 1AX, UK
    Trends Neurosci 33:307-16. 2010
    ..We also consider the implications for neuronal function. We argue that to gain an insight into neuronal information processing it is essential to understand the regulation of dendritic ion channel expression and properties...
  4. pmc Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons
    Mala M Shah
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 105:7869-74. 2008
    ..These results indicate that axonal Kv7 channels, by controlling axonal RMP and action potential threshold, are fundamental for regulating the inherent firing properties of CA1 hippocampal neurons...
  5. pmc Differential effects of Kv7 (M-) channels on synaptic integration in distinct subcellular compartments of rat hippocampal pyramidal neurons
    Mala M Shah
    Department of Pharmacology, School of Pharmacy, University of London, London, UK
    J Physiol 589:6029-38. 2011
    ..This may be important for their relative contributions to physiological processes such as synaptic plasticity as well as patho-physiological conditions such as epilepsy...
  6. pmc Loss of dendritic HCN1 subunits enhances cortical excitability and epileptogenesis
    Zhuo Huang
    Department of Pharmacology, The School of Pharmacy, University of London, London WC1N 1AX, United Kingdom
    J Neurosci 29:10979-88. 2009
    ..Furthermore, these findings suggest that the reduction in dendritic HCN1 subunit expression during epileptogenesis is likely to facilitate the disorder...
  7. doi request reprint TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels
    Zhuo Huang
    Department of Pharmacology, UCL School of Pharmacy, University College London, London, WC1N 1AX, United Kingdom
    J Neurosci 32:14835-48. 2012
    ....
  8. pmc Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077)
    Mala M Shah
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT UK
    Mol Pharmacol 70:1494-502. 2006
    ....
  9. ncbi request reprint Tritylamino aromatic heterocycles and related carbinols as blockers of ca 2+-activated potassium ion channels underlying neuronal hyperpolarization
    Patricia A Zunszain
    Department of Chemistry, University College London, 20 Gordon Street, UK
    Arch Pharm (Weinheim) 335:159-66. 2002
    ..1-1.2 microM) and are much more selective than clotrimazole since they have less effect on the high voltage-activated Ca2+ current...
  10. pmc Hippocalcin: a new solution to an old puzzle
    David A Brown
    Department of Pharmacology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
    Neuron 53:467-8. 2007
    ..In this issue of Neuron, Tzingounis et al. now show that calcium binding to hippocalcin, a member of the NCS family, is one of the necessary steps involved in production of the sAHP...
  11. ncbi request reprint K+ currents generated by NMDA receptor activation in rat hippocampal pyramidal neurons
    Mala M Shah
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurophysiol 87:2983-9. 2002
    ..The activation of these channels may, however, depend on their location relative to NMDA receptors as well as on the spatial Ca2+ buffering within individual neurons...
  12. pmc The LIM homeodomain protein Lhx6 regulates maturation of interneurons and network excitability in the mammalian cortex
    Guilherme Neves
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, London, UK
    Cereb Cortex 23:1811-23. 2013
    ..These results demonstrate that Lhx6 plays an important role in the maturation of cortical interneurons and the formation of inhibitory circuits in the mammalian cortex. ..
  13. doi request reprint Recording dendritic ion channel properties and function from cortical neurons
    Mala M Shah
    Department of Pharmacology, UCL School of Pharmacy, University College London, London, UK
    Methods Mol Biol 998:303-9. 2013
    ..In this chapter, I describe one such method that is suitable for making electrophysiological recordings from the apical dendrites of hippocampal and cortical pyramidal neurons...
  14. doi request reprint HCN1 channels: a new therapeutic target for depressive disorders?
    Mala M Shah
    UCL School of Pharmacy, University College, London WC1N 1AX, UK
    Sci Signal 5:pe44. 2012
    ..Recent evidence suggests that these channels may also be therapeutic targets for treatment of depressive disorders...
  15. pmc Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons
    Mala M Shah
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 44:495-508. 2004
    ..Our results suggest that dendritic I(h) plays an important role in determining the excitability of EC layer III neurons and their associated neural networks...