R A Seymour

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Antibiotic prophylaxis for endocarditis, prosthetic joints, and surgery
    Robin A Seymour
    Department of Restorative Dentistry, Dental School, Framlington Place, Newcastle upon Tyne, NE2 4BW, United Kingdom
    Dent Clin North Am 46:635-51. 2002
  2. ncbi request reprint Antibiotic prophylaxis for patients with joint prostheses - still a dilemma for dental practitioners
    R A Seymour
    Department of Restorative Dentistry, School of Dental Sciences, University of Newcastle upon Tyne, Framlington Place, NE2 4BW
    Br Dent J 194:649-53. 2003
  3. ncbi request reprint Cardiovascular diseases and periodontology
    R A Seymour
    Department of Restorative Dentistry, The Dental School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4BW, UK
    J Clin Periodontol 30:279-92. 2003
  4. ncbi request reprint Oral health and heart disease
    Robin A Seymour
    Department of Restorative Dentistry, The Dental School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4BW
    Prim Dent Care 9:125-31. 2002
  5. ncbi request reprint Determinants of gingival overgrowth severity in organ transplant patients. An examination of the rôle of HLA phenotype
    J M Thomason
    Department of Restorative Dentistry, University of Newcastle, Newcastle upon Tyne, UK
    J Clin Periodontol 23:628-34. 1996
  6. ncbi request reprint Nifedipine pharmacological variables as risk factors for gingival overgrowth in organ-transplant patients
    J M Thomason
    Department of Restorative Dentistry, Dental School, University of Newcastle upon Tyne, England
    Clin Oral Investig 1:35-9. 1997
  7. ncbi request reprint The effect of multiple anticonvulsant therapy on the expression of phenytoin-induced gingival overgrowth
    F Kamali
    Wolfson Unit of Clinical Pharmacology, University of Newcastle, Newcastle upon Tyne, UK
    J Clin Periodontol 26:802-5. 1999
  8. ncbi request reprint The efficacy of three different surgical techniques in the management of drug-induced gingival overgrowth
    M Mavrogiannis
    School of Dental Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    J Clin Periodontol 33:677-82. 2006
  9. ncbi request reprint Dentistry and the medically compromised patient
    R A Seymour
    School of Dental Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NED2 4BW
    Surgeon 1:207-14. 2003
  10. ncbi request reprint Change in cardiovascular risk status after dental clearance
    J S Ellis
    School of Dental Sciences, University of Newcastle upon Tyne, Framlington Place, UK
    Br Dent J 202:543-4. 2007

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Antibiotic prophylaxis for endocarditis, prosthetic joints, and surgery
    Robin A Seymour
    Department of Restorative Dentistry, Dental School, Framlington Place, Newcastle upon Tyne, NE2 4BW, United Kingdom
    Dent Clin North Am 46:635-51. 2002
    ..The profession does require clear, uniform guidelines that are evidence-based. At present, there is still significant debate as to who is at risk from dental-induced bacteremia and what procedures require chemoprophylaxis...
  2. ncbi request reprint Antibiotic prophylaxis for patients with joint prostheses - still a dilemma for dental practitioners
    R A Seymour
    Department of Restorative Dentistry, School of Dental Sciences, University of Newcastle upon Tyne, Framlington Place, NE2 4BW
    Br Dent J 194:649-53. 2003
    ..To provide a critical review of the current evidence that implicates dental-induced bacteraemia as a risk for joint infections in patients fitted with joint prostheses and appraise the need for antibiotic prophylaxis...
  3. ncbi request reprint Cardiovascular diseases and periodontology
    R A Seymour
    Department of Restorative Dentistry, The Dental School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4BW, UK
    J Clin Periodontol 30:279-92. 2003
    ..The various diseases and their treatments can have an impact upon the periodontium and the delivery of periodontal care...
  4. ncbi request reprint Oral health and heart disease
    Robin A Seymour
    Department of Restorative Dentistry, The Dental School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4BW
    Prim Dent Care 9:125-31. 2002
    ..A brief synopsis of the epidemiological studies to date and their outcomes is shown in Table 1...
  5. ncbi request reprint Determinants of gingival overgrowth severity in organ transplant patients. An examination of the rôle of HLA phenotype
    J M Thomason
    Department of Restorative Dentistry, University of Newcastle, Newcastle upon Tyne, UK
    J Clin Periodontol 23:628-34. 1996
    ..The data at present available would suggest that the severity of gingival overgrowth is also significantly associated with the HLA-B37 phenotype...
  6. ncbi request reprint Nifedipine pharmacological variables as risk factors for gingival overgrowth in organ-transplant patients
    J M Thomason
    Department of Restorative Dentistry, Dental School, University of Newcastle upon Tyne, England
    Clin Oral Investig 1:35-9. 1997
    ..01) once adjusted for other known risk factors (R2 for the model = 55%)...
  7. ncbi request reprint The effect of multiple anticonvulsant therapy on the expression of phenytoin-induced gingival overgrowth
    F Kamali
    Wolfson Unit of Clinical Pharmacology, University of Newcastle, Newcastle upon Tyne, UK
    J Clin Periodontol 26:802-5. 1999
    ....
  8. ncbi request reprint The efficacy of three different surgical techniques in the management of drug-induced gingival overgrowth
    M Mavrogiannis
    School of Dental Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    J Clin Periodontol 33:677-82. 2006
    ..The aim of the present study was to evaluate the efficacy of three different surgical techniques in both the management and effect upon rate of overgrowth recurrence of drug-induced gingival overgrowth (DIGO)...
  9. ncbi request reprint Dentistry and the medically compromised patient
    R A Seymour
    School of Dental Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NED2 4BW
    Surgeon 1:207-14. 2003
    ..Although the association is convincing, casualty has not been established. If casualty for this relationship can be confirmed then the delivery of dental care and the promotion of oral health will receive a significant impetus...
  10. ncbi request reprint Change in cardiovascular risk status after dental clearance
    J S Ellis
    School of Dental Sciences, University of Newcastle upon Tyne, Framlington Place, UK
    Br Dent J 202:543-4. 2007
    ..CRP levels have also been shown to decrease following periodontal therapy. CRP is a reliable marker of the acute phase reaction to infections and/or inflammation and is a powerful predictor of future coronary events...
  11. ncbi request reprint Incidence and severity of phenytoin-induced gingival overgrowth in epileptic patients in general medical practice
    J M Thomason
    Dental School, University of Newcastle upon Tyne, England
    Community Dent Oral Epidemiol 20:288-91. 1992
    ..The overall incidence of clinically significant overgrowth (13%) is considerably less than in other studies...
  12. ncbi request reprint An investigation into the efficacy of intravenous diclofenac in post-operative dental pain
    R A Seymour
    Department of Restorative Dentistry, Dental School, Newcastle upon Tyne, UK
    Eur J Clin Pharmacol 56:447-52. 2000
    ..To evaluate the efficacy of single doses of intravenous diclofenac sodium (25, 50 and 75 mg) in patients with post-operative pain after third-molar surgery in a randomised, placebo-controlled study...
  13. ncbi request reprint Gingival fibroblasts grown from cyclosporin-treated patients show a reduced production of matrix metalloproteinase-1 (MMP-1) compared with normal gingival fibroblasts, and cyclosporin down-regulates the production of MMP-1 stimulated by pro-inflammatory c
    T Z Sukkar
    School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, UK
    J Periodontal Res 42:580-8. 2007
    ....
  14. ncbi request reprint Immunolocalization of collagenase (MMP-1) and stromelysin (MMP-3) in the gingival tissues of organ transplant patients medicated with cyclosporin
    J M Thomason
    Department of Restorative Dentistry, The University of Newcastle, Newcastle upon Tyne, UK
    J Clin Periodontol 25:554-60. 1998
    ....
  15. ncbi request reprint Photographic scoring of gingival overgrowth
    J S Ellis
    The Dental School, University of Newcastle upon Tyne, UK
    J Clin Periodontol 28:81-5. 2001
    ..71). CONCLUSIONS: The results indicate that this method is suitable for large-scale population studies where it also has the advantage of providing a continuous scale of gingival changes for subsequent statistical analysis...
  16. ncbi request reprint Phenytoin metabolism to 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH) in man, cat and rat in vitro and in vivo, and susceptibility to phenytoin-induced gingival overgrowth
    F Kamali
    Wolfson Unit of Clinical Pharmacology, University of Newcastle, Newcastle upon Tyne, UK
    J Periodontal Res 34:145-53. 1999
    ..The results suggest that the rapid metabolism and elimination of PHT and HPPH in the rat may enable it to become more resistant towards developing gingival overgrowth, compared to the cat and man...
  17. ncbi request reprint Post-transplant lymphoproliferative disorders presenting as gingival overgrowth in patients immunosuppressed with ciclosporin. A report of two cases
    S L Rolland
    School of Dental Sciences, University of Newcastle, Framlington Place, Newcastle upon Tyne, UK
    J Clin Periodontol 31:581-5. 2004
    ..This paper describes two cases of PTLD occurring in gingival tissues, in patients receiving ciclosporin following cardiac transplantation...
  18. ncbi request reprint The management of drug-induced gingival overgrowth
    M Mavrogiannis
    School of Dental Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, UK
    J Clin Periodontol 33:434-9. 2006
    ..This review critically evaluates the different therapies that are available to manage drug-induced overgrowth (DIGO)...
  19. ncbi request reprint Infective endocarditis, dentistry and antibiotic prophylaxis; time for a rethink?
    R A Seymour
    Department of Restorative Dentistry, The Dental School, University of Newcastle upon Tyne
    Br Dent J 189:610-6. 2000
    ..To provide a critical review of the current evidence that links dental treatment to infective endocarditis (IE) and appraise the risks of antibiotic chemoprophylaxis...
  20. ncbi request reprint Human diseases - the Newcastle experience
    M Greenwood
    Newcastle University, School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4BW
    Br Dent J 203:595-8. 2007
    ..Previously, many of these topics were taught and examined separately. In this article, we would like to share the Newcastle experience of developing a course in human diseases alongside the GDC guidelines...
  21. ncbi request reprint Risk factors for gingival overgrowth in patients medicated with ciclosporin in the absence of calcium channel blockers
    J Mark Thomason
    School of Dental Sciences, University of Newcastle upon Tyne, UK
    J Clin Periodontol 32:273-9. 2005
    ..This study investigates the effect of a range of potential risk factors on the severity of gingival overgrowth in transplant patients medicated with ciclosporin in the absence of any calcium channel blockers...
  22. doi request reprint Antibiotics and chemoprophylaxis
    Robin A Seymour
    School of Dental Sciences, Newcastle University, Newcastle upon Tyne, UK
    Periodontol 2000 46:80-108. 2008
  23. ncbi request reprint Analysis of changes in gingival contour from three-dimensional co-ordinate data in subjects with drug-induced gingival overgrowth
    J M Thomason
    School of Dental Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4BW, UK
    J Clin Periodontol 32:1069-75. 2005
    ....
  24. doi request reprint Are alcohol containing mouthwashes safe?
    C W de A Werner
    School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne
    Br Dent J 207:E19; discussion 488-9. 2009
    ..In view of this outcome and the hypothetical risk of oral cancer, it would seem prudent that members of the dental team advise their patients accordingly...
  25. ncbi request reprint Dental treatment, antibiotic cover and infective endocarditis: a major rethink
    Robin A Seymour
    School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4BW, UK
    Dent Update 35:366-8, 370. 2008
    ..The NICE Guidelines on Prophylaxis against Infective Endocarditis were published early this year. In this review, consideration is given to the evidence that the Working Party evaluated in arriving at their recommendations...
  26. ncbi request reprint Prevalence of gingival overgrowth in transplant patients immunosuppressed with tacrolimus
    J S Ellis
    School of Dental Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4BW, UK
    J Clin Periodontol 31:126-31. 2004
    ....
  27. doi request reprint Is gum disease killing your patient?
    R A Seymour
    School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4BW
    Br Dent J 206:551-2. 2009
    ..This has been shown to improve hyperglycaemic control in diabetics, reduce the prevalence of adverse pregnancy outcomes and improve surrogate markers that may be of benefit in patients suffering from coronary heart disease...
  28. doi request reprint The efficacy of topical hyaluronic acid in the management of oral lichen planus
    A Nolan
    Department of Oral Medicine, University of Dundee, Dental School, Dundee, UK
    J Oral Pathol Med 38:299-303. 2009
    ..The aim of this study was to evaluate the efficacy of a topical hyaluronic acid (HA) gel preparation (0.2%) in the management of oral lichen planus (OLP)...
  29. ncbi request reprint An investigation into the comparative efficacy of soluble aspirin and solid paracetamol in postoperative pain after third molar surgery
    R A Seymour
    Department of Restorative Dentistry, Dental School, University of Newcastle, Newcastle upon Tyne, England R A
    Br Dent J 194:153-7; discussion 149. 2003
    ..To compare the efficacy of soluble aspirin 900 mg and paracetamol 1,000 mg in patients with postoperative pain after third molar surgery...
  30. ncbi request reprint Are dental infections a cause of brain abscess? Case report and review of the literature
    M A Corson
    Newcastle upon Tyne NHS Trust, Dental Hospital and School, Richardson Road, Newcastle upon Tyne, NE2 4AZ, UK
    Oral Dis 7:61-5. 2001
    ..The causal organism should be identified in both oral and cranial sites...
  31. ncbi request reprint Oral myofibromatosis: an unusual cause of gingival overgrowth
    M A Corson
    The Dental School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, UK
    J Clin Periodontol 29:1048-50. 2002
    ..This case report describes a rare benign tumour, which presented as discrete areas of gingival hyperplasia affecting both the mandible and the maxilla...
  32. doi request reprint Oral and dental adverse drug reactions
    Robin A Seymour
    School of Dental Sciences, Newcastle University, Newcastle upon Tyne, UK
    Periodontol 2000 46:9-26. 2008
  33. ncbi request reprint Does periodontal treatment improve general health?
    Robin A Seymour
    School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4BW, UK
    Dent Update 37:206-8, 210-2. 2010
    ..Despite such reservations, there are indications that any form of periodontal treatment may have outcomes that extend beyond improving life expectancy of the dentition...
  34. ncbi request reprint Effects of medications on the periodontal tissues in health and disease
    Robin A Seymour
    School of Dental Sciences, University of Newcastle upon Tyne, UK
    Periodontol 2000 40:120-9. 2006
  35. ncbi request reprint Malignant disease and dentistry
    Graham Walton
    Department of Restorative Dentistry, The Dental Hospital, Richardson Road, Newcastle upon Tyne NE2 4AZ, UK
    Dent Update 36:527-30, 533-4. 2009
    ..In this first of three articles, we shall describe the important epidemiological and clinical features of the commonest malignancies in the United Kingdom...
  36. ncbi request reprint Effect of malignant disease and treatments on oral structures
    Robin A Seymour
    School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4BW, UK
    Dent Update 36:594-6, 598-600, 602-3. 2009
    ..All members of the dental team need to be aware of adverse effects arising from such treatments and how they can affect oral function and quality of life...
  37. ncbi request reprint Malignant disease and the delivery of dental care
    Robin A Seymour
    School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4BW, UK
    Dent Update 37:20-2, 25-6. 2010
    ..Chemotherapy-induced bone marrow depression is likely to have the most profound effect on routine dental treatment...
  38. ncbi request reprint Is oral health a risk for malignant disease?
    Robin A Seymour
    School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4BW, UK
    Dent Update 37:279-80, 282-3. 2010
    ..Clinical Relevance: This paper reviews the association between oral health (especially the extent and severity of periodontal disease and tooth loss) as a risk for certain malignancies...
  39. ncbi request reprint Current concepts in periodontal pathogenesis
    Philip M Preshaw
    School of Dental Sciences, University of Newcastle upon Tyne, UK
    Dent Update 31:570-2, 574-8. 2004
    ..The purpose of this paper is to review current thinking in periodontics with special reference to periodontal epidemiology, microbiology, and pathogenesis...
  40. ncbi request reprint Sedation with midazolam leads to reduced pain after dental surgery
    Cliff K S Ong
    Department of Oral and Maxillofacial Surgery, National University of Singapore
    Anesth Analg 98:1289-93, table of contents. 2004
    ..IMPLICATIONS: In this observer blinded study, we found that i.v. midazolam treatment (0.09 mg/kg) has a pain-reducing effect after third molar surgery, thus improving postoperative pain management...
  41. ncbi request reprint Analgesic efficacy of the cyclooxygenase-inhibiting nitric oxide donor AZD3582 in postoperative dental pain: Comparison with naproxen and rofecoxib in two randomized, double-blind, placebo-controlled studies
    C Michael Hill
    University Dental Hospital, Heath Park, Cardiff, United Kingdom
    Clin Ther 28:1279-95. 2006
    ....
  42. doi request reprint An evidence-based update of the use of analgesics in dentistry
    Cliff K S Ong
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, National University of Singapure
    Periodontol 2000 46:143-64. 2008