Ben Seymour

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Temporal difference models describe higher-order learning in humans
    Ben Seymour
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
    Nature 429:664-7. 2004
  2. pmc Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network
    Raffael Kalisch
    Wellcome Department of Imaging Neuroscience, Functional Imaging Laboratory, Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom
    J Neurosci 26:9503-11. 2006
  3. ncbi request reprint Carry on eating: neural pathways mediating conditioned potentiation of feeding
    Ben Seymour
    Wellcome Department of Imaging Neuroscience, UCL, London WC1N 3BG, United Kingdom
    J Neurosci 26:1061-2; discussion 1062. 2006
  4. pmc Differential encoding of losses and gains in the human striatum
    Ben Seymour
    Wellcome Trust Centre for Neuroimaging, UCL, London, United Kingdom
    J Neurosci 27:4826-31. 2007
  5. ncbi request reprint Opponent appetitive-aversive neural processes underlie predictive learning of pain relief
    Ben Seymour
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
    Nat Neurosci 8:1234-40. 2005
  6. pmc Choking on the money: reward-based performance decrements are associated with midbrain activity
    Dean Mobbs
    Wellcome Trust Centre for Neuroimaging, Functional Imaging Laboratory, University College London, UK
    Psychol Sci 20:955-62. 2009
  7. doi request reprint Serotonin selectively modulates reward value in human decision-making
    Ben Seymour
    Wellcome Trust Centre for Neuroimaging, University College London UCL, London WC1N 3BG, United Kingdom
    J Neurosci 32:5833-42. 2012
  8. pmc Dopamine and performance in a reinforcement learning task: evidence from Parkinson's disease
    Tamara Shiner
    Wellcome Trust Centre for Neuroimaging, UCL, London, WC1N 3BG, UK
    Brain 135:1871-83. 2012
  9. pmc From threat to fear: the neural organization of defensive fear systems in humans
    Dean Mobbs
    Wellcome Trust Centre for Neuroimaging, University College London, London WC1 3BG, United Kingdom
    J Neurosci 29:12236-43. 2009
  10. pmc Dopamine, time, and impulsivity in humans
    Alex Pine
    Wellcome Trust Centre for Neuroimaging, London WC1N 3BG, United Kingdom
    J Neurosci 30:8888-96. 2010

Detail Information

Publications37

  1. ncbi request reprint Temporal difference models describe higher-order learning in humans
    Ben Seymour
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
    Nature 429:664-7. 2004
    ..Taken with existing data on reward learning, our results suggest a critical role for the ventral striatum in integrating complex appetitive and aversive predictions to coordinate behaviour...
  2. pmc Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network
    Raffael Kalisch
    Wellcome Department of Imaging Neuroscience, Functional Imaging Laboratory, Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom
    J Neurosci 26:9503-11. 2006
    ..Thus, a VMPFC-hippocampal network provides for context-dependent recall of human extinction memory, consistent with a view that hippocampus confers context dependence on VMPFC...
  3. ncbi request reprint Carry on eating: neural pathways mediating conditioned potentiation of feeding
    Ben Seymour
    Wellcome Department of Imaging Neuroscience, UCL, London WC1N 3BG, United Kingdom
    J Neurosci 26:1061-2; discussion 1062. 2006
  4. pmc Differential encoding of losses and gains in the human striatum
    Ben Seymour
    Wellcome Trust Centre for Neuroimaging, UCL, London, United Kingdom
    J Neurosci 27:4826-31. 2007
    ....
  5. ncbi request reprint Opponent appetitive-aversive neural processes underlie predictive learning of pain relief
    Ben Seymour
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
    Nat Neurosci 8:1234-40. 2005
    ..This dual coding has parallels to 'opponent process' theories in psychology and promotes a formal account of prediction and expectation during pain...
  6. pmc Choking on the money: reward-based performance decrements are associated with midbrain activity
    Dean Mobbs
    Wellcome Trust Centre for Neuroimaging, Functional Imaging Laboratory, University College London, UK
    Psychol Sci 20:955-62. 2009
    ..These data cast light on the neurobiological basis of choking under pressure and are consistent with overmotivation accounts...
  7. doi request reprint Serotonin selectively modulates reward value in human decision-making
    Ben Seymour
    Wellcome Trust Centre for Neuroimaging, University College London UCL, London WC1N 3BG, United Kingdom
    J Neurosci 32:5833-42. 2012
    ..Our results provide evidence for a surprising role for serotonin in reward processing, while illustrating its complex and multifarious effects...
  8. pmc Dopamine and performance in a reinforcement learning task: evidence from Parkinson's disease
    Tamara Shiner
    Wellcome Trust Centre for Neuroimaging, UCL, London, WC1N 3BG, UK
    Brain 135:1871-83. 2012
    ....
  9. pmc From threat to fear: the neural organization of defensive fear systems in humans
    Dean Mobbs
    Wellcome Trust Centre for Neuroimaging, University College London, London WC1 3BG, United Kingdom
    J Neurosci 29:12236-43. 2009
    ....
  10. pmc Dopamine, time, and impulsivity in humans
    Alex Pine
    Wellcome Trust Centre for Neuroimaging, London WC1N 3BG, United Kingdom
    J Neurosci 30:8888-96. 2010
    ..Thus our findings reveal a novel mechanism by which dopamine influences human decision-making that can account for behavioral aberrations associated with a hyperfunctioning dopamine system...
  11. pmc Differentiable neural substrates for learned and described value and risk
    Thomas H B FitzGerald
    Wellcome Trust Centre for Neuroimaging, 12 Queen Square, London, UK
    Curr Biol 20:1823-9. 2010
    ..Our data indicate that, during decision making under risk, both behavior and the neural encoding of key decision variables are strongly influenced by the manner in which value information is presented...
  12. pmc The role of human orbitofrontal cortex in value comparison for incommensurable objects
    Thomas H B FitzGerald
    Wellcome Trust Centre for Neuroimaging, London WC1N 3BG, United Kingdom
    J Neurosci 29:8388-95. 2009
    ..These findings indicate that orbitofrontal cortex plays a pivotal role in valuation for incommensurable goods, a critical component process in human decision making...
  13. pmc Uncertainty increases pain: evidence for a novel mechanism of pain modulation involving the periaqueductal gray
    Wako Yoshida
    Wellcome Trust Centre for Neuroimaging, UCL, London WC1N 3BG, United Kingdom
    J Neurosci 33:5638-46. 2013
    ..Our results provide evidence for a novel form of cognitive hyperalgesia relating to perceptual uncertainty, induced here by vicarious observation, with control mediated by the brainstem pain modulatory system...
  14. pmc Blocking central opiate function modulates hedonic impact and anterior cingulate response to rewards and losses
    Predrag Petrovic
    Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 28:10509-16. 2008
    ..Our data indicate that a central opioid system contributes to both reward and loss processing in humans and directly modulates the hedonic experience of outcomes...
  15. pmc Empathic neural responses are modulated by the perceived fairness of others
    Tania Singer
    Wellcome Department of Imaging Neuroscience, University College of London, London WC1N 3AR, UK
    Nature 439:466-9. 2006
    ....
  16. pmc When fear is near: threat imminence elicits prefrontal-periaqueductal gray shifts in humans
    Dean Mobbs
    Wellcome Trust Centre for Neuroimaging, Functional Imaging Laboratory, University College London, London WC1N 3BG, UK
    Science 317:1079-83. 2007
    ..Our findings cast light on the neural dynamics of threat anticipation and have implications for the neurobiology of human anxiety-related disorders...
  17. pmc The effect of motivation on movement: a study of bradykinesia in Parkinson's disease
    Tamara Shiner
    Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom
    PLoS ONE 7:e47138. 2012
    ..In this paper we test the hypothesis that movement time in PD can be modulated by the specific nature of the motivational salience of possible action-outcomes...
  18. pmc Encoding of marginal utility across time in the human brain
    Alex Pine
    Wellcome Trust Centre for Neuroimaging, London, United Kingdom
    J Neurosci 29:9575-81. 2009
    ..Our data support an integrative architecture for decision making, revealing the neural representation of distinct subcomponents of value that may contribute to impulsivity and decisiveness...
  19. pmc Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans
    Mathias Pessiglione
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
    Nature 442:1042-5. 2006
    ..We conclude that dopamine-dependent modulation of striatal activity can account for how the human brain uses reward prediction errors to improve future decisions...
  20. ncbi request reprint Predictive neural coding of reward preference involves dissociable responses in human ventral midbrain and ventral striatum
    JOHN P O'DOHERTY
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
    Neuron 49:157-66. 2006
    ..These results provide insight into the neural mechanisms underlying human preference behavior...
  21. pmc Human pavlovian-instrumental transfer
    Deborah Talmi
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, WC1N 3BG London, United Kingdom
    J Neurosci 28:360-8. 2008
    ..Our data dovetails well with the animal literature and sheds light on the neural control of vigor...
  22. pmc Neural mechanisms of belief inference during cooperative games
    Wako Yoshida
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 30:10744-51. 2010
    ..These findings reveal putative computational representations within prefrontal cortex regions, supporting the maintenance of cooperation in complex social decision making...
  23. pmc Striatal activity underlies novelty-based choice in humans
    Bianca C Wittmann
    Wellcome Trust Centre for Neuroimaging, University College London, 12 Queen Square, London WC1N3BG, UK
    Neuron 58:967-73. 2008
    ..These data indicate that the brain uses perceptual novelty to approximate choice uncertainty in decision making, which in certain contexts gives rise to a newly identified and quantifiable source of human irrationality...
  24. pmc Neural activity associated with the passive prediction of ambiguity and risk for aversive events
    Dominik R Bach
    Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 29:1648-56. 2009
    ..Our findings suggest that these regions subserve a general function of contextual analysis when search for hidden information during outcome anticipation is both necessary and meaningful...
  25. ncbi request reprint Empathy for pain involves the affective but not sensory components of pain
    Tania Singer
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College of London, 12 Queen Square, WC1N 3AR London, UK
    Science 303:1157-62. 2004
    ..We conclude that only that part of the pain network associated with its affective qualities, but not its sensory qualities, mediates empathy...
  26. ncbi request reprint The neurobiology of punishment
    Ben Seymour
    The Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, 12 Queen Square, London WC1X 3BG, UK
    Nat Rev Neurosci 8:300-11. 2007
    ..Here, we review the proximate neurobiological basis of punishment, considering the motivational processes that underlie punishing actions...
  27. ncbi request reprint Modulation of pain processing in hyperalgesia by cognitive demand
    Katja Wiech
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 27:59-69. 2005
    ..Within the limitations of an experimental model of pain, we suggest that the findings are relevant to understanding both the neurobiology and pathophysiology of chronic pain and its amelioration by cognitive strategies...
  28. pmc Frames, biases, and rational decision-making in the human brain
    Benedetto De Martino
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1 3AR, UK
    Science 313:684-7. 2006
    ..This finding highlights the importance of incorporating emotional processes within models of human choice and suggests how the brain may modulate the effect of these biasing influences to approximate rationality...
  29. doi request reprint Anchors, scales and the relative coding of value in the brain
    Ben Seymour
    Wellcome Trust Centre for Neuroimaging and ELSE, UCL, London, UK
    Curr Opin Neurobiol 18:173-8. 2008
    ..Recent findings in neuroscience support both accounts, and implicate regions in the orbitofrontal cortex, striatum, and ventromedial prefrontal cortex in the construction of value...
  30. doi request reprint Emotion, decision making, and the amygdala
    Ben Seymour
    Wellcome Trust Centre for Imaging Neuroscience, University College London, 12 Queen Square, London WC1N3BG, UK
    Neuron 58:662-71. 2008
    ..This yields a neurobiological account of emotion in which it may operate, often covertly, to optimize rather than corrupt economic choice...
  31. ncbi request reprint Anxiety reduction through detachment: subjective, physiological, and neural effects
    Raffael Kalisch
    University College London, UK
    J Cogn Neurosci 17:874-83. 2005
    ..Using functional magnetic resonance imaging, we locate the potential site and source of this modulation of anticipatory anxiety in the medial prefrontal/anterior cingulate and anterolateral prefrontal cortex, respectively...
  32. pmc Cortical substrates for exploratory decisions in humans
    Nathaniel D Daw
    Gatsby Computational Neuroscience Unit, University College London UCL, Alexandra House, 17 Queen Square, London WC1N 3AR, UK
    Nature 441:876-9. 2006
    ....
  33. ncbi request reprint The misbehavior of value and the discipline of the will
    Peter Dayan
    Gatsby Computational Neuroscience Unit, UCL, 17 Queen Square, London, UK
    Neural Netw 19:1153-60. 2006
    ..The misbehavior created by Pavlovian values can be quite debilitating; we discuss how it may be disciplined...
  34. pmc The price of pain and the value of suffering
    Ivo Vlaev
    Department of Psychology, University College London, London, WC1H 0AP, United Kingdom
    Psychol Sci 20:309-17. 2009
    ..We conclude that the results follow the dynamics of habit-formation models of economic theory, and thus, this study provides the first scientific basis for this type of preference modeling...
  35. pmc Dread and the disvalue of future pain
    Giles W Story
    Centre for Health Policy, Institute of Global Health Innovation, Imperial College London, London, United Kingdom Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom
    PLoS Comput Biol 9:e1003335. 2013
    ....
  36. ncbi request reprint Contingency awareness in human aversive conditioning involves the middle frontal gyrus
    Ronald McKell Carter
    MC216 76 Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Neuroimage 29:1007-12. 2006
    ..These results demonstrate that brain regions known to be involved in other aspects of learning and memory also play a specific role, reflecting on each trial the acquisition and representation of contingency awareness...
  37. ncbi request reprint Modulation of pain ratings by expectation and uncertainty: Behavioral characteristics and anticipatory neural correlates
    Christopher A Brown
    Human Pain Research Group, Clinical Sciences Building, Hope Hospital, Salford M6 8HD, United Kingdom
    Pain 135:240-50. 2008
    ..This suggests that biasing of pain reports and LEPs by expectation involves temporally precise activity in specific cortical networks...