## Research Topics- statistical data interpretation
- statistical models
- simple mastectomy
- cross over studies
- medical journalism
- correspondence
- logic
- methods
- segmental mastectomy
- otitis media
- meta analysis
- computer simulation
- pharmacogenetics
- biometry
- drug therapy
- analysis of variance
- absorption
- osteoarthritis
- biomedical research
- epidemiologic methods
- ascorbic acid
- likelihood functions
- bayes theorem
- 19th century history
- cooperative behavior
- adrenal cortex hormones
- monte carlo method
- antihypertensive agents
- dietary supplements
- patient selection
| ## S Senn## SummaryAffiliation: University of Glasgow Country: UK ## Publications- Change from baseline and analysis of covariance revisitedStephen Senn
Department of Statistics, 15 University Gardens, University of Glasgow, Glasgow G12 8QQ, UK*Stat Med*25:4334-44. 2006 - Statisticians and pharmacokineticists: what they can still learn from each otherS Senn
Department of Statistics, University of Glasgow, Glasgow, UK*Clin Pharmacol Ther*88:328-34. 2010 - Comparisons of minimization and Atkinson's algorithmStephen Senn
Department of Statistics, University of Glasgow, Glasgow G12 8QW, U K*Stat Med*29:721-30. 2010 - Measurement in clinical trials: a neglected issue for statisticians?Stephen Senn
Department of Statistics, University of Glasgow, Glasgow G12 9LL, U K*Stat Med*28:3189-209. 2009 - Overstating the evidence: double counting in meta-analysis and related problemsStephen J Senn
Department of Statistics, University of Glasgow, Glasgow, UK*BMC Med Res Methodol*9:10. 2009 - Transposed conditionals, shrinkage, and direct and indirect unbiasednessStephen Senn
Department of Statistics, University of Glasgow, UK*Epidemiology*19:652-4; discussion 657-8. 2008 - Lessons from TGN1412 and TARGET: implications for observational studies and meta-analysisStephen Senn
Department of Statistics, University of Glasgow, Glasgow, UK*Pharm Stat*7:294-301. 2008 - Stratification for the propensity score compared with linear regression techniques to assess the effect of treatment or exposureStephen Senn
Department of Statistics, University of Glasgow, Glasgow, G12 8QQ, U K*Stat Med*26:5529-44. 2007 - Drawbacks to noninteger scoring for ordered categorical dataStephen Senn
Department of Statistics, University of Glasgow, Glasgow G12 8QQ, UK*Biometrics*63:296-8; discussion 298-9. 2007 - Cross-over trials in Statistics in Medicine: the first '25' yearsStephen Senn
Department of Statistics, University of Glasgow, Glasgow G12 8QQ, UK*Stat Med*25:3430-42. 2006
| ## Collaborators |

## Detail Information

### Publications

- Change from baseline and analysis of covariance revisitedStephen Senn

Department of Statistics, 15 University Gardens, University of Glasgow, Glasgow G12 8QQ, UK*Stat Med*25:4334-44. 2006..It is also shown that although many situations can be envisaged where ANCOVA is biased it is very difficult to imagine circumstances under which SACS would then be unbiased and a causal interpretation could be made... - Statisticians and pharmacokineticists: what they can still learn from each otherS Senn

Department of Statistics, University of Glasgow, Glasgow, UK*Clin Pharmacol Ther*88:328-34. 2010..It is concluded that there would be much benefit in increasing collaboration between these disciplines... - Comparisons of minimization and Atkinson's algorithmStephen Senn

Department of Statistics, University of Glasgow, Glasgow G12 8QW, U K*Stat Med*29:721-30. 2010..Both are more efficient than simple randomization, although it is concluded that fitting covariates may make a more valuable and instructive contribution to inferences about treatment effects than only balancing them... - Measurement in clinical trials: a neglected issue for statisticians?Stephen Senn

Department of Statistics, University of Glasgow, Glasgow G12 9LL, U K*Stat Med*28:3189-209. 2009..We consider the losses involved in inappropriate measures and suggest that statisticians should pay more attention to this aspect of their work... - Overstating the evidence: double counting in meta-analysis and related problemsStephen J Senn

Department of Statistics, University of Glasgow, Glasgow, UK*BMC Med Res Methodol*9:10. 2009..The problem of missing studies in meta-analysis has received much attention. Less attention has been paid to the more serious problem of double counting of evidence... - Transposed conditionals, shrinkage, and direct and indirect unbiasednessStephen Senn

Department of Statistics, University of Glasgow, UK*Epidemiology*19:652-4; discussion 657-8. 2008..This would require the very different property of inverse unbiasedness. When this phenomenon is understood, shrinkage of results can be seen to be a necessary fact of life... - Lessons from TGN1412 and TARGET: implications for observational studies and meta-analysisStephen Senn

Department of Statistics, University of Glasgow, Glasgow, UK*Pharm Stat*7:294-301. 2008..These two cases are examined in detail and some general lessons for the analysis of clinical trials and observational studies and collections of studies are drawn... - Stratification for the propensity score compared with linear regression techniques to assess the effect of treatment or exposureStephen Senn

Department of Statistics, University of Glasgow, Glasgow, G12 8QQ, U K*Stat Med*26:5529-44. 2007..We conclude that the propensity score estimator inherits the potential for overfitting and that care should be taken to restrict covariates to those relevant for outcome... - Drawbacks to noninteger scoring for ordered categorical dataStephen Senn

Department of Statistics, University of Glasgow, Glasgow G12 8QQ, UK*Biometrics*63:296-8; discussion 298-9. 2007..A proposal to improve trend tests by using noninteger scores is examined. It is concluded that despite improved power such tests are usually inferior to the simpler integer scored approach... - Cross-over trials in Statistics in Medicine: the first '25' yearsStephen Senn

Department of Statistics, University of Glasgow, Glasgow G12 8QQ, UK*Stat Med*25:3430-42. 2006..Baselines, 3. Binary and categorical data, 4. Survival data, 5. Modelling carry-over, 6. Bioequivalence and 7. Components of variation. Finally, a brief assessment of the importance in this field of Statistics in Medicine is given... - Trying to be precise about vaguenessStephen Senn

Department of Statistics, University of Glasgow, UK*Stat Med*26:1417-30. 2007..Finally, some practical recommendations are made that stress the value both of fixed effect analyses and of frequentist approaches as well as various diagnostic investigations... - Individual response to treatment: is it a valid assumption?Stephen Senn

Department of Statistics, University of Glasgow, Glasgow G12 8QQ*BMJ*329:966-8. 2004 - An early "Atkins' Diet": RA Fisher analyses a medical "experiment"Stephen Senn

Department of Statistics, University of Glasgow, Glasgow, G12 8QQ, UK*Biom J*48:193-204. 2006..A study on vitamin absorption which RA Fisher analysed for WRG Atkins and co-authored with him is critically examined. The historical background as well as correspondence between Atkins and Fisher is presented... - Power and sample size when multiple endpoints are consideredStephen Senn

Department of Statistics, University of Glasgow, Glasgow, Scotland, UK*Pharm Stat*6:161-70. 2007..We conduct a numerical study and conclude again that power is not reduced as the number of tested variables increases... - Misunderstandings regarding clinical cross-over trialsStephen Senn
*Stat Med*24:3675-8. 2005 - Probabilistic index: an intuitive non-parametric approach to measuring the size of the treatment effects by L. Acion, J. J. Peterson, S. Temple and S. Arndt, Statistics in Medicine 2006; 25(4):591-602Stephen Senn
*Stat Med*25:3944-6; author reply 3946-8. 2006 - A 4-year trial of tiotropium in chronic obstructive pulmonary diseaseDonald P Tashkin

David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA*N Engl J Med*359:1543-54. 2008..Previous studies showing that tiotropium improves multiple end points in patients with chronic obstructive pulmonary disease (COPD) led us to examine the long-term effects of tiotropium therapy... - Controversies concerning randomization and additivity in clinical trialsStephen Senn

Department of Statistical Science, University College London, London WC1E 6BT, UK*Stat Med*23:3729-53. 2004..More generally, however, this is not the case... - Bronchodilation of formoterol administered with budesonide: device and formulation effectsChristopher J Miller

AstraZeneca, 1800 Concord Pike, Wilmington, DE 19850, United States*Contemp Clin Trials*29:114-24. 2008.... - A note on non-parametric ANCOVA for covariate adjustment in randomized clinical trialsEmmanuel Lesaffre

Biostatistical Centre, University of Leuven, Belgium*Stat Med*22:3583-96. 2003..Med. 1998; 17: 1863-1892). Finally, we propose a correction factor for Koch's test statistic that better preserves the type I error... - A comment on replication, p-values and evidence, S.N.Goodman, Statistics in Medicine 1992; 11:875-879Stephen Senn
*Stat Med*21:2437-44; author reply 2445-7. 2002