S Senn

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi Statisticians and pharmacokineticists: what they can still learn from each other
    S Senn
    Department of Statistics, University of Glasgow, Glasgow, UK
    Clin Pharmacol Ther 88:328-34. 2010
  2. ncbi Comparisons of minimization and Atkinson's algorithm
    Stephen Senn
    Department of Statistics, University of Glasgow, Glasgow G12 8QW, U K
    Stat Med 29:721-30. 2010
  3. ncbi Measurement in clinical trials: a neglected issue for statisticians?
    Stephen Senn
    Department of Statistics, University of Glasgow, Glasgow G12 9LL, U K
    Stat Med 28:3189-209. 2009
  4. ncbi Overstating the evidence: double counting in meta-analysis and related problems
    Stephen J Senn
    Department of Statistics, University of Glasgow, Glasgow, UK
    BMC Med Res Methodol 9:10. 2009
  5. ncbi Transposed conditionals, shrinkage, and direct and indirect unbiasedness
    Stephen Senn
    Department of Statistics, University of Glasgow, UK
    Epidemiology 19:652-4; discussion 657-8. 2008
  6. ncbi Lessons from TGN1412 and TARGET: implications for observational studies and meta-analysis
    Stephen Senn
    Department of Statistics, University of Glasgow, Glasgow, UK
    Pharm Stat 7:294-301. 2008
  7. ncbi Stratification for the propensity score compared with linear regression techniques to assess the effect of treatment or exposure
    Stephen Senn
    Department of Statistics, University of Glasgow, Glasgow, G12 8QQ, U K
    Stat Med 26:5529-44. 2007
  8. ncbi Drawbacks to noninteger scoring for ordered categorical data
    Stephen Senn
    Department of Statistics, University of Glasgow, Glasgow G12 8QQ, UK
    Biometrics 63:296-8; discussion 298-9. 2007
  9. ncbi Cross-over trials in Statistics in Medicine: the first '25' years
    Stephen Senn
    Department of Statistics, University of Glasgow, Glasgow G12 8QQ, UK
    Stat Med 25:3430-42. 2006
  10. ncbi Change from baseline and analysis of covariance revisited
    Stephen Senn
    Department of Statistics, 15 University Gardens, University of Glasgow, Glasgow G12 8QQ, UK
    Stat Med 25:4334-44. 2006

Detail Information

Publications21

  1. ncbi Statisticians and pharmacokineticists: what they can still learn from each other
    S Senn
    Department of Statistics, University of Glasgow, Glasgow, UK
    Clin Pharmacol Ther 88:328-34. 2010
    ..It is concluded that there would be much benefit in increasing collaboration between these disciplines...
  2. ncbi Comparisons of minimization and Atkinson's algorithm
    Stephen Senn
    Department of Statistics, University of Glasgow, Glasgow G12 8QW, U K
    Stat Med 29:721-30. 2010
    ..Both are more efficient than simple randomization, although it is concluded that fitting covariates may make a more valuable and instructive contribution to inferences about treatment effects than only balancing them...
  3. ncbi Measurement in clinical trials: a neglected issue for statisticians?
    Stephen Senn
    Department of Statistics, University of Glasgow, Glasgow G12 9LL, U K
    Stat Med 28:3189-209. 2009
    ..We consider the losses involved in inappropriate measures and suggest that statisticians should pay more attention to this aspect of their work...
  4. ncbi Overstating the evidence: double counting in meta-analysis and related problems
    Stephen J Senn
    Department of Statistics, University of Glasgow, Glasgow, UK
    BMC Med Res Methodol 9:10. 2009
    ..The problem of missing studies in meta-analysis has received much attention. Less attention has been paid to the more serious problem of double counting of evidence...
  5. ncbi Transposed conditionals, shrinkage, and direct and indirect unbiasedness
    Stephen Senn
    Department of Statistics, University of Glasgow, UK
    Epidemiology 19:652-4; discussion 657-8. 2008
    ..This would require the very different property of inverse unbiasedness. When this phenomenon is understood, shrinkage of results can be seen to be a necessary fact of life...
  6. ncbi Lessons from TGN1412 and TARGET: implications for observational studies and meta-analysis
    Stephen Senn
    Department of Statistics, University of Glasgow, Glasgow, UK
    Pharm Stat 7:294-301. 2008
    ..These two cases are examined in detail and some general lessons for the analysis of clinical trials and observational studies and collections of studies are drawn...
  7. ncbi Stratification for the propensity score compared with linear regression techniques to assess the effect of treatment or exposure
    Stephen Senn
    Department of Statistics, University of Glasgow, Glasgow, G12 8QQ, U K
    Stat Med 26:5529-44. 2007
    ..We conclude that the propensity score estimator inherits the potential for overfitting and that care should be taken to restrict covariates to those relevant for outcome...
  8. ncbi Drawbacks to noninteger scoring for ordered categorical data
    Stephen Senn
    Department of Statistics, University of Glasgow, Glasgow G12 8QQ, UK
    Biometrics 63:296-8; discussion 298-9. 2007
    ..A proposal to improve trend tests by using noninteger scores is examined. It is concluded that despite improved power such tests are usually inferior to the simpler integer scored approach...
  9. ncbi Cross-over trials in Statistics in Medicine: the first '25' years
    Stephen Senn
    Department of Statistics, University of Glasgow, Glasgow G12 8QQ, UK
    Stat Med 25:3430-42. 2006
    ..Baselines, 3. Binary and categorical data, 4. Survival data, 5. Modelling carry-over, 6. Bioequivalence and 7. Components of variation. Finally, a brief assessment of the importance in this field of Statistics in Medicine is given...
  10. ncbi Change from baseline and analysis of covariance revisited
    Stephen Senn
    Department of Statistics, 15 University Gardens, University of Glasgow, Glasgow G12 8QQ, UK
    Stat Med 25:4334-44. 2006
    ..It is also shown that although many situations can be envisaged where ANCOVA is biased it is very difficult to imagine circumstances under which SACS would then be unbiased and a causal interpretation could be made...
  11. ncbi Trying to be precise about vagueness
    Stephen Senn
    Department of Statistics, University of Glasgow, UK
    Stat Med 26:1417-30. 2007
    ..Finally, some practical recommendations are made that stress the value both of fixed effect analyses and of frequentist approaches as well as various diagnostic investigations...
  12. ncbi Individual response to treatment: is it a valid assumption?
    Stephen Senn
    Department of Statistics, University of Glasgow, Glasgow G12 8QQ
    BMJ 329:966-8. 2004
  13. ncbi An early "Atkins' Diet": RA Fisher analyses a medical "experiment"
    Stephen Senn
    Department of Statistics, University of Glasgow, Glasgow, G12 8QQ, UK
    Biom J 48:193-204. 2006
    ..A study on vitamin absorption which RA Fisher analysed for WRG Atkins and co-authored with him is critically examined. The historical background as well as correspondence between Atkins and Fisher is presented...
  14. ncbi Power and sample size when multiple endpoints are considered
    Stephen Senn
    Department of Statistics, University of Glasgow, Glasgow, Scotland, UK
    Pharm Stat 6:161-70. 2007
    ..We conduct a numerical study and conclude again that power is not reduced as the number of tested variables increases...
  15. ncbi Misunderstandings regarding clinical cross-over trials
    Stephen Senn
    Stat Med 24:3675-8. 2005
  16. ncbi Probabilistic index: an intuitive non-parametric approach to measuring the size of the treatment effects by L. Acion, J. J. Peterson, S. Temple and S. Arndt, Statistics in Medicine 2006; 25(4):591-602
    Stephen Senn
    Stat Med 25:3944-6; author reply 3946-8. 2006
  17. ncbi A 4-year trial of tiotropium in chronic obstructive pulmonary disease
    Donald P Tashkin
    David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA
    N Engl J Med 359:1543-54. 2008
    ..Previous studies showing that tiotropium improves multiple end points in patients with chronic obstructive pulmonary disease (COPD) led us to examine the long-term effects of tiotropium therapy...
  18. ncbi Controversies concerning randomization and additivity in clinical trials
    Stephen Senn
    Department of Statistical Science, University College London, London WC1E 6BT, UK
    Stat Med 23:3729-53. 2004
    ..More generally, however, this is not the case...
  19. ncbi Bronchodilation of formoterol administered with budesonide: device and formulation effects
    Christopher J Miller
    AstraZeneca, 1800 Concord Pike, Wilmington, DE 19850, United States
    Contemp Clin Trials 29:114-24. 2008
    ....
  20. ncbi A note on non-parametric ANCOVA for covariate adjustment in randomized clinical trials
    Emmanuel Lesaffre
    Biostatistical Centre, University of Leuven, Belgium
    Stat Med 22:3583-96. 2003
    ..Med. 1998; 17: 1863-1892). Finally, we propose a correction factor for Koch's test statistic that better preserves the type I error...
  21. ncbi A comment on replication, p-values and evidence, S.N.Goodman, Statistics in Medicine 1992; 11:875-879
    Stephen Senn
    Stat Med 21:2437-44; author reply 2445-7. 2002