Colin Selman

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Short-term caloric restriction and regulatory proteins of apoptosis in heart, skeletal muscle and kidney of Fischer 344 rats
    Colin Selman
    University of Florida, Biochemistry of Aging Laboratory, College of Health and Human Performance, Box 118206, Gainesville, FL 32611, USA
    Biogerontology 4:141-7. 2003
  2. ncbi request reprint Life-long vitamin C supplementation in combination with cold exposure does not affect oxidative damage or lifespan in mice, but decreases expression of antioxidant protection genes
    Colin Selman
    Aberdeen Centre for Energy Regulation and Obesity ACERO, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Mech Ageing Dev 127:897-904. 2006
  3. ncbi request reprint Energy expenditure of calorically restricted rats is higher than predicted from their altered body composition
    Colin Selman
    University of Florida, Department of Aging and Geriatric Research, College of Medicine, Gainesville, 32608, USA
    Mech Ageing Dev 126:783-93. 2005
  4. ncbi request reprint Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice
    Colin Selman
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Institute, London, United Kingdom
    Physiol Genomics 27:187-200. 2006
  5. pmc Alterations in tissue aerobic capacity may play a role in premigratory fattening in shorebirds
    Colin Selman
    Department of Biological Sciences, Science Laboratories, University of Durham, Durham DH1 3LE, UK
    Biol Lett 1:101-4. 2005
  6. doi request reprint Lifelong alpha-tocopherol supplementation increases the median life span of C57BL/6 mice in the cold but has only minor effects on oxidative damage
    Colin Selman
    Integrative Physiology, School of Biological Sciences, University of Aberdeen, Aberdeen, United Kingdom
    Rejuvenation Res 11:83-96. 2008
  7. pmc AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
    Marc Claret
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
    J Clin Invest 117:2325-36. 2007
  8. doi request reprint Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
    Colin Selman
    Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK
    Science 326:140-4. 2009
  9. pmc Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons
    Hind Al-Qassab
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London WC1E 6JJ, UK
    Cell Metab 10:343-54. 2009
  10. ncbi request reprint Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice
    Colin Selman
    Centre for Diabetes and Endocrinology, Department of Medicine, Rayne Institute, University College London, University St, London, UK
    FASEB J 22:807-18. 2008

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Short-term caloric restriction and regulatory proteins of apoptosis in heart, skeletal muscle and kidney of Fischer 344 rats
    Colin Selman
    University of Florida, Biochemistry of Aging Laboratory, College of Health and Human Performance, Box 118206, Gainesville, FL 32611, USA
    Biogerontology 4:141-7. 2003
    ....
  2. ncbi request reprint Life-long vitamin C supplementation in combination with cold exposure does not affect oxidative damage or lifespan in mice, but decreases expression of antioxidant protection genes
    Colin Selman
    Aberdeen Centre for Energy Regulation and Obesity ACERO, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Mech Ageing Dev 127:897-904. 2006
    ....
  3. ncbi request reprint Energy expenditure of calorically restricted rats is higher than predicted from their altered body composition
    Colin Selman
    University of Florida, Department of Aging and Geriatric Research, College of Medicine, Gainesville, 32608, USA
    Mech Ageing Dev 126:783-93. 2005
    ....
  4. ncbi request reprint Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice
    Colin Selman
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Institute, London, United Kingdom
    Physiol Genomics 27:187-200. 2006
    ..Mice undergoing acute CR rapidly adopt many transcriptional and metabolic changes of long-term CR, suggesting that the beneficial effects of CR may require only a short-term reduction in caloric intake...
  5. pmc Alterations in tissue aerobic capacity may play a role in premigratory fattening in shorebirds
    Colin Selman
    Department of Biological Sciences, Science Laboratories, University of Durham, Durham DH1 3LE, UK
    Biol Lett 1:101-4. 2005
    ..Thus, physiological adjustments in tissue metabolism may be an important factor in the life-history strategies of migrating shorebirds...
  6. doi request reprint Lifelong alpha-tocopherol supplementation increases the median life span of C57BL/6 mice in the cold but has only minor effects on oxidative damage
    Colin Selman
    Integrative Physiology, School of Biological Sciences, University of Aberdeen, Aberdeen, United Kingdom
    Rejuvenation Res 11:83-96. 2008
    ..However, these signaling pathways now require further investigation to establish their exact role in life span extension following alpha-tocopherol supplementation...
  7. pmc AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
    Marc Claret
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
    J Clin Invest 117:2325-36. 2007
    ....
  8. doi request reprint Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
    Colin Selman
    Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK
    Science 326:140-4. 2009
    ..Our results demonstrate that S6K1 influences healthy mammalian life-span and suggest that therapeutic manipulation of S6K1 and AMPK might mimic CR and could provide broad protection against diseases of aging...
  9. pmc Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons
    Hind Al-Qassab
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London WC1E 6JJ, UK
    Cell Metab 10:343-54. 2009
    ..These results demonstrate distinct metabolic roles for the p110alpha and p110beta isoforms of PI3K in hypothalamic energy regulation...
  10. ncbi request reprint Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice
    Colin Selman
    Centre for Diabetes and Endocrinology, Department of Medicine, Rayne Institute, University College London, University St, London, UK
    FASEB J 22:807-18. 2008
    ..Our results therefore suggest that IRS1 signaling is an evolutionarily conserved pathway regulating mammalian life span and may be a point of intervention for therapies with the potential to delay age-related processes...
  11. pmc Deleterious consequences of antioxidant supplementation on lifespan in a wild-derived mammal
    Colin Selman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Biol Lett 9:20130432. 2013
    ....
  12. ncbi request reprint Exercise by lifelong voluntary wheel running reduces subsarcolemmal and interfibrillar mitochondrial hydrogen peroxide production in the heart
    Sharon Judge
    Univ of Florida, College of Medicine, Dept of Aging and Geriatric Research, Genomics and Biomarkers Core Institute on Aging, Biochemistry of Aging Laboratory, Gainesville, FL 32608, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1564-72. 2005
    ..The health benefits of chronic exercise may be, at least partially, due to a reduction in mitochondrial oxidant production; however, we could not detect a significant reduction in several selected parameters of oxidative stress...
  13. ncbi request reprint Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse
    Irina Neganova
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London WC1E 6JJ, United Kingdom
    Biol Reprod 76:1045-53. 2007
    ..Our data suggest that ovarian rather than central nervous system IRS2 signaling is important in the regulation of female reproductive function...
  14. ncbi request reprint Antioxidant enzyme activities, lipid peroxidation, and DNA oxidative damage: the effects of short-term voluntary wheel running
    Colin Selman
    Aberdeen Centre for Energy Expenditure and Obesity ACERO, Department of Zoology, Aberdeen University, Aberdeen AB24 2TZ, Scotland, UK
    Arch Biochem Biophys 401:255-61. 2002
    ..There was no evidence of any significant increase in any oxidative stress parameter in running individuals, despite having significantly elevated energy expenditures compared to sedentary controls...
  15. ncbi request reprint Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female rats
    Young Mok Jang
    Biochemistry of Aging Laboratory, University of Florida, P O Box 118206, Gainesville, FL 32611, USA
    FEBS Lett 577:483-90. 2004
    ..Moreover, no major sex differences exist in apoptosis signaling transduction cascade due to doxorubicin treatment...
  16. doi request reprint The free-radical damage theory: Accumulating evidence against a simple link of oxidative stress to ageing and lifespan
    John R Speakman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, Scotland, UK
    Bioessays 33:255-9. 2011
    ..Combined, these findings raise fundamental questions over whether the free-radical damage theory remains useful for understanding the ageing process, and variation in lifespan and life histories...
  17. doi request reprint Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"
    Colin Selman
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Institute, 5 University Street, London WC1E 6JJ, UK
    Science 320:1012; author reply 1012. 2008
    ..However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals...
  18. pmc Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice
    James Cantley
    Centre for Diabetes and Endocrinology, Faculty of Medicine, Rayne Institute, University College London, London, UK
    J Clin Invest 119:125-35. 2009
    ..These data suggest that VHL/HIF oxygen-sensing mechanisms play a critical role in glucose homeostasis and that activation of this pathway in response to decreased islet oxygenation may contribute to beta cell dysfunction...
  19. ncbi request reprint Increased hepatic apoptosis during short-term caloric restriction is not associated with an enhancement in caspase levels
    Colin Selman
    Biochemistry of Aging Laboratory, College of Health and Human Performance, University of Florida, P O Box 118206, Gainesville, FL 32611 8206, USA
    Exp Gerontol 38:897-903. 2003
    ....
  20. pmc Longevity of insulin receptor substrate1 null mice is not associated with increased basal antioxidant protection or reduced oxidative damage
    Melissa M Page
    Integrative and Environmental Physiology, Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, AB24 2TZ, UK
    Age (Dordr) 35:647-58. 2013
    ..Overall, our results do not support the premise that lifespan extension in Irs1 (-/-) mice is associated with greater tissue antioxidant protection or reduced oxidative damage...
  21. pmc The impact of experimentally elevated energy expenditure on oxidative stress and lifespan in the short-tailed field vole Microtus agrestis
    Colin Selman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Proc Biol Sci 275:1907-16. 2008
    ..These data suggest that in captive animals physiologically mediated costs on life history do not result from increased energy expenditure and consequent elevations in oxidative stress and reduced survival...
  22. doi request reprint The impact of acute caloric restriction on the metabolic phenotype in male C57BL/6 and DBA/2 mice
    Sarah Hempenstall
    Integrative Physiology, Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Mech Ageing Dev 131:111-8. 2010
    ..These strain-specific differences in glucose homeostatic parameters may underlie the reported unresponsiveness of DBA/2 mice to CR. We also demonstrate delineation in the response of insulin and IGF-1 to acute CR in mice...
  23. ncbi request reprint Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity ACERO, School of Biological Sciences, University of Aberdeen, Aberdeen, Scotland, UK AB24 2TZ
    Aging Cell 3:87-95. 2004
    ..Individuals with high metabolism were therefore more uncoupled, had greater resting and total daily energy expenditures and survived longest - supporting the 'uncoupling to survive' hypothesis...
  24. pmc Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1
    Colin Selman
    Institute of Biological and Environmental Sciences, School of Biological Sciences, University of Aberdeen, Aberdeen, United Kingdom
    PLoS ONE 6:e16144. 2011
    ..In addition, an augmented and completed study demonstrates lifespan extension in male Irs1 null mice. Therefore, we show that reduced IRS1-dependent signalling is a robust mechanism through which mammalian lifespan can be modulated...
  25. pmc Evolutionary conservation of regulated longevity assurance mechanisms
    Joshua J McElwee
    Department of Biology, University College London, London WC1E 6BT, UK
    Genome Biol 8:R132. 2007
    ..To address this, we have applied a novel, multi-level cross-species comparative analysis to compare gene expression changes accompanying increased longevity in mutant nematodes, fruitflies and mice with reduced IIS...
  26. ncbi request reprint Living fast, dying when? The link between aging and energetics
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, University of Aberdeen, Aberdeen, UK
    J Nutr 132:1583S-97S. 2002
    ..This review reveals that there might be contrasting effects of resting and nonresting energy expenditure on aging, with increases in the former being protective and increases in the latter being harmful...
  27. ncbi request reprint Oxidative damage, ageing, and life-history evolution: where now?
    Colin Selman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, AB24 2TZ, UK
    Trends Ecol Evol 27:570-7. 2012
    ..We conclude by emphasising the value of using multiple assays to determine oxidative protection and damage. We also highlight the importance of using standardised and appropriate protocols, and discuss future research directions...
  28. doi request reprint Dietary restriction increases skeletal muscle mitochondrial respiration but not mitochondrial content in C57BL/6 mice
    Sarah Hempenstall
    Integrative and Environmental Physiology, Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, UK
    Mech Ageing Dev 133:37-45. 2012
    ..Thus, we suggest that a functionally 'efficient' mitochondrial electron transport chain may be a critical mechanism underlying DR, rather than any net increase in mitochondrial content per se...
  29. doi request reprint Vitamin E supplementation and mammalian lifespan
    Ruth Banks
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK
    Mol Nutr Food Res 54:719-25. 2010
    ..We suggest that the role of this pathway in life span extension following supplementation of vitamin E now requires further investigation...
  30. pmc The role of insulin receptor substrate 2 in hypothalamic and beta cell function
    Agharul I Choudhury
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
    J Clin Invest 115:940-50. 2005
    ..Our findings demonstrate a critical role for IRS2 in beta cell and hypothalamic function and provide insights into the role of RIPCre neurons, a distinct hypothalamic neuronal population, in growth and energy homeostasis...
  31. pmc Mammalian models of extended healthy lifespan
    Colin Selman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Philos Trans R Soc Lond B Biol Sci 366:99-107. 2011
    ..Given that the elderly are making up an increasingly greater proportion of society, this focused approach in model organisms should help identify tractable interventions that can ultimately be translated to humans...
  32. ncbi request reprint Effects of a specific MCHR1 antagonist (GW803430) on energy budget and glucose metabolism in diet-induced obese mice
    Li Na Zhang
    Integrative Physiology, Institute of Biological Sciences, University of Aberdeen, Aberdeen, Scotland, UK
    Obesity (Silver Spring) 22:681-90. 2014
    ..Our objective was to determine effects of MCHR1 antagonism on energy budgets and glucose homeostasis in mice...
  33. ncbi request reprint Short-term caloric restriction and sites of oxygen radical generation in kidney and skeletal muscle mitochondria
    Ricardo Gredilla
    Department of Animal Biology II Animal Physiology, Faculty of Biology, Complutense University, 28040 Madrid, Spain
    Ann N Y Acad Sci 1019:333-42. 2004
    ....
  34. ncbi request reprint Physical activity and resting metabolic rate
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, Division of Energy Balance and Obesity, Rowett Research Institute, Aberdeen AB21 9SB, UK
    Proc Nutr Soc 62:621-34. 2003
    ..Extreme interventions, however, may induce reductions in RMR, in spite of the increased lean tissue mass, similar to the changes observed in animals in response to flight...
  35. pmc Birds sacrifice oxidative protection for reproduction
    Popko Wiersma
    Zoological Laboratory of the University of Groningen, 9750 AA Haren, The Netherlands
    Proc Biol Sci 271:S360-3. 2004
    ..This result suggests that senescence acceleration by increased reproductive effort is at least in part mediated by oxidative stress...
  36. ncbi request reprint The role of Id2 and apoptosis during skeletal muscle remodeling
    Colin Selman
    Am J Physiol Regul Integr Comp Physiol 284:R538-9. 2003
  37. ncbi request reprint Effects of dietary calcium restriction and acute exercise on the antioxidant enzyme system and oxidative stress in rat diaphragm
    Masayuki Itoh
    Fifth Dept of Internal Medicine, Tokyo Medical Univ, 3 20 1, Chuou, Ami, Inashiki, Ibaraki 300 0395, Japan
    Am J Physiol Regul Integr Comp Physiol 287:R33-8. 2004
    ....
  38. ncbi request reprint Voluntary exercise has only limited effects on activity of antioxidant enzymes and does not cause oxidative damage in a small mammal
    Colin Selman
    Aberdeen Centre for Energy Expenditure and Obesity, Department of Zoology, Aberdeen University, Aberdeen, UK
    J Nutr 132:1784S-6S. 2002
  39. ncbi request reprint The consequences of acute cold exposure on protein oxidation and proteasome activity in short-tailed field voles, microtus agrestis
    Colin Selman
    Aberdeen Centre for Energy Expenditure and Obesity ACERO, Department of Zoology, Aberdeen University, UK
    Free Radic Biol Med 33:259-65. 2002
    ..This protection may be a very important factor in sustaining uncoupled respiration, which underpins nonshivering thermogenesis at cold temperatures...