Affiliation: University of Aberdeen
- Oxidative damage, ageing, and life-history evolution: where now?Colin Selman
Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, AB24 2TZ, UK
Trends Ecol Evol 27:570-7. 2012..We conclude by emphasising the value of using multiple assays to determine oxidative protection and damage. We also highlight the importance of using standardised and appropriate protocols, and discuss future research directions...
- Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1Colin Selman
Institute of Biological and Environmental Sciences, School of Biological Sciences, University of Aberdeen, Aberdeen, United Kingdom
PLoS ONE 6:e16144. 2011..In addition, an augmented and completed study demonstrates lifespan extension in male Irs1 null mice. Therefore, we show that reduced IRS1-dependent signalling is a robust mechanism through which mammalian lifespan can be modulated...
- Lifelong alpha-tocopherol supplementation increases the median life span of C57BL/6 mice in the cold but has only minor effects on oxidative damageColin Selman
Integrative Physiology, School of Biological Sciences, University of Aberdeen, Aberdeen, United Kingdom
Rejuvenation Res 11:83-96. 2008..However, these signaling pathways now require further investigation to establish their exact role in life span extension following alpha-tocopherol supplementation...
- Antioxidant enzyme activities, lipid peroxidation, and DNA oxidative damage: the effects of short-term voluntary wheel runningColin Selman
Aberdeen Centre for Energy Expenditure and Obesity ACERO, Department of Zoology, Aberdeen University, Aberdeen AB24 2TZ, Scotland, UK
Arch Biochem Biophys 401:255-61. 2002..There was no evidence of any significant increase in any oxidative stress parameter in running individuals, despite having significantly elevated energy expenditures compared to sedentary controls...
- Voluntary exercise has only limited effects on activity of antioxidant enzymes and does not cause oxidative damage in a small mammalColin Selman
Aberdeen Centre for Energy Expenditure and Obesity, Department of Zoology, Aberdeen University, Aberdeen, UK
J Nutr 132:1784S-6S. 2002
- Thermoregulatory responses of two mouse Mus musculus strains selectively bred for high and low food intakeC Selman
Aberdeen Centre for Energy Regulation and Obesity, Department of Zoology, University of Aberdeen, UK
J Comp Physiol B 171:661-8. 2001..The greater levels of food intake were also associated with higher resting metabolic rates at 30 degrees C...
- Resting metabolic rate and morphology in mice (Mus musculus) selected for high and low food intakeC Selman
Aberdeen Centre for Energy Regulation and Obesity, Department of Zoology, University of Aberdeen, Aberdeen AB24 2TZ, UK
J Exp Biol 204:777-84. 2001..The effects of strain on RMR independent of the effect on body mass were consistent with the anticipated effect from the strain differences in the size of the liver...
- Effect of long-term cold exposure on antioxidant enzyme activities in a small mammalC Selman
Aberdeen Centre for Energy Regulation and Obesity, Department of Zoology, University of Aberdeen, Aberdeen, Scotland, UK
Free Radic Biol Med 28:1279-85. 2000....
- The impact of experimentally elevated energy expenditure on oxidative stress and lifespan in the short-tailed field vole Microtus agrestisColin Selman
Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
Proc Biol Sci 275:1907-16. 2008..These data suggest that in captive animals physiologically mediated costs on life history do not result from increased energy expenditure and consequent elevations in oxidative stress and reduced survival...
- Life-long vitamin C supplementation in combination with cold exposure does not affect oxidative damage or lifespan in mice, but decreases expression of antioxidant protection genesColin Selman
Aberdeen Centre for Energy Regulation and Obesity ACERO, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
Mech Ageing Dev 127:897-904. 2006....
- Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longerJohn R Speakman
Aberdeen Centre for Energy Regulation and Obesity ACERO, School of Biological Sciences, University of Aberdeen, Aberdeen, Scotland, UK AB24 2TZ
Aging Cell 3:87-95. 2004..Individuals with high metabolism were therefore more uncoupled, had greater resting and total daily energy expenditures and survived longest - supporting the 'uncoupling to survive' hypothesis...
- Physical activity and resting metabolic rateJohn R Speakman
Aberdeen Centre for Energy Regulation and Obesity, Division of Energy Balance and Obesity, Rowett Research Institute, Aberdeen AB21 9SB, UK
Proc Nutr Soc 62:621-34. 2003..Extreme interventions, however, may induce reductions in RMR, in spite of the increased lean tissue mass, similar to the changes observed in animals in response to flight...
- The free-radical damage theory: Accumulating evidence against a simple link of oxidative stress to ageing and lifespanJohn R Speakman
Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, Scotland, UK
Bioessays 33:255-9. 2011..Combined, these findings raise fundamental questions over whether the free-radical damage theory remains useful for understanding the ageing process, and variation in lifespan and life histories...
- Living fast, dying when? The link between aging and energeticsJohn R Speakman
Aberdeen Centre for Energy Regulation and Obesity, University of Aberdeen, Aberdeen, UK
J Nutr 132:1583S-97S. 2002..This review reveals that there might be contrasting effects of resting and nonresting energy expenditure on aging, with increases in the former being protective and increases in the latter being harmful...
- Circadian desynchrony and metabolic dysfunction; did light pollution make us fat?C A Wyse
Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 3TZ, UK
Med Hypotheses 77:1139-44. 2011..Attention to the rhythmicity of daily sleep, exercise, work and feeding schedules could be beneficial in targeting or reversing the modern human predisposition to obesity...
- Male short-tailed field voles (Microtus agrestis) build better insulated nests than femalesP Redman
Department of Zoology, University of Aberdeen, UK
J Comp Physiol B 169:581-7. 1999..This was a 28% saving on intake for a 22-g vole but only an 18% saving for a 40-g individual. When voles had nests for short periods they used the energy they saved to reduce food intake and increase body mass...
- The consequences of acute cold exposure on protein oxidation and proteasome activity in short-tailed field voles, microtus agrestisColin Selman
Aberdeen Centre for Energy Expenditure and Obesity ACERO, Department of Zoology, Aberdeen University, UK
Free Radic Biol Med 33:259-65. 2002..This protection may be a very important factor in sustaining uncoupled respiration, which underpins nonshivering thermogenesis at cold temperatures...
- Association between mammalian lifespan and circadian free-running period: the circadian resonance hypothesis revisitedC A Wyse
Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, AB24 2TZ, UK
Biol Lett 6:696-8. 2010..These findings support the hypothesis that misalignment of endogenous rhythms and 24 h environmental cycles may be associated with a physiological cost that has an effect on longevity...
- Vitamin E supplementation and mammalian lifespanRuth Banks
Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK
Mol Nutr Food Res 54:719-25. 2010..We suggest that the role of this pathway in life span extension following supplementation of vitamin E now requires further investigation...
- The impact of acute caloric restriction on the metabolic phenotype in male C57BL/6 and DBA/2 miceSarah Hempenstall
Integrative Physiology, Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
Mech Ageing Dev 131:111-8. 2010..These strain-specific differences in glucose homeostatic parameters may underlie the reported unresponsiveness of DBA/2 mice to CR. We also demonstrate delineation in the response of insulin and IGF-1 to acute CR in mice...
- Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in miceColin Selman
Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Institute, London, United Kingdom
Physiol Genomics 27:187-200. 2006..Mice undergoing acute CR rapidly adopt many transcriptional and metabolic changes of long-term CR, suggesting that the beneficial effects of CR may require only a short-term reduction in caloric intake...
- The role of insulin receptor substrate 2 in hypothalamic and beta cell functionAgharul I Choudhury
Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
J Clin Invest 115:940-50. 2005..Our findings demonstrate a critical role for IRS2 in beta cell and hypothalamic function and provide insights into the role of RIPCre neurons, a distinct hypothalamic neuronal population, in growth and energy homeostasis...
- Birds sacrifice oxidative protection for reproductionPopko Wiersma
Zoological Laboratory of the University of Groningen, 9750 AA Haren, The Netherlands
Proc Biol Sci 271:S360-3. 2004..This result suggests that senescence acceleration by increased reproductive effort is at least in part mediated by oxidative stress...
- Effects of dietary calcium restriction and acute exercise on the antioxidant enzyme system and oxidative stress in rat diaphragmMasayuki Itoh
Fifth Dept of Internal Medicine, Tokyo Medical Univ, 3 20 1, Chuou, Ami, Inashiki, Ibaraki 300 0395, Japan
Am J Physiol Regul Integr Comp Physiol 287:R33-8. 2004....
- Short-term caloric restriction and regulatory proteins of apoptosis in heart, skeletal muscle and kidney of Fischer 344 ratsColin Selman
University of Florida, Biochemistry of Aging Laboratory, College of Health and Human Performance, Box 118206, Gainesville, FL 32611, USA
Biogerontology 4:141-7. 2003....
- Energy expenditure of calorically restricted rats is higher than predicted from their altered body compositionColin Selman
University of Florida, Department of Aging and Geriatric Research, College of Medicine, Gainesville, 32608, USA
Mech Ageing Dev 126:783-93. 2005....
- Evolutionary conservation of regulated longevity assurance mechanismsJoshua J McElwee
Department of Biology, University College London, London WC1E 6BT, UK
Genome Biol 8:R132. 2007..To address this, we have applied a novel, multi-level cross-species comparative analysis to compare gene expression changes accompanying increased longevity in mutant nematodes, fruitflies and mice with reduced IIS...
- Exercise by lifelong voluntary wheel running reduces subsarcolemmal and interfibrillar mitochondrial hydrogen peroxide production in the heartSharon Judge
Univ of Florida, College of Medicine, Dept of Aging and Geriatric Research, Genomics and Biomarkers Core Institute on Aging, Biochemistry of Aging Laboratory, Gainesville, FL 32608, USA
Am J Physiol Regul Integr Comp Physiol 289:R1564-72. 2005..The health benefits of chronic exercise may be, at least partially, due to a reduction in mitochondrial oxidant production; however, we could not detect a significant reduction in several selected parameters of oxidative stress...
- Alterations in tissue aerobic capacity may play a role in premigratory fattening in shorebirdsColin Selman
Department of Biological Sciences, Science Laboratories, University of Durham, Durham DH1 3LE, UK
Biol Lett 1:101-4. 2005..Thus, physiological adjustments in tissue metabolism may be an important factor in the life-history strategies of migrating shorebirds...
- Short-term caloric restriction and sites of oxygen radical generation in kidney and skeletal muscle mitochondriaRicardo Gredilla
Department of Animal Biology II Animal Physiology, Faculty of Biology, Complutense University, 28040 Madrid, Spain
Ann N Y Acad Sci 1019:333-42. 2004....
- The role of Id2 and apoptosis during skeletal muscle remodelingColin Selman
Am J Physiol Regul Integr Comp Physiol 284:R538-9. 2003
- Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"Colin Selman
Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Institute, 5 University Street, London WC1E 6JJ, UK
Science 320:1012; author reply 1012. 2008..However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals...
- Increased hepatic apoptosis during short-term caloric restriction is not associated with an enhancement in caspase levelsColin Selman
Biochemistry of Aging Laboratory, College of Health and Human Performance, University of Florida, P O Box 118206, Gainesville, FL 32611 8206, USA
Exp Gerontol 38:897-903. 2003....
- Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null miceColin Selman
Centre for Diabetes and Endocrinology, Department of Medicine, Rayne Institute, University College London, University St, London, UK
FASEB J 22:807-18. 2008..Our results therefore suggest that IRS1 signaling is an evolutionarily conserved pathway regulating mammalian life span and may be a point of intervention for therapies with the potential to delay age-related processes...
- AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neuronsMarc Claret
Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
J Clin Invest 117:2325-36. 2007....
- Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouseIrina Neganova
Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London WC1E 6JJ, United Kingdom
Biol Reprod 76:1045-53. 2007..Our data suggest that ovarian rather than central nervous system IRS2 signaling is important in the regulation of female reproductive function...
- Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female ratsYoung Mok Jang
Biochemistry of Aging Laboratory, University of Florida, P O Box 118206, Gainesville, FL 32611, USA
FEBS Lett 577:483-90. 2004..Moreover, no major sex differences exist in apoptosis signaling transduction cascade due to doxorubicin treatment...