C Selman

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. doi Oxidative damage, ageing, and life-history evolution: where now?
    Colin Selman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, AB24 2TZ, UK
    Trends Ecol Evol 27:570-7. 2012
  2. pmc Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1
    Colin Selman
    Institute of Biological and Environmental Sciences, School of Biological Sciences, University of Aberdeen, Aberdeen, United Kingdom
    PLoS ONE 6:e16144. 2011
  3. doi Lifelong alpha-tocopherol supplementation increases the median life span of C57BL/6 mice in the cold but has only minor effects on oxidative damage
    Colin Selman
    Integrative Physiology, School of Biological Sciences, University of Aberdeen, Aberdeen, United Kingdom
    Rejuvenation Res 11:83-96. 2008
  4. ncbi Antioxidant enzyme activities, lipid peroxidation, and DNA oxidative damage: the effects of short-term voluntary wheel running
    Colin Selman
    Aberdeen Centre for Energy Expenditure and Obesity ACERO, Department of Zoology, Aberdeen University, Aberdeen AB24 2TZ, Scotland, UK
    Arch Biochem Biophys 401:255-61. 2002
  5. ncbi Voluntary exercise has only limited effects on activity of antioxidant enzymes and does not cause oxidative damage in a small mammal
    Colin Selman
    Aberdeen Centre for Energy Expenditure and Obesity, Department of Zoology, Aberdeen University, Aberdeen, UK
    J Nutr 132:1784S-6S. 2002
  6. ncbi Thermoregulatory responses of two mouse Mus musculus strains selectively bred for high and low food intake
    C Selman
    Aberdeen Centre for Energy Regulation and Obesity, Department of Zoology, University of Aberdeen, UK
    J Comp Physiol B 171:661-8. 2001
  7. ncbi Resting metabolic rate and morphology in mice (Mus musculus) selected for high and low food intake
    C Selman
    Aberdeen Centre for Energy Regulation and Obesity, Department of Zoology, University of Aberdeen, Aberdeen AB24 2TZ, UK
    J Exp Biol 204:777-84. 2001
  8. ncbi Effect of long-term cold exposure on antioxidant enzyme activities in a small mammal
    C Selman
    Aberdeen Centre for Energy Regulation and Obesity, Department of Zoology, University of Aberdeen, Aberdeen, Scotland, UK
    Free Radic Biol Med 28:1279-85. 2000
  9. pmc The impact of experimentally elevated energy expenditure on oxidative stress and lifespan in the short-tailed field vole Microtus agrestis
    Colin Selman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Proc Biol Sci 275:1907-16. 2008
  10. ncbi Life-long vitamin C supplementation in combination with cold exposure does not affect oxidative damage or lifespan in mice, but decreases expression of antioxidant protection genes
    Colin Selman
    Aberdeen Centre for Energy Regulation and Obesity ACERO, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Mech Ageing Dev 127:897-904. 2006

Collaborators

Detail Information

Publications37

  1. doi Oxidative damage, ageing, and life-history evolution: where now?
    Colin Selman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, AB24 2TZ, UK
    Trends Ecol Evol 27:570-7. 2012
    ..We conclude by emphasising the value of using multiple assays to determine oxidative protection and damage. We also highlight the importance of using standardised and appropriate protocols, and discuss future research directions...
  2. pmc Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1
    Colin Selman
    Institute of Biological and Environmental Sciences, School of Biological Sciences, University of Aberdeen, Aberdeen, United Kingdom
    PLoS ONE 6:e16144. 2011
    ..In addition, an augmented and completed study demonstrates lifespan extension in male Irs1 null mice. Therefore, we show that reduced IRS1-dependent signalling is a robust mechanism through which mammalian lifespan can be modulated...
  3. doi Lifelong alpha-tocopherol supplementation increases the median life span of C57BL/6 mice in the cold but has only minor effects on oxidative damage
    Colin Selman
    Integrative Physiology, School of Biological Sciences, University of Aberdeen, Aberdeen, United Kingdom
    Rejuvenation Res 11:83-96. 2008
    ..However, these signaling pathways now require further investigation to establish their exact role in life span extension following alpha-tocopherol supplementation...
  4. ncbi Antioxidant enzyme activities, lipid peroxidation, and DNA oxidative damage: the effects of short-term voluntary wheel running
    Colin Selman
    Aberdeen Centre for Energy Expenditure and Obesity ACERO, Department of Zoology, Aberdeen University, Aberdeen AB24 2TZ, Scotland, UK
    Arch Biochem Biophys 401:255-61. 2002
    ..There was no evidence of any significant increase in any oxidative stress parameter in running individuals, despite having significantly elevated energy expenditures compared to sedentary controls...
  5. ncbi Voluntary exercise has only limited effects on activity of antioxidant enzymes and does not cause oxidative damage in a small mammal
    Colin Selman
    Aberdeen Centre for Energy Expenditure and Obesity, Department of Zoology, Aberdeen University, Aberdeen, UK
    J Nutr 132:1784S-6S. 2002
  6. ncbi Thermoregulatory responses of two mouse Mus musculus strains selectively bred for high and low food intake
    C Selman
    Aberdeen Centre for Energy Regulation and Obesity, Department of Zoology, University of Aberdeen, UK
    J Comp Physiol B 171:661-8. 2001
    ..The greater levels of food intake were also associated with higher resting metabolic rates at 30 degrees C...
  7. ncbi Resting metabolic rate and morphology in mice (Mus musculus) selected for high and low food intake
    C Selman
    Aberdeen Centre for Energy Regulation and Obesity, Department of Zoology, University of Aberdeen, Aberdeen AB24 2TZ, UK
    J Exp Biol 204:777-84. 2001
    ..The effects of strain on RMR independent of the effect on body mass were consistent with the anticipated effect from the strain differences in the size of the liver...
  8. ncbi Effect of long-term cold exposure on antioxidant enzyme activities in a small mammal
    C Selman
    Aberdeen Centre for Energy Regulation and Obesity, Department of Zoology, University of Aberdeen, Aberdeen, Scotland, UK
    Free Radic Biol Med 28:1279-85. 2000
    ....
  9. pmc The impact of experimentally elevated energy expenditure on oxidative stress and lifespan in the short-tailed field vole Microtus agrestis
    Colin Selman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Proc Biol Sci 275:1907-16. 2008
    ..These data suggest that in captive animals physiologically mediated costs on life history do not result from increased energy expenditure and consequent elevations in oxidative stress and reduced survival...
  10. ncbi Life-long vitamin C supplementation in combination with cold exposure does not affect oxidative damage or lifespan in mice, but decreases expression of antioxidant protection genes
    Colin Selman
    Aberdeen Centre for Energy Regulation and Obesity ACERO, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Mech Ageing Dev 127:897-904. 2006
    ....
  11. ncbi Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity ACERO, School of Biological Sciences, University of Aberdeen, Aberdeen, Scotland, UK AB24 2TZ
    Aging Cell 3:87-95. 2004
    ..Individuals with high metabolism were therefore more uncoupled, had greater resting and total daily energy expenditures and survived longest - supporting the 'uncoupling to survive' hypothesis...
  12. ncbi Physical activity and resting metabolic rate
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, Division of Energy Balance and Obesity, Rowett Research Institute, Aberdeen AB21 9SB, UK
    Proc Nutr Soc 62:621-34. 2003
    ..Extreme interventions, however, may induce reductions in RMR, in spite of the increased lean tissue mass, similar to the changes observed in animals in response to flight...
  13. doi The free-radical damage theory: Accumulating evidence against a simple link of oxidative stress to ageing and lifespan
    John R Speakman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, Scotland, UK
    Bioessays 33:255-9. 2011
    ..Combined, these findings raise fundamental questions over whether the free-radical damage theory remains useful for understanding the ageing process, and variation in lifespan and life histories...
  14. ncbi Living fast, dying when? The link between aging and energetics
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, University of Aberdeen, Aberdeen, UK
    J Nutr 132:1583S-97S. 2002
    ..This review reveals that there might be contrasting effects of resting and nonresting energy expenditure on aging, with increases in the former being protective and increases in the latter being harmful...
  15. doi Circadian desynchrony and metabolic dysfunction; did light pollution make us fat?
    C A Wyse
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 3TZ, UK
    Med Hypotheses 77:1139-44. 2011
    ..Attention to the rhythmicity of daily sleep, exercise, work and feeding schedules could be beneficial in targeting or reversing the modern human predisposition to obesity...
  16. ncbi Male short-tailed field voles (Microtus agrestis) build better insulated nests than females
    P Redman
    Department of Zoology, University of Aberdeen, UK
    J Comp Physiol B 169:581-7. 1999
    ..This was a 28% saving on intake for a 22-g vole but only an 18% saving for a 40-g individual. When voles had nests for short periods they used the energy they saved to reduce food intake and increase body mass...
  17. ncbi The consequences of acute cold exposure on protein oxidation and proteasome activity in short-tailed field voles, microtus agrestis
    Colin Selman
    Aberdeen Centre for Energy Expenditure and Obesity ACERO, Department of Zoology, Aberdeen University, UK
    Free Radic Biol Med 33:259-65. 2002
    ..This protection may be a very important factor in sustaining uncoupled respiration, which underpins nonshivering thermogenesis at cold temperatures...
  18. pmc Association between mammalian lifespan and circadian free-running period: the circadian resonance hypothesis revisited
    C A Wyse
    Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, AB24 2TZ, UK
    Biol Lett 6:696-8. 2010
    ..These findings support the hypothesis that misalignment of endogenous rhythms and 24 h environmental cycles may be associated with a physiological cost that has an effect on longevity...
  19. doi Vitamin E supplementation and mammalian lifespan
    Ruth Banks
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK
    Mol Nutr Food Res 54:719-25. 2010
    ..We suggest that the role of this pathway in life span extension following supplementation of vitamin E now requires further investigation...
  20. doi The impact of acute caloric restriction on the metabolic phenotype in male C57BL/6 and DBA/2 mice
    Sarah Hempenstall
    Integrative Physiology, Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Mech Ageing Dev 131:111-8. 2010
    ..These strain-specific differences in glucose homeostatic parameters may underlie the reported unresponsiveness of DBA/2 mice to CR. We also demonstrate delineation in the response of insulin and IGF-1 to acute CR in mice...
  21. ncbi Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice
    Colin Selman
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Institute, London, United Kingdom
    Physiol Genomics 27:187-200. 2006
    ..Mice undergoing acute CR rapidly adopt many transcriptional and metabolic changes of long-term CR, suggesting that the beneficial effects of CR may require only a short-term reduction in caloric intake...
  22. pmc The role of insulin receptor substrate 2 in hypothalamic and beta cell function
    Agharul I Choudhury
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
    J Clin Invest 115:940-50. 2005
    ..Our findings demonstrate a critical role for IRS2 in beta cell and hypothalamic function and provide insights into the role of RIPCre neurons, a distinct hypothalamic neuronal population, in growth and energy homeostasis...
  23. pmc Birds sacrifice oxidative protection for reproduction
    Popko Wiersma
    Zoological Laboratory of the University of Groningen, 9750 AA Haren, The Netherlands
    Proc Biol Sci 271:S360-3. 2004
    ..This result suggests that senescence acceleration by increased reproductive effort is at least in part mediated by oxidative stress...
  24. ncbi Effects of dietary calcium restriction and acute exercise on the antioxidant enzyme system and oxidative stress in rat diaphragm
    Masayuki Itoh
    Fifth Dept of Internal Medicine, Tokyo Medical Univ, 3 20 1, Chuou, Ami, Inashiki, Ibaraki 300 0395, Japan
    Am J Physiol Regul Integr Comp Physiol 287:R33-8. 2004
    ....
  25. ncbi Short-term caloric restriction and regulatory proteins of apoptosis in heart, skeletal muscle and kidney of Fischer 344 rats
    Colin Selman
    University of Florida, Biochemistry of Aging Laboratory, College of Health and Human Performance, Box 118206, Gainesville, FL 32611, USA
    Biogerontology 4:141-7. 2003
    ....
  26. ncbi Energy expenditure of calorically restricted rats is higher than predicted from their altered body composition
    Colin Selman
    University of Florida, Department of Aging and Geriatric Research, College of Medicine, Gainesville, 32608, USA
    Mech Ageing Dev 126:783-93. 2005
    ....
  27. pmc Evolutionary conservation of regulated longevity assurance mechanisms
    Joshua J McElwee
    Department of Biology, University College London, London WC1E 6BT, UK
    Genome Biol 8:R132. 2007
    ..To address this, we have applied a novel, multi-level cross-species comparative analysis to compare gene expression changes accompanying increased longevity in mutant nematodes, fruitflies and mice with reduced IIS...
  28. ncbi Exercise by lifelong voluntary wheel running reduces subsarcolemmal and interfibrillar mitochondrial hydrogen peroxide production in the heart
    Sharon Judge
    Univ of Florida, College of Medicine, Dept of Aging and Geriatric Research, Genomics and Biomarkers Core Institute on Aging, Biochemistry of Aging Laboratory, Gainesville, FL 32608, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1564-72. 2005
    ..The health benefits of chronic exercise may be, at least partially, due to a reduction in mitochondrial oxidant production; however, we could not detect a significant reduction in several selected parameters of oxidative stress...
  29. pmc Alterations in tissue aerobic capacity may play a role in premigratory fattening in shorebirds
    Colin Selman
    Department of Biological Sciences, Science Laboratories, University of Durham, Durham DH1 3LE, UK
    Biol Lett 1:101-4. 2005
    ..Thus, physiological adjustments in tissue metabolism may be an important factor in the life-history strategies of migrating shorebirds...
  30. ncbi Short-term caloric restriction and sites of oxygen radical generation in kidney and skeletal muscle mitochondria
    Ricardo Gredilla
    Department of Animal Biology II Animal Physiology, Faculty of Biology, Complutense University, 28040 Madrid, Spain
    Ann N Y Acad Sci 1019:333-42. 2004
    ....
  31. ncbi The role of Id2 and apoptosis during skeletal muscle remodeling
    Colin Selman
    Am J Physiol Regul Integr Comp Physiol 284:R538-9. 2003
  32. doi Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"
    Colin Selman
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Institute, 5 University Street, London WC1E 6JJ, UK
    Science 320:1012; author reply 1012. 2008
    ..However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals...
  33. ncbi Increased hepatic apoptosis during short-term caloric restriction is not associated with an enhancement in caspase levels
    Colin Selman
    Biochemistry of Aging Laboratory, College of Health and Human Performance, University of Florida, P O Box 118206, Gainesville, FL 32611 8206, USA
    Exp Gerontol 38:897-903. 2003
    ....
  34. ncbi Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice
    Colin Selman
    Centre for Diabetes and Endocrinology, Department of Medicine, Rayne Institute, University College London, University St, London, UK
    FASEB J 22:807-18. 2008
    ..Our results therefore suggest that IRS1 signaling is an evolutionarily conserved pathway regulating mammalian life span and may be a point of intervention for therapies with the potential to delay age-related processes...
  35. pmc AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
    Marc Claret
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
    J Clin Invest 117:2325-36. 2007
    ....
  36. ncbi Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse
    Irina Neganova
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London WC1E 6JJ, United Kingdom
    Biol Reprod 76:1045-53. 2007
    ..Our data suggest that ovarian rather than central nervous system IRS2 signaling is important in the regulation of female reproductive function...
  37. ncbi Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female rats
    Young Mok Jang
    Biochemistry of Aging Laboratory, University of Florida, P O Box 118206, Gainesville, FL 32611, USA
    FEBS Lett 577:483-90. 2004
    ..Moreover, no major sex differences exist in apoptosis signaling transduction cascade due to doxorubicin treatment...