M L Seghier

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Dissociating functional brain networks by decoding the between-subject variability
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Wellcome Department of Imaging Neuroscience, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 45:349-59. 2009
  2. pmc Predicting language lateralization from gray matter
    Goulven Josse
    Wellcome Trust Centre for Neuroimaging, UCL, London, United Kingdom
    J Neurosci 29:13516-23. 2009
  3. pmc Regional and hemispheric determinants of language laterality: implications for preoperative fMRI
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK
    Hum Brain Mapp 32:1602-14. 2011
  4. pmc Reading aloud boosts connectivity through the putamen
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London WC1N 3BG, UK
    Cereb Cortex 20:570-82. 2010
  5. pmc The left superior temporal gyrus is a shared substrate for auditory short-term memory and speech comprehension: evidence from 210 patients with stroke
    Alexander P Leff
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK
    Brain 132:3401-10. 2009
  6. doi request reprint The angular gyrus: multiple functions and multiple subdivisions
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK
    Neuroscientist 19:43-61. 2013
  7. pmc Reading without the left ventral occipito-temporal cortex
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London WC1N 3BG, UK
    Neuropsychologia 50:3621-35. 2012
  8. pmc Laterality index in functional MRI: methodological issues
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL London, UK
    Magn Reson Imaging 26:594-601. 2008
  9. ncbi request reprint Functional MRI of the newborn
    Mohamed L Seghier
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK
    Semin Fetal Neonatal Med 11:479-88. 2006
  10. pmc Lesion identification using unified segmentation-normalisation models and fuzzy clustering
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London UK
    Neuroimage 41:1253-66. 2008

Detail Information

Publications40

  1. pmc Dissociating functional brain networks by decoding the between-subject variability
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Wellcome Department of Imaging Neuroscience, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 45:349-59. 2009
    ....
  2. pmc Predicting language lateralization from gray matter
    Goulven Josse
    Wellcome Trust Centre for Neuroimaging, UCL, London, United Kingdom
    J Neurosci 29:13516-23. 2009
    ..This is the first demonstration that structural brain scans can be used to predict language lateralization on a voxel-by-voxel basis in the normal healthy brain...
  3. pmc Regional and hemispheric determinants of language laterality: implications for preoperative fMRI
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK
    Hum Brain Mapp 32:1602-14. 2011
    ..We therefore highlight the importance of investigating within hemisphere regional variations in fMRI activation, prior to neuro-surgical intervention, to determine how each hemisphere and each region contributes to language processing...
  4. pmc Reading aloud boosts connectivity through the putamen
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London WC1N 3BG, UK
    Cereb Cortex 20:570-82. 2010
    ..We conclude that the putamen plays a special role in reading but this is likely to vary with individual reading preferences and strategies...
  5. pmc The left superior temporal gyrus is a shared substrate for auditory short-term memory and speech comprehension: evidence from 210 patients with stroke
    Alexander P Leff
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK
    Brain 132:3401-10. 2009
    ..The method applied here will be particularly useful for modelling structure-function relationships within other complex cognitive domains...
  6. doi request reprint The angular gyrus: multiple functions and multiple subdivisions
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK
    Neuroscientist 19:43-61. 2013
    ..Several interesting questions that warrant further investigations are finally emphasized...
  7. pmc Reading without the left ventral occipito-temporal cortex
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London WC1N 3BG, UK
    Neuropsychologia 50:3621-35. 2012
    ..Preservation and use of this pathway may explain how patients are still able to read short words accurately when LvOT has been damaged...
  8. pmc Laterality index in functional MRI: methodological issues
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL London, UK
    Magn Reson Imaging 26:594-601. 2008
    ..Although these factors are common to a range of fMRI domains, they are discussed here in the context of fMRI of the language system...
  9. ncbi request reprint Functional MRI of the newborn
    Mohamed L Seghier
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK
    Semin Fetal Neonatal Med 11:479-88. 2006
    ..We expect a rapid expansion of this field and the establishment of fMRI as a valid clinical diagnostic tool in the newborn...
  10. pmc Lesion identification using unified segmentation-normalisation models and fuzzy clustering
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London UK
    Neuroimage 41:1253-66. 2008
    ..From a clinical perspective, our method should help to compute the total volume of lesion or to trace precisely lesion boundaries that might be pertinent for surgical or diagnostic purposes...
  11. pmc Inter-subject variability in the use of two different neuronal networks for reading aloud familiar words
    M L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK
    Neuroimage 42:1226-36. 2008
    ..We discuss the implications of these results which may be important for understanding how reading is learnt in childhood or re-learnt following brain damage in adulthood...
  12. pmc Detecting subject-specific activations using fuzzy clustering
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 36:594-605. 2007
    ..The advantage of using FCP is that it searches all voxels systematically and can identify atypical activation patterns in a quantitative and unsupervised manner...
  13. doi request reprint The role of functional magnetic resonance imaging in the study of brain development, injury, and recovery in the newborn
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom
    Semin Perinatol 34:79-86. 2010
    ....
  14. pmc Lateralization is predicted by reduced coupling from the left to right prefrontal cortex during semantic decisions on written words
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London WC1N 3BG, UK
    Cereb Cortex 21:1519-31. 2011
    ..These results have theoretical implications for understanding how left and right hemispheres communicate with one another during the processing of lateralized functions...
  15. pmc Functional subdivisions in the left angular gyrus where the semantic system meets and diverges from the default network
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 30:16809-17. 2010
    ..Our findings provide a framework for reporting and interpreting AG activations with greater definition...
  16. pmc Explaining left lateralization for words in the ventral occipitotemporal cortex
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, UK
    J Neurosci 31:14745-53. 2011
    ..Moreover, the determinants of lateralization include both visual and semantic factors depending on the subregion tested...
  17. pmc Predicting IQ change from brain structure: a cross-validation study
    C J Price
    Wellcome Trust Centre for Neuroimaging, UCL, London, UK
    Dev Cogn Neurosci 5:172-84. 2013
    ..We discuss how these out-of-sample estimates compare to in-sample estimates; and draw some recommendations for k-fold cross-validation procedures when dealing with small datasets that are typical in the neuroimaging literature...
  18. pmc Predicting language outcome and recovery after stroke: the PLORAS system
    Cathy J Price
    Wellcome Trust Center for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Nat Rev Neurol 6:202-10. 2010
    ..The outputs of this system are the longitudinal language outcomes of corresponding patients in the database. This approach will provide the patient with a range of probable recovery patterns over a variety of language measures...
  19. pmc Explaining function with anatomy: language lateralization and corpus callosum size
    Goulven Josse
    Wellcome Trust Centre for Neuroimaging, UCL, London WC1N 3BG, UK
    J Neurosci 28:14132-9. 2008
    ..We discuss the complex interhemispheric processes that might underlie this effect...
  20. pmc The main sources of intersubject variability in neuronal activation for reading aloud
    Ferath Kherif
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, London, UK
    J Cogn Neurosci 21:654-68. 2009
    ..We therefore conclude that, of the variables tested, age and reading strategy were the most prominent source of variability in activation for reading familiar words aloud...
  21. pmc Multinomial inference on distributed responses in SPM
    J R Chumbley
    The Wellcome Trust Centre for Neuroimaging, UCL, UK
    Neuroimage 53:161-70. 2010
    ..We illustrate the method by characterising the anatomy of language at different scales of functional segregation...
  22. ncbi request reprint Lesion sites that predict the ability to gesture how an object is used
    C J Price
    Wellcome Trust Centre for Neuro imaging, Institute of Neurology, University College London, UK
    Arch Ital Biol 148:243-58. 2010
    ..Our methods provide a framework for future studies aiming to predict the consequences of brain damage...
  23. ncbi request reprint Rhyme processing in the brain: an ERP mapping study
    Asaid Khateb
    Laboratory of Experimental Neuropsychology, Department of Neurology, University Hospital, Geneva, Switzerland
    Int J Psychophysiol 63:240-50. 2007
    ..Our results suggest that, similar to the N400 component that is also induced by mismatch contexts, the N450 might rely on temporal generators...
  24. ncbi request reprint Portraits or people? Distinct representations of face identity in the human visual cortex
    Gilles Pourtois
    Neurology and Imaging of Cognition, Clinic of Neurology and Department of Neurosciences, University of Geneva, Switzerland
    J Cogn Neurosci 17:1043-57. 2005
    ..This pattern provides new insights into the nature of face representation in the human visual system...
  25. ncbi request reprint Brain activation using triggered event-related fMRI
    Ivan Zimine
    Department of Radiology, Geneva University Hospitals, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Neuroimage 18:410-5. 2003
    ..We conclude that this can be a useful technique for studying brain activation associated with irregularly appearing stimuli...
  26. ncbi request reprint Neural systems for orienting attention to the location of threat signals: an event-related fMRI study
    Gilles Pourtois
    Neurology and Imaging of Cognition, Clinic of Neurology, University Hospital and Department of Neurosciences, University Medical Center, Switzerland
    Neuroimage 31:920-33. 2006
    ..Neural mechanisms responsible for orienting attention towards emotional vs. non-emotional stimuli are thus partly shared in parietal and visual areas, but also partly distinct...
  27. ncbi request reprint Group analysis and the subject factor in functional magnetic resonance imaging: analysis of fifty right-handed healthy subjects in a semantic language task
    Mohamed L Seghier
    Department of Radiology, Geneva University Hospitals, Geneva, Switzerland
    Hum Brain Mapp 29:461-77. 2008
    ....
  28. ncbi request reprint WSPM: wavelet-based statistical parametric mapping
    Dimitri van de Ville
    Biomedical Imaging Group, Ecole Polytechnique Federale de Lausanne EPFL, and Department of Radiology and Medical Informatics, University Hospital Geneva, Switzerland
    Neuroimage 37:1205-17. 2007
    ..The full approach is available as a toolbox, named WSPM, for the SPM2 software; it takes advantage of multiple options and features of SPM such as the general linear model...
  29. ncbi request reprint Tactile awareness and limb position in neglect: functional magnetic resonance imaging
    Nathalie Valenza
    Department of Neurology and Neurosciences, University of Geneva, Switzerland
    Ann Neurol 55:139-43. 2004
    ..Activity in bilateral middle frontal gyri also was modulated by limb position and may contribute to integrate sensory inputs into a supramodal, egocentric representation of space...
  30. ncbi request reprint Transient crossed aphasia evidenced by functional brain imagery
    Asaid Khateb
    Neuropsychology Unit, Department of Neurology, Geneva University Hospitals, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Neuroreport 15:785-90. 2004
    ..In the light of previous studies reporting much frequent bilateral than exclusive right hemisphere representations, we hypothesise that some crossed aphasia cases could occur in subjects with bilateral language representation...
  31. ncbi request reprint FMRI evidence for activation of multiple cortical regions in the primary auditory cortex of deaf subjects users of multichannel cochlear implants
    Mohamed L Seghier
    Department of Radiology, University Hospital of Geneva, Micheli du Crest 24, 1211 Geneva, Switzerland
    Cereb Cortex 15:40-8. 2005
    ..These arguments, obtained without interference with unwanted scanner noise, plead in favor of a functional subdivision of the primary auditory cortex into multiple cortical regions in cochlear implant users...
  32. ncbi request reprint Variability of fMRI activation during a phonological and semantic language task in healthy subjects
    Mohamed L Seghier
    Department of Radiology, Geneva University Hospital, CH 1211 Geneva, Switzerland
    Hum Brain Mapp 23:140-55. 2004
    ....
  33. ncbi request reprint Anatomical variability of the lateral frontal lobe surface: implication for intersubject variability in language neuroimaging
    Heike Juch
    Department of Morphology, Division of Anatomy, Medical School, University of Geneva, 1, Geneva, CH 1211, Switzerland
    Neuroimage 24:504-14. 2005
    ..We therefore suggest to express functional activation in relation to landmarks obtained from individual anatomy. This approach may contribute to a better analysis of the differences between individuals...
  34. ncbi request reprint The voices of wrath: brain responses to angry prosody in meaningless speech
    Didier Grandjean
    Geneva Emotion Research Group, Department of Psychology, University of Geneva, Bd du Pont d Arve 40, CH 1205 Geneva, Switzerland
    Nat Neurosci 8:145-6. 2005
    ..Attention and emotion seem to have separate effects on stimulus processing, reflecting a fundamental principle of human brain organization shared by voice and face perception...
  35. ncbi request reprint Language control and lexical competition in bilinguals: an event-related FMRI study
    Jubin Abutalebi
    Centre for Cognitive Neurosciences, Vita Salute San Raffaele University and Scientific Institute San Raffaele, 20132 Milan, Italy
    Cereb Cortex 18:1496-505. 2008
    ....
  36. ncbi request reprint View-independent coding of face identity in frontal and temporal cortices is modulated by familiarity: an event-related fMRI study
    Gilles Pourtois
    Department of Neurosciences, Neurology and Imaging of Cognition, Clinic of Neurology, University Hospital, University Medical Center, Switzerland
    Neuroimage 24:1214-24. 2005
    ....
  37. ncbi request reprint Functional magnetic resonance imaging and diffusion tensor imaging in a case of central poststroke pain
    Mohamed L Seghier
    Department of Radiology, University of Hospital of Geneva, Switzerland
    J Pain 6:208-12. 2005
    ..Our investigations show, for CPSP pathogenesis, the role of damage of lateral nociceptive thalamoparietal fibers together with the release of activity of anterior cingulate and posterior parietal regions...
  38. ncbi request reprint Emotion and attention interactions in social cognition: brain regions involved in processing anger prosody
    David Sander
    Geneva Emotion Research Group, Department of Psychology, University of Geneva, Switzerland
    Neuroimage 28:848-58. 2005
    ....
  39. ncbi request reprint The fusiform face area is tuned for curvilinear patterns with more high-contrasted elements in the upper part
    Roberto Caldara
    Centre for Cognitive Neuroimaging, Department of Psychology, University of Glasgow, 58 Hillhead Street, Glasgow, G12 8QB, UK
    Neuroimage 31:313-9. 2006
    ..These findings provide direct evidence that the FFA is tuned for geometrical properties fitting best with the structure of faces, a computational mechanism that might drive the automatic detection of faces in the visual world...
  40. pmc Visual recovery after perinatal stroke evidenced by functional and diffusion MRI: case report
    Mohamed L Seghier
    Department of Radiology, Geneva University Hospitals, Micheli du Crest 24, 1211 Geneva, Switzerland
    BMC Neurol 5:17. 2005
    ..Thus, new non-invasive methods capable of early functional diagnosis are needed in young infants...