Jonathan R Seckl

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint Glucocorticoid programming
    Jonathan R Seckl
    Endocrinology Unit, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh, EH4 2XU, UK
    Ann N Y Acad Sci 1032:63-84. 2004
  2. ncbi request reprint 11 beta-hydroxysteroid dehydrogenase type 1 induction in the arcuate nucleus by high-fat feeding: A novel constraint to hyperphagia?
    Valerie S Densmore
    Endocrinology Unit, Queen s Medical Research Institute, Edinburgh EH16 4TJ, Scotland, United Kingdom
    Endocrinology 147:4486-95. 2006
  3. ncbi request reprint Glucocorticoids, developmental 'programming' and the risk of affective dysfunction
    Jonathan R Seckl
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, Edinburgh, UK
    Prog Brain Res 167:17-34. 2008
  4. pmc Cerebrospinal fluid cortisol levels are higher in patients with delirium versus controls
    Andrew Pearson
    Geriatric Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK
    BMC Res Notes 3:33. 2010
  5. pmc Association between umbilical cord glucocorticoids and blood pressure at age 3 years
    Susanna Y Huh
    Division of Gastroenterology and Nutrition, Children s Hospital Boston, Boston, MA, USA
    BMC Med 6:25. 2008
  6. ncbi request reprint Physiologic programming of the fetus
    J R Seckl
    Molecular Medicine Centre, University of Edinburgh, Western General Hospital, United Kingdom, USA
    Clin Perinatol 25:939-62, vii. 1998
  7. ncbi request reprint 11Beta-hydroxysteroid dehydrogenases: a novel control of glucocorticoid action in the brain
    Jonathan R Seckl
    Endocrinology Unit, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, UK
    Endocr Res 28:701-7. 2002
  8. ncbi request reprint Glucocorticoids, 11beta-hydroxysteroid dehydrogenase, and fetal programming
    J R Seckl
    Molecular Medicine Center, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom
    Kidney Int 57:1412-7. 2000
  9. ncbi request reprint Glucocorticoid "programming" and PTSD risk
    Jonathan R Seckl
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Ann N Y Acad Sci 1071:351-78. 2006
  10. ncbi request reprint Minireview: 11beta-hydroxysteroid dehydrogenase type 1- a tissue-specific amplifier of glucocorticoid action
    J R Seckl
    Endocrinology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, United Kingdom
    Endocrinology 142:1371-6. 2001

Detail Information

Publications171 found, 100 shown here

  1. ncbi request reprint Glucocorticoid programming
    Jonathan R Seckl
    Endocrinology Unit, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh, EH4 2XU, UK
    Ann N Y Acad Sci 1032:63-84. 2004
    ..Overall, the data suggest that either pharmacological or physiological exposure to excess glucocorticoids prenatally programs pathologies in adult life...
  2. ncbi request reprint 11 beta-hydroxysteroid dehydrogenase type 1 induction in the arcuate nucleus by high-fat feeding: A novel constraint to hyperphagia?
    Valerie S Densmore
    Endocrinology Unit, Queen s Medical Research Institute, Edinburgh EH16 4TJ, Scotland, United Kingdom
    Endocrinology 147:4486-95. 2006
    ..These data suggest that 11 beta-HSD1 in brain plays a role in the adaptive restraint of excess fat intake, in part by increasing inhibitory opioid tone on AGRP expression in the arcuate nucleus...
  3. ncbi request reprint Glucocorticoids, developmental 'programming' and the risk of affective dysfunction
    Jonathan R Seckl
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, Edinburgh, UK
    Prog Brain Res 167:17-34. 2008
    ..Posttraumatic stress disorder and other affective diseases may both act as environmental challenges if present in early life and may themselves be more likely in individuals made 'vulnerable' by early life stress...
  4. pmc Cerebrospinal fluid cortisol levels are higher in patients with delirium versus controls
    Andrew Pearson
    Geriatric Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK
    BMC Res Notes 3:33. 2010
    ..abstract:..
  5. pmc Association between umbilical cord glucocorticoids and blood pressure at age 3 years
    Susanna Y Huh
    Division of Gastroenterology and Nutrition, Children s Hospital Boston, Boston, MA, USA
    BMC Med 6:25. 2008
    ..Data in humans are limited. We examined in humans the association between venous umbilical cord blood glucocorticoids, a potential marker for placental 11beta-HSD2 enzyme activity, and blood pressure at age 3 years...
  6. ncbi request reprint Physiologic programming of the fetus
    J R Seckl
    Molecular Medicine Centre, University of Edinburgh, Western General Hospital, United Kingdom, USA
    Clin Perinatol 25:939-62, vii. 1998
    ....
  7. ncbi request reprint 11Beta-hydroxysteroid dehydrogenases: a novel control of glucocorticoid action in the brain
    Jonathan R Seckl
    Endocrinology Unit, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, UK
    Endocr Res 28:701-7. 2002
    ..The striking protection against cognitive decline seen in elderly 11beta-HSD1 knockout mice suggest that manipulation of this isozyme may be a useful therapeutic avenue to explore...
  8. ncbi request reprint Glucocorticoids, 11beta-hydroxysteroid dehydrogenase, and fetal programming
    J R Seckl
    Molecular Medicine Center, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom
    Kidney Int 57:1412-7. 2000
    ..Thus, glucocorticoid programming may explain, in part, the association between fetal events and subsequent disorders in adult life...
  9. ncbi request reprint Glucocorticoid "programming" and PTSD risk
    Jonathan R Seckl
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Ann N Y Acad Sci 1071:351-78. 2006
    ....
  10. ncbi request reprint Minireview: 11beta-hydroxysteroid dehydrogenase type 1- a tissue-specific amplifier of glucocorticoid action
    J R Seckl
    Endocrinology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, United Kingdom
    Endocrinology 142:1371-6. 2001
    ..Inhibition of 11beta-HSD1 represents a potential target for therapy of disorders that might be ameliorated by local reduction of glucocorticoid action, including type 2 diabetes, obesity, and age-related cognitive dysfunction...
  11. ncbi request reprint Prenatal glucocorticoids and long-term programming
    Jonathan R Seckl
    Endocrinology Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Eur J Endocrinol 151:U49-62. 2004
    ..Overall, the data suggest that both pharmacological and physiological exposure prenatally to excess glucocorticoids programmes cardiovascular, metabolic and neuroendocrine disorders in adult life...
  12. ncbi request reprint 11beta-hydroxysteroid dehydrogenases: changing glucocorticoid action
    Jonathan R Seckl
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK
    Curr Opin Pharmacol 4:597-602. 2004
    ..Overexpression of this isozyme may contribute to the pathogenesis of the metabolic syndrome. Its inhibition is a potential therapeutic target for both metabolic and glucocorticoid-associated CNS disorders...
  13. ncbi request reprint 11beta-hydroxysteroid dehydrogenase type 1 as a modulator of glucocorticoid action: from metabolism to memory
    Jonathan R Seckl
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK
    Trends Endocrinol Metab 15:418-24. 2004
    ..The ongoing development of selective 11beta-HSD1 inhibitors affords the opportunity to explore a new approach to some major common disorders...
  14. ncbi request reprint Glucocorticoid programming of the fetus; adult phenotypes and molecular mechanisms
    J R Seckl
    Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Mol Cell Endocrinol 185:61-71. 2001
    ..Detailed molecular mechanisms are being dissected. Analogous stress axis hyperreactivity occurs in lower birth weight humans and may be an early manifestation and indicate approaches to manipulation or prevention of the phenotype...
  15. ncbi request reprint 11beta-Hydroxysteroid dehydrogenase in the brain: a novel regulator of glucocorticoid action?
    J R Seckl
    Department of Medicine, University of Edinburgh, Edinburgh, EH4 2XU, United Kingdom
    Front Neuroendocrinol 18:49-99. 1997
    ..Enzyme modulation by pharmacological or other agents may provide a useful means to target increased or attenuated glucocorticoid action to specific sites in the brain...
  16. doi request reprint Minireview: Stress-related psychiatric disorders with low cortisol levels: a metabolic hypothesis
    Rachel Yehuda
    Mount Sinai School of Medicine, Department of Psychiatry, Traumatology and Stress Studies Division, New York, New York 10029, USA
    Endocrinology 152:4496-503. 2011
    ..This notion implies a vulnerable early-life phenotype may be discernable and indicates potential therapy by modest glucocorticoid replacement. Indeed, early clinical trials with cortisol have shown a modicum of promise...
  17. ncbi request reprint Medical and physiological aspects of the 11beta-hydroxysteroid dehydrogenase system
    J R Seckl
    Molecular Endocrinology Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, UK
    Eur J Biochem 249:361-4. 1997
    ..Both isozymes are regulated during ontogeny and by a series of hormonal and other factors. 11Beta-HSD provide an important control of glucocorticoid action at a cellular level, and may represent new targets for therapeutic intervention...
  18. doi request reprint Prenatal dexamethasone programs expression of genes in liver and adipose tissue and increased hepatic lipid accumulation but not obesity on a high-fat diet
    Amanda J Drake
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 151:1581-7. 2010
    ..This may be due to depot-specific-programmed alterations in fat metabolism in adipose tissue...
  19. pmc Dietary manipulation reveals an unexpected inverse relationship between fat mass and adipose 11β-hydroxysteroid dehydrogenase type 1
    Tak Yung Man
    Endocrinology Unit, Centre for Cardiovascular Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    Am J Physiol Endocrinol Metab 300:E1076-84. 2011
    ..The dynamic depot-selective relationship between adipose 11β-HSD1 and fat mass strongly implicates a dominant physiological role for local tissue glucocorticoid reactivation in fat mobilization...
  20. pmc 11beta-hydroxysteroid dehydrogenase type 1 expression is increased in the aged mouse hippocampus and parietal cortex and causes memory impairments
    Megan C Holmes
    Endocrinology Unit, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    J Neurosci 30:6916-20. 2010
    ..Thus, excess 11beta-HSD1 in forebrain is a cause of as well as a therapeutic target in memory impairments with aging...
  21. ncbi request reprint Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice
    Nicholas M Morton
    Endocrinology Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Diabetes 53:931-8. 2004
    ..These data provide the first in vivo evidence that adipose 11 beta-HSD-1 deficiency beneficially alters adipose tissue distribution and function, complementing the reported effects of hepatic 11 beta-HSD-1 deficiency or inhibition...
  22. doi request reprint 11beta-hydroxysteroid dehydrogenase type 1 and obesity
    Nicholas M Morton
    Endocrinology Unit, Centre for Cardiovascular Sciences, Queens Medical Research Institute, Edinburgh University, Edinburgh, UK
    Front Horm Res 36:146-64. 2008
    ....
  23. ncbi request reprint Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia
    Maggie Lai
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, UK
    Eur J Neurosci 25:1832-42. 2007
    ..The induction of neuronal MR appears to offer a protective response which has potential therapeutic implications in cerebral ischaemia and cognitive and affective disorders...
  24. ncbi request reprint A polygenic model of the metabolic syndrome with reduced circulating and intra-adipose glucocorticoid action
    Nicholas M Morton
    Endocrinology Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, UK
    Diabetes 54:3371-8. 2005
    ..Our data suggest that idiopathic metabolic syndrome might associate with such a novel pattern of glucocorticoid action and sensitivity in humans, with implications for tissue-specific therapeutic targeting of 11beta-HSD-1...
  25. ncbi request reprint Liver-selective transgene rescue of hypothalamic-pituitary-adrenal axis dysfunction in 11beta-hydroxysteroid dehydrogenase type 1-deficient mice
    Janice M Paterson
    Centre for Cardiovascular Science, Endocrinology Unit, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
    Endocrinology 148:961-6. 2007
    ..Therefore, hepatic glucocorticoid metabolism influences basal as well as stress-associated functions of the HPA axis...
  26. pmc Prenatal programming of metabolic syndrome in the common marmoset is associated with increased expression of 11beta-hydroxysteroid dehydrogenase type 1
    Moffat J Nyirenda
    Endocrinology Unit, Queen s Medical Research Institute, University of Edinburgh, U K
    Diabetes 58:2873-9. 2009
    ..Here, we tested whether 11beta-HSD1 expression, like the metabolic syndrome, is "programmed" by prenatal environmental events in a nonhuman primate model, the common marmoset monkey...
  27. ncbi request reprint Reduced adipose glucocorticoid reactivation and increased hepatic glucocorticoid clearance as an early adaptation to high-fat feeding in Wistar rats
    Amanda J Drake
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Endocrinology 146:913-9. 2005
    ..Acute exposure to HF diet alters glucocorticoid metabolism, predicting lower hepatic and adipose intracellular glucocorticoid concentrations, which may be a key mechanism protecting against the metabolic complications of obesity...
  28. pmc Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone
    Zoi Michailidou
    Endocrine Unit, Queen s Medical Research Institute, Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    J Endocrinol 194:161-70. 2007
    ..These data suggest that CORT-inducible 11beta-HSD1 expression in fat contributes to the adverse cardiometabolic effects of CORT in POMC deficiency, whereas higher GR levels may be more important in liver...
  29. pmc Partial deficiency or short-term inhibition of 11beta-hydroxysteroid dehydrogenase type 1 improves cognitive function in aging mice
    Karen Sooy
    Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Neurosci 30:13867-72. 2010
    ..These data support the use of selective 11β-HSD1 inhibitors in the treatment of age-related cognitive impairments...
  30. doi request reprint Maternal obesity has little effect on the immediate offspring but impacts on the next generation
    Vicky King
    Medical Research Council University of Edinburgh Centre for Reproductive Health, University British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 154:2514-24. 2013
    ..This suggests that the consequences of the current dietary obesity epidemic may also have an impact on the descendants of obese individuals, even when the phenotype of the F1 appears largely unaffected. ..
  31. doi request reprint Leptin levels and depressive symptoms in people with type 2 diabetes: the edinburgh type 2 diabetes study
    Javier Labad
    Endocrinology Unit, Centre for Cardiovascular Sciences, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK
    Psychosom Med 74:39-45. 2012
    ..We sought to assess whether leptin is related to depressive symptoms in people with Type 2 diabetes...
  32. pmc Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity
    Erin E Kershaw
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 54:1023-31. 2005
    ..These data suggest that reduction of active GCs exclusively in adipose tissue is an important determinant of a favorable metabolic phenotype with respect to energy homeostasis and the metabolic syndrome...
  33. ncbi request reprint Enhanced hippocampal long-term potentiation and spatial learning in aged 11beta-hydroxysteroid dehydrogenase type 1 knock-out mice
    Joyce L W Yau
    Endocrinology Unit, Molecular University of Edinburgh, Queen s Medical Research Institute, EH16 4TJ Edinburgh, United Kingdom
    J Neurosci 27:10487-96. 2007
    ..These data suggest that 11beta-HSD1 deficiency enhances synaptic potentiation in the aged hippocampus and this may underlie the better maintenance of learning and memory with aging, which occurs in the absence of increased neurogenesis...
  34. pmc Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization
    Mark Nixon
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, Scotland, U K
    Diabetes 61:790-6. 2012
    ..Reduced intra-adipose glucocorticoid regeneration by 11β-HSD1 is a novel mechanism that contributes to the metabolic efficacy of salicylates...
  35. doi request reprint 11β-hydroxysteroid dehydrogenase type 1, brain atrophy and cognitive decline
    Alasdair M J MacLullich
    Endocrinology, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, Scotland, UK
    Neurobiol Aging 33:207.e1-8. 2012
    ..55, p = 0.0002) over 6 years. The predictive link between systemic 11β-HSD1 activity and progressive brain atrophy and cognitive decline suggests 11β-HSD1 inhibition as a plausible therapy for brain aging...
  36. ncbi request reprint 11beta-hydroxysteroid dehydrogenase type 1 as a novel therapeutic target in metabolic and neurodegenerative disease
    Brian R Walker
    University of Edinburgh, Endocrinology Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Expert Opin Ther Targets 7:771-83. 2003
    ..The clinical development of potent selective 11HSD1 inhibitors is now a high priority...
  37. pmc 11beta-hydroxysteroid dehydrogenase type 1 deficiency prevents memory deficits with aging by switching from glucocorticoid receptor to mineralocorticoid receptor-mediated cognitive control
    Joyce L W Yau
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, and Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    J Neurosci 31:4188-93. 2011
    ....
  38. ncbi request reprint Plasma cortisol levels, brain volumes and cognition in healthy elderly men
    Alasdair M J MacLullich
    Geriatric Medicine, University of Edinburgh, Room SU220, The Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Psychoneuroendocrinology 30:505-15. 2005
    ..This study examined the hypotheses that higher plasma cortisol levels and altered sensitivity to glucocorticoids are associated with worse cognition and more brain atrophy in elderly men...
  39. doi request reprint 7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type
    Malgorzata Wamil
    Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 149:5909-18. 2008
    ..Thus, the activity and reaction direction of adipose 11beta-HSD1 is altered under conditions of oxysterol excess, and could impact upon the pathophysiology of obesity and its complications...
  40. pmc Morning cortisol levels and cognitive abilities in people with type 2 diabetes: the Edinburgh type 2 diabetes study
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Diabetes Care 33:714-20. 2010
    ..We aimed to determine whether fasting cortisol levels are associated with cognitive ability and estimated lifetime cognitive change in an elderly population with type 2 diabetes...
  41. ncbi request reprint Obese Zucker rats have reduced mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type 1 expression in hippocampus-implications for dysregulation of the hypothalamic-pituitary-adrenal axis in obesity
    Cecilia Mattsson
    Endocrinology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, United Kingdom
    Endocrinology 144:2997-3003. 2003
    ..This may be exacerbated by impaired local regeneration of corticosterone by 11betaHSD1. These abnormalities could contribute to the subtle changes in the HPA axis in rodent and human obesity...
  42. pmc Prenatal dexamethasone 'programmes' hypotension, but stress-induced hypertension in adult offspring
    David O'Regan
    Endocrinology Unit, Queen s Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    J Endocrinol 196:343-52. 2008
    ..We therefore conclude that altered sympathetic responses mediate the stress-induced hypertension associated with prenatal DEX programming...
  43. ncbi request reprint 11beta-hydroxysteroid dehydrogenase type 2 in mouse aorta: localization and influence on response to glucocorticoids
    Clare Christy
    School of Molecular and Clinical Medicine, Endocrinology Unit, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Hypertension 42:580-7. 2003
    ..Therefore, additional mechanisms, possibly involving indirect effects of enhanced corticosterone action in the kidney and the resultant hypertension, must be involved...
  44. ncbi request reprint The mother or the fetus? 11beta-hydroxysteroid dehydrogenase type 2 null mice provide evidence for direct fetal programming of behavior by endogenous glucocorticoids
    Megan C Holmes
    Endocrinology Unit, Centre for Cardiovascular Disease, Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
    J Neurosci 26:3840-4. 2006
    ..This provides clear evidence for the key role of fetoplacental 11beta-HSD2 in prenatal glucocorticoid programming...
  45. doi request reprint An unbalanced maternal diet in pregnancy associates with offspring epigenetic changes in genes controlling glucocorticoid action and foetal growth
    Amanda J Drake
    Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Clin Endocrinol (Oxf) 77:808-15. 2012
    ..We aimed to investigate relationships between an unbalanced maternal diet in pregnancy, neonatal and adult anthropometric variables with methylation at key genes controlling tissue glucocorticoid action and foetal growth...
  46. doi request reprint Cerebellar vermis size and cognitive ability in community-dwelling elderly men
    Thomas D Miller
    SFC Brain Imaging Research Centre, Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, Scotland, UK
    Cerebellum 12:68-73. 2013
    ..47 (p = 0.001) with a general cognitive factor accounting for almost half of the cognitive test variance. These findings support the hypothesis that variations in cerebellar structure are associated with cognitive ability in older adults...
  47. doi request reprint Sex-specific effects of prenatal stress on glucose homoeostasis and peripheral metabolism in rats
    Paula J Brunton
    Division of Neurobiology, The Roslin Institute and R D SVS, University of Edinburgh, Easter Bush Campus, Midlothian, EH25 9RG, UK
    J Endocrinol 217:161-73. 2013
    ..Thus, prenatal social stress differentially programmes glucose homoeostasis and peripheral metabolism in male and female offspring. These long-term alterations in physiology may increase susceptibility to metabolic disease...
  48. pmc A stratified transcriptomics analysis of polygenic fat and lean mouse adipose tissues identifies novel candidate obesity genes
    Nicholas M Morton
    Molecular Metabolism Group, BHF University Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, United Kingdom
    PLoS ONE 6:e23944. 2011
    ....
  49. pmc Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice
    Janice M Paterson
    Wellcome Trust CVRI Molecular Physiology Group, University of Edinburgh Medical School, Wilkie Building, Teviot Place, Edinburgh EH8 9AG, Scotland, United Kingdom
    Proc Natl Acad Sci U S A 101:7088-93. 2004
    ....
  50. doi request reprint Altered placental function of 11beta-hydroxysteroid dehydrogenase 2 knockout mice
    Caitlin S Wyrwoll
    Endocrinology Unit, Queen s Medical Research Institute, Centre for Cardiovascular Science, Edinburgh, United Kingdom
    Endocrinology 150:1287-93. 2009
    ..Our data suggest that restriction of fetal growth in 11beta-HSD2(-/-) mice is mediated, at least in part, via altered placental transport of nutrients and reduction in placental vascularization...
  51. ncbi request reprint Developmental and tissue-specific regulation of hepatocyte nuclear factor 4-alpha (HNF4-alpha) isoforms in rodents
    Samena Dean
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Gene Expr 14:337-44. 2010
    ....
  52. ncbi request reprint Programming of rat muscle and fat metabolism by in utero overexposure to glucocorticoids
    Mark E Cleasby
    Endocrinology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, United Kingdom
    Endocrinology 144:999-1007. 2003
    ..However, increased GR and attenuated fatty acid uptake specifically in visceral adipose are consistent with insulin resistance in this crucial metabolic depot and could indirectly contribute to increased hepatic glucose output...
  53. ncbi request reprint Tissue-specific messenger ribonucleic acid expression of 11beta-hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor within rat placenta suggests exquisite local control of glucocorticoid action
    B J Waddell
    Department of Medicine, The University of Edinburgh, Western General Hospital, Scotland, United Kingdom
    Endocrinology 139:1517-23. 1998
    ..Moreover, the changes in 11beta-HSD expression appear to be unrelated to development of the fetal adrenal cortex and are likely to reduce the placental glucocorticoid barrier near the end of pregnancy...
  54. pmc Stable conditional expression and effect of C/ebpβ-LIP in adipocytes using the pSLIK system
    Cristina L Esteves
    Endocrinology Unit, Queen s Medical Research Institute, University BHF Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK
    J Mol Endocrinol 51:91-8. 2013
    ..The use of the pSLIK system to conditionally express transgenes in 3T3-L1 cells could be a valuable tool to dissect adipocyte physiology...
  55. ncbi request reprint Local amplification of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes
    James S Gilmour
    Endocrinology Unit, Centre for Cardiovascular Sciences, Centre for Cardiovascular Sciences, The Queen s Medical Research Institute, University of Edinburgh, UK
    J Immunol 176:7605-11. 2006
    ..These data point to an early role for 11beta-HSD1 in promoting the rapid clearance of apoptotic cells during the resolution of inflammation and indicate a novel target for therapy...
  56. pmc 11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis
    Tiina Kipari
    British Heart Foundation Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    FASEB J 27:1519-31. 2013
    ..Selective 11β-HSD1 inhibitors promise novel antiatherosclerosis effects over and above their benefits for metabolic risk factors via effects on BM cells, plausibly macrophages...
  57. pmc Mast cells express 11β-hydroxysteroid dehydrogenase type 1: a role in restraining mast cell degranulation
    Agnes E Coutinho
    University British Heart Foundation Centre for Cardiovascular Research, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e54640. 2013
    ..These findings suggest that 11β-HSD1-generated glucocorticoids may tonically restrain mast cell degranulation, potentially influencing allergic, anaphylactic and inflammatory responses...
  58. pmc Association of 11β-hydroxysteroid dehydrogenase type I expression and activity with estrogen receptor β in adipose tissue from postmenopausal women
    Kerry J McInnes
    Endocrinology Unit, Center for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Menopause 19:1347-52. 2012
    ..The purpose of this current study was to establish whether estrogen signaling through estrogen receptor α (ER-α) and estrogen receptor β (ER-β) could influence 11βHSD1 in premenopausal and postmenopausal adipose tissues...
  59. doi request reprint Serum leptin and cognitive function in people with type 2 diabetes
    Javier Labad
    Endocrinology Unit, University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Neurobiol Aging 33:2938-2941.e2. 2012
    ..05). High morning leptin levels in elderly men with type 2 diabetes are associated with estimated age-related cognitive change...
  60. ncbi request reprint Glucocorticoids and 11beta-hydroxysteroid dehydrogenase in adipose tissue
    Jonathan R Seckl
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, United Kingdom
    Recent Prog Horm Res 59:359-93. 2004
    ..Adipose 11beta-HSD1 deficiency contributes to a protective metabolic phenotype, supporting its role as a therapeutic target for the metabolic syndrome...
  61. pmc Optimal elevation of β-cell 11β-hydroxysteroid dehydrogenase type 1 is a compensatory mechanism that prevents high-fat diet-induced β-cell failure
    Sophie Turban
    Molecular Metabolism Group, University of Edinburgh British Heart Foundation Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Diabetes 61:642-52. 2012
    ..These findings have immediate significance for current therapeutic strategies for type 2 diabetes...
  62. pmc Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice
    Zoi Michailidou
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland
    J Biol Chem 287:4188-97. 2012
    ..Improved adipose angiogenesis and reduced fibrosis provide a novel mechanism whereby suppression of intracellular glucocorticoid regeneration promotes safer fat expansion with weight gain...
  63. pmc 11β-Hydroxysteroid dehydrogenase type 1, but not type 2, deficiency worsens acute inflammation and experimental arthritis in mice
    Agnes E Coutinho
    Centre for Cardiovascular Sciences, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 153:234-40. 2012
    ..In contrast, 11β-HSD2 plays no role in acute inflammatory responses in mice. Regulation of local 11β-HSD1 expression and/or delivery of substrate may afford a novel approach for antiinflammatory therapy...
  64. doi request reprint Reconciling the nutritional and glucocorticoid hypotheses of fetal programming
    Elizabeth C Cottrell
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    FASEB J 26:1866-74. 2012
    ..Thus, maternal malnutrition and placental 11β-HSD2 deficiency act via distinct processes to retard fetal growth, both involving fetoplacental overexposure to glucocorticoids but from distinct sources...
  65. ncbi request reprint Smaller left anterior cingulate cortex volumes are associated with impaired hypothalamic-pituitary-adrenal axis regulation in healthy elderly men
    Alasdair M J MacLullich
    Endocrinology Unit, Center for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
    J Clin Endocrinol Metab 91:1591-4. 2006
    ..Studies in animals suggest that the limbic prefrontal cortex, including the anterior cingulate cortex, is involved in regulation of the hypothalamic-pituitary-adrenal (HPA) axis, but human data are lacking...
  66. ncbi request reprint The antidepressant desipramine requires the ABCB1 (Mdr1)-type p-glycoprotein to upregulate the glucocorticoid receptor in mice
    Joyce L W Yau
    Endocrinology Unit, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Neuropsychopharmacology 32:2520-9. 2007
    ..These data support the notion that the MDR PGP is one of the molecular targets through which antidepressants regulate the HPA axis...
  67. ncbi request reprint Is programming of glucocorticoid receptor expression by prenatal dexamethasone in the rat secondary to metabolic derangement in adulthood?
    Mark E Cleasby
    Endocrinology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Eur J Endocrinol 148:129-38. 2003
    ..However, cause and effect between altered GR expression, hypercorticosteronaemia, and hyperinsulinaemia remains to be established...
  68. pmc Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents
    Sander van den Driesche
    MRC Centre for Reproductive Health, The Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 7:e37064. 2012
    ....
  69. pmc Novel fat depot-specific mechanisms underlie resistance to visceral obesity and inflammation in 11 β-hydroxysteroid dehydrogenase type 1-deficient mice
    Malgorzata Wamil
    Endocrinology Unit, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, Scotland
    Diabetes 60:1158-67. 2011
    ....
  70. ncbi request reprint Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats
    Amanda J Drake
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Center, Western General Hospital, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 288:R34-8. 2005
    ....
  71. doi request reprint The role and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in the inflammatory response
    Karen E Chapman
    Endocrinology Unit, Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Mol Cell Endocrinol 301:123-31. 2009
    ..Finally, the mechanisms that regulate 11beta-HSD1 transcription will be discussed...
  72. doi request reprint Prenatal overexposure to glucocorticoids programs renal 11β-hydroxysteroid dehydrogenase type 2 expression and salt-sensitive hypertension in the rat
    Justin I Tang
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, UK
    J Hypertens 29:282-9. 2011
    ..Prenatal glucocorticoid excess programs hypertension in adulthood. The underlying mechanisms are unknown. Here, we tested whether hypertension in this model is due to increased renal mineralocorticoid activity...
  73. doi request reprint Prenatal glucocorticoid overexposure causes permanent increases in renal erythropoietin expression and red blood cell mass in the rat offspring
    Justin I Tang
    Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4 TJ, Scotland, United Kingdom
    Endocrinology 152:2716-21. 2011
    ..These data indicate that RBC mass can be programmed by prenatal glucocorticoid excess, and if extrapolatable to humans, provide a novel mechanism for fetal origins of polycythemia and its associated complications...
  74. doi request reprint Elevated fasting plasma cortisol is associated with ischemic heart disease and its risk factors in people with type 2 diabetes: the Edinburgh type 2 diabetes study
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    J Clin Endocrinol Metab 95:1602-8. 2010
    ..People with type 2 diabetes are at increased cardiovascular disease risk and thus are suitable to study associations of plasma cortisol with cardiovascular risk...
  75. ncbi request reprint A transgenic model of visceral obesity and the metabolic syndrome
    H Masuzaki
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA
    Science 294:2166-70. 2001
    ..Increased adipocyte 11beta HSD-1 activity may be a common molecular etiology for visceral obesity and the metabolic syndrome...
  76. ncbi request reprint Glucocorticoid exposure in late gestation in the rat permanently programs gender-specific differences in adult cardiovascular and metabolic physiology
    D O'Regan
    Endocrinology Unit, Molecular Medicine Centre, School of Molecular and Clinical Medicine, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK
    Am J Physiol Endocrinol Metab 287:E863-70. 2004
    ....
  77. pmc Regulation of adipocyte 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) by CCAAT/enhancer-binding protein (C/EBP) β isoforms, LIP and LAP
    Cristina L Esteves
    Endocrinology Unit, University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 7:e37953. 2012
    ..Down-regulation of 11β-HSD1 by increased C/EBPβ-LIP:LAP in adipocytes may be part of a nutrient-sensing mechanism counteracting nutritional stress generated by HF diet...
  78. pmc A switch in the mechanism of hypertension in the syndrome of apparent mineralocorticoid excess
    Matthew A Bailey
    Centre for Cardiovascular Science, The University of Edinburgh, QMRI, 47, Little France Crescent, Edinburgh, EH16 4TJ, UK
    J Am Soc Nephrol 19:47-58. 2008
    ..In summary, it is proposed that renal sodium retention remains a key event in apparent mineralocorticoid excess but that the accompanying hypertension changes from a renal to a vascular etiology over time...
  79. ncbi request reprint Mineralocorticoid receptor expression and increased survival following neuronal injury
    Malcolm R Macleod
    Endocrinology Unit, Molecular Medicine Centre, Edinburgh University, Scotland
    Eur J Neurosci 17:1549-55. 2003
    ..Modulation of mineralocorticoid receptor gene expression may therefore be an important target for reduction of brain injury in conditions caused by cerebral ischaemia including brain damage following cardiac arrest and stroke...
  80. doi request reprint Glucocorticoid regulation of the promoter of 11beta-hydroxysteroid dehydrogenase type 1 is indirect and requires CCAAT/enhancer-binding protein-beta
    Shuji Sai
    Endocrinology Unit, Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
    Mol Endocrinol 22:2049-60. 2008
    ..Positive regulation of 11beta-HSD1 by C/EBPbeta may link amplification of glucocorticoid action with metabolic and inflammatory pathways and may represent an endogenous innate host-defense mechanism...
  81. ncbi request reprint Entrainment to feeding but not to light: circadian phenotype of VPAC2 receptor-null mice
    W John Sheward
    Centre for Neuroscience Research, School of Biomedical Sciences, University of Edinburgh, Edinburgh, EH8 9JZ, United Kingdom
    J Neurosci 27:4351-8. 2007
    ..Thus, food intake is an effective zeitgeber capable of coordinating circadian rhythms of behavior, peripheral clock gene expression, and hormone secretion, even in the absence of a functional SCN clock...
  82. ncbi request reprint Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD11B1) and lifetime cognitive change
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, UK
    Neurosci Lett 393:74-7. 2006
    ..91) and rs846910-A/G (p=.90) between the groups. We conclude that these variants in HSD11B1 are not significant contributors to the range of cognitive ageing examined here...
  83. ncbi request reprint Size of the neocerebellar vermis is associated with cognition in healthy elderly men
    Alasdair M J MacLullich
    Geriatric Medicine Unit, University of Edinburgh, Room SU220, The Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Brain Cogn 56:344-8. 2004
    ..Total cerebellar volumes correlated significantly with a test of nonverbal reasoning (r=.030, p=.42). These findings suggest a specific association of neocerebellar vermis size with variations in cognitive ability in older adults...
  84. pmc 11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics
    Thekkepat C Sandeep
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Proc Natl Acad Sci U S A 101:6734-9. 2004
    ..11beta-HSD1 inhibition may be a new approach to prevent/ameliorate cognitive decline...
  85. doi request reprint Injury-induced mineralocorticoid receptor expression involves differential promoter usage: a novel role for the rat MRbeta variant
    Peng Kang
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Scotland, UK
    Mol Cell Endocrinol 305:56-62. 2009
    ..These results demonstrate a novel key role for the MRbeta transcript in response to injury and suggest that some of the known neuroprotective effects of hypothermia may be mediated through increased MR expression...
  86. ncbi request reprint Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity
    Zoi Michailidou
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Obesity (Silver Spring) 15:1155-63. 2007
    ..Our objective was to determine the association between 11betaHSD1 and GRalpha mRNA levels in four distinct adipose depots and measures of obesity and the metabolic syndrome...
  87. ncbi request reprint 11 beta-hydroxysteroid dehydrogenase in vascular smooth muscle and heart: implications for cardiovascular responses to glucocorticoids
    B R Walker
    University of Edinburgh, Department of Medicine, Western General Hospital, United Kingdom
    Endocrinology 129:3305-12. 1991
    ..Thus, 11 beta-OHSD is appropriately sited to modulate access of corticosterone to vascular receptors and could influence vascular resistance, cardiac output and thereby blood pressure...
  88. ncbi request reprint Ontogeny of glucocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type-1 gene expression identifies potential critical periods of glucocorticoid susceptibility during development
    H J L Speirs
    Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, UK
    J Endocrinol 181:105-16. 2004
    ....
  89. ncbi request reprint Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: possible implications for behaviour
    L A Welberg
    Molecular Endocrinology Laboratory, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, EH4 2XU, Scotland, Edinburgh, UK
    Neuroscience 104:71-9. 2001
    ..Overexposure to glucocorticoids, especially late in gestation, may explain the link between reduced early growth and adult affective dysfunction...
  90. doi request reprint 11β-hydroxysteroid dehydrogenase type 2 deficiency accelerates atherogenesis and causes proinflammatory changes in the endothelium in apoe-/- mice
    Graeme A Deuchar
    Centre for Cardiovascular Science, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 152:236-46. 2011
    ..Thus, loss of 11β-HSD2 leads to striking atherogenesis associated with activation of MR, stimulating proinflammatory processes in the endothelium of E/b2 mice...
  91. ncbi request reprint The role of corticosterone in human hypothalamic-pituitary-adrenal axis feedback
    Peter J Raubenheimer
    Department of Endocrinology, University of Edinburgh, Centre for Cardiovascular Science, The Queen s Medical Research Institute, Edinburgh, UK
    Clin Endocrinol (Oxf) 65:22-6. 2006
    ..Additionally, the relative affinities for the glucocorticoid and mineralocorticoid receptors differ, such that corticosterone may play a significant role in human brain function...
  92. ncbi request reprint Assessing the HPA axis in patients with pituitary disease: a UK survey
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Sciences, University of Edinburgh, Queen s Medical Research Institute, Little France Crescent, Edinburgh EH16 4TJ, UK
    Clin Endocrinol (Oxf) 64:82-5. 2006
    ....
  93. ncbi request reprint Altered peripheral sensitivity to glucocorticoids in primary open-angle glaucoma
    John Stokes
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, U K
    Invest Ophthalmol Vis Sci 44:5163-7. 2003
    ..This study was an investigation of the central and peripheral sensitivity to glucocorticoids in patients with POAG or ocular hypertension (OHT) and the differential metabolism of glucocorticoids by 11beta-HSDs...
  94. ncbi request reprint Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target
    Malgorzata Wamil
    Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Drug Discov Today 12:504-20. 2007
    ..11beta-HSD1 null mice also resist cognitive decline with ageing, and this is seen in humans with a prototypic inhibitor. Thus 11beta-HSD1 inhibition is an emerging pleiotropic therapeutic target...
  95. ncbi request reprint C/EBP regulates hepatic transcription of 11beta -hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways
    L J Williams
    Molecular Endocrinology Group, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, United Kingdom
    J Biol Chem 275:30232-9. 2000
    ....
  96. pmc Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates hypothalamic-pituitary-adrenal axis and blood pressure adaptions to high-fat diet
    Z Michailidou
    Endocrinology Unit, Centre for Cardiovascular Sciences, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    FASEB J 22:3896-907. 2008
    ..Importantly, reduced GR limits HPA and blood pressure adaptions to obesogenic diet...
  97. ncbi request reprint 5'-heterogeneity of glucocorticoid receptor messenger RNA is tissue specific: differential regulation of variant transcripts by early-life events
    J A McCormick
    Molecular Endocrinology, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, United Kingdom
    Mol Endocrinol 14:506-17. 2000
    ..Such tissue specificity of promoter usage allows differential GR regulation and programming...
  98. ncbi request reprint Cloning, sequencing and tissue-distribution of mouse 11 beta-hydroxysteroid dehydrogenase-1 cDNA
    V Rajan
    Department of Medicine, University of Edinburgh, Western General Hospital, U K
    J Steroid Biochem Mol Biol 52:141-7. 1995
    ..Thus, despite the high inter-species conservation of 11 beta-HSD1, there are clear species and tissue-specific differences in its expression...
  99. pmc Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2
    R W Brown
    University Department of Medicine, Western General Hospital, Edinburgh, Scotland, UK
    Biochem J 313:1007-17. 1996
    ..11 beta-HSD2 transcripts are expressed in fetal kidney (but not lung, liver or brain) at 21-26 weeks, suggesting that an 11 beta-HSD2 distribution resembling that in the adult is established by this stage in human development...
  100. ncbi request reprint Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation
    K Rose
    Centre for Genome Research and Centre for Neuroscience, University of Edinburgh, King s Buildings, Edinburgh EH9 3JQ, United Kingdom
    J Biol Chem 276:23937-44. 2001
    ..CYP7B is thus a major extrahepatic steroid and oxysterol hydroxylase and provides the predominant route for local metabolism of DHEA and related molecules in brain and other tissues...
  101. ncbi request reprint Intracellular regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11beta-HSD-1-deficient mice
    H J Harris
    Molecular Endocrinology, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, Scotland, United Kingdom
    Endocrinology 142:114-20. 2001
    ..Thus 11beta-HSD-1 amplifies glucocorticoid feedback on the HPA axis and is an important regulator of neuronal glucocorticoid exposure under both basal and stress conditions in vivo...