Jonathan R Seckl

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi Glucocorticoid programming
    Jonathan R Seckl
    Endocrinology Unit, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh, EH4 2XU, UK
    Ann N Y Acad Sci 1032:63-84. 2004
  2. ncbi 11 beta-hydroxysteroid dehydrogenase type 1 induction in the arcuate nucleus by high-fat feeding: A novel constraint to hyperphagia?
    Valerie S Densmore
    Endocrinology Unit, Queen s Medical Research Institute, Edinburgh EH16 4TJ, Scotland, United Kingdom
    Endocrinology 147:4486-95. 2006
  3. ncbi Glucocorticoids, developmental 'programming' and the risk of affective dysfunction
    Jonathan R Seckl
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, Edinburgh, UK
    Prog Brain Res 167:17-34. 2008
  4. ncbi Cerebrospinal fluid cortisol levels are higher in patients with delirium versus controls
    Andrew Pearson
    Geriatric Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK
    BMC Res Notes 3:33. 2010
  5. ncbi Association between umbilical cord glucocorticoids and blood pressure at age 3 years
    Susanna Y Huh
    Division of Gastroenterology and Nutrition, Children s Hospital Boston, Boston, MA, USA
    BMC Med 6:25. 2008
  6. ncbi Medical and physiological aspects of the 11beta-hydroxysteroid dehydrogenase system
    J R Seckl
    Molecular Endocrinology Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, UK
    Eur J Biochem 249:361-4. 1997
  7. ncbi Glucocorticoid "programming" and PTSD risk
    Jonathan R Seckl
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Ann N Y Acad Sci 1071:351-78. 2006
  8. ncbi Prenatal glucocorticoids and long-term programming
    Jonathan R Seckl
    Endocrinology Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Eur J Endocrinol 151:U49-62. 2004
  9. ncbi Physiologic programming of the fetus
    J R Seckl
    Molecular Medicine Centre, University of Edinburgh, Western General Hospital, United Kingdom, USA
    Clin Perinatol 25:939-62, vii. 1998
  10. ncbi Minireview: 11beta-hydroxysteroid dehydrogenase type 1- a tissue-specific amplifier of glucocorticoid action
    J R Seckl
    Endocrinology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, United Kingdom
    Endocrinology 142:1371-6. 2001

Detail Information

Publications160 found, 100 shown here

  1. ncbi Glucocorticoid programming
    Jonathan R Seckl
    Endocrinology Unit, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh, EH4 2XU, UK
    Ann N Y Acad Sci 1032:63-84. 2004
    ..Overall, the data suggest that either pharmacological or physiological exposure to excess glucocorticoids prenatally programs pathologies in adult life...
  2. ncbi 11 beta-hydroxysteroid dehydrogenase type 1 induction in the arcuate nucleus by high-fat feeding: A novel constraint to hyperphagia?
    Valerie S Densmore
    Endocrinology Unit, Queen s Medical Research Institute, Edinburgh EH16 4TJ, Scotland, United Kingdom
    Endocrinology 147:4486-95. 2006
    ..These data suggest that 11 beta-HSD1 in brain plays a role in the adaptive restraint of excess fat intake, in part by increasing inhibitory opioid tone on AGRP expression in the arcuate nucleus...
  3. ncbi Glucocorticoids, developmental 'programming' and the risk of affective dysfunction
    Jonathan R Seckl
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, Edinburgh, UK
    Prog Brain Res 167:17-34. 2008
    ..Posttraumatic stress disorder and other affective diseases may both act as environmental challenges if present in early life and may themselves be more likely in individuals made 'vulnerable' by early life stress...
  4. ncbi Cerebrospinal fluid cortisol levels are higher in patients with delirium versus controls
    Andrew Pearson
    Geriatric Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK
    BMC Res Notes 3:33. 2010
    ..abstract:..
  5. ncbi Association between umbilical cord glucocorticoids and blood pressure at age 3 years
    Susanna Y Huh
    Division of Gastroenterology and Nutrition, Children s Hospital Boston, Boston, MA, USA
    BMC Med 6:25. 2008
    ..Data in humans are limited. We examined in humans the association between venous umbilical cord blood glucocorticoids, a potential marker for placental 11beta-HSD2 enzyme activity, and blood pressure at age 3 years...
  6. ncbi Medical and physiological aspects of the 11beta-hydroxysteroid dehydrogenase system
    J R Seckl
    Molecular Endocrinology Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, UK
    Eur J Biochem 249:361-4. 1997
    ..Both isozymes are regulated during ontogeny and by a series of hormonal and other factors. 11Beta-HSD provide an important control of glucocorticoid action at a cellular level, and may represent new targets for therapeutic intervention...
  7. ncbi Glucocorticoid "programming" and PTSD risk
    Jonathan R Seckl
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Ann N Y Acad Sci 1071:351-78. 2006
    ....
  8. ncbi Prenatal glucocorticoids and long-term programming
    Jonathan R Seckl
    Endocrinology Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Eur J Endocrinol 151:U49-62. 2004
    ..Overall, the data suggest that both pharmacological and physiological exposure prenatally to excess glucocorticoids programmes cardiovascular, metabolic and neuroendocrine disorders in adult life...
  9. ncbi Physiologic programming of the fetus
    J R Seckl
    Molecular Medicine Centre, University of Edinburgh, Western General Hospital, United Kingdom, USA
    Clin Perinatol 25:939-62, vii. 1998
    ....
  10. ncbi Minireview: 11beta-hydroxysteroid dehydrogenase type 1- a tissue-specific amplifier of glucocorticoid action
    J R Seckl
    Endocrinology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, United Kingdom
    Endocrinology 142:1371-6. 2001
    ..Inhibition of 11beta-HSD1 represents a potential target for therapy of disorders that might be ameliorated by local reduction of glucocorticoid action, including type 2 diabetes, obesity, and age-related cognitive dysfunction...
  11. ncbi Glucocorticoids, 11beta-hydroxysteroid dehydrogenase, and fetal programming
    J R Seckl
    Molecular Medicine Center, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom
    Kidney Int 57:1412-7. 2000
    ..Thus, glucocorticoid programming may explain, in part, the association between fetal events and subsequent disorders in adult life...
  12. ncbi 11beta-hydroxysteroid dehydrogenase type 1 as a modulator of glucocorticoid action: from metabolism to memory
    Jonathan R Seckl
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK
    Trends Endocrinol Metab 15:418-24. 2004
    ..The ongoing development of selective 11beta-HSD1 inhibitors affords the opportunity to explore a new approach to some major common disorders...
  13. ncbi 11beta-hydroxysteroid dehydrogenases: changing glucocorticoid action
    Jonathan R Seckl
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK
    Curr Opin Pharmacol 4:597-602. 2004
    ..Overexpression of this isozyme may contribute to the pathogenesis of the metabolic syndrome. Its inhibition is a potential therapeutic target for both metabolic and glucocorticoid-associated CNS disorders...
  14. ncbi Minireview: Stress-related psychiatric disorders with low cortisol levels: a metabolic hypothesis
    Rachel Yehuda
    Mount Sinai School of Medicine, Department of Psychiatry, Traumatology and Stress Studies Division, New York, New York 10029, USA
    Endocrinology 152:4496-503. 2011
    ..This notion implies a vulnerable early-life phenotype may be discernable and indicates potential therapy by modest glucocorticoid replacement. Indeed, early clinical trials with cortisol have shown a modicum of promise...
  15. ncbi 11Beta-hydroxysteroid dehydrogenases: a novel control of glucocorticoid action in the brain
    Jonathan R Seckl
    Endocrinology Unit, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, UK
    Endocr Res 28:701-7. 2002
    ..The striking protection against cognitive decline seen in elderly 11beta-HSD1 knockout mice suggest that manipulation of this isozyme may be a useful therapeutic avenue to explore...
  16. ncbi 11beta-Hydroxysteroid dehydrogenase in the brain: a novel regulator of glucocorticoid action?
    J R Seckl
    Department of Medicine, University of Edinburgh, Edinburgh, EH4 2XU, United Kingdom
    Front Neuroendocrinol 18:49-99. 1997
    ..Enzyme modulation by pharmacological or other agents may provide a useful means to target increased or attenuated glucocorticoid action to specific sites in the brain...
  17. ncbi Glucocorticoid programming of the fetus; adult phenotypes and molecular mechanisms
    J R Seckl
    Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Mol Cell Endocrinol 185:61-71. 2001
    ..Detailed molecular mechanisms are being dissected. Analogous stress axis hyperreactivity occurs in lower birth weight humans and may be an early manifestation and indicate approaches to manipulation or prevention of the phenotype...
  18. ncbi Prenatal dexamethasone programs expression of genes in liver and adipose tissue and increased hepatic lipid accumulation but not obesity on a high-fat diet
    Amanda J Drake
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 151:1581-7. 2010
    ..This may be due to depot-specific-programmed alterations in fat metabolism in adipose tissue...
  19. ncbi Dietary manipulation reveals an unexpected inverse relationship between fat mass and adipose 11β-hydroxysteroid dehydrogenase type 1
    Tak Yung Man
    Endocrinology Unit, Centre for Cardiovascular Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    Am J Physiol Endocrinol Metab 300:E1076-84. 2011
    ..The dynamic depot-selective relationship between adipose 11β-HSD1 and fat mass strongly implicates a dominant physiological role for local tissue glucocorticoid reactivation in fat mobilization...
  20. ncbi Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice
    Nicholas M Morton
    Endocrinology Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Diabetes 53:931-8. 2004
    ..These data provide the first in vivo evidence that adipose 11 beta-HSD-1 deficiency beneficially alters adipose tissue distribution and function, complementing the reported effects of hepatic 11 beta-HSD-1 deficiency or inhibition...
  21. ncbi 11beta-hydroxysteroid dehydrogenase type 1 expression is increased in the aged mouse hippocampus and parietal cortex and causes memory impairments
    Megan C Holmes
    Endocrinology Unit, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    J Neurosci 30:6916-20. 2010
    ..Thus, excess 11beta-HSD1 in forebrain is a cause of as well as a therapeutic target in memory impairments with aging...
  22. ncbi 11beta-hydroxysteroid dehydrogenase type 1 and obesity
    Nicholas M Morton
    Endocrinology Unit, Centre for Cardiovascular Sciences, Queens Medical Research Institute, Edinburgh University, Edinburgh, UK
    Front Horm Res 36:146-64. 2008
    ....
  23. ncbi A polygenic model of the metabolic syndrome with reduced circulating and intra-adipose glucocorticoid action
    Nicholas M Morton
    Endocrinology Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, UK
    Diabetes 54:3371-8. 2005
    ..Our data suggest that idiopathic metabolic syndrome might associate with such a novel pattern of glucocorticoid action and sensitivity in humans, with implications for tissue-specific therapeutic targeting of 11beta-HSD-1...
  24. ncbi Partial deficiency or short-term inhibition of 11beta-hydroxysteroid dehydrogenase type 1 improves cognitive function in aging mice
    Karen Sooy
    Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Neurosci 30:13867-72. 2010
    ..These data support the use of selective 11β-HSD1 inhibitors in the treatment of age-related cognitive impairments...
  25. ncbi Reduced adipose glucocorticoid reactivation and increased hepatic glucocorticoid clearance as an early adaptation to high-fat feeding in Wistar rats
    Amanda J Drake
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Endocrinology 146:913-9. 2005
    ..Acute exposure to HF diet alters glucocorticoid metabolism, predicting lower hepatic and adipose intracellular glucocorticoid concentrations, which may be a key mechanism protecting against the metabolic complications of obesity...
  26. ncbi Liver-selective transgene rescue of hypothalamic-pituitary-adrenal axis dysfunction in 11beta-hydroxysteroid dehydrogenase type 1-deficient mice
    Janice M Paterson
    Centre for Cardiovascular Science, Endocrinology Unit, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
    Endocrinology 148:961-6. 2007
    ..Therefore, hepatic glucocorticoid metabolism influences basal as well as stress-associated functions of the HPA axis...
  27. ncbi Prenatal programming of metabolic syndrome in the common marmoset is associated with increased expression of 11beta-hydroxysteroid dehydrogenase type 1
    Moffat J Nyirenda
    Endocrinology Unit, Queen s Medical Research Institute, University of Edinburgh, U K
    Diabetes 58:2873-9. 2009
    ..Here, we tested whether 11beta-HSD1 expression, like the metabolic syndrome, is "programmed" by prenatal environmental events in a nonhuman primate model, the common marmoset monkey...
  28. ncbi Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone
    Zoi Michailidou
    Endocrine Unit, Queen s Medical Research Institute, Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    J Endocrinol 194:161-70. 2007
    ..These data suggest that CORT-inducible 11beta-HSD1 expression in fat contributes to the adverse cardiometabolic effects of CORT in POMC deficiency, whereas higher GR levels may be more important in liver...
  29. ncbi Leptin levels and depressive symptoms in people with type 2 diabetes: the edinburgh type 2 diabetes study
    Javier Labad
    Endocrinology Unit, Centre for Cardiovascular Sciences, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK
    Psychosom Med 74:39-45. 2012
    ..We sought to assess whether leptin is related to depressive symptoms in people with Type 2 diabetes...
  30. ncbi Enhanced hippocampal long-term potentiation and spatial learning in aged 11beta-hydroxysteroid dehydrogenase type 1 knock-out mice
    Joyce L W Yau
    Endocrinology Unit, Molecular University of Edinburgh, Queen s Medical Research Institute, EH16 4TJ Edinburgh, United Kingdom
    J Neurosci 27:10487-96. 2007
    ..These data suggest that 11beta-HSD1 deficiency enhances synaptic potentiation in the aged hippocampus and this may underlie the better maintenance of learning and memory with aging, which occurs in the absence of increased neurogenesis...
  31. ncbi Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia
    Maggie Lai
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, UK
    Eur J Neurosci 25:1832-42. 2007
    ..The induction of neuronal MR appears to offer a protective response which has potential therapeutic implications in cerebral ischaemia and cognitive and affective disorders...
  32. ncbi Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity
    Erin E Kershaw
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 54:1023-31. 2005
    ..These data suggest that reduction of active GCs exclusively in adipose tissue is an important determinant of a favorable metabolic phenotype with respect to energy homeostasis and the metabolic syndrome...
  33. ncbi Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization
    Mark Nixon
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, Scotland, U K
    Diabetes 61:790-6. 2012
    ..Reduced intra-adipose glucocorticoid regeneration by 11β-HSD1 is a novel mechanism that contributes to the metabolic efficacy of salicylates...
  34. ncbi 11β-hydroxysteroid dehydrogenase type 1, brain atrophy and cognitive decline
    Alasdair M J MacLullich
    Endocrinology, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, Scotland, UK
    Neurobiol Aging 33:207.e1-8. 2012
    ..55, p = 0.0002) over 6 years. The predictive link between systemic 11β-HSD1 activity and progressive brain atrophy and cognitive decline suggests 11β-HSD1 inhibition as a plausible therapy for brain aging...
  35. ncbi Morning cortisol levels and cognitive abilities in people with type 2 diabetes: the Edinburgh type 2 diabetes study
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Diabetes Care 33:714-20. 2010
    ..We aimed to determine whether fasting cortisol levels are associated with cognitive ability and estimated lifetime cognitive change in an elderly population with type 2 diabetes...
  36. ncbi 11beta-hydroxysteroid dehydrogenase type 1 deficiency prevents memory deficits with aging by switching from glucocorticoid receptor to mineralocorticoid receptor-mediated cognitive control
    Joyce L W Yau
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, and Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    J Neurosci 31:4188-93. 2011
    ....
  37. ncbi 11beta-hydroxysteroid dehydrogenase type 1 as a novel therapeutic target in metabolic and neurodegenerative disease
    Brian R Walker
    University of Edinburgh, Endocrinology Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Expert Opin Ther Targets 7:771-83. 2003
    ..The clinical development of potent selective 11HSD1 inhibitors is now a high priority...
  38. ncbi 7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type
    Malgorzata Wamil
    Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 149:5909-18. 2008
    ..Thus, the activity and reaction direction of adipose 11beta-HSD1 is altered under conditions of oxysterol excess, and could impact upon the pathophysiology of obesity and its complications...
  39. ncbi Plasma cortisol levels, brain volumes and cognition in healthy elderly men
    Alasdair M J MacLullich
    Geriatric Medicine, University of Edinburgh, Room SU220, The Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Psychoneuroendocrinology 30:505-15. 2005
    ..CONCLUSIONS: In healthy older men, higher plasma cortisol levels are associated with worse ageing-related overall cognitive change but not ageing-related brain atrophy...
  40. ncbi Prenatal dexamethasone 'programmes' hypotension, but stress-induced hypertension in adult offspring
    David O'Regan
    Endocrinology Unit, Queen s Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    J Endocrinol 196:343-52. 2008
    ..We therefore conclude that altered sympathetic responses mediate the stress-induced hypertension associated with prenatal DEX programming...
  41. ncbi 11beta-hydroxysteroid dehydrogenase type 2 in mouse aorta: localization and influence on response to glucocorticoids
    Clare Christy
    School of Molecular and Clinical Medicine, Endocrinology Unit, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Hypertension 42:580-7. 2003
    ..Therefore, additional mechanisms, possibly involving indirect effects of enhanced corticosterone action in the kidney and the resultant hypertension, must be involved...
  42. ncbi Obese Zucker rats have reduced mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type 1 expression in hippocampus-implications for dysregulation of the hypothalamic-pituitary-adrenal axis in obesity
    Cecilia Mattsson
    Endocrinology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, United Kingdom
    Endocrinology 144:2997-3003. 2003
    ..This may be exacerbated by impaired local regeneration of corticosterone by 11betaHSD1. These abnormalities could contribute to the subtle changes in the HPA axis in rodent and human obesity...
  43. ncbi The mother or the fetus? 11beta-hydroxysteroid dehydrogenase type 2 null mice provide evidence for direct fetal programming of behavior by endogenous glucocorticoids
    Megan C Holmes
    Endocrinology Unit, Centre for Cardiovascular Disease, Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
    J Neurosci 26:3840-4. 2006
    ..This provides clear evidence for the key role of fetoplacental 11beta-HSD2 in prenatal glucocorticoid programming...
  44. ncbi A stratified transcriptomics analysis of polygenic fat and lean mouse adipose tissues identifies novel candidate obesity genes
    Nicholas M Morton
    Molecular Metabolism Group, BHF University Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, United Kingdom
    PLoS ONE 6:e23944. 2011
    ....
  45. ncbi Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice
    Janice M Paterson
    Wellcome Trust CVRI Molecular Physiology Group, University of Edinburgh Medical School, Wilkie Building, Teviot Place, Edinburgh EH8 9AG, Scotland, United Kingdom
    Proc Natl Acad Sci U S A 101:7088-93. 2004
    ....
  46. ncbi Altered placental function of 11beta-hydroxysteroid dehydrogenase 2 knockout mice
    Caitlin S Wyrwoll
    Endocrinology Unit, Queen s Medical Research Institute, Centre for Cardiovascular Science, Edinburgh, United Kingdom
    Endocrinology 150:1287-93. 2009
    ..Our data suggest that restriction of fetal growth in 11beta-HSD2(-/-) mice is mediated, at least in part, via altered placental transport of nutrients and reduction in placental vascularization...
  47. ncbi Developmental and tissue-specific regulation of hepatocyte nuclear factor 4-alpha (HNF4-alpha) isoforms in rodents
    Samena Dean
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Gene Expr 14:337-44. 2010
    ....
  48. ncbi Programming of rat muscle and fat metabolism by in utero overexposure to glucocorticoids
    Mark E Cleasby
    Endocrinology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, United Kingdom
    Endocrinology 144:999-1007. 2003
    ..However, increased GR and attenuated fatty acid uptake specifically in visceral adipose are consistent with insulin resistance in this crucial metabolic depot and could indirectly contribute to increased hepatic glucose output...
  49. ncbi Tissue-specific messenger ribonucleic acid expression of 11beta-hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor within rat placenta suggests exquisite local control of glucocorticoid action
    B J Waddell
    Department of Medicine, The University of Edinburgh, Western General Hospital, Scotland, United Kingdom
    Endocrinology 139:1517-23. 1998
    ..Moreover, the changes in 11beta-HSD expression appear to be unrelated to development of the fetal adrenal cortex and are likely to reduce the placental glucocorticoid barrier near the end of pregnancy...
  50. ncbi Glucocorticoids and 11beta-hydroxysteroid dehydrogenase in adipose tissue
    Jonathan R Seckl
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, United Kingdom
    Recent Prog Horm Res 59:359-93. 2004
    ..Adipose 11beta-HSD1 deficiency contributes to a protective metabolic phenotype, supporting its role as a therapeutic target for the metabolic syndrome...
  51. ncbi 11β-Hydroxysteroid dehydrogenase type 1, but not type 2, deficiency worsens acute inflammation and experimental arthritis in mice
    Agnes E Coutinho
    Centre for Cardiovascular Sciences, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 153:234-40. 2012
    ..In contrast, 11β-HSD2 plays no role in acute inflammatory responses in mice. Regulation of local 11β-HSD1 expression and/or delivery of substrate may afford a novel approach for antiinflammatory therapy...
  52. ncbi Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice
    Zoi Michailidou
    From the Medical Research Council MRC Centre for Inflammation Research and
    J Biol Chem 287:4188-97. 2012
    ..Improved adipose angiogenesis and reduced fibrosis provide a novel mechanism whereby suppression of intracellular glucocorticoid regeneration promotes safer fat expansion with weight gain...
  53. ncbi Optimal elevation of β-cell 11β-hydroxysteroid dehydrogenase type 1 is a compensatory mechanism that prevents high-fat diet-induced β-cell failure
    Sophie Turban
    Molecular Metabolism Group, University of Edinburgh British Heart Foundation Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Diabetes 61:642-52. 2012
    ..These findings have immediate significance for current therapeutic strategies for type 2 diabetes...
  54. ncbi Reconciling the nutritional and glucocorticoid hypotheses of fetal programming
    Elizabeth C Cottrell
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    FASEB J 26:1866-74. 2012
    ..Thus, maternal malnutrition and placental 11β-HSD2 deficiency act via distinct processes to retard fetal growth, both involving fetoplacental overexposure to glucocorticoids but from distinct sources...
  55. ncbi Smaller left anterior cingulate cortex volumes are associated with impaired hypothalamic-pituitary-adrenal axis regulation in healthy elderly men
    Alasdair M J MacLullich
    Endocrinology Unit, Center for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
    J Clin Endocrinol Metab 91:1591-4. 2006
    ..Studies in animals suggest that the limbic prefrontal cortex, including the anterior cingulate cortex, is involved in regulation of the hypothalamic-pituitary-adrenal (HPA) axis, but human data are lacking...
  56. ncbi The antidepressant desipramine requires the ABCB1 (Mdr1)-type p-glycoprotein to upregulate the glucocorticoid receptor in mice
    Joyce L W Yau
    Endocrinology Unit, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Neuropsychopharmacology 32:2520-9. 2007
    ..These data support the notion that the MDR PGP is one of the molecular targets through which antidepressants regulate the HPA axis...
  57. ncbi Is programming of glucocorticoid receptor expression by prenatal dexamethasone in the rat secondary to metabolic derangement in adulthood?
    Mark E Cleasby
    Endocrinology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Eur J Endocrinol 148:129-38. 2003
    ..However, cause and effect between altered GR expression, hypercorticosteronaemia, and hyperinsulinaemia remains to be established...
  58. ncbi Local amplification of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes
    James S Gilmour
    Endocrinology Unit, Centre for Cardiovascular Sciences, Centre for Cardiovascular Sciences, The Queen s Medical Research Institute, University of Edinburgh, UK
    J Immunol 176:7605-11. 2006
    ..These data point to an early role for 11beta-HSD1 in promoting the rapid clearance of apoptotic cells during the resolution of inflammation and indicate a novel target for therapy...
  59. ncbi Prenatal overexposure to glucocorticoids programs renal 11β-hydroxysteroid dehydrogenase type 2 expression and salt-sensitive hypertension in the rat
    Justin I Tang
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, UK
    J Hypertens 29:282-9. 2011
    ..Prenatal glucocorticoid excess programs hypertension in adulthood. The underlying mechanisms are unknown. Here, we tested whether hypertension in this model is due to increased renal mineralocorticoid activity...
  60. ncbi The role and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in the inflammatory response
    Karen E Chapman
    Endocrinology Unit, Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Mol Cell Endocrinol 301:123-31. 2009
    ..Finally, the mechanisms that regulate 11beta-HSD1 transcription will be discussed...
  61. ncbi Elevated fasting plasma cortisol is associated with ischemic heart disease and its risk factors in people with type 2 diabetes: the Edinburgh type 2 diabetes study
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    J Clin Endocrinol Metab 95:1602-8. 2010
    ..People with type 2 diabetes are at increased cardiovascular disease risk and thus are suitable to study associations of plasma cortisol with cardiovascular risk...
  62. ncbi Novel fat depot-specific mechanisms underlie resistance to visceral obesity and inflammation in 11 β-hydroxysteroid dehydrogenase type 1-deficient mice
    Malgorzata Wamil
    Endocrinology Unit, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, Scotland
    Diabetes 60:1158-67. 2011
    ....
  63. ncbi Prenatal glucocorticoid overexposure causes permanent increases in renal erythropoietin expression and red blood cell mass in the rat offspring
    Justin I Tang
    Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4 TJ, Scotland, United Kingdom
    Endocrinology 152:2716-21. 2011
    ..These data indicate that RBC mass can be programmed by prenatal glucocorticoid excess, and if extrapolatable to humans, provide a novel mechanism for fetal origins of polycythemia and its associated complications...
  64. ncbi Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats
    Amanda J Drake
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Center, Western General Hospital, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 288:R34-8. 2005
    ....
  65. ncbi A transgenic model of visceral obesity and the metabolic syndrome
    H Masuzaki
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA
    Science 294:2166-70. 2001
    ..Increased adipocyte 11beta HSD-1 activity may be a common molecular etiology for visceral obesity and the metabolic syndrome...
  66. ncbi Glucocorticoid exposure in late gestation in the rat permanently programs gender-specific differences in adult cardiovascular and metabolic physiology
    C J Kenyon
    Endocrinology Unit, Molecular Medicine Centre, School of Molecular and Clinical Medicine, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK
    Am J Physiol Endocrinol Metab 287:E863-70. 2004
    ....
  67. ncbi Size of the neocerebellar vermis is associated with cognition in healthy elderly men
    Alasdair M J MacLullich
    Geriatric Medicine Unit, University of Edinburgh, Room SU220, The Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Brain Cogn 56:344-8. 2004
    ..Total cerebellar volumes correlated significantly with a test of nonverbal reasoning (r=.030, p=.42). These findings suggest a specific association of neocerebellar vermis size with variations in cognitive ability in older adults...
  68. ncbi Glucocorticoid regulation of the promoter of 11beta-hydroxysteroid dehydrogenase type 1 is indirect and requires CCAAT/enhancer-binding protein-beta
    Shuji Sai
    Endocrinology Unit, Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
    Mol Endocrinol 22:2049-60. 2008
    ..Positive regulation of 11beta-HSD1 by C/EBPbeta may link amplification of glucocorticoid action with metabolic and inflammatory pathways and may represent an endogenous innate host-defense mechanism...
  69. ncbi Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD11B1) and lifetime cognitive change
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, UK
    Neurosci Lett 393:74-7. 2006
    ..91) and rs846910-A/G (p=.90) between the groups. We conclude that these variants in HSD11B1 are not significant contributors to the range of cognitive ageing examined here...
  70. ncbi A switch in the mechanism of hypertension in the syndrome of apparent mineralocorticoid excess
    Matthew A Bailey
    Centre for Cardiovascular Science, The University of Edinburgh, QMRI, 47, Little France Crescent, Edinburgh, EH16 4TJ, UK
    J Am Soc Nephrol 19:47-58. 2008
    ..In summary, it is proposed that renal sodium retention remains a key event in apparent mineralocorticoid excess but that the accompanying hypertension changes from a renal to a vascular etiology over time...
  71. ncbi Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity
    Zoi Michailidou
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Obesity (Silver Spring) 15:1155-63. 2007
    ..Our objective was to determine the association between 11betaHSD1 and GRalpha mRNA levels in four distinct adipose depots and measures of obesity and the metabolic syndrome...
  72. ncbi Injury-induced mineralocorticoid receptor expression involves differential promoter usage: a novel role for the rat MRbeta variant
    Peng Kang
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Scotland, UK
    Mol Cell Endocrinol 305:56-62. 2009
    ..These results demonstrate a novel key role for the MRbeta transcript in response to injury and suggest that some of the known neuroprotective effects of hypothermia may be mediated through increased MR expression...
  73. ncbi Mineralocorticoid receptor expression and increased survival following neuronal injury
    Malcolm R Macleod
    Endocrinology Unit, Molecular Medicine Centre, Edinburgh University, Scotland
    Eur J Neurosci 17:1549-55. 2003
    ..Modulation of mineralocorticoid receptor gene expression may therefore be an important target for reduction of brain injury in conditions caused by cerebral ischaemia including brain damage following cardiac arrest and stroke...
  74. ncbi Entrainment to feeding but not to light: circadian phenotype of VPAC2 receptor-null mice
    W John Sheward
    Centre for Neuroscience Research, School of Biomedical Sciences, University of Edinburgh, Edinburgh, EH8 9JZ, United Kingdom
    J Neurosci 27:4351-8. 2007
    ..Thus, food intake is an effective zeitgeber capable of coordinating circadian rhythms of behavior, peripheral clock gene expression, and hormone secretion, even in the absence of a functional SCN clock...
  75. ncbi 11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics
    Thekkepat C Sandeep
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Proc Natl Acad Sci U S A 101:6734-9. 2004
    ..11beta-HSD1 inhibition may be a new approach to prevent/ameliorate cognitive decline...
  76. ncbi 11 beta-hydroxysteroid dehydrogenase in vascular smooth muscle and heart: implications for cardiovascular responses to glucocorticoids
    B R Walker
    University of Edinburgh, Department of Medicine, Western General Hospital, United Kingdom
    Endocrinology 129:3305-12. 1991
    ..Thus, 11 beta-OHSD is appropriately sited to modulate access of corticosterone to vascular receptors and could influence vascular resistance, cardiac output and thereby blood pressure...
  77. ncbi Ontogeny of glucocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type-1 gene expression identifies potential critical periods of glucocorticoid susceptibility during development
    H J L Speirs
    Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, UK
    J Endocrinol 181:105-16. 2004
    ....
  78. ncbi Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: possible implications for behaviour
    L A Welberg
    Molecular Endocrinology Laboratory, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, EH4 2XU, Scotland, Edinburgh, UK
    Neuroscience 104:71-9. 2001
    ..Overexposure to glucocorticoids, especially late in gestation, may explain the link between reduced early growth and adult affective dysfunction...
  79. ncbi 11β-hydroxysteroid dehydrogenase type 2 deficiency accelerates atherogenesis and causes proinflammatory changes in the endothelium in apoe-/- mice
    Graeme A Deuchar
    Centre for Cardiovascular Science, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 152:236-46. 2011
    ..Thus, loss of 11β-HSD2 leads to striking atherogenesis associated with activation of MR, stimulating proinflammatory processes in the endothelium of E/b2 mice...
  80. ncbi Assessing the HPA axis in patients with pituitary disease: a UK survey
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Sciences, University of Edinburgh, Queen s Medical Research Institute, Little France Crescent, Edinburgh EH16 4TJ, UK
    Clin Endocrinol (Oxf) 64:82-5. 2006
    ....
  81. ncbi The role of corticosterone in human hypothalamic-pituitary-adrenal axis feedback
    Peter J Raubenheimer
    Department of Endocrinology, University of Edinburgh, Centre for Cardiovascular Science, The Queen s Medical Research Institute, Edinburgh, UK
    Clin Endocrinol (Oxf) 65:22-6. 2006
    ..Additionally, the relative affinities for the glucocorticoid and mineralocorticoid receptors differ, such that corticosterone may play a significant role in human brain function...
  82. ncbi Altered peripheral sensitivity to glucocorticoids in primary open-angle glaucoma
    John Stokes
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, U K
    Invest Ophthalmol Vis Sci 44:5163-7. 2003
    ..This study was an investigation of the central and peripheral sensitivity to glucocorticoids in patients with POAG or ocular hypertension (OHT) and the differential metabolism of glucocorticoids by 11beta-HSDs...
  83. ncbi Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target
    Malgorzata Wamil
    Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Drug Discov Today 12:504-20. 2007
    ..11beta-HSD1 null mice also resist cognitive decline with ageing, and this is seen in humans with a prototypic inhibitor. Thus 11beta-HSD1 inhibition is an emerging pleiotropic therapeutic target...
  84. ncbi Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates hypothalamic-pituitary-adrenal axis and blood pressure adaptions to high-fat diet
    Z Michailidou
    Endocrinology Unit, Centre for Cardiovascular Sciences, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    FASEB J 22:3896-907. 2008
    ..Importantly, reduced GR limits HPA and blood pressure adaptions to obesogenic diet...
  85. ncbi 5'-heterogeneity of glucocorticoid receptor messenger RNA is tissue specific: differential regulation of variant transcripts by early-life events
    J A McCormick
    Molecular Endocrinology, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, United Kingdom
    Mol Endocrinol 14:506-17. 2000
    ..Such tissue specificity of promoter usage allows differential GR regulation and programming...
  86. ncbi Intracellular regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11beta-HSD-1-deficient mice
    H J Harris
    Molecular Endocrinology, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, Scotland, United Kingdom
    Endocrinology 142:114-20. 2001
    ..Thus 11beta-HSD-1 amplifies glucocorticoid feedback on the HPA axis and is an important regulator of neuronal glucocorticoid exposure under both basal and stress conditions in vivo...
  87. ncbi Phenotypic analysis of mice bearing targeted deletions of 11beta-hydroxysteroid dehydrogenases 1 and 2 genes
    M C Holmes
    Molecular Endocrinology, Molecular Medicine Centre, Western General Hospital, Edinburgh, UK
    Mol Cell Endocrinol 171:15-20. 2001
    ..Overall, these transgenic models have proved very useful for elucidating the roles of 11beta-HSDs in vivo and will be a unique resource for investigating the importance of each enzyme in the diverse actions of glucocorticoids...
  88. ncbi Cloning, sequencing and tissue-distribution of mouse 11 beta-hydroxysteroid dehydrogenase-1 cDNA
    V Rajan
    Department of Medicine, University of Edinburgh, Western General Hospital, U K
    J Steroid Biochem Mol Biol 52:141-7. 1995
    ..Thus, despite the high inter-species conservation of 11 beta-HSD1, there are clear species and tissue-specific differences in its expression...
  89. ncbi Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation
    K Rose
    Centre for Genome Research and Centre for Neuroscience, University of Edinburgh, King s Buildings, Edinburgh EH9 3JQ, United Kingdom
    J Biol Chem 276:23937-44. 2001
    ..CYP7B is thus a major extrahepatic steroid and oxysterol hydroxylase and provides the predominant route for local metabolism of DHEA and related molecules in brain and other tissues...
  90. ncbi C/EBP regulates hepatic transcription of 11beta -hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways
    L J Williams
    Molecular Endocrinology Group, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, United Kingdom
    J Biol Chem 275:30232-9. 2000
    ....
  91. ncbi Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2
    R W Brown
    University Department of Medicine, Western General Hospital, Edinburgh, Scotland, UK
    Biochem J 313:1007-17. 1996
    ..11 beta-HSD2 transcripts are expressed in fetal kidney (but not lung, liver or brain) at 21-26 weeks, suggesting that an 11 beta-HSD2 distribution resembling that in the adult is established by this stage in human development...
  92. ncbi Modulation of oestrogen receptor-beta mRNA expression in rat paraventricular and supraoptic nucleus neurones following adrenal steroid manipulation and hyperosmotic stimulation
    S J Somponpun
    Laboratory of Neuroendocrinology, Division of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK
    J Neuroendocrinol 16:472-82. 2004
    ..Consequently, regulation of oxytocin and vasopressin neurone activity via ERbeta is expected to vary according to their functional state and, in particular, on basal glucocorticoid actions...
  93. ncbi Programming the offspring of the pig by prenatal social stress: neuroendocrine activity and behaviour
    Susan Jarvis
    Animal Behaviour and Welfare, Sustainable Livestock Systems, Scottish Agricultural College, Edinburgh, UK
    Horm Behav 49:68-80. 2006
    ..Indeed, Mix 2 and Mix 3 daughters also tended to bite at their piglets more than control daughters...
  94. ncbi Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice
    Hiroaki Masuzaki
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 112:83-90. 2003
    ..The potential role of adipose 11beta-HSD1 in mediating critical features of the metabolic syndrome extends beyond obesity and metabolic complications to include the most central cardiovascular feature of this disorder...
  95. ncbi Hypothalamic-pituitary-adrenal axis abnormalities in response to deletion of 11beta-HSD1 is strain-dependent
    R N Carter
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    J Neuroendocrinol 21:879-87. 2009
    ..Similar variations in plasticity may underpin inter-individual differences in vulnerability to disorders associated with HPA axis dysregulation. They also indicate that 11beta-HSD1 inhibition does not inevitably activate the HPA axis...
  96. ncbi Differential promoter usage by the rat 11 beta-hydroxysteroid dehydrogenase gene
    M P Moisan
    University of Edinburgh, Department of Medicine, Western General Hospital, Scotland
    Mol Endocrinol 6:1082-7. 1992
    ....
  97. ncbi CYP7B generates a selective estrogen receptor beta agonist in human prostate
    Cecile Martin
    Endocrinology Unit, Department of Oncology, University of Edinburgh Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    J Clin Endocrinol Metab 89:2928-35. 2004
    ..By this reaction, an ERbeta-specific agonist, 7HD, is produced. Therefore, CYP7B may be a novel regulator of the androgens/estrogenic balance within the prostate...
  98. ncbi Down-regulation of adipose 11beta-hydroxysteroid dehydrogenase type 1 by high-fat feeding in mice: a potential adaptive mechanism counteracting metabolic disease
    Nicholas M Morton
    Endocrinology Unit, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, Scotland, United Kingdom
    Endocrinology 145:2707-12. 2004
    ..Adaptive down-regulation of adipose 11beta-HSD-1 in response to chronic HF represents a novel mechanism that may counteract metabolic disease...
  99. ncbi Mechanisms of disease: glucocorticoids, their placental metabolism and fetal 'programming' of adult pathophysiology
    Jonathan R Seckl
    College of Medicine and Veterinary Medicine, University of Edinburgh, UK
    Nat Clin Pract Endocrinol Metab 3:479-88. 2007
    ..Intriguingly, some of these effects seem to be inherited by subsequent generations that are unexposed to exogenous glucocorticoids at any point in their lifespan from fertilization, which implies that these epigenetic effects persist...
  100. ncbi Glucocorticoids amplify dibutyl phthalate-induced disruption of testosterone production and male reproductive development
    Amanda J Drake
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 150:5055-64. 2009
    ..These findings suggest that exposure to common environmental chemicals in combination with, for example, maternal stress, may increase the risk of common male reproductive abnormalities, with implications for human populations...
  101. ncbi Diabetes and cognitive decline: are steroids the missing link?
    Alasdair M J MacLullich
    Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Cell Metab 7:286-7. 2008
    ..2008) shows that reducing glucocorticoid levels in rodent diabetes models prevents cognitive deficits and enhances neurogenesis and synaptic plasticity. The clinical relevance of these intriguing findings remains undetermined...