M N J Seaman

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Identification of the functional domains of yeast sorting nexins Vps5p and Vps17p
    Matthew N J Seaman
    Department of Clinical Biochemistry and Cambridge Institute for Medical Research, University of Cambridge, Addenbrookes Hospital, United Kingdom
    Mol Biol Cell 13:2826-40. 2002
  2. pmc Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer
    Matthew N J Seaman
    Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Addenbrookes Hospital, Hills Road, Cambridge CB2 2XY, England, UK
    J Cell Biol 165:111-22. 2004
  3. ncbi request reprint Endosome sorting: GSE complex minds the Gap
    Matthew N J Seaman
    Nat Cell Biol 8:648-9. 2006
  4. doi request reprint Endosome protein sorting: motifs and machinery
    M N J Seaman
    University of Cambridge, Cambridge Institute for Medical Research Dept of Clinical Biochemistry, Wellcome Trust MRC Building, Addenbrookes Hospital, Hills Road, Cambridge, CB2 0XY United Kingdom
    Cell Mol Life Sci 65:2842-58. 2008
  5. pmc A screen for endocytic motifs
    Patrycja Kozik
    University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
    Traffic 11:843-55. 2010
  6. ncbi request reprint Retromer-mediated endosomal protein sorting: all WASHed up!
    Matthew N J Seaman
    Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Cambridge CB2 0XY, UK Electronic address
    Trends Cell Biol 23:522-8. 2013
  7. pmc N-acetylation and phosphorylation of Sec complex subunits in the ER membrane
    Christina Soromani
    Department of Clinical Biochemistry, University College London Hospital, London, UK
    BMC Cell Biol 13:34. 2012
  8. pmc The retromer complex - endosomal protein recycling and beyond
    Matthew N J Seaman
    University of Cambridge, Cambridge Institute for Medical Research, UK
    J Cell Sci 125:4693-702. 2012
  9. ncbi request reprint Ricin toxin hits a retrograde roadblock
    Matthew N J Seaman
    Department of Clinical Biochemistry, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK
    Cell 141:222-4. 2010
  10. pmc Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5
    Matthew N J Seaman
    University of Cambridge, Cambridge Institute for Medical Research, Department of Clinical Biochemistry, Wellcome Trust MRC Building, Addenbrookes Hospital, Hills Road, Cambridge CB2 0XY, UK
    J Cell Sci 122:2371-82. 2009

Collaborators

Detail Information

Publications19

  1. pmc Identification of the functional domains of yeast sorting nexins Vps5p and Vps17p
    Matthew N J Seaman
    Department of Clinical Biochemistry and Cambridge Institute for Medical Research, University of Cambridge, Addenbrookes Hospital, United Kingdom
    Mol Biol Cell 13:2826-40. 2002
    ..Additionally, we have examined which domain(s) of Vps5p is necessary for membrane association...
  2. pmc Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer
    Matthew N J Seaman
    Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Addenbrookes Hospital, Hills Road, Cambridge CB2 2XY, England, UK
    J Cell Biol 165:111-22. 2004
    ..The data presented here support the hypothesis that retromer performs a selective function in endosome-to-Golgi transport, mediating retrieval of the CI-MPR, but not furin...
  3. ncbi request reprint Endosome sorting: GSE complex minds the Gap
    Matthew N J Seaman
    Nat Cell Biol 8:648-9. 2006
  4. doi request reprint Endosome protein sorting: motifs and machinery
    M N J Seaman
    University of Cambridge, Cambridge Institute for Medical Research Dept of Clinical Biochemistry, Wellcome Trust MRC Building, Addenbrookes Hospital, Hills Road, Cambridge, CB2 0XY United Kingdom
    Cell Mol Life Sci 65:2842-58. 2008
    ..Much of the protein machinery that recognises sorting motifs is conserved from yeast to man, and in this review I will discuss this machinery and the motifs that govern endosomal protein sorting...
  5. pmc A screen for endocytic motifs
    Patrycja Kozik
    University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
    Traffic 11:843-55. 2010
    ..Thus, the repertoire of endocytic motifs is more extensive than the three well-characterized sorting signals...
  6. ncbi request reprint Retromer-mediated endosomal protein sorting: all WASHed up!
    Matthew N J Seaman
    Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Cambridge CB2 0XY, UK Electronic address
    Trends Cell Biol 23:522-8. 2013
    ..In this review, recent progress in understanding the role of the WASH complex along with retromer in endosomal protein sorting is discussed. ..
  7. pmc N-acetylation and phosphorylation of Sec complex subunits in the ER membrane
    Christina Soromani
    Department of Clinical Biochemistry, University College London Hospital, London, UK
    BMC Cell Biol 13:34. 2012
    ..Little is known about the biogenesis and regulation of individual Sec complex subunits...
  8. pmc The retromer complex - endosomal protein recycling and beyond
    Matthew N J Seaman
    University of Cambridge, Cambridge Institute for Medical Research, UK
    J Cell Sci 125:4693-702. 2012
    ..In this Commentary, I will highlight recent advances in the understanding of retromer-mediated endosomal protein sorting and discuss how retromer contributes to a diverse set of physiological processes...
  9. ncbi request reprint Ricin toxin hits a retrograde roadblock
    Matthew N J Seaman
    Department of Clinical Biochemistry, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK
    Cell 141:222-4. 2010
    ..Stechmann et al. (2010) now identify two small-molecule inhibitors that selectively block endosome-to-Golgi retrieval of ricin and Shiga toxins and protect mice from ricin's deadly effects...
  10. pmc Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5
    Matthew N J Seaman
    University of Cambridge, Cambridge Institute for Medical Research, Department of Clinical Biochemistry, Wellcome Trust MRC Building, Addenbrookes Hospital, Hills Road, Cambridge CB2 0XY, UK
    J Cell Sci 122:2371-82. 2009
    ..We therefore propose that recruitment of the cargo-selective VPS35/29/26 complex is catalysed by Rab7 and inhibited by the Rab-GAP protein, TBC1D5...
  11. ncbi request reprint Identification of a novel conserved sorting motif required for retromer-mediated endosome-to-TGN retrieval
    Matthew N J Seaman
    University of Cambridge, Cambridge Institute for Medical Research Clinical Biochemistry, Wellcome Trust MRC Building, Addenbrookes Hospital, Cambridge, CB2 0XY, UK
    J Cell Sci 120:2378-89. 2007
    ....
  12. ncbi request reprint Recycle your receptors with retromer
    Matthew N J Seaman
    Cambridge Institute for Medical Research, Department of Clinical Biochemistry, Wellcome Trust and MRC building, Addenbrookes Hospital, Hills Road, Cambridge CB2 2XY, UK
    Trends Cell Biol 15:68-75. 2005
    ..Now, through a fusion of yeast genetics and mammalian cell biology, new insights have been gained into the molecular mechanisms that underlie the endosome-to-Golgi membrane-trafficking pathway...
  13. pmc The role of cargo proteins in GGA recruitment
    Jennifer Hirst
    Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK
    Traffic 8:594-604. 2007
    ..Together, these results demonstrate that cargo proteins contribute to the recruitment of GGAs onto membranes and to the formation of GGA-positive CCVs...
  14. pmc Identification of a conserved motif required for Vps35p/Vps26p interaction and assembly of the retromer complex
    Suzanne Gokool
    University of Cambridge, Cambridge Institute for Medical Research Department of Clinical Biochemistry, Wellcome Trust MRC Building, Addenbrookes Hospital, Cambridge CB2 0XY, UK
    Biochem J 408:287-95. 2007
    ..These data implicate Vps26p/VPS26 in regulating Vps35p/VPS35 membrane association and therefore suggest a role for Vps26p/VPS26 in cargo recognition...
  15. ncbi request reprint Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly
    Brett M Collins
    Cambridge Institute for Medical Research, Department of Clinical Biochemistry, University of Cambridge, Hills Road, Cambridge CB2 2XY, UK
    Nat Struct Mol Biol 12:594-602. 2005
    ....
  16. ncbi request reprint EHD1 interacts with retromer to stabilize SNX1 tubules and facilitate endosome-to-Golgi retrieval
    Suzanne Gokool
    Department of Clinical Biochemistry, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 0XY, UK
    Traffic 8:1873-86. 2007
    ..The interaction between EHD1 and retromer and the requirement for EHD1 to stabilize SNX1-tubules establish EHD1 as a novel facilitating component of endosome-to-Golgi retrieval...
  17. pmc Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment
    Margarita V Chibalina
    Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Hills Road, Cambridge, CB2 2XY, UK
    J Cell Sci 120:4278-88. 2007
    ....
  18. pmc Clathrin-mediated endocytosis in AP-2-depleted cells
    Alison Motley
    University of Cambridge, Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Cambridge CB2 2XY, UK
    J Cell Biol 162:909-18. 2003
    ..Uptake of the EGF and LDL receptors may be facilitated by alternative adaptors...
  19. ncbi request reprint Structure of Vps26B and mapping of its interaction with the retromer protein complex
    Brett M Collins
    Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
    Traffic 9:366-79. 2008
    ....