Marie Scully

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Successful management of pregnancy in women with a history of thrombotic thrombocytopaenic purpura
    Marie Scully
    Haemostasis Research Unit, Department of Haematology, University College London, UK
    Blood Coagul Fibrinolysis 17:459-63. 2006
  2. ncbi request reprint Cryosupernatant and solvent detergent fresh-frozen plasma (Octaplas) usage at a single centre in acute thrombotic thrombocytopenic purpura
    M Scully
    Haemostasis Research Unit, Department of Haematology, University College London, 51 Chenies Mews, London, UK
    Vox Sang 93:154-8. 2007
  3. doi request reprint Rituximab in the treatment of TTP
    Marie Scully
    University College London Hospitals, London, UK
    Hematology 17:S22-4. 2012
  4. doi request reprint Inhibitory anti-ADAMTS 13 antibodies: measurement and clinical application
    Marie Scully
    University College Hospital, London, United Kingdom
    Blood Rev 24:11-6. 2010
  5. doi request reprint A phase 2 study of the safety and efficacy of rituximab with plasma exchange in acute acquired thrombotic thrombocytopenic purpura
    Marie Scully
    Department of Haematology, University College London Hospital, London, United Kingdom
    Blood 118:1746-53. 2011
  6. doi request reprint Human leukocyte antigen association in idiopathic thrombotic thrombocytopenic purpura: evidence for an immunogenetic link
    M Scully
    Department of Haematology, University College of London Hospitals, and Haemostasis Research Unit, University College London, London, UK
    J Thromb Haemost 8:257-62. 2010
  7. ncbi request reprint Remission in acute refractory and relapsing thrombotic thrombocytopenic purpura following rituximab is associated with a reduction in IgG antibodies to ADAMTS-13
    Marie Scully
    Department of Haematology, University College London, London, UK
    Br J Haematol 136:451-61. 2007
  8. doi request reprint Regional UK TTP registry: correlation with laboratory ADAMTS 13 analysis and clinical features
    Marie Scully
    Department of Haematology, Haemostasis Research Unit, University College London, London, UK
    Br J Haematol 142:819-26. 2008
  9. ncbi request reprint The clinical utility of ADAMTS13 activity, antigen and autoantibody assays in thrombotic thrombocytopenic purpura
    Richard Starke
    Haemostasis Research Unit, Department of Haematology, University College London, London, UK
    Br J Haematol 136:649-55. 2007
  10. doi request reprint Acquired, noncongenital thrombotic thrombocytopenic purpura in children and adolescents: clinical management and the use of ADAMTS 13 assays
    Vickie McDonald
    Haemostasis Research Unit, Department of Haematology, University College London, UK
    Blood Coagul Fibrinolysis 21:245-50. 2010

Detail Information

Publications20

  1. ncbi request reprint Successful management of pregnancy in women with a history of thrombotic thrombocytopaenic purpura
    Marie Scully
    Haemostasis Research Unit, Department of Haematology, University College London, UK
    Blood Coagul Fibrinolysis 17:459-63. 2006
    ....
  2. ncbi request reprint Cryosupernatant and solvent detergent fresh-frozen plasma (Octaplas) usage at a single centre in acute thrombotic thrombocytopenic purpura
    M Scully
    Haemostasis Research Unit, Department of Haematology, University College London, 51 Chenies Mews, London, UK
    Vox Sang 93:154-8. 2007
    ..Thrombotic thrombocytopenic purpura (TTP) is an acute, life-threatening disorder and plasma exchange (PEX) remains the mainstay of treatment...
  3. doi request reprint Rituximab in the treatment of TTP
    Marie Scully
    University College London Hospitals, London, UK
    Hematology 17:S22-4. 2012
    ..The use of ADAMTS 13 activity for monitoring can identify patients at risk of a TTP relapse and preemptive therapy with an anti-CD 20 can be considered...
  4. doi request reprint Inhibitory anti-ADAMTS 13 antibodies: measurement and clinical application
    Marie Scully
    University College Hospital, London, United Kingdom
    Blood Rev 24:11-6. 2010
    ..Further investigation into the antibodies produced in TTP and other aspects of immune dysfunction, such as T cells will further our understanding of this devastating disorder...
  5. doi request reprint A phase 2 study of the safety and efficacy of rituximab with plasma exchange in acute acquired thrombotic thrombocytopenic purpura
    Marie Scully
    Department of Haematology, University College London Hospital, London, United Kingdom
    Blood 118:1746-53. 2011
    ..Rituximab should be considered in conjunction with standard therapy on acute presentation of TTP. This study was registered at www.clinicaltrials.gov as NCT009-3713...
  6. doi request reprint Human leukocyte antigen association in idiopathic thrombotic thrombocytopenic purpura: evidence for an immunogenetic link
    M Scully
    Department of Haematology, University College of London Hospitals, and Haemostasis Research Unit, University College London, London, UK
    J Thromb Haemost 8:257-62. 2010
    ..The majority of acute, idiopathic, adult TTP cases are associated with anti-ADAMTS 13 IgG antibodies. However, the factor(s) precipitating an acute TTP episode are not always obvious; indeed, a multifactorial etiology is likely...
  7. ncbi request reprint Remission in acute refractory and relapsing thrombotic thrombocytopenic purpura following rituximab is associated with a reduction in IgG antibodies to ADAMTS-13
    Marie Scully
    Department of Haematology, University College London, London, UK
    Br J Haematol 136:451-61. 2007
    ..In patients with acute refractory/relapsing idiopathic TTP, rituximab appears to be a safe, effective, targeted therapy with a significant reduction in the requirement for PEX...
  8. doi request reprint Regional UK TTP registry: correlation with laboratory ADAMTS 13 analysis and clinical features
    Marie Scully
    Department of Haematology, Haemostasis Research Unit, University College London, London, UK
    Br J Haematol 142:819-26. 2008
    ..Renal impairment and delayed normalisation of platelet count were the main differences between idiopathic and secondary TTP...
  9. ncbi request reprint The clinical utility of ADAMTS13 activity, antigen and autoantibody assays in thrombotic thrombocytopenic purpura
    Richard Starke
    Haemostasis Research Unit, Department of Haematology, University College London, London, UK
    Br J Haematol 136:649-55. 2007
    ....
  10. doi request reprint Acquired, noncongenital thrombotic thrombocytopenic purpura in children and adolescents: clinical management and the use of ADAMTS 13 assays
    Vickie McDonald
    Haemostasis Research Unit, Department of Haematology, University College London, UK
    Blood Coagul Fibrinolysis 21:245-50. 2010
    ..Treatment of acquired disease requires PEX and usually immunosuppressive treatment. Rituximab appears to be an effective adjunctive treatment modality...
  11. doi request reprint Human immunodeficiency virus associated thrombotic thrombocytopenic purpura--favourable outcome with plasma exchange and prompt initiation of highly active antiretroviral therapy
    Daniel Hart
    Department of Haematology, St Bartholomew s and the London Hospital, London, UK
    Br J Haematol 153:515-9. 2011
    ..More PEX is required in cases with higher viral loads. Continued HAART maintains remission. In a small proportion of cases, further immunomodulatory therapy may be required...
  12. ncbi request reprint Prevalence of the ADAMTS-13 missense mutation R1060W in late onset adult thrombotic thrombocytopenic purpura
    R S Camilleri
    Haemostasis Research Unit, Department of Haematology, University College London School of Medicine, London, UK
    J Thromb Haemost 6:331-8. 2008
    ..ADAMTS-13 mutations and polymorphisms have been reported in childhood congenital TTP, but their significance in adult onset TTP remains unclear...
  13. doi request reprint Discrepancies between ADAMTS13 activity assays in patients with thrombotic microangiopathies
    Ian Mackie
    Haemostasis Research Unit, Haematology Department, University College London and University College London Hospitals, 1st Floor, 51 Chenies Mews, London, WC1E 6HX, UK
    Thromb Haemost 109:488-96. 2013
    ..If the activity does not match the clinical picture, an alternative method should be performed. Where therapeutic monitoring is required, the same activity assay should be used throughout...
  14. ncbi request reprint The use of intermediate purity factor VIII concentrate BPL 8Y as prophylaxis and treatment in congenital thrombotic thrombocytopenic purpura
    Marie Scully
    Haemostasis Research Unit, UCL, London, UK
    Br J Haematol 135:101-4. 2006
    ..Effective prophylaxis and treatment is possible in congenital TTP using BPL 8Y...
  15. doi request reprint Cardiac involvement in acute thrombotic thrombocytopenic purpura: association with troponin T and IgG antibodies to ADAMTS 13
    C Hughes
    Department of Haematology, University College London Hospitals, London, UK
    J Thromb Haemost 7:529-36. 2009
    ..Evidence for cardiac involvement in thrombotic thrombocytopenic purpura (TTP) is uncommonly described...
  16. ncbi request reprint Thrombotic thrombocytopenic purpura and pregnancy: presentation, management, and subsequent pregnancy outcomes
    Marie Scully
    University College London Hospitals, London, United Kingdom
    Blood 124:211-9. 2014
    ..cTTP presents more frequently than acquired TTP during pregnancy and must be differentiated by ADAMTS13 analysis. Careful diagnosis, monitoring, and treatment in congenital and acquired TTP have assisted in excellent pregnancy outcomes. ..
  17. ncbi request reprint Complement and cytokine response in acute Thrombotic Thrombocytopenic Purpura
    John Paul Westwood
    Haemostasis Research Unit, University College London, London, UK
    Br J Haematol 164:858-66. 2014
    ..These results suggest complement anaphylatoxin levels are higher in acute TTP cases than in remission, and the complement response seen acutely may relate to anti-ADAMTS13 IgG antibody and IL-10 levels...
  18. ncbi request reprint Thrombotic thrombocytopaenic purpura in HIV-infected patients
    R F Miller
    Centre for Sexual Health and HIV Research, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, University College London, Mortimer Market Centre, Camden PCT, London WC1E 6AU, UK
    Int J STD AIDS 16:538-42. 2005
    ..Given the clear benefit from HAART in addition to plasma exchange, these data suggest that all patients presenting with TTP should undergo HIV testing...
  19. doi request reprint The impact of dose escalation and resistance modulation in older patients with acute myeloid leukaemia and high risk myelodysplastic syndrome: the results of the LRF AML14 trial
    Alan K Burnett
    Department of Haematology, School of Medicine, Cardiff University Heath Park, Cardiff, UK
    Br J Haematol 145:318-32. 2009
    ..In conclusion, these four interventions have not improved outcomes in older patients. New agents need to be explored and novel trial designs are required to maximise prospects of achieving timely progress...