Research Topics
Genomes and GenesSpecies | Marie ScullySummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Successful management of pregnancy in women with a history of thrombotic thrombocytopaenic purpuraMarie Scully
Haemostasis Research Unit, Department of Haematology, University College London, UK
Blood Coagul Fibrinolysis 17:459-63. 2006....
Inhibitory anti-ADAMTS 13 antibodies: measurement and clinical applicationMarie Scully
University College Hospital, London, United Kingdom
Blood Rev 24:11-6. 2010..Further investigation into the antibodies produced in TTP and other aspects of immune dysfunction, such as T cells will further our understanding of this devastating disorder...- Rituximab in the treatment of TTPMarie Scully
University College London Hospitals, London, UK
Hematology 17:S22-4. 2012..The use of ADAMTS 13 activity for monitoring can identify patients at risk of a TTP relapse and preemptive therapy with an anti-CD 20 can be considered... - Remission in acute refractory and relapsing thrombotic thrombocytopenic purpura following rituximab is associated with a reduction in IgG antibodies to ADAMTS-13Marie Scully
Department of Haematology, University College London, London, UK
Br J Haematol 136:451-61. 2007..In patients with acute refractory/relapsing idiopathic TTP, rituximab appears to be a safe, effective, targeted therapy with a significant reduction in the requirement for PEX... - Cryosupernatant and solvent detergent fresh-frozen plasma (Octaplas) usage at a single centre in acute thrombotic thrombocytopenic purpuraM Scully
Haemostasis Research Unit, Department of Haematology, University College London, 51 Chenies Mews, London, UK
Vox Sang 93:154-8. 2007..Thrombotic thrombocytopenic purpura (TTP) is an acute, life-threatening disorder and plasma exchange (PEX) remains the mainstay of treatment... - Human leukocyte antigen association in idiopathic thrombotic thrombocytopenic purpura: evidence for an immunogenetic linkM Scully
Department of Haematology, University College of London Hospitals, and Haemostasis Research Unit, University College London, London, UK
J Thromb Haemost 8:257-62. 2010..The majority of acute, idiopathic, adult TTP cases are associated with anti-ADAMTS 13 IgG antibodies. However, the factor(s) precipitating an acute TTP episode are not always obvious; indeed, a multifactorial etiology is likely... - A phase 2 study of the safety and efficacy of rituximab with plasma exchange in acute acquired thrombotic thrombocytopenic purpuraMarie Scully
Department of Haematology, University College London Hospital, London, United Kingdom
Blood 118:1746-53. 2011..Rituximab should be considered in conjunction with standard therapy on acute presentation of TTP. This study was registered at www.clinicaltrials.gov as NCT009-3713... - Regional UK TTP registry: correlation with laboratory ADAMTS 13 analysis and clinical featuresMarie Scully
Department of Haematology, Haemostasis Research Unit, University College London, London, UK
Br J Haematol 142:819-26. 2008..Renal impairment and delayed normalisation of platelet count were the main differences between idiopathic and secondary TTP... - Acquired, noncongenital thrombotic thrombocytopenic purpura in children and adolescents: clinical management and the use of ADAMTS 13 assaysVickie McDonald
Haemostasis Research Unit, Department of Haematology, University College London, UK
Blood Coagul Fibrinolysis 21:245-50. 2010..Treatment of acquired disease requires PEX and usually immunosuppressive treatment. Rituximab appears to be an effective adjunctive treatment modality... - The clinical utility of ADAMTS13 activity, antigen and autoantibody assays in thrombotic thrombocytopenic purpuraRichard Starke
Haemostasis Research Unit, Department of Haematology, University College London, London, UK
Br J Haematol 136:649-55. 2007.... - Human immunodeficiency virus associated thrombotic thrombocytopenic purpura--favourable outcome with plasma exchange and prompt initiation of highly active antiretroviral therapyDaniel Hart
Department of Haematology, St Bartholomew s and the London Hospital, London, UK
Br J Haematol 153:515-9. 2011..More PEX is required in cases with higher viral loads. Continued HAART maintains remission. In a small proportion of cases, further immunomodulatory therapy may be required... - Prevalence of the ADAMTS-13 missense mutation R1060W in late onset adult thrombotic thrombocytopenic purpuraR S Camilleri
Haemostasis Research Unit, Department of Haematology, University College London School of Medicine, London, UK
J Thromb Haemost 6:331-8. 2008..ADAMTS-13 mutations and polymorphisms have been reported in childhood congenital TTP, but their significance in adult onset TTP remains unclear... - Discrepancies between ADAMTS13 activity assays in patients with thrombotic microangiopathiesIan Mackie
Haemostasis Research Unit, Haematology Department, University College London and University College London Hospitals, 1st Floor, 51 Chenies Mews, London, WC1E 6HX, UK
Thromb Haemost 109:488-96. 2013..If the activity does not match the clinical picture, an alternative method should be performed. Where therapeutic monitoring is required, the same activity assay should be used throughout... - The use of intermediate purity factor VIII concentrate BPL 8Y as prophylaxis and treatment in congenital thrombotic thrombocytopenic purpuraMarie Scully
Haemostasis Research Unit, UCL, London, UK
Br J Haematol 135:101-4. 2006..Effective prophylaxis and treatment is possible in congenital TTP using BPL 8Y... - Cardiac involvement in acute thrombotic thrombocytopenic purpura: association with troponin T and IgG antibodies to ADAMTS 13C Hughes
Department of Haematology, University College London Hospitals, London, UK
J Thromb Haemost 7:529-36. 2009..Evidence for cardiac involvement in thrombotic thrombocytopenic purpura (TTP) is uncommonly described... - Thrombotic thrombocytopaenic purpura in HIV-infected patientsR F Miller
Centre for Sexual Health and HIV Research, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, University College London, Mortimer Market Centre, Camden PCT, London WC1E 6AU, UK
Int J STD AIDS 16:538-42. 2005..Given the clear benefit from HAART in addition to plasma exchange, these data suggest that all patients presenting with TTP should undergo HIV testing... - The impact of dose escalation and resistance modulation in older patients with acute myeloid leukaemia and high risk myelodysplastic syndrome: the results of the LRF AML14 trialAlan K Burnett
Department of Haematology, School of Medicine, Cardiff University Heath Park, Cardiff, UK
Br J Haematol 145:318-32. 2009..In conclusion, these four interventions have not improved outcomes in older patients. New agents need to be explored and novel trial designs are required to maximise prospects of achieving timely progress...