Jason L Scragg

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. ncbi request reprint Constitutive activity of human angiotensin II type-1 receptors by Gq overexpression
    Jason L Scragg
    CRISTAL Cardiovascular Research Institute at Leeds, School of Medicine, University of Leeds, Leeds LS2 9JT, UK
    Biochem Biophys Res Commun 334:134-9. 2005
  2. pmc Carbon monoxide inhibits L-type Ca2+ channels via redox modulation of key cysteine residues by mitochondrial reactive oxygen species
    Jason L Scragg
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health, and Therapeutics, Level 10, Worsley Bldg, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 283:24412-9. 2008
  3. ncbi request reprint Constitutive activity of endogenous receptors by inducible Gq overexpression
    Jason L Scragg
    Cardiovascular Research Institute at Leeds, School of Medicine, University of Leeds, Leeds LS2 9JT, UK
    Biochem Biophys Res Commun 331:1239-44. 2005
  4. ncbi request reprint Molecular requirements for L-type Ca2+ channel blockade by testosterone
    Jason L Scragg
    Institute for Cardiovascular Research, School of Medicine, University of Leeds, Leeds LS2 9JT, UK
    Cell Calcium 42:11-5. 2007
  5. pmc Carbon monoxide mediates the anti-apoptotic effects of heme oxygenase-1 in medulloblastoma DAOY cells via K+ channel inhibition
    Moza M A Al-Owais
    Division of Cardiovascular and Neuronal Remodelling, Light, Faculty of Medicine and Health, University of Leeds LS2 9JT, United Kingdom
    J Biol Chem 287:24754-64. 2012
  6. doi request reprint Modulation of hTREK-1 by carbon monoxide
    Mark L Dallas
    Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UK
    Neuroreport 19:345-8. 2008
  7. doi request reprint Carbon monoxide inhibition of Cav3.2 T-type Ca2+ channels reveals tonic modulation by thioredoxin
    Hannah E Boycott
    Leeds Institute of Genetics, Health, and Therapeutics, Faculty of Medicine and Health, University of Leeds, Leeds, UK
    FASEB J 27:3395-407. 2013
  8. pmc Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current
    Mark L Dallas
    Division of Cardiovascular and Neuronal Remodelling, Light, Faculty of Medicine and Health, University of Leeds, Clarendon Way, Leeds, UK
    Am J Respir Crit Care Med 186:648-56. 2012
  9. doi request reprint Cellular consequences of the expression of Alzheimer's disease-causing presenilin 1 mutations in human neuroblastoma (SH-SY5Y) cells
    John P Boyle
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    Brain Res 1443:75-88. 2012
  10. doi request reprint Hypoxia and neurodegeneration
    Chris Peers
    Faculties of Medicine, University of Leeds, Leeds, United Kingdom
    Ann N Y Acad Sci 1177:169-77. 2009

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Constitutive activity of human angiotensin II type-1 receptors by Gq overexpression
    Jason L Scragg
    CRISTAL Cardiovascular Research Institute at Leeds, School of Medicine, University of Leeds, Leeds LS2 9JT, UK
    Biochem Biophys Res Commun 334:134-9. 2005
    ..The data suggest that the resting equilibrium of hAT(1) receptors between the inactive (R) and active (R*) forms is predominantly weighted towards the inactive conformation...
  2. pmc Carbon monoxide inhibits L-type Ca2+ channels via redox modulation of key cysteine residues by mitochondrial reactive oxygen species
    Jason L Scragg
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health, and Therapeutics, Level 10, Worsley Bldg, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 283:24412-9. 2008
    ..This in turn leads to redox modulation of any or all of three critical cysteine residues in the channel's cytoplasmic C-terminal tail, resulting in channel inhibition...
  3. ncbi request reprint Constitutive activity of endogenous receptors by inducible Gq overexpression
    Jason L Scragg
    Cardiovascular Research Institute at Leeds, School of Medicine, University of Leeds, Leeds LS2 9JT, UK
    Biochem Biophys Res Commun 331:1239-44. 2005
    ..An inducible cell line, transiently expressing G proteins, can therefore be employed to induce constitutive activity of endogenously expressed GPCRs. This model system could be used to identify clinically important inverse agonists...
  4. ncbi request reprint Molecular requirements for L-type Ca2+ channel blockade by testosterone
    Jason L Scragg
    Institute for Cardiovascular Research, School of Medicine, University of Leeds, Leeds LS2 9JT, UK
    Cell Calcium 42:11-5. 2007
    ....
  5. pmc Carbon monoxide mediates the anti-apoptotic effects of heme oxygenase-1 in medulloblastoma DAOY cells via K+ channel inhibition
    Moza M A Al-Owais
    Division of Cardiovascular and Neuronal Remodelling, Light, Faculty of Medicine and Health, University of Leeds LS2 9JT, United Kingdom
    J Biol Chem 287:24754-64. 2012
    ....
  6. doi request reprint Modulation of hTREK-1 by carbon monoxide
    Mark L Dallas
    Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UK
    Neuroreport 19:345-8. 2008
    ..As both NO and CO are important neuronal gasotransmitters and TREK is crucial in regulating neuronal excitability, our results provide a novel means by which these gases may modulate neuronal activity...
  7. doi request reprint Carbon monoxide inhibition of Cav3.2 T-type Ca2+ channels reveals tonic modulation by thioredoxin
    Hannah E Boycott
    Leeds Institute of Genetics, Health, and Therapeutics, Faculty of Medicine and Health, University of Leeds, Leeds, UK
    FASEB J 27:3395-407. 2013
    ..CO modulation of T-type channels has widespread implications for diverse physiological and pathophysiological mechanisms, such as excitability, contractility, and proliferation...
  8. pmc Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current
    Mark L Dallas
    Division of Cardiovascular and Neuronal Remodelling, Light, Faculty of Medicine and Health, University of Leeds, Clarendon Way, Leeds, UK
    Am J Respir Crit Care Med 186:648-56. 2012
    ..Numerous case studies describe disruption of repolarization and prolongation of the QT interval, yet the mechanisms underlying CO-induced arrhythmias are unknown...
  9. doi request reprint Cellular consequences of the expression of Alzheimer's disease-causing presenilin 1 mutations in human neuroblastoma (SH-SY5Y) cells
    John P Boyle
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    Brain Res 1443:75-88. 2012
    ..This, rather than any potential disruption of ER Ca2+ stores, is likely to explain the extreme pathology of this mutant...
  10. doi request reprint Hypoxia and neurodegeneration
    Chris Peers
    Faculties of Medicine, University of Leeds, Leeds, United Kingdom
    Ann N Y Acad Sci 1177:169-77. 2009
    ..However, it remains to be determined whether inhibition of one or more of the effects of hypoxia may be of benefit in arresting the development of this neurodegenerative disease...
  11. doi request reprint Carbon monoxide protects against oxidant-induced apoptosis via inhibition of Kv2.1
    Mark L Dallas
    Division of Cardiovascular and Neuronal Remodelling, Faculty of Medicine and Health, University of Leeds, Leeds, UK
    FASEB J 25:1519-30. 2011
    ..Our results provide a novel mechanism to account for the neuroprotective effects of CO against oxidative apoptosis, which has potential for therapeutic exploitation to provide neuronal protection in situations of oxidative stress...
  12. ncbi request reprint H2O 2-stimulated Ca2+ influx via TRPM2 is not the sole determinant of subsequent cell death
    Jenny A Wilkinson
    School of Medicine, University of Leeds, Leeds LS2 9JT, UK
    Pflugers Arch 455:1141-51. 2008
    ....
  13. pmc A central role for ROS in the functional remodelling of L-type Ca2+ channels by hypoxia
    Chris Peers
    University of Leeds School of Medicine Worsley Building, Leeds LS2 9JT, UK
    Philos Trans R Soc Lond B Biol Sci 360:2247-54. 2005
    ..We suggest, therefore, that our data provide a cellular basis to account for the known increased incidence of Alzheimer's disease in patients who have suffered prolonged hypoxic episodes...
  14. ncbi request reprint Testosterone is a potent inhibitor of L-type Ca(2+) channels
    Jason L Scragg
    Institute for Cardiovascular Research, University of Leeds, Leeds LS2 9JT, UK
    Biochem Biophys Res Commun 318:503-6. 2004
    ..This effect is likely to account for its beneficial cardiovascular actions...
  15. doi request reprint Modulation of ion channels by hydrogen sulfide
    Chris Peers
    Division of Cardiovascular and Neuronal Remodelling, Faculty of Medicine and Health, Leeds Institute for Genetics Health and Therapeutics, University of Leeds, Leeds, United Kingdom
    Antioxid Redox Signal 17:95-105. 2012
    ..However, the mechanisms accounting for its many actions are not yet well understood...
  16. ncbi request reprint Analysis of oxygen-sensitive human cardiac L-type Ca2+ channel alpha1C subunit (hHT Isoform)
    Jason L Scragg
    Institute for Cardiovascular Research, University of Leeds, United Kingdom
    Methods Enzymol 381:290-302. 2004
  17. ncbi request reprint Mitochondrial ROS production initiates Abeta1-40-mediated up-regulation of L-type Ca2+ channels during chronic hypoxia
    Ian M Fearon
    Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, UK
    Adv Exp Med Biol 580:197-201; discussion 351-9. 2006
  18. ncbi request reprint Hypoxic augmentation of Ca2+ channel currents requires a functional electron transport chain
    Stephen T Brown
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada
    J Biol Chem 280:21706-12. 2005
    ..Thus oxidant production in the mitochondrial ETC is a critical factor, acting upstream of amyloid beta peptide production in the up-regulation of Ca(2+) channels in response to CH...
  19. ncbi request reprint Alzheimer's amyloid peptides mediate hypoxic up-regulation of L-type Ca2+ channels
    Jason L Scragg
    Institute for Cardiovascular Research, The University of Leeds, Leeds, UK
    FASEB J 19:150-2. 2005
    ..Such an action will likely contribute to the Ca2+ dyshomeostasis of Alzheimer's disease and may contribute to the mechanisms underlying the known increased incidence of this neurodegenerative disease following hypoxic episodes...