Jurgen Schwarze

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Reduced lung function in a chronic asthma model is associated with prolonged inflammation, but independent of peribronchial fibrosis
    Cordula Koerner-Rettberg
    Children s Hospital, Ruhr University of Bochum, Bochum, Germany
    PLoS ONE 3:e1575. 2008
  2. pmc Healthy but not RSV-infected lung epithelial cells profoundly inhibit T cell activation
    H Wang
    Department of Respiratory Medicine, National Heart and Lung Institute and Wright Fleming Institute of Infection and Immunity, Imperial College London, UK
    Thorax 64:283-90. 2009
  3. doi request reprint Republished: novel insights into immune and inflammatory responses to respiratory viruses
    Jurgen Schwarze
    MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Postgrad Med J 89:516-8. 2013
  4. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
  5. doi request reprint Novel insights into immune and inflammatory responses to respiratory viruses
    Jurgen Schwarze
    MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Thorax 68:108-10. 2013
  6. pmc Peptide immunotherapy for childhood allergy - addressing translational challenges
    Karen J Mackenzie
    MRC Centre for Inflammation Research, The University of Edinburgh, Edinburgh, UK
    Clin Transl Allergy 1:13. 2011
  7. doi request reprint Lung dendritic cells in respiratory syncytial virus bronchiolitis
    Jurgen Schwarze
    Child Life and Health and Centre for Inflammation Research, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh, UK
    Pediatr Infect Dis J 27:S89-91. 2008
  8. ncbi request reprint Local CD11c+ MHC class II- precursors generate lung dendritic cells during respiratory viral infection, but are depleted in the process
    Hongwei Wang
    Department of Respiratory Medicine, National Heart and Lung Institute and Wright Fleming Institute of Infection and Immunity, Imperial College London, Norfolk Place, London, United Kingdom
    J Immunol 177:2536-42. 2006
  9. pmc The chemokine MIP1alpha/CCL3 determines pathology in primary RSV infection by regulating the balance of T cell populations in the murine lung
    John S Tregoning
    Department of Respiratory Medicine, The Centre for Respiratory Infections Research, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    PLoS ONE 5:e9381. 2010
  10. ncbi request reprint Plasmacytoid dendritic cells limit viral replication, pulmonary inflammation, and airway hyperresponsiveness in respiratory syncytial virus infection
    Hongwei Wang
    Department of Respiratory Medicine, National Heart and Lung Institute and Wright Fleming Institute of Infection and Immunity, Imperial College London, London W2 1PG, United Kingdom
    J Immunol 177:6263-70. 2006

Collaborators

  • Peter J M Openshaw
  • Marc Beyer
  • H Wang
  • Michael R Edwards
  • Tracy Hussell
  • John S Tregoning
  • Nicholas Lukacs
  • Derek Macmillan
  • Henry N Jabbour
  • Alberto Papi
  • Fiona J Culley
  • Holger Bartz
  • Tobias J Tuthill
  • Gaetano Caramori
  • Adriano G Rossi
  • Donald J Davidson
  • Karen J Mackenzie
  • Silke M Currie
  • Paul M Fitch
  • Sarah E Wythe
  • Stephen M Anderton
  • Nikolaos G Papadopoulos
  • Alison E Wallace
  • Nathan W Bartlett
  • Cordula Koerner-Rettberg
  • Sarah E M Howie
  • Claire Wilson
  • Tian Man
  • Amanda J McFarlane
  • Annie Mackellar
  • Melanie D Leech
  • Anne Ilchmann
  • Brian J McHugh
  • Emily Gwyer Findlay
  • Antti Lauerma
  • Carsten Schmidt-Weber
  • Cezmi A Akdis
  • Javier Fernandez
  • Sevcan Celenk
  • Clare Mills
  • Francesco Annunziato
  • Knut Brockow
  • Omer Kalayci
  • Oliver Pfaar
  • Ewa Cichocka-Jarosz
  • Victoria Cardona
  • Jeroen Buters
  • Hans Jurgen Hoffmann
  • Claudia Traidl-Hoffmann
  • Lars K Poulsen
  • Massimo Triggiani
  • Adnan Custovic
  • Radoslaw Spiewak
  • Berber Vlieg-Boerstra
  • Ulrike Raap
  • Miguel Blanca
  • Paula Robson-Ansley
  • Christian Scharf
  • Valerie Hox
  • Ewa Bogacka
  • Isabel Skypala
  • Indre Butiene
  • Karin Hoffmann-Sommergruber
  • Alexandra F Santos
  • Adriano Mari
  • Paraskevi Mangina
  • Sevim Bavbek
  • Filippo Fassio
  • Nicolette Dejong
  • Angel Mazon
  • Darío Antolín-Amérigo
  • Isabella Annesi-Maesano
  • Heidi Makrinioti
  • Carsten Flohr
  • Monika Raulf-Heimsoth
  • Roger Lauener
  • Cansin Sackesen
  • Philippe Eigenmann
  • Michael Perkin
  • Jan Lotvall
  • Kirsty Logan
  • Gabriele Rumi
  • Paul Whitacker
  • Stefano Del Giacco
  • Marek Jutel
  • Antoine Magnan
  • Gianni Passalacqua
  • Clive Grattan
  • Santiago Quirce
  • Jan Demonchy

Detail Information

Publications17

  1. pmc Reduced lung function in a chronic asthma model is associated with prolonged inflammation, but independent of peribronchial fibrosis
    Cordula Koerner-Rettberg
    Children s Hospital, Ruhr University of Bochum, Bochum, Germany
    PLoS ONE 3:e1575. 2008
    ..This study was performed to delineate functional, structural and immunological airway changes after cessation of long term challenges to elucidate factors contributing to the development of prolonged lung function changes...
  2. pmc Healthy but not RSV-infected lung epithelial cells profoundly inhibit T cell activation
    H Wang
    Department of Respiratory Medicine, National Heart and Lung Institute and Wright Fleming Institute of Infection and Immunity, Imperial College London, UK
    Thorax 64:283-90. 2009
    ..A study was performed to determine whether healthy LECs regulate antigen-specific T cell responses and if this regulation is lost during RSV infection...
  3. doi request reprint Republished: novel insights into immune and inflammatory responses to respiratory viruses
    Jurgen Schwarze
    MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Postgrad Med J 89:516-8. 2013
    ....
  4. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
    ..Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein...
  5. doi request reprint Novel insights into immune and inflammatory responses to respiratory viruses
    Jurgen Schwarze
    MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Thorax 68:108-10. 2013
    ....
  6. pmc Peptide immunotherapy for childhood allergy - addressing translational challenges
    Karen J Mackenzie
    MRC Centre for Inflammation Research, The University of Edinburgh, Edinburgh, UK
    Clin Transl Allergy 1:13. 2011
    ..This provides a context for discussion of the challenges for the application of PIT, both generally and more specifically in relation to children...
  7. doi request reprint Lung dendritic cells in respiratory syncytial virus bronchiolitis
    Jurgen Schwarze
    Child Life and Health and Centre for Inflammation Research, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh, UK
    Pediatr Infect Dis J 27:S89-91. 2008
    ..As central players in the induction of adaptive immune responses, lung DCs need to be considered as targets for novel therapies and vaccination approaches...
  8. ncbi request reprint Local CD11c+ MHC class II- precursors generate lung dendritic cells during respiratory viral infection, but are depleted in the process
    Hongwei Wang
    Department of Respiratory Medicine, National Heart and Lung Institute and Wright Fleming Institute of Infection and Immunity, Imperial College London, Norfolk Place, London, United Kingdom
    J Immunol 177:2536-42. 2006
    ..This depletion of local DC precursors in respiratory viral infections may be important in explaining complex interactions between multiple and intercurrent pulmonary infections...
  9. pmc The chemokine MIP1alpha/CCL3 determines pathology in primary RSV infection by regulating the balance of T cell populations in the murine lung
    John S Tregoning
    Department of Respiratory Medicine, The Centre for Respiratory Infections Research, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    PLoS ONE 5:e9381. 2010
    ..The chemokine CCL3 (MIP1alpha) is produced following RSV infection and is broadly chemotactic for both T cells and natural killer (NK) cells. We therefore investigated its role in RSV disease...
  10. ncbi request reprint Plasmacytoid dendritic cells limit viral replication, pulmonary inflammation, and airway hyperresponsiveness in respiratory syncytial virus infection
    Hongwei Wang
    Department of Respiratory Medicine, National Heart and Lung Institute and Wright Fleming Institute of Infection and Immunity, Imperial College London, London W2 1PG, United Kingdom
    J Immunol 177:6263-70. 2006
    ..In addition to this innate response, pDC also may play an immune regulatory role in reducing pulmonary inflammation and inhibiting the development of airway hyperresponsiveness...
  11. ncbi request reprint Sustained increases in numbers of pulmonary dendritic cells after respiratory syncytial virus infection
    Marc Beyer
    Klinik fur Kinder und Jugendmedizin, St Josef Hospital, Bochum, Germany
    J Allergy Clin Immunol 113:127-33. 2004
    ..Dendritic cells are critical in inducing T-cell responses to both viruses and allergens and could be pivotal in regulating interactions between these...
  12. pmc OX40 ligand and programmed cell death 1 ligand 2 expression on inflammatory dendritic cells regulates CD4 T cell cytokine production in the lung during viral disease
    Sarah E Wythe
    Center for Respiratory Infections, National Heart and Lung Institute, St Mary s Campus, Imperial College London, London W2 1PG, UK
    J Immunol 188:1647-55. 2012
    ..Manipulation of these costimulatory pathways may provide a novel approach to controlling pulmonary inflammatory responses...
  13. pmc The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus
    Silke M Currie
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, Scotland, United Kingdom
    PLoS ONE 8:e73659. 2013
    ..Prophylactic modulation of LL-37 expression and/or use of synthetic analogues post-infection may represent future novel strategies against RSV infection. ..
  14. pmc The beta2 integrin CD11c distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo
    Marc Beyer
    Department of Respiratory Medicine, NHLI, Imperial College London, Norfolk Place, London, UK
    Respir Res 6:70. 2005
    ..Here, we characterise CD11c bearing T cells in a murine model of localised pulmonary infection with respiratory syncytial virus (RSV)...
  15. pmc Combination peptide immunotherapy based on T-cell epitope mapping reduces allergen-specific IgE and eosinophilia in allergic airway inflammation
    Karen J Mackenzie
    MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Immunology 138:258-68. 2013
    ..This model holds important potential for future mechanistic studies using peptide immunotherapy in allergy...
  16. pmc Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation
    Nathan W Bartlett
    Department of Respiratory Medicine, UK National Heart and Lung Institute, and Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, Norfolk Place, London W2 1PG, UK
    Nat Med 14:199-204. 2008
    ..These models have features similar to those observed in rhinovirus infection in humans, including augmentation of allergic airway inflammation, and will be useful in the development of future therapies for colds and asthma exacerbations...
  17. pmc Prostaglandin F2alpha-F-prostanoid receptor signaling promotes neutrophil chemotaxis via chemokine (C-X-C motif) ligand 1 in endometrial adenocarcinoma
    Alison E Wallace
    Medical Research Council Human Reproductive Sciences Unit, Department of Reproductive and Developmental Sciences, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    Cancer Res 69:5726-33. 2009
    ..In conclusion, our results show a novel PGF(2alpha)-FP pathway that may regulate the inflammatory microenvironment in endometrial adenocarcinoma via neutrophil chemotaxis...