Jean Marc Schwartz
Affiliation: University of Manchester
- Schwartz J, Nacher J. Local and global modes of drug action in biochemical networks. BMC Chem Biol. 2009;9:4 pubmed publisher..These findings demonstrate the relevance of metabolic drug scopes to the characterization of drug-metabolism interactions and to understanding the mechanisms of drug action in a system-wide context. ..
- Dunn S, Soul J, Anand S, Schwartz J, Boot Handford R, Hardingham T. Gene expression changes in damaged osteoarthritic cartilage identify a signature of non-chondrogenic and mechanical responses. Osteoarthritis Cartilage. 2016;24:1431-40 pubmed publisher..PhenomeExpress analysis identified a hub of DEGs linked by a core of four differentially regulated TFs. ..
- Chapman S, Trindade Dos Santos M, Johnson G, Kritz M, Schwartz J. Cyclic decomposition explains a photosynthetic down regulation for Chlamydomonas reinhardtii. Biosystems. 2017;162:119-127 pubmed publisher..These results show how the decomposition of metabolic flux into cyclic and acyclic components helps to understand the impact of metabolic cycling on organismal behaviour at the genome scale...