John W R Schwabe

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Nuclear receptors: the evolution of diversity
    John W R Schwabe
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Sci STKE 2004:pe4. 2004
  2. ncbi request reprint A dynamic mechanism of nuclear receptor activation and its perturbation in a human disease
    Bettina C Kallenberger
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Nat Struct Biol 10:136-40. 2003
  3. pmc A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling
    Mariko Ariyoshi
    Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 2QH, UK
    Genes Dev 17:1909-20. 2003
  4. ncbi request reprint Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma
    Maura Agostini
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, United Kingdom
    Endocrinology 145:1527-38. 2004
  5. ncbi request reprint Mechanism of the nuclear receptor molecular switch
    Laszlo Nagy
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Nagyerdei körút 98, Debrecen H 4012, Hungary
    Trends Biochem Sci 29:317-24. 2004

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Nuclear receptors: the evolution of diversity
    John W R Schwabe
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Sci STKE 2004:pe4. 2004
    ....
  2. ncbi request reprint A dynamic mechanism of nuclear receptor activation and its perturbation in a human disease
    Bettina C Kallenberger
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Nat Struct Biol 10:136-40. 2003
    ..Our findings provide the first direct observations of the mobility of helix 12 and suggest that the dynamic properties of this helix are key to the regulation of transcriptional activity...
  3. pmc A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling
    Mariko Ariyoshi
    Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 2QH, UK
    Genes Dev 17:1909-20. 2003
    ..These findings suggest that the conserved function of the SPOC domain is to mediate interaction with SMRT/NCoR corepressors, and that Spen proteins play an essential role in the repression complex...
  4. ncbi request reprint Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma
    Maura Agostini
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, United Kingdom
    Endocrinology 145:1527-38. 2004
    ..Having shown that rosiglitazone is of variable and limited efficacy in these subjects, we suggest that TAs may represent a more rational therapeutic approach...
  5. ncbi request reprint Mechanism of the nuclear receptor molecular switch
    Laszlo Nagy
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Nagyerdei körút 98, Debrecen H 4012, Hungary
    Trends Biochem Sci 29:317-24. 2004
    ..This remarkable dynamic mechanism has facilitated the evolution of a family of nuclear receptors with highly diverse ligand recognition and signalling properties...