Marie A Schroeder

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart
    Marie A Schroeder
    Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room M326A, Toronto, Ontario M4N 3M5, Canada
    Eur J Heart Fail 15:130-40. 2013
  2. pmc The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study
    Marie A Schroeder
    Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Circ Cardiovasc Imaging 5:201-9. 2012
  3. pmc Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a 13C and 31P magnetic resonance spectroscopy study
    Marie A Schroeder
    Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK
    Cardiovasc Res 86:82-91. 2010
  4. pmc Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy
    Marie A Schroeder
    Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, Sherrington Bldg, University of Oxford, Parks Rd, Oxford, UK
    FASEB J 23:2529-38. 2009
  5. doi request reprint In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart
    Michael S Dodd
    Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, UK
    Cardiovasc Res 95:69-76. 2012
  6. doi request reprint Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate
    Marie A Schroeder
    Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    NMR Biomed 24:980-7. 2011
  7. doi request reprint Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH, using hyperpolarized [1,2-(13)C2]pyruvate in vivo
    Albert P Chen
    GE Healthcare, Toronto, ON, Canada
    NMR Biomed 25:305-11. 2012
  8. doi request reprint The effect of hyperpolarized tracer concentration on myocardial uptake and metabolism
    Marie A Schroeder
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Magn Reson Med 61:1007-14. 2009
  9. pmc Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics
    Marie A Schroeder
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom
    Proc Natl Acad Sci U S A 110:E958-67. 2013
  10. pmc In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance
    Marie A Schroeder
    Cardiac Metabolism Research Group, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom
    Proc Natl Acad Sci U S A 105:12051-6. 2008

Detail Information

Publications11

  1. pmc Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart
    Marie A Schroeder
    Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room M326A, Toronto, Ontario M4N 3M5, Canada
    Eur J Heart Fail 15:130-40. 2013
    ..We investigated the hypothesis that if we serially examined a model of heart failure using non-invasive hyperpolarized [(13)C]pyruvate with MR, the profile of in vivo pyruvate oxidation would change throughout the course of the disease...
  2. pmc The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study
    Marie A Schroeder
    Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Circ Cardiovasc Imaging 5:201-9. 2012
    ..The aim of this study was to use the metabolic tracer hyperpolarized [2-(13)C]pyruvate with magnetic resonance spectroscopy to determine whether carnitine acetyltransferase facilitates carbohydrate oxidation in the heart...
  3. pmc Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a 13C and 31P magnetic resonance spectroscopy study
    Marie A Schroeder
    Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK
    Cardiovasc Res 86:82-91. 2010
    ..The aim of this study was to evaluate the potential of hyperpolarized [1-(13)C]pyruvate, coupled with (13)C magnetic resonance spectroscopy (MRS), to measure pH(i) in the healthy and diseased heart...
  4. pmc Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy
    Marie A Schroeder
    Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, Sherrington Bldg, University of Oxford, Parks Rd, Oxford, UK
    FASEB J 23:2529-38. 2009
    ..These results showed that the control and fluxes of the Krebs cycle in heart disease can be studied using hyperpolarized [2-(13)C]pyruvate...
  5. doi request reprint In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart
    Michael S Dodd
    Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, UK
    Cardiovasc Res 95:69-76. 2012
    ..One of the cellular adaptations to hypertrophy is a reduction in β-oxidation, and it has previously been shown that in response to hypertrophy the SHR heart switches to a glycolytic/glucose-oxidative phenotype...
  6. doi request reprint Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate
    Marie A Schroeder
    Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    NMR Biomed 24:980-7. 2011
    ..Therefore, in the case of PDH, and potentially other enzymes, hyperpolarised (13)C MRI can be used to assess noninvasively enzymatic regulation...
  7. doi request reprint Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH, using hyperpolarized [1,2-(13)C2]pyruvate in vivo
    Albert P Chen
    GE Healthcare, Toronto, ON, Canada
    NMR Biomed 25:305-11. 2012
    ....
  8. doi request reprint The effect of hyperpolarized tracer concentration on myocardial uptake and metabolism
    Marie A Schroeder
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Magn Reson Med 61:1007-14. 2009
    ..This protocol could be useful to optimize the infused concentration of other hyperpolarized metabolites in different organs, to ensure adequate MR signal with minimum metabolic perturbation...
  9. pmc Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics
    Marie A Schroeder
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom
    Proc Natl Acad Sci U S A 110:E958-67. 2013
    ..Aberrant distribution of CA activity therefore may reduce the heart's energetic efficiency...
  10. pmc In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance
    Marie A Schroeder
    Cardiac Metabolism Research Group, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom
    Proc Natl Acad Sci U S A 105:12051-6. 2008
    ....
  11. doi request reprint Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS
    Helen J Atherton
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    NMR Biomed 24:201-8. 2011
    ..Hence, during the 60-s data acquisition period, metabolism was minimally affected by pyruvate infusion...