Anette Schrag

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Development of a measure of the impact of chronic parental illness on adolescent and adult children. The parental illness impact scale (Parkinson's disease)
    Anette Schrag
    Royal Free and University College Medical School, University College London, London NW3 2PF, UK
    Parkinsonism Relat Disord 10:399-405. 2004
  2. pmc PREDICT-PD: identifying risk of Parkinson's disease in the community: methods and baseline results
    Alastair J Noyce
    Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 85:31-7. 2014
  3. pmc Meta-analysis of early nonmotor features and risk factors for Parkinson disease
    Alastair J Noyce
    Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 72:893-901. 2012
  4. pmc Mapping the EQ-5D index by UPDRS and PDQ-8 in patients with Parkinson's disease
    Judith Dams
    Department of Neurology, Philipps University, Marburg, Germany
    Health Qual Life Outcomes 11:35. 2013
  5. pmc The functional neuroimaging correlates of psychogenic versus organic dystonia
    Anette E Schrag
    UCL Institute of Neurology, University College London, Royal Free Campus, Clinical Neurosciences, Rowland Hill Street, London, NW3 2PF, UK
    Brain 136:770-81. 2013
  6. doi What is the clinically relevant change on the ADAS-Cog?
    Anette Schrag
    Department of Clinical Neurosciences, Institute of Neurology, Royal Free Campus, University College London, London NW3 2PF, UK
    J Neurol Neurosurg Psychiatry 83:171-3. 2012
  7. ncbi A comparison of depression, anxiety, and health status in patients with progressive supranuclear palsy and multiple system atrophy
    Anette Schrag
    Institute of Neurology, University College London, London, UK
    Mov Disord 25:1077-81. 2010
  8. ncbi Caregiver-burden in parkinson's disease is closely associated with psychiatric symptoms, falls, and disability
    Anette Schrag
    Royal Free and University College Medical School, University College London NW3 2PF, London, UK
    Parkinsonism Relat Disord 12:35-41. 2006
  9. doi Validation of the MDS-UPDRS Part I for nonmotor symptoms in Parkinson's disease
    David A Gallagher
    Institute of Neurology, University College London, London, UK
    Mov Disord 27:79-83. 2012
  10. doi Comparative responsiveness of Parkinson's disease scales to change over time
    Anette Schrag
    Department of Clinical Neurosciences, Royal Free Hospital, University College, Rowland Hill Street, London, UK
    Mov Disord 24:813-8. 2009

Detail Information

Publications39

  1. ncbi Development of a measure of the impact of chronic parental illness on adolescent and adult children. The parental illness impact scale (Parkinson's disease)
    Anette Schrag
    Royal Free and University College Medical School, University College London, London NW3 2PF, UK
    Parkinsonism Relat Disord 10:399-405. 2004
    ..Its psychometric properties should be tested further in larger samples, including children of patients with other chronic disorders such as multiple sclerosis or chronic heart disease...
  2. pmc PREDICT-PD: identifying risk of Parkinson's disease in the community: methods and baseline results
    Alastair J Noyce
    Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 85:31-7. 2014
    ..To present methods and baseline results for an online screening tool to identify increased risk for Parkinson's disease (PD) in the UK population...
  3. pmc Meta-analysis of early nonmotor features and risk factors for Parkinson disease
    Alastair J Noyce
    Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 72:893-901. 2012
    ..To evaluate the association between diagnosis of Parkinson disease (PD) and risk factors or early symptoms amenable to population-based screening...
  4. pmc Mapping the EQ-5D index by UPDRS and PDQ-8 in patients with Parkinson's disease
    Judith Dams
    Department of Neurology, Philipps University, Marburg, Germany
    Health Qual Life Outcomes 11:35. 2013
    ..We aimed to develop an estimation algorithm for EuroQol- 5 dimensions (EQ-5D)-based utilities from the clinical UPDRS or disease-specific HrQoL data in the absence of original utilities estimates...
  5. pmc The functional neuroimaging correlates of psychogenic versus organic dystonia
    Anette E Schrag
    UCL Institute of Neurology, University College London, Royal Free Campus, Clinical Neurosciences, Rowland Hill Street, London, NW3 2PF, UK
    Brain 136:770-81. 2013
    ..This suggests that psychogenic and organic dystonia have different cortical and subcortical pathophysiology, while a derangement in mechanisms of motor attention may be a feature of both conditions...
  6. doi What is the clinically relevant change on the ADAS-Cog?
    Anette Schrag
    Department of Clinical Neurosciences, Institute of Neurology, Royal Free Campus, University College London, London NW3 2PF, UK
    J Neurol Neurosurg Psychiatry 83:171-3. 2012
    ..To establish the minimal clinically relevant change (MCRC) on the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) for patients with mild Alzheimer's disease (AD)...
  7. ncbi A comparison of depression, anxiety, and health status in patients with progressive supranuclear palsy and multiple system atrophy
    Anette Schrag
    Institute of Neurology, University College London, London, UK
    Mov Disord 25:1077-81. 2010
    ..Anxiety symptoms affected 37% of patients in both groups and contributed to impaired subjective health status. Pain was more problematic in MSA than PSP...
  8. ncbi Caregiver-burden in parkinson's disease is closely associated with psychiatric symptoms, falls, and disability
    Anette Schrag
    Royal Free and University College Medical School, University College London NW3 2PF, London, UK
    Parkinsonism Relat Disord 12:35-41. 2006
    ....
  9. doi Validation of the MDS-UPDRS Part I for nonmotor symptoms in Parkinson's disease
    David A Gallagher
    Institute of Neurology, University College London, London, UK
    Mov Disord 27:79-83. 2012
    ..0001; other nonmotor features factor score: r = 0.87, P < 0.0001). Our data demonstrate that the MDS-UPDRS Part I total score has a strong relationship with a composite score of validated scales for the nonmotor aspects of PD...
  10. doi Comparative responsiveness of Parkinson's disease scales to change over time
    Anette Schrag
    Department of Clinical Neurosciences, Royal Free Hospital, University College, Rowland Hill Street, London, UK
    Mov Disord 24:813-8. 2009
    ..Global assessment of overall impairment and disability (which incorporates motor and nonmotor features of PD), however, appeared relatively responsive to change over time in patients in a naturalistic setting...
  11. pmc Depression rating scales in Parkinson's disease: critique and recommendations
    Anette Schrag
    University Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
    Mov Disord 22:1077-92. 2007
    ..The complex and time-consuming task of developing a new scale to measure depression specifically for patients with PD is currently not warranted...
  12. ncbi Health-related quality of life in multiple system atrophy
    Anette Schrag
    Department of Clinical Neurosciences, Royal Free and University College Medical School, London, United Kingdom
    Mov Disord 21:809-15. 2006
    ....
  13. doi What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them?
    David A Gallagher
    Department of Clinical Neuroscience, Institute of Neurology, Royal Free Campus, London, United Kingdom
    Mov Disord 25:2493-500. 2010
    ..However, whilst psychiatric problems are increasingly documented, many symptoms (particularly those possibly perceived as embarrassing or unrelated) remain under-reported...
  14. ncbi Rate of clinical progression in Parkinson's disease. A prospective study
    Anette Schrag
    Department of Clinical Neurosciences, Royal Free Hospital, University College London, London, United Kingdom
    Mov Disord 22:938-45. 2007
    ..However, disability continues to deteriorate with advancing disease and with the development of disease complications that are likely to be related to additional extrastriatal pathology...
  15. ncbi Impact of Parkinson's disease on patients' adolescent and adult children
    Anette Schrag
    Royal Free and University College Medical School, University College London, London NW3 2PF, UK
    Parkinsonism Relat Disord 10:391-7. 2004
    ..PD has a marked effect on the well-being of the adult and adolescent children of patients. The difficulties of children of parents with PD should receive greater attention...
  16. ncbi Measuring health-related quality of life in MSA: the MSA-QoL
    Anette Schrag
    Department of Clinical Neurosciences, Royal Free and University College Medical School, University College London, London, United Kingdom
    Mov Disord 22:2332-8. 2007
    ..In conclusion, the patient-rated MSA health-related Quality of life scale (MSA-QoL) may be a suitable patient-reported scale for use in clinical trials and studies in MSA...
  17. ncbi Time of loss of employment in Parkinson's disease
    Anette Schrag
    Royal Free and University College Medical School, University College London, London, United Kingdom
    Mov Disord 21:1839-43. 2006
    ..However, the variability of time to loss of employment is large, indicating that other factors than onset age and disease duration influence loss of patients' employment...
  18. doi Psychosis, apathy, depression and anxiety in Parkinson's disease
    David A Gallagher
    Institute of Neurology, University College London, UK
    Neurobiol Dis 46:581-9. 2012
    ..However, the future challenge will be to develop treatments developed specifically for the pathogenesis of these disorders in PD...
  19. doi Testing an aetiological model of visual hallucinations in Parkinson's disease
    David A Gallagher
    Institute of Neurology, University College London, UK
    Brain 134:3299-309. 2011
    ..These clinical data are supported by the pathological study, in which higher overall cortical Lewy body counts, and in particular areas implicated in visuoperception and executive function, were associated with visual hallucinations...
  20. ncbi Impact of newer pharmacological treatments on quality of life in patients with Parkinson's disease
    David A Gallagher
    Department of Clinical Neurosciences, Royal Free and University College Medical School, London, EnglandInstitute of Neurology, University College London, London, England
    CNS Drugs 22:563-86. 2008
    ..The evidence for antidepressant efficacy of antiparkinsonian medications is limited...
  21. doi Apathy and depression scales in Parkinson's disease: are they good enough?
    Anette Schrag
    Department of Clinical Neurosciences, Institute of Neurology, University College London, Royal Free Campus, London, UK
    J Neurol Sci 310:216-9. 2011
    ..Overall, there is no perfect scale, but the choice of scale needs to take into account clinimetric properties, validity in the sample examined, content and purpose...
  22. doi Cortical excitability is abnormal in patients with the "fixed dystonia" syndrome
    Laura Avanzino
    Sobell Department of Motor Neuroscience, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 23:646-52. 2008
    ..SAI and LAI did not significantly differ between the three groups. The abnormal cortical excitability observed in FD might represent an underlying trait predisposing to different clinical forms of dystonia...
  23. doi Health-related quality of life in Gilles de la Tourette syndrome: a decade of research
    Andrea Eugenio Cavanna
    Sobell Department of Movement Disorders, Institute of Neurology and University College London, London, UK
    Behav Neurol 27:83-93. 2013
    ..These findings offer some general directions for both current clinical practice and future research...
  24. ncbi Dissociation, childhood interpersonal trauma, and family functioning in patients with somatization disorder
    Richard J Brown
    Department of Clinical Neurology, Institute of Neurology, London, UK
    Am J Psychiatry 162:899-905. 2005
    ....
  25. ncbi How common are complications of Parkinson's disease?
    Anette Schrag
    Department of Clinical Neurology, Institute of Neurology, Queen Square, London WC1N3BG, UK
    J Neurol 249:419-23. 2002
    ..Parkinson's disease (PD) can be associated with a wide range of complications of advancing disease and treatment. However, it is unclear how often these occur in the overall population of patients with PD...
  26. ncbi Psychiatric aspects of Parkinson's disease--an update
    Anette Schrag
    University Department of Clinical Neurosciences, Royal Free and University College Medical School, London NW3 2PF, UK
    J Neurol 251:795-804. 2004
    ..Randomised, controlled studies are required to assess the differential efficacy and tolerability of antidepressants in patients with PD, including the newer antidepressants with serotonergic and noradrenergic properties...
  27. pmc Adolescent and adult children of parents with Parkinson's disease: incorporating their needs in clinical guidelines
    David Morley
    Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Parkinsons Dis 2011:951874. 2011
    ..There is a need to similarly acknowledge the potential impact of parental Parkinson's in UK guidelines for PD...
  28. ncbi Pathological gambling in Parkinson's disease: risk factors and differences from dopamine dysregulation. An analysis of published case series
    David A Gallagher
    Department of Clinical Neurosciences, Royal Free and University College Medical School, London, United Kingdom
    Mov Disord 22:1757-63. 2007
    ..PG is predominantly associated with oral DA. It often occurs in isolation and may not be associated with DDS, which typically occurs on treatment with levodopa or subcutaneous apomorphine...
  29. ncbi Quality of life and depression in Parkinson's disease
    Anette Schrag
    Royal Free and University College Medical School, University College London NW3 2PF, London, United Kingdom
    J Neurol Sci 248:151-7. 2006
    ..While a number of treatment approaches have been suggested, double-blind randomized controlled trials to demonstrate improvement of depression and overall Hr-QoL in PD are warranted...
  30. ncbi Minimal clinically important change on the unified Parkinson's disease rating scale
    Anette Schrag
    Royal Free and University College Medical School, University College London, London, United Kingdom
    Mov Disord 21:1200-7. 2006
    ..Further studies using larger databases from more diverse study populations are encouraged to better define and solidify the MCIC for the UPDRS...
  31. ncbi Epidemiological, clinical, and genetic characteristics of early-onset parkinsonism
    Anette Schrag
    Royal Free and University College Medical School, University College London, Department of Clinical Neurosciences, London, UK
    Lancet Neurol 5:355-63. 2006
    ....
  32. ncbi Entacapone in the treatment of Parkinson's disease
    Anette Schrag
    University Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
    Lancet Neurol 4:366-70. 2005
    ..5), and in some but not all studies improvement of health-related quality of life [HRQOL] scores...
  33. doi Time trends in incidence of Parkinson's disease diagnosis in UK primary care
    Laura Horsfall
    Research Department of Primary Care and Population Health, University College London, London, UK
    J Neurol 260:1351-7. 2013
    ..There was a decline in PD diagnosis in the primary care setting, which may largely represent changes in diagnosis and/or coding rather than a true decline in incidence...
  34. ncbi Survival in multiple system atrophy
    Anette Schrag
    Department of Clinical Neurosciences, Royal Free and University College Medical School, London, United Kingdom
    Mov Disord 23:294-6. 2008
    ..49, 95% CI 0.97-2.31, P = 0.07). Except for rediagnosis as PD, no predictive factors for better survival could be identified. These data confirm the relatively poor prognosis of MSA of less than 9 years on average...
  35. ncbi The syndrome of fixed dystonia: an evaluation of 103 patients
    Anette Schrag
    University Department of Clinical Neurosciences, Royal Free and University College Medical School, London NW3 2PF, UK
    Brain 127:2360-72. 2004
    ....
  36. ncbi Health-related quality of life in patients with progressive supranuclear palsy
    Anette Schrag
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 18:1464-9. 2003
    ..The item pool created in these interviews provides the basis for the development of disease-specific QoL instruments for patients with PSP...
  37. ncbi Psychogenic movement disorders
    Anette Schrag
    Royal Free and University College Medical School, University College London, London, UK
    Curr Opin Neurol 18:399-404. 2005
    ....
  38. pmc The role of cognitive-behavioural therapy for patients with depression in Parkinson's disease
    Andreas Charidimou
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, University College London UCL, Queen Square, London WC1N 3BG, UK
    Parkinsons Dis 2011:737523. 2011
    ..However, a number of case reports, case series, and small pilot studies suggest that this is a promising treatment for patients with PD. We here summarise the published evidence on this treatment in dPD...