Research Topics
| Anette SchragSummaryAffiliation: University College London Country: UK Publications
| Collaborators
|
Detail Information
Publications
The functional neuroimaging correlates of psychogenic versus organic dystoniaAnette E Schrag
UCL Institute of Neurology, University College London, Royal Free Campus, Clinical Neurosciences, Rowland Hill Street, London, NW3 2PF, UK
Brain 136:770-81. 2013..This suggests that psychogenic and organic dystonia have different cortical and subcortical pathophysiology, while a derangement in mechanisms of motor attention may be a feature of both conditions...
What is the clinically relevant change on the ADAS-Cog?Anette Schrag
Department of Clinical Neurosciences, Institute of Neurology, Royal Free Campus, University College London, London NW3 2PF, UK
J Neurol Neurosurg Psychiatry 83:171-3. 2012..To establish the minimal clinically relevant change (MCRC) on the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) for patients with mild Alzheimer's disease (AD)...
Development of a measure of the impact of chronic parental illness on adolescent and adult children. The parental illness impact scale (Parkinson's disease)Anette Schrag
Royal Free and University College Medical School, University College London, London NW3 2PF, UK
Parkinsonism Relat Disord 10:399-405. 2004..Its psychometric properties should be tested further in larger samples, including children of patients with other chronic disorders such as multiple sclerosis or chronic heart disease...- A comparison of depression, anxiety, and health status in patients with progressive supranuclear palsy and multiple system atrophyAnette Schrag
Institute of Neurology, University College London, London, UK
Mov Disord 25:1077-81. 2010..Anxiety symptoms affected 37% of patients in both groups and contributed to impaired subjective health status. Pain was more problematic in MSA than PSP... - Validation of the MDS-UPDRS Part I for nonmotor symptoms in Parkinson's diseaseDavid A Gallagher
Institute of Neurology, University College London, London, UK
Mov Disord 27:79-83. 2012..0001; other nonmotor features factor score: r = 0.87, P < 0.0001). Our data demonstrate that the MDS-UPDRS Part I total score has a strong relationship with a composite score of validated scales for the nonmotor aspects of PD... - Comparative responsiveness of Parkinson's disease scales to change over timeAnette Schrag
Department of Clinical Neurosciences, Royal Free Hospital, University College, Rowland Hill Street, London, UK
Mov Disord 24:813-8. 2009..Global assessment of overall impairment and disability (which incorporates motor and nonmotor features of PD), however, appeared relatively responsive to change over time in patients in a naturalistic setting... - What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them?David A Gallagher
Department of Clinical Neuroscience, Institute of Neurology, Royal Free Campus, London, United Kingdom
Mov Disord 25:2493-500. 2010..However, whilst psychiatric problems are increasingly documented, many symptoms (particularly those possibly perceived as embarrassing or unrelated) remain under-reported... - Depression rating scales in Parkinson's disease: critique and recommendationsAnette Schrag
University Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
Mov Disord 22:1077-92. 2007..The complex and time-consuming task of developing a new scale to measure depression specifically for patients with PD is currently not warranted... - Testing an aetiological model of visual hallucinations in Parkinson's diseaseDavid A Gallagher
Institute of Neurology, University College London, UK
Brain 134:3299-309. 2011..These clinical data are supported by the pathological study, in which higher overall cortical Lewy body counts, and in particular areas implicated in visuoperception and executive function, were associated with visual hallucinations... - Apathy and depression scales in Parkinson's disease: are they good enough?Anette Schrag
Department of Clinical Neurosciences, Institute of Neurology, University College London, Royal Free Campus, London, UK
J Neurol Sci 310:216-9. 2011..Overall, there is no perfect scale, but the choice of scale needs to take into account clinimetric properties, validity in the sample examined, content and purpose... - Impact of newer pharmacological treatments on quality of life in patients with Parkinson's diseaseDavid A Gallagher
Department of Clinical Neurosciences, Royal Free and University College Medical School, London, EnglandInstitute of Neurology, University College London, London, England
CNS Drugs 22:563-86. 2008..The evidence for antidepressant efficacy of antiparkinsonian medications is limited... - Meta-analysis of early nonmotor features and risk factors for Parkinson diseaseAlastair J Noyce
Institute of Neurology, University College London, London, United Kingdom
Ann Neurol 72:893-901. 2012..To evaluate the association between diagnosis of Parkinson disease (PD) and risk factors or early symptoms amenable to population-based screening... - Rate of clinical progression in Parkinson's disease. A prospective studyAnette Schrag
Department of Clinical Neurosciences, Royal Free Hospital, University College London, London, United Kingdom
Mov Disord 22:938-45. 2007..However, disability continues to deteriorate with advancing disease and with the development of disease complications that are likely to be related to additional extrastriatal pathology... - How common are complications of Parkinson's disease?Anette Schrag
Department of Clinical Neurology, Institute of Neurology, Queen Square, London WC1N3BG, UK
J Neurol 249:419-23. 2002..Parkinson's disease (PD) can be associated with a wide range of complications of advancing disease and treatment. However, it is unclear how often these occur in the overall population of patients with PD... - Time of loss of employment in Parkinson's diseaseAnette Schrag
Royal Free and University College Medical School, University College London, London, United Kingdom
Mov Disord 21:1839-43. 2006..However, the variability of time to loss of employment is large, indicating that other factors than onset age and disease duration influence loss of patients' employment... - The syndrome of fixed dystonia: an evaluation of 103 patientsAnette Schrag
University Department of Clinical Neurosciences, Royal Free and University College Medical School, London NW3 2PF, UK
Brain 127:2360-72. 2004.... - Quality of life and depression in Parkinson's diseaseAnette Schrag
Royal Free and University College Medical School, University College London NW3 2PF, London, United Kingdom
J Neurol Sci 248:151-7. 2006..While a number of treatment approaches have been suggested, double-blind randomized controlled trials to demonstrate improvement of depression and overall Hr-QoL in PD are warranted... - Health-related quality of life in patients with progressive supranuclear palsyAnette Schrag
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
Mov Disord 18:1464-9. 2003..The item pool created in these interviews provides the basis for the development of disease-specific QoL instruments for patients with PSP... - Entacapone in the treatment of Parkinson's diseaseAnette Schrag
University Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
Lancet Neurol 4:366-70. 2005..In addition, future trials should specifically assess the effect of entacapone on HRQOL in PD... - Cortical excitability is abnormal in patients with the "fixed dystonia" syndromeLaura Avanzino
Sobell Department of Motor Neuroscience, Institute of Neurology, University College London, London, United Kingdom
Mov Disord 23:646-52. 2008..SAI and LAI did not significantly differ between the three groups. The abnormal cortical excitability observed in FD might represent an underlying trait predisposing to different clinical forms of dystonia... - Psychosis, apathy, depression and anxiety in Parkinson's diseaseDavid A Gallagher
Institute of Neurology, University College London, UK
Neurobiol Dis 46:581-9. 2012..However, the future challenge will be to develop treatments developed specifically for the pathogenesis of these disorders in PD... - Psychiatric aspects of Parkinson's disease--an updateAnette Schrag
University Department of Clinical Neurosciences, Royal Free and University College Medical School, London NW3 2PF, UK
J Neurol 251:795-804. 2004..Randomised, controlled studies are required to assess the differential efficacy and tolerability of antidepressants in patients with PD, including the newer antidepressants with serotonergic and noradrenergic properties... - Psychogenic movement disordersAnette Schrag
Royal Free and University College Medical School, University College London, London, UK
Curr Opin Neurol 18:399-404. 2005.... - Health-related quality of life in Gilles de la Tourette syndrome: A decade of researchAndrea Eugenio Cavanna
Sobell Department of Movement Disorders, Institute of Neurology and University College London, London, UK Department of Neuropsychiatry, BSMHFT and University of Birmingham, Birmingham, UK
Behav Neurol 27:83-93. 2013..These findings offer some general directions for both current clinical practice and future research... - Adolescent and adult children of parents with Parkinson's disease: incorporating their needs in clinical guidelinesDavid Morley
Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Parkinsons Dis 2011:951874. 2011..There is a need to similarly acknowledge the potential impact of parental Parkinson's in UK guidelines for PD... - Measuring health-related quality of life in MSA: the MSA-QoLAnette Schrag
Department of Clinical Neurosciences, Royal Free and University College Medical School, University College London, London, United Kingdom
Mov Disord 22:2332-8. 2007..In conclusion, the patient-rated MSA health-related Quality of life scale (MSA-QoL) may be a suitable patient-reported scale for use in clinical trials and studies in MSA... - Epidemiological, clinical, and genetic characteristics of early-onset parkinsonismAnette Schrag
Royal Free and University College Medical School, University College London, Department of Clinical Neurosciences, London, UK
Lancet Neurol 5:355-63. 2006.... - Minimal clinically important change on the unified Parkinson's disease rating scaleAnette Schrag
Royal Free and University College Medical School, University College London, London, United Kingdom
Mov Disord 21:1200-7. 2006..Further studies using larger databases from more diverse study populations are encouraged to better define and solidify the MCIC for the UPDRS... - Survival in multiple system atrophyAnette Schrag
Department of Clinical Neurosciences, Royal Free and University College Medical School, London, United Kingdom
Mov Disord 23:294-6. 2008..49, 95% CI 0.97-2.31, P = 0.07). Except for rediagnosis as PD, no predictive factors for better survival could be identified. These data confirm the relatively poor prognosis of MSA of less than 9 years on average... - Pathological gambling in Parkinson's disease: risk factors and differences from dopamine dysregulation. An analysis of published case seriesDavid A Gallagher
Department of Clinical Neurosciences, Royal Free and University College Medical School, London, United Kingdom
Mov Disord 22:1757-63. 2007..PG is predominantly associated with oral DA. It often occurs in isolation and may not be associated with DDS, which typically occurs on treatment with levodopa or subcutaneous apomorphine... - Impact of Parkinson's disease on patients' adolescent and adult childrenAnette Schrag
Royal Free and University College Medical School, University College London, London NW3 2PF, UK
Parkinsonism Relat Disord 10:391-7. 2004..PD has a marked effect on the well-being of the adult and adolescent children of patients. The difficulties of children of parents with PD should receive greater attention... - The role of cognitive-behavioural therapy for patients with depression in Parkinson's diseaseAndreas Charidimou
Institute of Neurology, The National Hospital for Neurology and Neurosurgery, University College London UCL, Queen Square, London WC1N 3BG, UK
Parkinsons Dis 2011:737523. 2011..However, a number of case reports, case series, and small pilot studies suggest that this is a promising treatment for patients with PD. We here summarise the published evidence on this treatment in dPD... - Dissociation, childhood interpersonal trauma, and family functioning in patients with somatization disorderRichard J Brown
Department of Clinical Neurology, Institute of Neurology, London, UK
Am J Psychiatry 162:899-905. 2005....