Research Topics
| A SchragSummaryAffiliation: University College London Country: UK Publications
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Publications
Rate of clinical progression in Parkinson's disease. A prospective studyAnette Schrag
Department of Clinical Neurosciences, Royal Free Hospital, University College London, London, United Kingdom
Mov Disord 22:938-45. 2007..However, disability continues to deteriorate with advancing disease and with the development of disease complications that are likely to be related to additional extrastriatal pathology...- Epidemiological, clinical, and genetic characteristics of early-onset parkinsonismAnette Schrag
Royal Free and University College Medical School, University College London, Department of Clinical Neurosciences, London, UK
Lancet Neurol 5:355-63. 2006.... - Psychiatric aspects of Parkinson's disease--an updateAnette Schrag
University Department of Clinical Neurosciences, Royal Free and University College Medical School, London NW3 2PF, UK
J Neurol 251:795-804. 2004..Randomised, controlled studies are required to assess the differential efficacy and tolerability of antidepressants in patients with PD, including the newer antidepressants with serotonergic and noradrenergic properties... - The syndrome of fixed dystonia: an evaluation of 103 patientsAnette Schrag
University Department of Clinical Neurosciences, Royal Free and University College Medical School, London NW3 2PF, UK
Brain 127:2360-72. 2004.... - Apathy and depression scales in Parkinson's disease: are they good enough?Anette Schrag
Department of Clinical Neurosciences, Institute of Neurology, University College London, Royal Free Campus, London, UK
J Neurol Sci 310:216-9. 2011..Overall, there is no perfect scale, but the choice of scale needs to take into account clinimetric properties, validity in the sample examined, content and purpose... - Depression rating scales in Parkinson's disease: critique and recommendationsAnette Schrag
University Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
Mov Disord 22:1077-92. 2007..The complex and time-consuming task of developing a new scale to measure depression specifically for patients with PD is currently not warranted... - Time of loss of employment in Parkinson's diseaseAnette Schrag
Royal Free and University College Medical School, University College London, London, United Kingdom
Mov Disord 21:1839-43. 2006..However, the variability of time to loss of employment is large, indicating that other factors than onset age and disease duration influence loss of patients' employment... - Testing the validity of the PDQ-39 in patients with MSAA Schrag
Department of Clinical Neurosciences, Royal Free and University College Medical School, University College London, London NW3 2PF, UK
Parkinsonism Relat Disord 13:152-6. 2007..However, many of the specific features of MSA are not reflected in the PDQ-39. Higher order factor analysis did not support the use of a single summary index. We conclude that the PDQ-39 has only limited validity in patients with MSA... - Measuring quality of life in PSP: the PSP-QoLA Schrag
Royal Free and University College Medical School, Department of Clinical Neurosciences, Institute of Neurology, University College London, UK
Neurology 67:39-44. 2006..To develop a new patient-reported outcome measure for progressive supranuclear palsy (PSP) and to test its psychometric properties... - Comparative responsiveness of Parkinson's disease scales to change over timeAnette Schrag
Department of Clinical Neurosciences, Royal Free Hospital, University College, Rowland Hill Street, London, UK
Mov Disord 24:813-8. 2009..Global assessment of overall impairment and disability (which incorporates motor and nonmotor features of PD), however, appeared relatively responsive to change over time in patients in a naturalistic setting... - Entacapone in the treatment of Parkinson's diseaseAnette Schrag
University Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
Lancet Neurol 4:366-70. 2005..In addition, future trials should specifically assess the effect of entacapone on HRQOL in PD... - Streptococcal infection, Tourette syndrome, and OCD: is there a connection?A Schrag
Department of Clinical Neurosciences, Royal Free Campus, Institute of Neurology, University College London, London, UK
Neurology 73:1256-63. 2009..A causal relationship of common streptococcal infections and childhood neuropsychiatric disorders has been postulated... - Psychogenic movement disordersAnette Schrag
Royal Free and University College Medical School, University College London, London, UK
Curr Opin Neurol 18:399-404. 2005.... - Quality of life and depression in Parkinson's diseaseAnette Schrag
Royal Free and University College Medical School, University College London NW3 2PF, London, United Kingdom
J Neurol Sci 248:151-7. 2006..While a number of treatment approaches have been suggested, double-blind randomized controlled trials to demonstrate improvement of depression and overall Hr-QoL in PD are warranted... - Minimal clinically important change on the unified Parkinson's disease rating scaleAnette Schrag
Royal Free and University College Medical School, University College London, London, United Kingdom
Mov Disord 21:1200-7. 2006..Further studies using larger databases from more diverse study populations are encouraged to better define and solidify the MCIC for the UPDRS... - Fourteen-year final report of the randomized PDRG-UK trial comparing three initial treatments in PDR Katzenschlager
National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Neurology 71:474-80. 2008..Increased mortality in patients on selegiline combined with l-dopa led to premature termination of this arm after 6 years... - The EQ-5D--a generic quality of life measure-is a useful instrument to measure quality of life in patients with Parkinson's diseaseA Schrag
Department of Neurology, Institute of Neurology, London, UK
J Neurol Neurosurg Psychiatry 69:67-73. 2000.... - Quantifying the impact of dyskinesias in PD: the PDYS-26: a patient-based outcome measureR Katzenschlager
National Hospital for Neurology and Neurosurgery, University College, London, UK
Neurology 69:555-63. 2007..Their management and the development of new treatments rely on rigorous and meaningful dyskinesia measurement. Although clinician-based approaches exist, patient-based measures are limited... - Measuring health-related quality of life in patients with progressive supranuclear palsyA Schrag
University Department of Clinical Neurosciences, Royal Free and University College Medical School, Sobell Department of Motor Neuroscience and Movement Disorders, London, UK a
Neurocase 11:246-9. 2005..The psychometric properties of this questionnaire are undergoing further evaluation... - The prognosis of fixed dystonia: a follow-up studyN M Ibrahim
Department of Motor Neurosciences and Movement Disorders, Institute of Neurology, University College London, UK
Parkinsonism Relat Disord 15:592-7. 2009..The syndrome of fixed dystonia includes both CRPS-dystonia and psychogenic dystonia. The underlying mechanisms are unclear, but a high prevalence of neuropsychiatric illness has previously been reported... - Anti-basal ganglia antibodies in patients with atypical dystonia and tics: a prospective studyM J Edwards
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London, UK
Neurology 63:156-8. 2004..An autoimmune mechanism may underlie a proportion of cases of atypical movement disorders... - Quality of life in patients with orthostatic tremorW Gerschlager
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
J Neurol 250:212-5. 2003..The BDI score correlated significantly with several SF-36 subscores. We conclude that OT strongly impacts on QoL. The results highlight the importance of recognizing and treating depression in patients with OT... - The Gilles de la Tourette syndrome-quality of life scale (GTS-QOL): development and validationA E Cavanna
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N3BG, UK
Neurology 71:1410-6. 2008..However, no patient-reported HR-QOL measures have been developed for this population... - What contributes to depression in Parkinson's disease?A Schrag
Department of Clinical Neurology, Institute of Neurology, London
Psychol Med 31:65-73. 2001..Using a community-based sample of patients with Parkinson's disease, we investigated the contributions of impairment, disability and handicap to depression in Parkinson's disease... - Young- versus older-onset Parkinson's disease: impact of disease and psychosocial consequencesAnette Schrag
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College, London, United Kingdom
Mov Disord 18:1250-6. 2003..In addition to more severe treatment-related motor complications, social and psychosocial factors may contribute to greater impairment of quality of life in young patients with PD... - How valid is the clinical diagnosis of Parkinson's disease in the community?A Schrag
Sobell Department of Motor Neurosciences and Movement Disorders, Institute of Neurology, London WC1, UK
J Neurol Neurosurg Psychiatry 73:529-34. 2002..Many patients diagnosed with Parkinson's disease are later found to have an erroneous diagnosis, often only when they come to necropsy; conversely, many patients with Parkinson's disease in the community remain undiagnosed... - Effect of ApoE and tau on age of onset of progressive supranuclear palsy and multiple system atrophyH R Morris
Neurogenetics Section, University Department of Clinical Neurology, Institute of Neurology, Queen Square, London WC1N 3BG, UK
Neurosci Lett 312:118-20. 2001..We have not found any effect of possession of the tau H1 haplotype or the ApoE epsilon4 allele on the age of onset of MSA or PSP... - Arm tremor in cervical dystonia differs from essential tremor and can be classified by onset age and spread of symptomsA Munchau
Sobell Department of Neurophysiology, University College London, London, UK
Brain 124:1765-76. 2001..These groups do not correspond to the currently proposed clinical subdivision of 'dystonic tremor' and 'tremor associated with dystonia'... - Health-related quality of life in multiple system atrophyAnette Schrag
Department of Clinical Neurosciences, Royal Free and University College Medical School, London, United Kingdom
Mov Disord 21:809-15. 2006.... - Caregiver-burden in parkinson's disease is closely associated with psychiatric symptoms, falls, and disabilityAnette Schrag
Royal Free and University College Medical School, University College London NW3 2PF, London, UK
Parkinsonism Relat Disord 12:35-41. 2006.... - Impact of Parkinson's disease on patients' adolescent and adult childrenAnette Schrag
Royal Free and University College Medical School, University College London, London NW3 2PF, UK
Parkinsonism Relat Disord 10:391-7. 2004..PD has a marked effect on the well-being of the adult and adolescent children of patients. The difficulties of children of parents with PD should receive greater attention... - Reliability of self-reported diagnoses in patients with neurologically unexplained symptomsA Schrag
Division of Neuropsychiatry and Neuropsychology, Institute of Neurology, Queen Square, London WC1N 3BG, UK
J Neurol Neurosurg Psychiatry 75:608-11. 2004..However, information on past medical diagnoses is primarily obtained from patient interviews and may be inaccurate, particularly in patients with NUS... - Patterns of EMG-EMG coherence in limb dystoniaPascal Grosse
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
Mov Disord 19:758-69. 2004..We conclude that the nature of the abnormal drive to dystonic muscles may vary according to the muscles under consideration and, particularly, with aetiology... - Health-related quality of life in patients with progressive supranuclear palsyAnette Schrag
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
Mov Disord 18:1464-9. 2003..The item pool created in these interviews provides the basis for the development of disease-specific QoL instruments for patients with PSP... - Development of a measure of the impact of chronic parental illness on adolescent and adult children. The parental illness impact scale (Parkinson's disease)Anette Schrag
Royal Free and University College Medical School, University College London, London NW3 2PF, UK
Parkinsonism Relat Disord 10:399-405. 2004..Its psychometric properties should be tested further in larger samples, including children of patients with other chronic disorders such as multiple sclerosis or chronic heart disease... - How common are complications of Parkinson's disease?Anette Schrag
Department of Clinical Neurology, Institute of Neurology, Queen Square, London WC1N3BG, UK
J Neurol 249:419-23. 2002..Parkinson's disease (PD) can be associated with a wide range of complications of advancing disease and treatment. However, it is unclear how often these occur in the overall population of patients with PD... - Poetic talent unmasked by treatment of Parkinson's diseaseA Schrag
Raymond Way Neuropsychiatry Research Group, Institute of Neurology, University College London, London, United Kingdom
Mov Disord 16:1175-6. 2001..This case offers insight into the neurology of the artistic process as well as into the pathophysiology of psychiatric adverse reactions to the treatment of PD... - Sweating dysfunction in Parkinson's diseaseLesley Swinn
National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
Mov Disord 18:1459-63. 2003..Sweating disturbances are common and distressing symptoms of PD that are related mainly to autonomic dysfunction, off periods, and dyskinesias... - Quality of life in stiff-person syndromeWillibald Gerschlager
Sobell Department of Motor Neurosciences and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
Mov Disord 17:1064-7. 2002..We have shown that SPS has a significant impact on patients' reported QoL. The association between depression and QoL highlights the importance of recognizing and treating depression in SPS... - A comparison of depression, anxiety, and health status in patients with progressive supranuclear palsy and multiple system atrophyAnette Schrag
Institute of Neurology, University College London, London, UK
Mov Disord 25:1077-81. 2010..Anxiety symptoms affected 37% of patients in both groups and contributed to impaired subjective health status. Pain was more problematic in MSA than PSP... - Impact of newer pharmacological treatments on quality of life in patients with Parkinson's diseaseDavid A Gallagher
Department of Clinical Neurosciences, Royal Free and University College Medical School, London, EnglandInstitute of Neurology, University College London, London, England
CNS Drugs 22:563-86. 2008..The evidence for antidepressant efficacy of antiparkinsonian medications is limited... - Ropinirole for the treatment of tremor in early Parkinson's diseaseA Schrag
Department of Clinical Neurology, Institute of Neurology, London, UK
Eur J Neurol 9:253-7. 2002..On the other hand, response of postural/action tremor to dopaminergic treatment in early PD was not significantly better than to placebo at the dosages used in these trials... - Measuring health-related quality of life in MSA: the MSA-QoLAnette Schrag
Department of Clinical Neurosciences, Royal Free and University College Medical School, University College London, London, United Kingdom
Mov Disord 22:2332-8. 2007..In conclusion, the patient-rated MSA health-related Quality of life scale (MSA-QoL) may be a suitable patient-reported scale for use in clinical trials and studies in MSA... - Cortical excitability is abnormal in patients with the "fixed dystonia" syndromeLaura Avanzino
Sobell Department of Motor Neuroscience, Institute of Neurology, University College London, London, United Kingdom
Mov Disord 23:646-52. 2008..SAI and LAI did not significantly differ between the three groups. The abnormal cortical excitability observed in FD might represent an underlying trait predisposing to different clinical forms of dystonia... - Pathological gambling in Parkinson's disease: risk factors and differences from dopamine dysregulation. An analysis of published case seriesDavid A Gallagher
Department of Clinical Neurosciences, Royal Free and University College Medical School, London, United Kingdom
Mov Disord 22:1757-63. 2007..PG is predominantly associated with oral DA. It often occurs in isolation and may not be associated with DDS, which typically occurs on treatment with levodopa or subcutaneous apomorphine... - Dissociation, childhood interpersonal trauma, and family functioning in patients with somatization disorderRichard J Brown
Department of Clinical Neurology, Institute of Neurology, London, UK
Am J Psychiatry 162:899-905. 2005.... - Red flags for multiple system atrophyMartin Köllensperger
Section for Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Austria
Mov Disord 23:1093-9. 2008..9 (+/-7.0) months earlier than with the Consensus criteria alone. We propose a combination of two out of six red flag categories as additional diagnostic criteria for probable MSA-P... - A questionnaire-based (UM-PDHQ) study of hallucinations in Parkinson's diseaseSpiridon Papapetropoulos
Divisions of Movement Disorders Department of Neurology, University of Miami, Miller School of Medicine Miami, FL, USA
BMC Neurol 8:21. 2008..To this end, we developed the University of Miami Parkinson's disease Hallucinations Questionnaire (UM-PDHQ) that allows comprehensive assessment of hallucinations in clinical or research settings... - Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Process, format, and clinimetric testing planChristopher G Goetz
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
Mov Disord 22:41-7. 2007.... - Depressive symptoms and life satisfaction in patients with multiple system atrophyLisa M Benrud-Larson
Department of Neurology, Mayo Clinic, Rochester, Minnesota 55095, USA
Mov Disord 20:951-7. 2005..Adequate treatment of comorbid depression may improve quality of life in this population, despite the presence of other debilitating deficits... - Estimated life expectancy of Parkinson's patients compared with the UK populationLianna S Ishihara
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
J Neurol Neurosurg Psychiatry 78:1304-9. 2007..These may be of greater value to patients than standardised mortality ratios (SMRs), which are usually reported in studies on mortality in PD... - Survival in multiple system atrophyAnette Schrag
Department of Clinical Neurosciences, Royal Free and University College Medical School, London, United Kingdom
Mov Disord 23:294-6. 2008..49, 95% CI 0.97-2.31, P = 0.07). Except for rediagnosis as PD, no predictive factors for better survival could be identified. These data confirm the relatively poor prognosis of MSA of less than 9 years on average...