Jonathan M Schott

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Transient ischaemic attacks are associated with increased rates of global cerebral atrophy
    R J L Walters
    Department of Clinical Neurology, St Mary s Hospital, London W2 1NY, UK
    J Neurol Neurosurg Psychiatry 74:213-6. 2003
  2. ncbi request reprint A comparison of methods for the automated calculation of volumes and atrophy rates in the hippocampus
    J Barnes
    Dementia Research Centre, UCL, Institute of Neurology, London, UK
    Neuroimage 40:1655-71. 2008
  3. pmc Using CSF biomarkers to replicate genetic associations in Alzheimer's disease
    Jonathan M Schott
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Neurobiol Aging 33:1486.e9-15. 2012
  4. pmc Short echo time proton magnetic resonance spectroscopy in Alzheimer's disease: a longitudinal multiple time point study
    Jonathan M Schott
    Dementia Research Centre, UCL Institute of Neurology, London WC1N 3BG, UK
    Brain 133:3315-22. 2010
  5. ncbi request reprint Neuropsychological correlates of whole brain atrophy in Alzheimer's disease
    J M Schott
    Dementia Research Centre National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Neuropsychologia 46:1732-7. 2008
  6. pmc Development of selective verbal memory impairment secondary to a left thalamic infarct: a longitudinal case study
    J M Schott
    Dementia Research Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 74:255-7. 2003
  7. pmc Reduced sample sizes for atrophy outcomes in Alzheimer's disease trials: baseline adjustment
    J M Schott
    Dementia Research Centre, Institute of Neurology, UCL, London WC1N 3BG, UK
    Neurobiol Aging 31:1452-62, 1462.e1-2. 2010
  8. ncbi request reprint A neurological MRI menagerie
    J M Schott
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, UK
    Pract Neurol 7:186-90. 2007
  9. doi request reprint Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1-42
    Jonathan M Schott
    Dementia Research Centre, University College London, Institute of Neurology, London, United Kingdom
    Ann Neurol 68:825-34. 2010
  10. ncbi request reprint Genetic influences on atrophy patterns in familial Alzheimer's disease: a comparison of APP and PSEN1 mutations
    Rachael I Scahill
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, London, UK
    J Alzheimers Dis 35:199-212. 2013

Detail Information

Publications66

  1. pmc Transient ischaemic attacks are associated with increased rates of global cerebral atrophy
    R J L Walters
    Department of Clinical Neurology, St Mary s Hospital, London W2 1NY, UK
    J Neurol Neurosurg Psychiatry 74:213-6. 2003
    ....
  2. ncbi request reprint A comparison of methods for the automated calculation of volumes and atrophy rates in the hippocampus
    J Barnes
    Dementia Research Centre, UCL, Institute of Neurology, London, UK
    Neuroimage 40:1655-71. 2008
    ..The change over time can then be calculated automatically using boundary shift or fluid measures, with boundary shift giving most similar results to manual...
  3. pmc Using CSF biomarkers to replicate genetic associations in Alzheimer's disease
    Jonathan M Schott
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Neurobiol Aging 33:1486.e9-15. 2012
    ..61-7.06); and possession of 1 or more APOE ε4 alleles (OR, 9.84; 95% CI, 5.48-17.67). These results suggest that using biomarkers of AD pathology to define case and control status may increase power in genetic association studies...
  4. pmc Short echo time proton magnetic resonance spectroscopy in Alzheimer's disease: a longitudinal multiple time point study
    Jonathan M Schott
    Dementia Research Centre, UCL Institute of Neurology, London WC1N 3BG, UK
    Brain 133:3315-22. 2010
    ....
  5. ncbi request reprint Neuropsychological correlates of whole brain atrophy in Alzheimer's disease
    J M Schott
    Dementia Research Centre National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Neuropsychologia 46:1732-7. 2008
    ..This methodology whereby data from patients falling to floor on a given test may be included and accounted for, rather than discarded, may find broader application in clinical studies incorporating neuropsychometric outcomes...
  6. pmc Development of selective verbal memory impairment secondary to a left thalamic infarct: a longitudinal case study
    J M Schott
    Dementia Research Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 74:255-7. 2003
    ..High resolution volumetric MRI may be helpful in demonstrating small subcortical infarcts that may not be seen using computed tomography or conventional MRI...
  7. pmc Reduced sample sizes for atrophy outcomes in Alzheimer's disease trials: baseline adjustment
    J M Schott
    Dementia Research Centre, Institute of Neurology, UCL, London WC1N 3BG, UK
    Neurobiol Aging 31:1452-62, 1462.e1-2. 2010
    ..Adjusting for 11 predefined covariates reduced sample sizes by up to 30%. Treatment trials in AD should consider the effects of normal aging; adjusting for baseline characteristics can significantly reduce required sample sizes...
  8. ncbi request reprint A neurological MRI menagerie
    J M Schott
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, UK
    Pract Neurol 7:186-90. 2007
  9. doi request reprint Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1-42
    Jonathan M Schott
    Dementia Research Centre, University College London, Institute of Neurology, London, United Kingdom
    Ann Neurol 68:825-34. 2010
    ..To identify cognitively normal individuals at risk of Alzheimer disease (AD) based on cerebrospinal fluid (CSF) Aβ1-42, and to determine rates of cerebral atrophy...
  10. ncbi request reprint Genetic influences on atrophy patterns in familial Alzheimer's disease: a comparison of APP and PSEN1 mutations
    Rachael I Scahill
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, London, UK
    J Alzheimers Dis 35:199-212. 2013
    ..We conclude that the mechanisms by which APP and PSEN1 mutations cause neuronal loss may differ which furthers our understanding of the neuropathology underlying AD and may inform future therapeutic strategies and trial designs...
  11. pmc Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls
    Josephine Barnes
    Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK
    Neurobiol Aging 34:1996-2002. 2013
    ..There was no evidence of independent effects of WMH or CSF measures on BSI in AD. These data support findings that vascular damage is associated with increased brain atrophy in the context of AD pathology in pre-dementia stages...
  12. ncbi request reprint Does Alzheimer's disease affect hippocampal asymmetry? Evidence from a cross-sectional and longitudinal volumetric MRI study
    Josephine Barnes
    Dementia Research Centre, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    Dement Geriatr Cogn Disord 19:338-44. 2005
    ..To determine whether Alzheimer's disease (AD) is associated with preferential atrophy of either the left or right hippocampus...
  13. ncbi request reprint Application of automated medial temporal lobe atrophy scale to Alzheimer disease
    Basil H Ridha
    Dementia Research Centre, Institute of Neurology, University College London, WC1N 3BG, England
    Arch Neurol 64:849-54. 2007
    ..To compare an automated intensity-based measure of medial temporal atrophy in Alzheimer disease (AD) with existing volumetric and visually based methods...
  14. ncbi request reprint Automated measurement of hippocampal atrophy using fluid-registered serial MRI in AD and controls
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, Queen Square, London, UK
    J Comput Assist Tomogr 31:581-7. 2007
    ..To assess hippocampal atrophy rates calculated from fluid registration methods...
  15. pmc Altered body schema processing in frontotemporal dementia with C9ORF72 mutations
    Laura E Downey
    Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 85:1016-23. 2014
    ..However, the pathophysiology of C9ORF72-FTD has not been elucidated...
  16. pmc An algorithmic approach to structural imaging in dementia
    Lorna Harper
    Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 85:692-8. 2014
    ..In this article we describe the characteristic MRI findings of the various dementias and provide a structured algorithm with the aim of providing clinicians with a practical guide to assessing scans. ..
  17. doi request reprint Visual ratings of atrophy in MCI: prediction of conversion and relationship with CSF biomarkers
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Neurobiol Aging 34:73-82. 2013
    ..These findings suggest both that posterior atrophy may predict conversion to AD in late-onset MCI, and that there may be differential relationships between CSF biomarkers and regional atrophy patterns...
  18. pmc White matter tract signatures of the progressive aphasias
    Colin J Mahoney
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Neurobiol Aging 34:1687-99. 2013
    ..These WM signatures of PPA syndromes illustrate the selective vulnerability of brain language networks in these diseases and might have some pathologic specificity...
  19. pmc Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: clinical, neuroanatomical and neuropathological features
    Colin J Mahoney
    Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London WC1N 3BG, UK
    Brain 135:736-50. 2012
    ....
  20. ncbi request reprint Profiles of white matter tract pathology in frontotemporal dementia
    Colin J Mahoney
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom
    Hum Brain Mapp 35:4163-79. 2014
    ..Hum Brain Mapp 35:4163-4179, 2014. © 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc. ..
  21. doi request reprint Validation of next-generation sequencing technologies in genetic diagnosis of dementia
    John Beck
    MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 35:261-5. 2014
    ..The MRC Dementia Gene Panel and similar technologies are likely to be transformational in EOD diagnosis with a significant impact on the proportion of patients in whom a genetic cause is identified. ..
  22. ncbi request reprint Shining a light on posterior cortical atrophy
    Sebastian J Crutch
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Alzheimers Dement 9:463-5. 2013
    ....
  23. pmc Gray matter atrophy rate as a marker of disease progression in AD
    Valerie M Anderson
    Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 33:1194-202. 2012
    ..Jacobian integration could be useful for measuring GM atrophy rate in Alzheimer's disease as a marker of disease progression and treatment efficacy...
  24. ncbi request reprint Delineating the sites and progression of in vivo atrophy in multiple system atrophy using fluid-registered MRI
    Jonathan M Schott
    Dementia Research Group, Institute of Neurology, London, United Kingdom
    Mov Disord 18:955-8. 2003
    ..The in vivo findings were consistent with those found at postmortem, including significant supratentorial atrophy concurrent with an unusual degree of cognitive impairment for MSA...
  25. ncbi request reprint Imaging cerebral atrophy: normal ageing to Alzheimer's disease
    Nick C Fox
    Dementia Research Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Lancet 363:392-4. 2004
    ..Such use of MRI requires accurate understanding of how brain changes in normal ageing differ from those in dementia...
  26. ncbi request reprint Assessing the onset of structural change in familial Alzheimer's disease
    Jonathan M Schott
    Dementia Research Group, Institute of Neurology, University College London, Queen Square, United Kingdom
    Ann Neurol 53:181-8. 2003
    ..We conclude that increased medial temporal lobe atrophy rates are an early and distinguishing feature of AD and that pathological atrophy probably is occurring several years before the onset of symptoms...
  27. ncbi request reprint Posterior cingulate neurometabolite profiles and clinical phenotype in frontotemporal dementia
    Peter Garrard
    Institute of Cognitive Neuroscience, University College London, and Department of Clinical Neurosciences, Royal Free Hospital, Pond Street, Hampstead, London, UK
    Cogn Behav Neurol 19:185-9. 2006
    ..Such values may index cases with atrophy in posterior cortical regions presenting with progressive nonfluent aphasia...
  28. pmc Molecular nexopathies: a new paradigm of neurodegenerative disease
    Jason D Warren
    Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK Electronic address
    Trends Neurosci 36:561-9. 2013
    ..g., toxic-gain-of-function versus loss-of-function) on gradients of network damage. The paradigm has implications for understanding and predicting neurodegenerative disease biology. ..
  29. pmc MIRIAD--Public release of a multiple time point Alzheimer's MR imaging dataset
    Ian B Malone
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Neuroimage 70:33-6. 2013
    ....
  30. ncbi request reprint Targeted recruitment using cerebrospinal fluid biomarkers: implications for Alzheimer's disease therapeutic trials
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    J Alzheimers Dis 34:431-7. 2013
    ..Whether targeted recruitment reduces required sample sizes depends critically on assumptions regarding treatment effects...
  31. pmc Atrophy rates in asymptomatic amyloidosis: implications for Alzheimer prevention trials
    K Abigail Andrews
    Dementia Research Centre, University College London, London, United Kingdom
    PLoS ONE 8:e58816. 2013
    ..We conclude that hippocampal atrophy may be a feasible outcome measure for secondary prevention studies in asymptomatic amyloidosis...
  32. pmc Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population
    Jon Beck
    Medical Research Council Prion Unit, Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, UK
    Am J Hum Genet 92:345-53. 2013
    ..C9orf72-related disease might mimic several neurodegenerative disorders and, with potentially 90,000 carriers in the United Kingdom, is more common than previously realized...
  33. pmc Posterior cortical atrophy
    Sebastian J Crutch
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Lancet Neurol 11:170-8. 2012
    ..Greater awareness of the syndrome and agreement over the correspondence between syndrome-level and disease-level classifications are needed to improve diagnostic accuracy, clinical management, and the design of research studies...
  34. ncbi request reprint Patterns of cortical thickness according to APOE genotype in Alzheimer's disease
    Leticia Gutiérrez-Galve
    Dementia Research Centre, Institute of Neurology, University College London UCL, London WC1N 3BG, UK
    Dement Geriatr Cogn Disord 28:476-85. 2009
    ..We aimed to assess the influence of APOE genotype on cortical thickness and regional brain volumes in AD (Alzheimer's disease)...
  35. ncbi request reprint Clinical relevance of positive voltage-gated potassium channel (VGKC)-complex antibodies: experience from a tertiary referral centre
    Ross W Paterson
    Dementia Research Centre, National Hospital for Neurology and Neurosurgery, Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 85:625-30. 2014
    ..However, there are patients with positive levels in whom the significance is uncertain...
  36. ncbi request reprint Determining cut-points for Alzheimer's disease biomarkers: statistical issues, methods and challenges
    Jonathan W Bartlett
    Centre for Statistical Methodology, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Biomark Med 6:391-400. 2012
    ..We also emphasize that how a cut-point is selected must be made in reference to how the resulting dichotomized biomarker is to be used, and in particular what actions will follow from a positive or negative test result...
  37. doi request reprint Algorithms, atrophy and Alzheimer's disease: cautionary tales for clinical trials
    Nick C Fox
    The Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Neuroimage 57:15-8. 2011
    ..In the absence of a "gold standard", we discuss a number of steps against which methodologies designed to quantify atrophy from serial scans can be assessed...
  38. pmc The diagnosis of young-onset dementia
    Martin N Rossor
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, Queen Square, London, UK
    Lancet Neurol 9:793-806. 2010
    ..This understanding offers the potential for future treatments to be tailored to a specific diagnosis of both young-onset and late-onset dementia...
  39. ncbi request reprint New developments in mild cognitive impairment and Alzheimer's disease
    Jonathan M Schott
    Institute of Neurology, Dementia Research Centre, National Hospital for Neurology and Neurosurgery, London, UK
    Curr Opin Neurol 19:552-8. 2006
    ....
  40. doi request reprint Imaging the onset and progression of Alzheimer's disease: implications for prevention trials
    Yuying Liang
    Dementia Research Centre, University College London Institute of Neurology, London, UK
    J Alzheimers Dis 33:S305-12. 2013
    ....
  41. doi request reprint What is the clinically relevant change on the ADAS-Cog?
    Anette Schrag
    Department of Clinical Neurosciences, Institute of Neurology, Royal Free Campus, University College London, London NW3 2PF, UK
    J Neurol Neurosurg Psychiatry 83:171-3. 2012
    ..To establish the minimal clinically relevant change (MCRC) on the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) for patients with mild Alzheimer's disease (AD)...
  42. ncbi request reprint Epidemiological, clinical, and genetic characteristics of early-onset parkinsonism
    Anette Schrag
    Royal Free and University College Medical School, University College London, Department of Clinical Neurosciences, London, UK
    Lancet Neurol 5:355-63. 2006
    ....
  43. ncbi request reprint Brain biopsy in dementia
    J D Warren
    Dementia Research Centre, Institute of Neurology, London, UK
    Brain 128:2016-25. 2005
    ....
  44. pmc Pathological substrate for regional distribution of increased atrophy rates in progressive supranuclear palsy
    D C Paviour
    The Sara Koe PSP Research Centre, Institute of Neurology UCL, London, UK
    J Neurol Neurosurg Psychiatry 75:1772-5. 2004
    ..MRI features described previously in PSP correspond to regions of pathological involvement demonstrated in separate studies, but serial MRI with pathological follow up has not been undertaken...
  45. pmc Mapping the onset and progression of atrophy in familial frontotemporal lobar degeneration
    J C Janssen
    Dementia Research Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 76:162-8. 2005
    ..Frontotemporal lobar degeneration (FTLD) may be inherited as an autosomal dominant disease. Studying patients "at risk" for developing FTLD can provide insights into the earliest onset and evolution of the disease...
  46. ncbi request reprint Increased hippocampal atrophy rates in AD over 6 months using serial MR imaging
    J Barnes
    Dementia Research Centre, UCL, Institute of Neurology, London, United Kingdom
    Neurobiol Aging 29:1199-203. 2008
    ..This has implications where shorter inter-scan intervals may be advantageous, such as rapid diagnosis, and tracking of disease progression including in a clinical trial...
  47. ncbi request reprint Automatic calculation of hippocampal atrophy rates using a hippocampal template and the boundary shift integral
    J Barnes
    Dementia Research Centre, UCL, Institute of Neurology, London, UK
    Neurobiol Aging 28:1657-63. 2007
    ..4 GHz Intel Xeon server, whereas manual delineation of each hippocampal pair took approximately 90 min of operator-intensive labour. This method may be useful diagnostically or in studies where analysis of many scans may be required...
  48. pmc Agnosia for accents in primary progressive aphasia
    Phillip D Fletcher
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom
    Neuropsychologia 51:1709-15. 2013
    ....
  49. ncbi request reprint Using nine degrees-of-freedom registration to correct for changes in voxel size in serial MRI studies
    Jennifer L Whitwell
    Dementia Research Group, Institute of Neurology, University College London, WCIN 3BG, UK
    Magn Reson Imaging 22:993-9. 2004
    ..It is important that such changes are adjusted for: 9dof registration, which is automated and computationally inexpensive, may be superior to the more labour-intensive TIV correction for this purpose...
  50. ncbi request reprint Knight's move thinking? Mild cognitive impairment in a chess player
    H A Archer
    The Dementia Research Centre, The National Hospital for Neurology and Neurosurgery, London, UK
    Neurocase 11:26-31. 2005
    ....
  51. ncbi request reprint Measuring atrophy in Alzheimer disease: a serial MRI study over 6 and 12 months
    J M Schott
    Dementia Research Centre, Institute of Neurology, University College London, UK
    Neurology 65:119-24. 2005
    ..Global brain atrophy rate calculated from serial MRI scans may be a surrogate marker of Alzheimer disease (AD) progression. Few studies have assessed atrophy in AD over short intervals...
  52. pmc A data-driven model of biomarker changes in sporadic Alzheimer's disease
    Alexandra L Young
    1 Centre for Medical Image Computing, Department of Computer Science, University College London, Gower Street, London, WC1E 6BT, UK
    Brain 137:2564-77. 2014
    ..This approach has broad application across neurodegenerative disease, providing insights into disease biology, as well as staging and prognostication. ..
  53. pmc Binding deficits in memory following medial temporal lobe damage in patients with voltage-gated potassium channel complex antibody-associated limbic encephalitis
    Yoni Pertzov
    Institute of Neurology, University College London, London, UK
    Brain 136:2474-85. 2013
    ..Our novel behavioural measures also have the potential to assist in monitoring response to treatment in patients with memory disorders, such as those with voltage-gated potassium channel complex antibody limbic encephalitis. ..
  54. pmc Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration
    Jonathan D Rohrer
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Brain 134:2565-81. 2011
    ....
  55. ncbi request reprint Brain biopsy in dementia: clinical indications and diagnostic approach
    Jonathan M Schott
    Dementia Research Centre, The National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK
    Acta Neuropathol 120:327-41. 2010
    ..We propose algorithms to aid the clinician in selecting appropriate patients for a biopsy and the neuropathologist in assessing a biopsy specimen...
  56. pmc Mapping the evolution of regional atrophy in Alzheimer's disease: unbiased analysis of fluid-registered serial MRI
    Rachael I Scahill
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 99:4703-7. 2002
    ..This technique provides insights into the natural history of AD, and may be a valuable tool in assessing the efficacy of disease-modifying treatments, especially if these treatments were to have region-specific effects...
  57. ncbi request reprint Cerebral atrophy measurements using Jacobian integration: comparison with the boundary shift integral
    Richard G Boyes
    Dementia Research Centre, Institute of Neurology, Box 16, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 32:159-69. 2006
    ..The results showed the Jacobian integration technique was significantly more accurate in calculating scaled atrophy (P < 0.001) and was able to distinguish between control and AD subjects more clearly (P < 0.01)...
  58. ncbi request reprint EEG abnormalities in frontotemporal lobar degeneration
    D Chan
    Dementia Research Group, National Hospital for Neurology, London, UK
    Neurology 62:1628-30. 2004
    ..There was no significant difference in the severity of EEG abnormality between the FTLD and AD patient groups. These data suggest a need for reappraisal of the role of the EEG in the diagnostic differentiation of FTLD from AD...
  59. pmc Population screening for variant Creutzfeldt-Jakob disease using a novel blood test: diagnostic accuracy and feasibility study
    Graham S Jackson
    MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, England
    JAMA Neurol 71:421-8. 2014
    ..In a clinical diagnostic capacity, the assay's likelihood ratios dramatically change an individual's pretest disease odds to posttest probabilities and can confirm vCJD infection...
  60. doi request reprint Biomarker modelling of early molecular changes in Alzheimer's disease
    Ross W Paterson
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, London, UK
    Mol Diagn Ther 18:213-27. 2014
    ..Here we appraise this evidence before reviewing novel, particularly fluid, biomarkers that may provide insights into AD pathogenesis and relate these to existing hypothetical disease models. ..
  61. ncbi request reprint MRS shows abnormalities before symptoms in familial Alzheimer disease
    A K Godbolt
    Dementia Research Centre, Institute of Neurology, University College of London, London, UK
    Neurology 66:718-22. 2006
    ..Presenilin 1 (PS1) and amyloid precursor protein (APP) mutation carriers have a nearly 100% risk of developing AD and may be studied prior to symptom onset...
  62. ncbi request reprint Combining short interval MRI in Alzheimer's disease: Implications for therapeutic trials
    J M Schott
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, Box 16, WC1N 3BG, London, UK
    J Neurol 253:1147-53. 2006
    ..We conclude that sample sizes required in short interval therapeutic trials using cerebral atrophy as an outcome measure may be reduced if multiple serial MRI is performed...
  63. pmc Genetics of the dementias
    J M Schott
    Dementia Research Group, National Hospital for Neurology and Neurosurgery, Institute of Neurology, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 73:II27-31. 2002
  64. ncbi request reprint Corticobasal degeneration
    Robert K Mahapatra
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Lancet Neurol 3:736-43. 2004
    ..Although definitive diagnosis of corticobasal degeneration can only be made at post-mortem examination, recent advances in imaging can assist the clinician with diagnosis. Treatment options remain limited and mostly address symptoms...
  65. ncbi request reprint Amnesia, cerebral atrophy, and autoimmunity
    J M Schott
    Dementia Research Group, Institute of Neurology, University College WC1N 3BG, London, UK
    Lancet 361:1266. 2003
  66. ncbi request reprint Mirror writing, left-handedness, and leftward scripts
    G D Schott
    The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, England
    Arch Neurol 61:1849-51. 2004
    ....