Research Topics
| Jonathan M SchottSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Transient ischaemic attacks are associated with increased rates of global cerebral atrophyR J L Walters
Department of Clinical Neurology, St Mary's Hospital, London W2 1NY, UK
J Neurol Neurosurg Psychiatry 74:213-6. 2003..Future studies should assess whether this atrophy inevitably leads to cognitive decline, and whether aggressive treatment of risk factors for cerebrovascular disease (particularly hypertension) after a TIA can influence outcome...
A comparison of methods for the automated calculation of volumes and atrophy rates in the hippocampusJ Barnes
Dementia Research Centre, UCL, Institute of Neurology, London, UK
Neuroimage 40:1655-71. 2008..The change over time can then be calculated automatically using boundary shift or fluid measures, with boundary shift giving most similar results to manual...- Using CSF biomarkers to replicate genetic associations in Alzheimer's diseaseJonathan M Schott
Dementia Research Centre, UCL Institute of Neurology, London, UK
Neurobiol Aging 33:1486.e9-15. 2012..61-7.06); and possession of 1 or more APOE ε4 alleles (OR, 9.84; 95% CI, 5.48-17.67). These results suggest that using biomarkers of AD pathology to define case and control status may increase power in genetic association studies... - Reduced sample sizes for atrophy outcomes in Alzheimer's disease trials: baseline adjustmentJ M Schott
Dementia Research Centre, Institute of Neurology, UCL, London WC1N 3BG, UK
Neurobiol Aging 31:1452-62, 1462.e1-2. 2010..Adjusting for 11 predefined covariates reduced sample sizes by up to 30%. Treatment trials in AD should consider the effects of normal aging; adjusting for baseline characteristics can significantly reduce required sample sizes... - Short echo time proton magnetic resonance spectroscopy in Alzheimer's disease: a longitudinal multiple time point studyJonathan M Schott
Dementia Research Centre, UCL Institute of Neurology, London WC1N 3BG, UK
Brain 133:3315-22. 2010.... 
A neurological MRI menagerieJ M Schott
Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, UK
Pract Neurol 7:186-90. 2007- Neuropsychological correlates of whole brain atrophy in Alzheimer's diseaseJ M Schott
Dementia Research Centre National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Neuropsychologia 46:1732-7. 2008..This methodology whereby data from patients falling to floor on a given test may be included and accounted for, rather than discarded, may find broader application in clinical studies incorporating neuropsychometric outcomes... - Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1-42Jonathan M Schott
Dementia Research Centre, University College London, Institute of Neurology, London, United Kingdom
Ann Neurol 68:825-34. 2010..To identify cognitively normal individuals at risk of Alzheimer disease (AD) based on cerebrospinal fluid (CSF) Aβ1-42, and to determine rates of cerebral atrophy... - Development of selective verbal memory impairment secondary to a left thalamic infarct: a longitudinal case studyJ M Schott
Dementia Research Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
J Neurol Neurosurg Psychiatry 74:255-7. 2003..High resolution volumetric MRI may be helpful in demonstrating small subcortical infarcts that may not be seen using computed tomography or conventional MRI... - Does Alzheimer's disease affect hippocampal asymmetry? Evidence from a cross-sectional and longitudinal volumetric MRI studyJosephine Barnes
Dementia Research Centre, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
Dement Geriatr Cogn Disord 19:338-44. 2005..To determine whether Alzheimer's disease (AD) is associated with preferential atrophy of either the left or right hippocampus... - Automated measurement of hippocampal atrophy using fluid-registered serial MRI in AD and controlsJosephine Barnes
Dementia Research Centre, University College London, Institute of Neurology, Queen Square, London, UK
J Comput Assist Tomogr 31:581-7. 2007..To assess hippocampal atrophy rates calculated from fluid registration methods... - Application of automated medial temporal lobe atrophy scale to Alzheimer diseaseBasil H Ridha
Dementia Research Centre, Institute of Neurology, University College London, WC1N 3BG, England
Arch Neurol 64:849-54. 2007..To compare an automated intensity-based measure of medial temporal atrophy in Alzheimer disease (AD) with existing volumetric and visually based methods... - Visual ratings of atrophy in MCI: prediction of conversion and relationship with CSF biomarkersManja Lehmann
Dementia Research Centre, UCL Institute of Neurology, London, UK
Neurobiol Aging 34:73-82. 2013..These findings suggest both that posterior atrophy may predict conversion to AD in late-onset MCI, and that there may be differential relationships between CSF biomarkers and regional atrophy patterns... - Genetic influences on atrophy patterns in familial Alzheimer's Disease: a comparison of APP and PSEN1 mutationsRachael I Scahill
Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, London, UK
J Alzheimers Dis 35:199-212. 2013..We conclude that the mechanisms by which APP and PSEN1 mutations cause neuronal loss may differ which furthers our understanding of the neuropathology underlying AD and may inform future therapeutic strategies and trial designs... - Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: clinical, neuroanatomical and neuropathological featuresColin J Mahoney
Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London WC1N 3BG, UK
Brain 135:736-50. 2012.... - Posterior cingulate neurometabolite profiles and clinical phenotype in frontotemporal dementiaPeter Garrard
Institute of Cognitive Neuroscience, University College London, and Department of Clinical Neurosciences, Royal Free Hospital, Pond Street, Hampstead, London, UK
Cogn Behav Neurol 19:185-9. 2006..Such values may index cases with atrophy in posterior cortical regions presenting with progressive nonfluent aphasia... - Imaging cerebral atrophy: normal ageing to Alzheimer's diseaseNick C Fox
Dementia Research Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
Lancet 363:392-4. 2004..As the precision of imaging improves, the ability to distinguish healthy ageing from degenerative dementia should improve... - Assessing the onset of structural change in familial Alzheimer's diseaseJonathan M Schott
Dementia Research Group, Institute of Neurology, University College London, Queen Square, United Kingdom
Ann Neurol 53:181-8. 2003..We conclude that increased medial temporal lobe atrophy rates are an early and distinguishing feature of AD and that pathological atrophy probably is occurring several years before the onset of symptoms... - Delineating the sites and progression of in vivo atrophy in multiple system atrophy using fluid-registered MRIJonathan M Schott
Dementia Research Group, Institute of Neurology, London, United Kingdom
Mov Disord 18:955-8. 2003..The in vivo findings were consistent with those found at postmortem, including significant supratentorial atrophy concurrent with an unusual degree of cognitive impairment for MSA... - White matter tract signatures of the progressive aphasiasColin J Mahoney
Dementia Research Centre, UCL Institute of Neurology, London, UK
Neurobiol Aging 34:1687-99. 2013..These WM signatures of PPA syndromes illustrate the selective vulnerability of brain language networks in these diseases and might have some pathologic specificity... - Posterior cortical atrophySebastian J Crutch
Dementia Research Centre, Institute of Neurology, University College London, London, UK
Lancet Neurol 11:170-8. 2012..Greater awareness of the syndrome and agreement over the correspondence between syndrome-level and disease-level classifications are needed to improve diagnostic accuracy, clinical management, and the design of research studies... - Patterns of cortical thickness according to APOE genotype in Alzheimer's diseaseLeticia Gutiérrez-Galve
Dementia Research Centre, Institute of Neurology, University College London UCL, London WC1N 3BG, UK
Dement Geriatr Cogn Disord 28:476-85. 2009..We aimed to assess the influence of APOE genotype on cortical thickness and regional brain volumes in AD (Alzheimer's disease)... - Determining cut-points for Alzheimer's disease biomarkers: statistical issues, methods and challengesJonathan W Bartlett
Centre for Statistical Methodology, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
Biomark Med 6:391-400. 2012..We also emphasize that how a cut-point is selected must be made in reference to how the resulting dichotomized biomarker is to be used, and in particular what actions will follow from a positive or negative test result... - Algorithms, atrophy and Alzheimer's disease: cautionary tales for clinical trialsNick C Fox
The Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
Neuroimage 57:15-8. 2011..In the absence of a "gold standard", we discuss a number of steps against which methodologies designed to quantify atrophy from serial scans can be assessed... - The diagnosis of young-onset dementiaMartin N Rossor
Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, Queen Square, London, UK
Lancet Neurol 9:793-806. 2010..This understanding offers the potential for future treatments to be tailored to a specific diagnosis of both young-onset and late-onset dementia... - MIRIAD--Public release of a multiple time point Alzheimer's MR imaging datasetIan B Malone
Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
Neuroimage 70:33-6. 2013.... - What is the clinically relevant change on the ADAS-Cog?Anette Schrag
Department of Clinical Neurosciences, Institute of Neurology, Royal Free Campus, University College London, London NW3 2PF, UK
J Neurol Neurosurg Psychiatry 83:171-3. 2012..To establish the minimal clinically relevant change (MCRC) on the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) for patients with mild Alzheimer's disease (AD)... - Epidemiological, clinical, and genetic characteristics of early-onset parkinsonismAnette Schrag
Royal Free and University College Medical School, University College London, Department of Clinical Neurosciences, London, UK
Lancet Neurol 5:355-63. 2006.... - Pathological substrate for regional distribution of increased atrophy rates in progressive supranuclear palsyD C Paviour
The Sara Koe PSP Research Centre, Institute of Neurology UCL, London, UK
J Neurol Neurosurg Psychiatry 75:1772-5. 2004..MRI features described previously in PSP correspond to regions of pathological involvement demonstrated in separate studies, but serial MRI with pathological follow up has not been undertaken... - Increased hippocampal atrophy rates in AD over 6 months using serial MR imagingJ Barnes
Dementia Research Centre, UCL, Institute of Neurology, London, United Kingdom
Neurobiol Aging 29:1199-203. 2008..This has implications where shorter inter-scan intervals may be advantageous, such as rapid diagnosis, and tracking of disease progression including in a clinical trial... - Mapping the onset and progression of atrophy in familial frontotemporal lobar degenerationJ C Janssen
Dementia Research Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
J Neurol Neurosurg Psychiatry 76:162-8. 2005..Fluid registered MRI may be a useful technique in assessing patterns of focal atrophy in vivo and demonstrating the progression of degenerative diseases... - Automatic calculation of hippocampal atrophy rates using a hippocampal template and the boundary shift integralJ Barnes
Dementia Research Centre, UCL, Institute of Neurology, London, UK
Neurobiol Aging 28:1657-63. 2007..4 GHz Intel Xeon server, whereas manual delineation of each hippocampal pair took approximately 90 min of operator-intensive labour. This method may be useful diagnostically or in studies where analysis of many scans may be required... - Brain biopsy in dementiaJ D Warren
Dementia Research Centre, Institute of Neurology, London, UK
Brain 128:2016-25. 2005.... - Atrophy rates in asymptomatic amyloidosis: implications for Alzheimer prevention trialsK Abigail Andrews
Dementia Research Centre DRC, University College London, London, United Kingdom Centre for Medical Image Computing CMIC, University College London, London, United Kingdom
PLoS ONE 8:e58816. 2013..We conclude that hippocampal atrophy may be a feasible outcome measure for secondary prevention studies in asymptomatic amyloidosis... - Targeted recruitment using cerebrospinal fluid biomarkers: implications for Alzheimer's disease therapeutic trialsJosephine Barnes
Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
J Alzheimers Dis 34:431-7. 2013..Whether targeted recruitment reduces required sample sizes depends critically on assumptions regarding treatment effects... - Using nine degrees-of-freedom registration to correct for changes in voxel size in serial MRI studiesJennifer L Whitwell
Dementia Research Group, Institute of Neurology, University College London, WCIN 3BG, UK
Magn Reson Imaging 22:993-9. 2004..It is important that such changes are adjusted for: 9dof registration, which is automated and computationally inexpensive, may be superior to the more labour-intensive TIV correction for this purpose... - New developments in mild cognitive impairment and Alzheimer's diseaseJonathan M Schott
Institute of Neurology, Dementia Research Centre, National Hospital for Neurology and Neurosurgery, London, UK
Curr Opin Neurol 19:552-8. 2006.... - Measuring atrophy in Alzheimer disease: a serial MRI study over 6 and 12 monthsJ M Schott
Dementia Research Centre, Institute of Neurology, University College London, UK
Neurology 65:119-24. 2005..This potential benefit must be balanced against the possibility that ventricular volumes may be more likely to be affected by factors other than neurodegeneration... - Knight's move thinking? Mild cognitive impairment in a chess playerH A Archer
The Dementia Research Centre, The National Hospital for Neurology and Neurosurgery, London, UK
Neurocase 11:26-31. 2005.... - Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK populationJon Beck
Medical Research Council Prion Unit, Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, UK
Am J Hum Genet 92:345-53. 2013..C9orf72-related disease might mimic several neurodegenerative disorders and, with potentially 90,000 carriers in the United Kingdom, is more common than previously realized... - Gray matter atrophy rate as a marker of disease progression in ADValerie M Anderson
Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London, UK
Neurobiol Aging 33:1194-202. 2012..Jacobian integration could be useful for measuring GM atrophy rate in Alzheimer's disease as a marker of disease progression and treatment efficacy... - Mapping the evolution of regional atrophy in Alzheimer's disease: unbiased analysis of fluid-registered serial MRIRachael I Scahill
Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom
Proc Natl Acad Sci U S A 99:4703-7. 2002..This technique provides insights into the natural history of AD, and may be a valuable tool in assessing the efficacy of disease-modifying treatments, especially if these treatments were to have region-specific effects... - Cerebral atrophy measurements using Jacobian integration: comparison with the boundary shift integralRichard G Boyes
Dementia Research Centre, Institute of Neurology, Box 16, University College London, Queen Square, London WC1N 3BG, UK
Neuroimage 32:159-69. 2006..The results showed the Jacobian integration technique was significantly more accurate in calculating scaled atrophy (P < 0.001) and was able to distinguish between control and AD subjects more clearly (P < 0.01)... - Brain biopsy in dementia: clinical indications and diagnostic approachJonathan M Schott
Dementia Research Centre, The National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK
Acta Neuropathol 120:327-41. 2010..We propose algorithms to aid the clinician in selecting appropriate patients for a biopsy and the neuropathologist in assessing a biopsy specimen... - EEG abnormalities in frontotemporal lobar degenerationD Chan
Dementia Research Group, National Hospital for Neurology, London, UK
Neurology 62:1628-30. 2004..There was no significant difference in the severity of EEG abnormality between the FTLD and AD patient groups. These data suggest a need for reappraisal of the role of the EEG in the diagnostic differentiation of FTLD from AD... - Imaging the onset and progression of Alzheimer's disease: implications for prevention trialsYuying Liang
Dementia Research Centre, University College London Institute of Neurology, London, UK
J Alzheimers Dis 33:S305-12. 2013.... - Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degenerationJonathan D Rohrer
Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
Brain 134:2565-81. 2011.... - MRS shows abnormalities before symptoms in familial Alzheimer diseaseA K Godbolt
Dementia Research Centre, Institute of Neurology, University College of London, London, UK
Neurology 66:718-22. 2006..CONCLUSIONS: Metabolic changes are detectable in presymptomatic mutation carriers years before expected onset of Alzheimer disease. Their magnitude is related to proximity of expected age at onset... - Genetics of the dementiasJ M Schott
Dementia Research Group, National Hospital for Neurology and Neurosurgery, Institute of Neurology, Queen Square, London, UK
J Neurol Neurosurg Psychiatry 73:II27-31. 2002 - Combining short interval MRI in Alzheimer's disease: Implications for therapeutic trialsJ M Schott
Dementia Research Centre, Institute of Neurology, University College London, Queen Square, Box 16, WC1N 3BG, London, UK
J Neurol 253:1147-53. 2006..We conclude that sample sizes required in short interval therapeutic trials using cerebral atrophy as an outcome measure may be reduced if multiple serial MRI is performed... - Corticobasal degenerationRobert K Mahapatra
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
Lancet Neurol 3:736-43. 2004..Although definitive diagnosis of corticobasal degeneration can only be made at post-mortem examination, recent advances in imaging can assist the clinician with diagnosis. Treatment options remain limited and mostly address symptoms... - Mirror writing, left-handedness, and leftward scriptsG D Schott
The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, England
Arch Neurol 61:1849-51. 2004.... - Amnesia, cerebral atrophy, and autoimmunityJ M Schott
Dementia Research Group, Institute of Neurology, University College WC1N 3BG, London, UK
Lancet 361:1266. 2003