Jurgen E Schneider

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint How to perform an accurate assessment of cardiac function in mice using high-resolution magnetic resonance imaging
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, UK
    J Cardiovasc Magn Reson 8:693-701. 2006
  2. pmc Accelerating cine-MR imaging in mouse hearts using compressed sensing
    Tobias Wech
    Institute of Radiology, University of Wurzburg, Wurzburg, Germany
    J Magn Reson Imaging 34:1072-9. 2011
  3. pmc Development and characterization of rodent cardiac phantoms: comparison with in vivo cardiac imaging
    Steven Fortune
    Medical Physics and Medical Engineering, University of Edinburgh
    Magn Reson Imaging 30:1186-91. 2012
  4. pmc A quantitative comparison of regional myocardial motion in mice, rabbits and humans using in-vivo phase contrast CMR
    Bernd Jung
    Department of Radiology, Medical Physics, University Medical Center, Freiburg, Germany
    J Cardiovasc Magn Reson 14:87. 2012
  5. pmc Accelerating global left-ventricular function assessment in mice using reduced slice acquisition and three-dimensional guide-point modelling
    Alistair A Young
    Department of Anatomy with Radiology, University of Auckland, Auckland, New Zealand
    J Cardiovasc Magn Reson 13:49. 2011
  6. pmc Semi-automatic segmentation of multiple mouse embryos in MR images
    Leila Baghdadi
    Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Canada
    BMC Bioinformatics 12:237. 2011
  7. pmc Cardiac structure and function during ageing in energetically compromised Guanidinoacetate N-methyltransferase (GAMT)-knockout mice - a one year longitudinal MRI study
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    J Cardiovasc Magn Reson 10:9. 2008
  8. ncbi request reprint High-resolution, multicontrast three-dimensional-MRI characterizes atherosclerotic plaque composition in ApoE-/- mice ex vivo
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    J Magn Reson Imaging 20:981-9. 2004
  9. ncbi request reprint Long-term stability of cardiac function in normal and chronically failing mouse hearts in a vertical-bore MR system
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    MAGMA 17:162-9. 2004
  10. doi request reprint Ultra-fast and accurate assessment of cardiac function in rats using accelerated MRI at 9.4 Tesla
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, United Kingdom
    Magn Reson Med 59:636-41. 2008

Detail Information

Publications65

  1. ncbi request reprint How to perform an accurate assessment of cardiac function in mice using high-resolution magnetic resonance imaging
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, UK
    J Cardiovasc Magn Reson 8:693-701. 2006
    ..Here, we describe a protocol that allows for a quick and reproducible approach of obtaining the relevant cardiac views for cine-MRI, and we explain how an accurate experimental image analysis can be performed...
  2. pmc Accelerating cine-MR imaging in mouse hearts using compressed sensing
    Tobias Wech
    Institute of Radiology, University of Wurzburg, Wurzburg, Germany
    J Magn Reson Imaging 34:1072-9. 2011
    ..To combine global cardiac function imaging with compressed sensing (CS) in order to reduce scan time and to validate this technique in normal mouse hearts and in a murine model of chronic myocardial infarction...
  3. pmc Development and characterization of rodent cardiac phantoms: comparison with in vivo cardiac imaging
    Steven Fortune
    Medical Physics and Medical Engineering, University of Edinburgh
    Magn Reson Imaging 30:1186-91. 2012
    ..The phantoms can be used for future development work with reduced need of live animals...
  4. pmc A quantitative comparison of regional myocardial motion in mice, rabbits and humans using in-vivo phase contrast CMR
    Bernd Jung
    Department of Radiology, Medical Physics, University Medical Center, Freiburg, Germany
    J Cardiovasc Magn Reson 14:87. 2012
    ..It is therefore important to identify animal models that closely mimic physiological and pathological human cardiac function...
  5. pmc Accelerating global left-ventricular function assessment in mice using reduced slice acquisition and three-dimensional guide-point modelling
    Alistair A Young
    Department of Anatomy with Radiology, University of Auckland, Auckland, New Zealand
    J Cardiovasc Magn Reson 13:49. 2011
    ....
  6. pmc Semi-automatic segmentation of multiple mouse embryos in MR images
    Leila Baghdadi
    Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Canada
    BMC Bioinformatics 12:237. 2011
    ..The motivation behind this paper is to aid the automatic phenotyping of mouse embryos, wherein multiple embryos embedded within a single tube were scanned using Magnetic Resonance Imaging (MRI)...
  7. pmc Cardiac structure and function during ageing in energetically compromised Guanidinoacetate N-methyltransferase (GAMT)-knockout mice - a one year longitudinal MRI study
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    J Cardiovasc Magn Reson 10:9. 2008
    ..Since creatine plays an important role in the buffering and transfer of high-energy phosphate bonds in the heart, it was hypothesized that lack of creatine would be detrimental for resting cardiac performance during ageing...
  8. ncbi request reprint High-resolution, multicontrast three-dimensional-MRI characterizes atherosclerotic plaque composition in ApoE-/- mice ex vivo
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    J Magn Reson Imaging 20:981-9. 2004
    ..To systematically investigate intrinsic MR contrast mechanisms that would facilitate plaque characterization and quantification in the aortic root and brachiocephalic artery of ApoE-/- mice ex vivo...
  9. ncbi request reprint Long-term stability of cardiac function in normal and chronically failing mouse hearts in a vertical-bore MR system
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    MAGMA 17:162-9. 2004
    ..Thus, mice can be studied in high-field MR systems positioned vertically for 3 h...
  10. doi request reprint Ultra-fast and accurate assessment of cardiac function in rats using accelerated MRI at 9.4 Tesla
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, United Kingdom
    Magn Reson Med 59:636-41. 2008
    ..This finding demonstrates that it is possible to complete a rat cine-MRI study under 3 min with low variability and without losing temporal or spatial resolution, making high throughput screening programs feasible...
  11. ncbi request reprint In vivo cardiac 1H-MRS in the mouse
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, UK
    Magn Reson Med 52:1029-35. 2004
    ..Creatine deficiency was confirmed noninvasively in myocardium of anesthetized GAMT-/- mice. This is the first study to report the application of cardiac 1H-MRS in mice in vivo...
  12. pmc Accelerated cardiac magnetic resonance imaging in the mouse using an eight-channel array at 9.4 Tesla
    Jurgen E Schneider
    British Heart Foundation Experimental MR Unit BMRU, Department of Cardiovascular Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom
    Magn Reson Med 65:60-70. 2011
    ..This strategy may eventually pave the way for routine, multiparametric phenotyping of mouse hearts in vivo within one imaging session of tolerable duration...
  13. ncbi request reprint Assessment of global cardiac function
    Jurgen E Schneider
    British Heart Foundation Experimental MR Unit BMRU, Department of Cardiovascular Medicine, University of Oxford, Headington, Oxford, OX3 9DU, UK
    Methods Mol Biol 771:387-405. 2011
    ..We have established protocols that allow for a quick and reproducible way of obtaining the relevant cardiac views for cine-MRI, and for accurate image analysis...
  14. ncbi request reprint Fast, high-resolution in vivo cine magnetic resonance imaging in normal and failing mouse hearts on a vertical 11.7 T system
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
    J Magn Reson Imaging 18:691-701. 2003
    ..To establish fast, high-resolution in vivo cine magnetic resonance imaging (cine-MRI) on a vertical 11.7-T MR system and to investigate the stability of normal and failing mouse hearts in the vertical position...
  15. ncbi request reprint High-resolution, high-throughput magnetic paragraph sign resonance imaging of mouse embryonic paragraph sign anatomy using a fast gradient-echo sequence
    Jurgen E Schneider
    Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, OX3 9DU UK
    MAGMA 16:43-51. 2003
    ..Our approach combines speed, high resolution and contrast with a simple preparation technique and minimal operator time (<1 h). It allows rapid routine 3D characterisation of normal and abnormal mouse embryonic anatomy...
  16. pmc Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency
    Simon T MacDonald
    Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Cardiovasc Res 79:448-57. 2008
    ..Cited2 functions partly via a Nodal-->Pitx2c pathway controlling left-right patterning. In this present study we investigated the primary site of Cited2 function and mechanisms of haploinsufficiency...
  17. pmc Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction
    Craig A Lygate
    Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Cardiovasc Res 96:466-75. 2012
    ....
  18. ncbi request reprint Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice
    Julie Wallis
    Department of Cardiovascular Medicine, University of Oxford, Oxford, England
    Circulation 112:3131-9. 2005
    ..Previously, it has not been possible to increase myocardial creatine and phosphocreatine concentrations to supranormal levels because they are subject to tight regulation by the sarcolemmal creatine transporter (CrT)...
  19. pmc A cell-autonomous role of Cited2 in controlling myocardial and coronary vascular development
    Simon T MacDonald
    Department of Cardiovascular Medicine, University of Oxford and Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Eur Heart J 34:2557-65. 2013
    ..We examined the cardiomyocyte specific role of the transcriptional co-activator Cited2 on myocardial microstructure and vessel growth, in relation to Vegfa expression...
  20. ncbi request reprint Quantification and 3D reconstruction of atherosclerotic plaque components in apolipoprotein E knockout mice using ex vivo high-resolution MRI
    Martina A McAteer
    Department of Cardiovascular Medicine, University of Oxford, United Kingdom
    Arterioscler Thromb Vasc Biol 24:2384-90. 2004
    ..To investigate the ability of high-resolution MRI to determine composition and microanatomy of atherosclerosis in mouse aortic root and brachiocephalic artery...
  21. pmc A leukocyte-mimetic magnetic resonance imaging contrast agent homes rapidly to activated endothelium and tracks with atherosclerotic lesion macrophage content
    Martina A McAteer
    Department of Cardiovascular Medicine, Level 6 West Wing, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Arterioscler Thromb Vasc Biol 32:1427-35. 2012
    ..We hypothesized that high-affinity dual-ligand microparticles of iron oxide (MPIO), targeted to P-selectin and vascular cell adhesion molecule-1 (PV-MPIO), would identify activated endothelial cells during atherosclerosis progression...
  22. pmc Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity
    Darci Phillips
    Department of Cardiovascular Medicine, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK
    J Mol Cell Cardiol 48:582-90. 2010
    ....
  23. pmc A novel role for transcription factor Lmo4 in thymus development through genetic interaction with Cited2
    Anna C Michell
    Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, United Kingdom
    Dev Dyn 239:1988-94. 2010
    ..Our data suggest that this may occur, in part, through control of expression of a common target gene, Tbx1, which is necessary for normal thymus development...
  24. pmc Maternal high-fat diet interacts with embryonic Cited2 genotype to reduce Pitx2c expression and enhance penetrance of left-right patterning defects
    Jamie Bentham
    Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 19:3394-401. 2010
    ..They suggest that appropriate modifications of maternal diet may prevent such defects in humans...
  25. ncbi request reprint Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway
    Simon D Bamforth
    Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 36:1189-96. 2004
    ..We propose that an abnormal Nodal-Pitx2c pathway represents a unifying mechanism for the cardiovascular malformations observed in Cited2(-/-) mice, and that such malformations may be the sole manifestation of a laterality defect...
  26. ncbi request reprint CINE-MR imaging of the normal and infarcted rat heart using an 11.7 T vertical bore MR system
    Damian J Tyler
    Department of Physiology, University of Oxford, Oxford, United Kingdom
    J Cardiovasc Magn Reson 8:327-33. 2006
    ..Hence, we conclude that vertical bore MR systems can be used to measure in vivo cardiac function in normal and infarcted rat hearts...
  27. ncbi request reprint Iron particles for noninvasive monitoring of bone marrow stromal cell engraftment into, and isolation of viable engrafted donor cells from, the heart
    Daniel J Stuckey
    Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, UK, OX1 3PT
    Stem Cells 24:1968-75. 2006
    ..The magnetic properties of the iron-labeled donor cells can be used for their isolation from host tissue to enable further characterization...
  28. ncbi request reprint Assessment of motion gating strategies for mouse magnetic resonance at high magnetic fields
    Paul J Cassidy
    Oxford Cardiac Research Group Magnetic Resonance Unit, University Laboratory of Physiology, University of Oxford, Oxford, UK
    J Magn Reson Imaging 19:229-37. 2004
    ..To assess the performance of motion gating strategies for mouse cardiac magnetic resonance (MR) at high magnetic fields by quantifying the levels of motion artifact observed in images and spectra in vivo...
  29. pmc Advanced methods for quantification of infarct size in mice using three-dimensional high-field late gadolinium enhancement MRI
    Steffen Bohl
    BHF Experimental MR Unit, Wellcome Trust Centre for Human Genetics, Univ of Oxford, Roosevelt Dr, Oxford, OX3 7BN, United Kingdom
    Am J Physiol Heart Circ Physiol 296:H1200-8. 2009
    ..This method is particularly suited to studies requiring early quantification of initial infarct size, for example, to measure damage before intervention with stem cells...
  30. doi request reprint Abnormal cardiac morphology, function and energy metabolism in the dystrophic mdx mouse: an MRI and MRS study
    Wen Zhang
    Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Oxford, UK
    J Mol Cell Cardiol 45:754-60. 2008
    ..We conclude that the absence of dystrophin in adult mdx mouse heart, as in the heart of human patient, is associated with right ventricular dilatation, left ventricular diastolic dysfunction and abnormal energy metabolism...
  31. pmc Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN UK
    BMC Dev Biol 4:16. 2004
    ..The identification of murine models of congenital cardiac malformations in high-throughput mutagenesis screens and in gene-targeted models is hindered by the opacity of the mouse embryo...
  32. pmc Magnetic resonance imaging of endothelial adhesion molecules in mouse atherosclerosis using dual-targeted microparticles of iron oxide
    Martina A McAteer
    Department of Cardiovascular Medicine, University of Oxford, Oxford, OX3 9DU, United Kingdom
    Arterioscler Thromb Vasc Biol 28:77-83. 2008
    ..We hypothesized that antibody-conjugated MPIO would enable magnetic resonance imaging (MRI) of endothelial cell adhesion molecules in mouse atherosclerosis...
  33. ncbi request reprint Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice
    Michiel Ten Hove
    Department of Cardiovascular Medicine, University of Oxford, Oxford, England
    Circulation 111:2477-85. 2005
    ..To characterize the role of a substantially impaired CK/PCr system in heart, we studied the cardiac phenotype of wild-type (WT) and GAMT-/- mice...
  34. pmc Refined approach for quantification of in vivo ischemia-reperfusion injury in the mouse heart
    Steffen Bohl
    Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Physiol Heart Circ Physiol 297:H2054-8. 2009
    ..We have tested published approaches and challenged their practicality. As a result, we propose an improved and streamlined protocol, which consistently yields high-quality histology, thereby minimizing experimental noise and group sizes...
  35. ncbi request reprint Quantitative 3-dimensional echocardiography for accurate and rapid cardiac phenotype characterization in mice
    Dana Dawson
    Department of Cardiovascular Medicine, University of Oxford, Oxford, England
    Circulation 110:1632-7. 2004
    ....
  36. pmc Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age
    Craig A Lygate
    Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
    Basic Res Cardiol 107:276. 2012
    ..However, the observation that a primary defect in CK can, under the right conditions, result in heart failure suggests that impaired CK activity in the failing heart could contribute to disease progression...
  37. ncbi request reprint Dystrophin- and MLP-deficient mouse hearts: marked differences in morphology and function, but similar accumulation of cytoskeletal proteins
    James R Wilding
    Department of Physiology, University of Oxford, Oxford, England, UK
    FASEB J 19:79-81. 2005
    ....
  38. pmc High-resolution imaging of normal anatomy, and neural and adrenal malformations in mouse embryos using magnetic resonance microscopy
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, British Heart Foundation Molecular Cardiology Laboratory, Wellcome Trust Centre for Human Genetics, Oxford, UK
    J Anat 202:239-47. 2003
    ....
  39. ncbi request reprint Investigating cardiac energetics in heart failure
    Craig A Lygate
    Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Exp Physiol 98:601-5. 2013
    ....
  40. pmc Functional significance of SRJ domain mutations in CITED2
    Chiann Mun Chen
    Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e46256. 2012
    ....
  41. pmc Improved method for quantification of regional cardiac function in mice using phase-contrast MRI
    Erica Dall'Armellina
    Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
    Magn Reson Med 67:541-51. 2012
    ....
  42. pmc Visualization of activated platelets by targeted magnetic resonance imaging utilizing conformation-specific antibodies against glycoprotein IIb/IIIa
    Constantin von zur Muhlen
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    J Vasc Res 46:6-14. 2009
    ..This presents an opportunity to specifically image activated platelets involved in acute atherothrombosis with MRI...
  43. pmc (1)H-MR spectroscopy for analysis of cardiac lipid and creatine metabolism
    Kiterie M E Faller
    Department of Cardiovascular Medicine, British Heart Foundation Experimental Magnetic Resonance Unit BMRU, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Heart Fail Rev 18:657-68. 2013
    ..However, recent technical advances in MR hardware and software have facilitated the application of 1H-MRS in humans and animal models of heart disease as detailed in this review...
  44. pmc Histo-anatomical structure of the living isolated rat heart in two contraction states assessed by diffusion tensor MRI
    Patrick W Hales
    Department of Cardiovascular Medicine, University of Oxford, Oxford OX3 7BN, UK
    Prog Biophys Mol Biol 110:319-30. 2012
    ....
  45. pmc High-energy phosphotransfer in the failing mouse heart: role of adenylate kinase and glycolytic enzymes
    Dunja Aksentijevic
    Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Eur J Heart Fail 12:1282-9. 2010
    ..To measure the activity of the key phosphotransfer enzymes creatine kinase (CK), adenylate kinase (AK), and glycolytic enzymes in two common mouse models of chronic heart failure...
  46. pmc Rapid quantification of myocardial lipid content in humans using single breath-hold 1H MRS at 3 Tesla
    Belen Rial
    Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
    Magn Reson Med 66:619-24. 2011
    ..Thus, single breath-hold proton spectroscopy allows reliable and quick quantification of myocardial lipids at 3 T...
  47. ncbi request reprint Comprehensive cardiac magnetic resonance imaging and spectroscopy reveal a high burden of myocardial disease in HIV patients
    Cameron J Holloway
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom
    Circulation 128:814-22. 2013
    ..The purpose of this study was to characterize myocardial abnormalities in a contemporary group of HIV-infected individuals undergoing combination antiretroviral therapy...
  48. ncbi request reprint Myocardial steatosis and left ventricular contractile dysfunction in patients with severe aortic stenosis
    Masliza Mahmod
    Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom
    Circ Cardiovasc Imaging 6:808-16. 2013
    ..Aortic stenosis (AS) leads to left ventricular (LV) hypertrophy and dysfunction. We hypothesized that cardiac steatosis is involved in the pathophysiology and also assessed whether it is reversible after aortic valve replacement...
  49. pmc Three-dimensional models of individual cardiac histoanatomy: tools and challenges
    Rebecca A B Burton
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK
    Ann N Y Acad Sci 1080:301-19. 2006
    ..It provides an overview of the tools used in this quest and outlines challenges posed by the approach in the light of applications that may benefit from the availability of such data and tools...
  50. ncbi request reprint Making the mouse embryo transparent: identifying developmental malformations using magnetic resonance imaging
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Center for Human Genetics, Oxford, United Kingdom
    Birth Defects Res C Embryo Today 72:241-9. 2004
    ..In this review, we describe recent advances in magnetic resonance imaging that make it possible to rapidly identify malformations in the developing mouse embryo with high efficiency...
  51. ncbi request reprint Microscopic magnetic resonance imaging reveals high prevalence of third coronary artery in human and rabbit heart
    Rebecca A B Burton
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Europace 14:v73-v81. 2012
    ..Using high-resolution magnetic resonance imaging, we identified TCA prevalence and characteristics in rabbit and human hearts...
  52. pmc In vivo magnetic resonance imaging of acute brain inflammation using microparticles of iron oxide
    Martina A McAteer
    Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
    Nat Med 13:1253-8. 2007
    ..Their rapid clearance from blood results in minimal background contrast. This technology is adaptable to monitor the expression of endovascular molecules in vivo in various pathologies...
  53. ncbi request reprint Progressive changes in T₁, T₂ and left-ventricular histo-architecture in the fixed and embedded rat heart
    Patrick W Hales
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    NMR Biomed 24:836-43. 2011
    ....
  54. ncbi request reprint Rapid identification and 3D reconstruction of complex cardiac malformations in transgenic mouse embryos using fast gradient echo sequence magnetic resonance imaging
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, British Heart Foundation Molecular Cardiology Laboratory, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    J Mol Cell Cardiol 35:217-22. 2003
    ..Our data indicate that fast gradient echo sequence magnetic resonance imaging can be used to rapidly and accurately identify complex cardiovascular malformations in transgenic and mutant mouse embryos...
  55. ncbi request reprint Abnormal function and glucose metabolism in the type-2 diabetic db/db mouse heart
    Marcello Panagia
    University Laboratory of Physiology, Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Rd, OX1 3PT, Oxford, England
    Can J Physiol Pharmacol 85:289-94. 2007
    ..01) in db/db mice than in controls. In summary, the db/db mouse has abnormal left ventricular function in vivo, with impaired glucose uptake during ischemia, leading to increased myocardial damage...
  56. pmc In vivo quantification of VCAM-1 expression in renal ischemia reperfusion injury using non-invasive magnetic resonance molecular imaging
    Asim M Akhtar
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS ONE 5:e12800. 2010
    ..We hypothesized that microparticles of iron oxide targeting VCAM-1 (VCAM-MPIO) would depict "ischemic memory" and enable in vivo assessment of VCAM-1 expression...
  57. pmc Generation of histo-anatomically representative models of the individual heart: tools and application
    Gernot Plank
    Computational Biology Group, University of Oxford, Oxford OX1 2JD, UK
    Philos Trans A Math Phys Eng Sci 367:2257-92. 2009
    ....
  58. ncbi request reprint Serial high resolution 3D-MRI after aortic banding in mice: band internalization is a source of variability in the hypertrophic response
    Craig A Lygate
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, England
    Basic Res Cardiol 101:8-16. 2006
    ..This is the first observation that a significant subset of animals following TAC bypass the stenosis resulting in partial regression of hypertrophy...
  59. pmc Bone marrow-derived stromal cells home to and remain in the infarcted rat heart but fail to improve function: an in vivo cine-MRI study
    Carolyn A Carr
    Cardiac Metabolism Research Group, Dept of Physiology, Anatomy and Genetics, Sherrington Bldg, Univ of Oxford, Parks Road Oxford, United Kingdom OX1 3PT
    Am J Physiol Heart Circ Physiol 295:H533-42. 2008
    ..However, no significant improvement in any measure of cardiac function was observed at any time. We conclude that cultured BMSCs are not the optimal cell population to treat the infarcted heart...
  60. pmc Development of an anatomically detailed MRI-derived rabbit ventricular model and assessment of its impact on simulations of electrophysiological function
    Martin J Bishop
    University of Oxford Computing Laboratory, Parks Road, Oxford OX1 3QD, UK
    Am J Physiol Heart Circ Physiol 298:H699-718. 2010
    ..This highlights the utility of histoanatomically detailed models for investigations of cardiac function, in particular for future patient-specific modeling...
  61. pmc Quantitative study of the effect of tissue microstructure on contraction in a computational model of rat left ventricle
    Valentina Carapella
    Department of Computer Science, University of Oxford, Oxford, United Kingdom
    PLoS ONE 9:e92792. 2014
    ..We conclude that further investigation of the modelling of sheet dynamics is necessary to fully understand the impact of tissue structure on cardiac deformation. ..
  62. doi request reprint Cardiac valve annulus manual segmentation using computer assisted visual feedback in three-dimensional image data
    Ramon Casero
    Computational Biology Group, Computing Laboratory, University of Oxford, Wolfson Building, Parks Rd, OX1 3QD, UK
    Conf Proc IEEE Eng Med Biol Soc 2010:738-41. 2010
    ..The Spline Tool was tested successfully on 14 rat hearts, on all four valves...
  63. ncbi request reprint Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection
    Lampson M Fan
    From the BHF Centre of Research Excellence, Division of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK L M F, G D, J K B, E M, M J C, A B H, M A M, J E S, R P L, K M C and Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK A M, J M L
    Circulation 129:2661-72. 2014
    ....
  64. pmc Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease
    Rajarshi Banerjee
    Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, West Wing, Level 6, John Radcliffe Hospital, Oxford, UK
    J Hepatol 60:69-77. 2014
    ..In this study, we aimed to assess the diagnostic accuracy of a novel magnetic resonance protocol for liver tissue characterisation...
  65. pmc VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5
    Dorota Szumska
    Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
    Genes Dev 22:1465-77. 2008
    ..We propose that Pcsk5, at least in part via GDF11, coordinately regulates caudal Hox paralogs, to control anteroposterior patterning, nephrogenesis, skeletal, and anorectal development...