Research Topics
Genomes and Genes
| Jurgen E SchneiderSummaryAffiliation: University of Oxford Country: UK Publications
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Detail Information
Publications
How to perform an accurate assessment of cardiac function in mice using high-resolution magnetic resonance imagingJurgen E Schneider
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, UK
J Cardiovasc Magn Reson 8:693-701. 2006..Here, we describe a protocol that allows for a quick and reproducible approach of obtaining the relevant cardiac views for cine-MRI, and we explain how an accurate experimental image analysis can be performed...
Accelerating global left-ventricular function assessment in mice using reduced slice acquisition and three-dimensional guide-point modellingAlistair A Young
Department of Anatomy with Radiology, University of Auckland, Auckland, New Zealand
J Cardiovasc Magn Reson 13:49. 2011....- Semi-automatic segmentation of multiple mouse embryos in MR imagesLeila Baghdadi
Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Canada
BMC Bioinformatics 12:237. 2011..The motivation behind this paper is to aid the automatic phenotyping of mouse embryos, wherein multiple embryos embedded within a single tube were scanned using Magnetic Resonance Imaging (MRI)... - High-resolution, multicontrast three-dimensional-MRI characterizes atherosclerotic plaque composition in ApoE-/- mice ex vivoJurgen E Schneider
Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
J Magn Reson Imaging 20:981-9. 2004..To systematically investigate intrinsic MR contrast mechanisms that would facilitate plaque characterization and quantification in the aortic root and brachiocephalic artery of ApoE-/- mice ex vivo... - Long-term stability of cardiac function in normal and chronically failing mouse hearts in a vertical-bore MR systemJurgen E Schneider
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
MAGMA 17:162-9. 2004..Thus, mice can be studied in high-field MR systems positioned vertically for 3 h... 
Assessment of global cardiac functionJurgen E Schneider
British Heart Foundation Experimental MR Unit BMRU, Department of Cardiovascular Medicine, University of Oxford, Headington, Oxford, OX3 9DU, UK
Methods Mol Biol 771:387-405. 2011..We have established protocols that allow for a quick and reproducible way of obtaining the relevant cardiac views for cine-MRI, and for accurate image analysis...- Cardiac structure and function during ageing in energetically compromised Guanidinoacetate N-methyltransferase (GAMT)-knockout mice - a one year longitudinal MRI studyJurgen E Schneider
Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
J Cardiovasc Magn Reson 10:9. 2008..Since creatine plays an important role in the buffering and transfer of high-energy phosphate bonds in the heart, it was hypothesized that lack of creatine would be detrimental for resting cardiac performance during ageing... - Ultra-fast and accurate assessment of cardiac function in rats using accelerated MRI at 9.4 TeslaJurgen E Schneider
Department of Cardiovascular Medicine, University of Oxford, United Kingdom
Magn Reson Med 59:636-41. 2008..This finding demonstrates that it is possible to complete a rat cine-MRI study under 3 min with low variability and without losing temporal or spatial resolution, making high throughput screening programs feasible... - Accelerated cardiac magnetic resonance imaging in the mouse using an eight-channel array at 9.4 TeslaJurgen E Schneider
British Heart Foundation Experimental MR Unit BMRU, Department of Cardiovascular Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom
Magn Reson Med 65:60-70. 2011..This strategy may eventually pave the way for routine, multiparametric phenotyping of mouse hearts in vivo within one imaging session of tolerable duration... - In vivo cardiac 1H-MRS in the mouseJurgen E Schneider
Department of Cardiovascular Medicine, University of Oxford, UK
Magn Reson Med 52:1029-35. 2004..Creatine deficiency was confirmed noninvasively in myocardium of anesthetized GAMT-/- mice. This is the first study to report the application of cardiac 1H-MRS in mice in vivo... - High-resolution, high-throughput magnetic paragraph sign resonance imaging of mouse embryonic paragraph sign anatomy using a fast gradient-echo sequenceJurgen E Schneider
Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, OX3 9DU UK
MAGMA 16:43-51. 2003..Our approach combines speed, high resolution and contrast with a simple preparation technique and minimal operator time (<1 h). It allows rapid routine 3D characterisation of normal and abnormal mouse embryonic anatomy... - Fast, high-resolution in vivo cine magnetic resonance imaging in normal and failing mouse hearts on a vertical 11.7 T systemJurgen E Schneider
Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
J Magn Reson Imaging 18:691-701. 2003..To establish fast, high-resolution in vivo cine magnetic resonance imaging (cine-MRI) on a vertical 11.7-T MR system and to investigate the stability of normal and failing mouse hearts in the vertical position... - Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiencySimon T MacDonald
Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
Cardiovasc Res 79:448-57. 2008..Cited2 functions partly via a Nodal-->Pitx2c pathway controlling left-right patterning. In this present study we investigated the primary site of Cited2 function and mechanisms of haploinsufficiency... - Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarctionCraig A Lygate
Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Cardiovasc Res 96:466-75. 2012.... - A leukocyte-mimetic magnetic resonance imaging contrast agent homes rapidly to activated endothelium and tracks with atherosclerotic lesion macrophage contentMartina A McAteer
Department of Cardiovascular Medicine, Level 6 West Wing, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
Arterioscler Thromb Vasc Biol 32:1427-35. 2012..We hypothesized that high-affinity dual-ligand microparticles of iron oxide (MPIO), targeted to P-selectin and vascular cell adhesion molecule-1 (PV-MPIO), would identify activated endothelial cells during atherosclerosis progression... - A novel role for transcription factor Lmo4 in thymus development through genetic interaction with Cited2Anna C Michell
Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, United Kingdom
Dev Dyn 239:1988-94. 2010..Our data suggest that this may occur, in part, through control of expression of a common target gene, Tbx1, which is necessary for normal thymus development... - Maternal high-fat diet interacts with embryonic Cited2 genotype to reduce Pitx2c expression and enhance penetrance of left-right patterning defectsJamie Bentham
Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
Hum Mol Genet 19:3394-401. 2010..They suggest that appropriate modifications of maternal diet may prevent such defects in humans... - Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacityDarci Phillips
Department of Cardiovascular Medicine, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK
J Mol Cell Cardiol 48:582-90. 2010.... - CINE-MR imaging of the normal and infarcted rat heart using an 11.7 T vertical bore MR systemDamian J Tyler
Department of Physiology, University of Oxford, Oxford, United Kingdom
J Cardiovasc Magn Reson 8:327-33. 2006..Hence, we conclude that vertical bore MR systems can be used to measure in vivo cardiac function in normal and infarcted rat hearts... - Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathwaySimon D Bamforth
Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Nat Genet 36:1189-96. 2004..We propose that an abnormal Nodal-Pitx2c pathway represents a unifying mechanism for the cardiovascular malformations observed in Cited2(-/-) mice, and that such malformations may be the sole manifestation of a laterality defect... - Advanced methods for quantification of infarct size in mice using three-dimensional high-field late gadolinium enhancement MRISteffen Bohl
BHF Experimental MR Unit, Wellcome Trust Centre for Human Genetics, Univ of Oxford, Roosevelt Dr, Oxford, OX3 7BN, United Kingdom
Am J Physiol Heart Circ Physiol 296:H1200-8. 2009..This method is particularly suited to studies requiring early quantification of initial infarct size, for example, to measure damage before intervention with stem cells... - Assessment of motion gating strategies for mouse magnetic resonance at high magnetic fieldsPaul J Cassidy
Oxford Cardiac Research Group Magnetic Resonance Unit, University Laboratory of Physiology, University of Oxford, Oxford, UK
J Magn Reson Imaging 19:229-37. 2004..To assess the performance of motion gating strategies for mouse cardiac magnetic resonance (MR) at high magnetic fields by quantifying the levels of motion artifact observed in images and spectra in vivo... - Abnormal cardiac morphology, function and energy metabolism in the dystrophic mdx mouse: an MRI and MRS studyWen Zhang
Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Oxford, UK
J Mol Cell Cardiol 45:754-60. 2008..We conclude that the absence of dystrophin in adult mdx mouse heart, as in the heart of human patient, is associated with right ventricular dilatation, left ventricular diastolic dysfunction and abnormal energy metabolism... - Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging techniqueJurgen E Schneider
Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN UK
BMC Dev Biol 4:16. 2004..The identification of murine models of congenital cardiac malformations in high-throughput mutagenesis screens and in gene-targeted models is hindered by the opacity of the mouse embryo... - Magnetic resonance imaging of endothelial adhesion molecules in mouse atherosclerosis using dual-targeted microparticles of iron oxideMartina A McAteer
Department of Cardiovascular Medicine, University of Oxford, Oxford, OX3 9DU, United Kingdom
Arterioscler Thromb Vasc Biol 28:77-83. 2008..We hypothesized that antibody-conjugated MPIO would enable magnetic resonance imaging (MRI) of endothelial cell adhesion molecules in mouse atherosclerosis... - Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout miceMichiel Ten Hove
Department of Cardiovascular Medicine, University of Oxford, Oxford, England
Circulation 111:2477-85. 2005..To characterize the role of a substantially impaired CK/PCr system in heart, we studied the cardiac phenotype of wild-type (WT) and GAMT-/- mice... - Refined approach for quantification of in vivo ischemia-reperfusion injury in the mouse heartSteffen Bohl
Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Am J Physiol Heart Circ Physiol 297:H2054-8. 2009..We have tested published approaches and challenged their practicality. As a result, we propose an improved and streamlined protocol, which consistently yields high-quality histology, thereby minimizing experimental noise and group sizes... - Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and ageCraig A Lygate
Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
Basic Res Cardiol 107:276. 2012..However, the observation that a primary defect in CK can, under the right conditions, result in heart failure suggests that impaired CK activity in the failing heart could contribute to disease progression... - High-resolution imaging of normal anatomy, and neural and adrenal malformations in mouse embryos using magnetic resonance microscopyJurgen E Schneider
Department of Cardiovascular Medicine, University of Oxford, British Heart Foundation Molecular Cardiology Laboratory, Wellcome Trust Centre for Human Genetics, Oxford, UK
J Anat 202:239-47. 2003.... - Dystrophin- and MLP-deficient mouse hearts: marked differences in morphology and function, but similar accumulation of cytoskeletal proteinsJames R Wilding
Department of Physiology, University of Oxford, Oxford, England, UK
FASEB J 19:79-81. 2005.... - Iron particles for noninvasive monitoring of bone marrow stromal cell engraftment into, and isolation of viable engrafted donor cells from, the heartDaniel J Stuckey
Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, UK, OX1 3PT
Stem Cells 24:1968-75. 2006..The magnetic properties of the iron-labeled donor cells can be used for their isolation from host tissue to enable further characterization... - Functional significance of SRJ domain mutations in CITED2Chiann Mun Chen
Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
PLoS ONE 7:e46256. 2012.... - Improved method for quantification of regional cardiac function in mice using phase-contrast MRIErica Dall'Armellina
Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
Magn Reson Med 67:541-51. 2012.... - Visualization of activated platelets by targeted magnetic resonance imaging utilizing conformation-specific antibodies against glycoprotein IIb/IIIaConstantin von zur Muhlen
Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
J Vasc Res 46:6-14. 2009..This presents an opportunity to specifically image activated platelets involved in acute atherothrombosis with MRI... - High-energy phosphotransfer in the failing mouse heart: role of adenylate kinase and glycolytic enzymesDunja Aksentijevic
Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
Eur J Heart Fail 12:1282-9. 2010..To measure the activity of the key phosphotransfer enzymes creatine kinase (CK), adenylate kinase (AK), and glycolytic enzymes in two common mouse models of chronic heart failure... - Quantification and 3D reconstruction of atherosclerotic plaque components in apolipoprotein E knockout mice using ex vivo high-resolution MRIMartina A McAteer
Department of Cardiovascular Medicine, University of Oxford, United Kingdom
Arterioscler Thromb Vasc Biol 24:2384-90. 2004..Reconstruction and volumetric quantification of segmented brachiocephalic arteries demonstrated greater sensitivity in detecting changes in plaque size and lipid composition over time than 2D analysis... - Microscopic magnetic resonance imaging reveals high prevalence of third coronary artery in human and rabbit heartRebecca A B Burton
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
Europace 14:v73-v81. 2012..Using high-resolution magnetic resonance imaging, we identified TCA prevalence and characteristics in rabbit and human hearts... - Making the mouse embryo transparent: identifying developmental malformations using magnetic resonance imagingJurgen E Schneider
Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Center for Human Genetics, Oxford, United Kingdom
Birth Defects Res C Embryo Today 72:241-9. 2004..In this review, we describe recent advances in magnetic resonance imaging that make it possible to rapidly identify malformations in the developing mouse embryo with high efficiency... - Rapid identification and 3D reconstruction of complex cardiac malformations in transgenic mouse embryos using fast gradient echo sequence magnetic resonance imagingJurgen E Schneider
Department of Cardiovascular Medicine, University of Oxford, British Heart Foundation Molecular Cardiology Laboratory, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
J Mol Cell Cardiol 35:217-22. 2003..Our data indicate that fast gradient echo sequence magnetic resonance imaging can be used to rapidly and accurately identify complex cardiovascular malformations in transgenic and mutant mouse embryos... - Progressive changes in T₁, T₂ and left-ventricular histo-architecture in the fixed and embedded rat heartPatrick W Hales
Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
NMR Biomed 24:836-43. 2011.... - Rapid quantification of myocardial lipid content in humans using single breath-hold 1H MRS at 3 TeslaBelen Rial
Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
Magn Reson Med 66:619-24. 2011..Thus, single breath-hold proton spectroscopy allows reliable and quick quantification of myocardial lipids at 3 T... - In vivo magnetic resonance imaging of acute brain inflammation using microparticles of iron oxideMartina A McAteer
Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
Nat Med 13:1253-8. 2007..Their rapid clearance from blood results in minimal background contrast. This technology is adaptable to monitor the expression of endovascular molecules in vivo in various pathologies... - Abnormal function and glucose metabolism in the type-2 diabetic db/db mouse heartMarcello Panagia
University Laboratory of Physiology, Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Rd, OX1 3PT, Oxford, England
Can J Physiol Pharmacol 85:289-94. 2007..01) in db/db mice than in controls. In summary, the db/db mouse has abnormal left ventricular function in vivo, with impaired glucose uptake during ischemia, leading to increased myocardial damage... - Histo-anatomical structure of the living isolated rat heart in two contraction states assessed by diffusion tensor MRIPatrick W Hales
Department of Cardiovascular Medicine, University of Oxford, Oxford OX3 7BN, UK
Prog Biophys Mol Biol 110:319-30. 2012.... - In vivo quantification of VCAM-1 expression in renal ischemia reperfusion injury using non-invasive magnetic resonance molecular imagingAsim M Akhtar
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
PLoS ONE 5:e12800. 2010..We hypothesized that microparticles of iron oxide targeting VCAM-1 (VCAM-MPIO) would depict "ischemic memory" and enable in vivo assessment of VCAM-1 expression... - Generation of histo-anatomically representative models of the individual heart: tools and applicationGernot Plank
Computational Biology Group, University of Oxford, Oxford OX1 2JD, UK
Philos Trans A Math Phys Eng Sci 367:2257-92. 2009.... - Development of an anatomically detailed MRI-derived rabbit ventricular model and assessment of its impact on simulations of electrophysiological functionMartin J Bishop
University of Oxford Computing Laboratory, Parks Road, Oxford OX1 3QD, UK
Am J Physiol Heart Circ Physiol 298:H699-718. 2010..This highlights the utility of histoanatomically detailed models for investigations of cardiac function, in particular for future patient-specific modeling... - Bone marrow-derived stromal cells home to and remain in the infarcted rat heart but fail to improve function: an in vivo cine-MRI studyCarolyn A Carr
Cardiac Metabolism Research Group, Dept of Physiology, Anatomy and Genetics, Sherrington Bldg, Univ of Oxford, Parks Road Oxford, United Kingdom OX1 3PT
Am J Physiol Heart Circ Physiol 295:H533-42. 2008..However, no significant improvement in any measure of cardiac function was observed at any time. We conclude that cultured BMSCs are not the optimal cell population to treat the infarcted heart... - Serial high resolution 3D-MRI after aortic banding in mice: band internalization is a source of variability in the hypertrophic responseCraig A Lygate
Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, England
Basic Res Cardiol 101:8-16. 2006..This is the first observation that a significant subset of animals following TAC bypass the stenosis resulting in partial regression of hypertrophy... - Quantitative 3-dimensional echocardiography for accurate and rapid cardiac phenotype characterization in miceDana Dawson
Department of Cardiovascular Medicine, University of Oxford, Oxford, England
Circulation 110:1632-7. 2004..CONCLUSIONS: This new, fast, and highly reproducible 3D-echo technique should be of widespread applicability for high-throughput murine cardiac phenotyping studies... - Investigating cardiac energetics in heart failureCraig A Lygate
Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Exp Physiol 98:601-5. 2013.... - Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic miceJulie Wallis
Department of Cardiovascular Medicine, University of Oxford, Oxford, England
Circulation 112:3131-9. 2005..These findings caution against the uncritical use of creatine as a therapeutic agent in heart disease... - VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5Dorota Szumska
Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
Genes Dev 22:1465-77. 2008..We propose that Pcsk5, at least in part via GDF11, coordinately regulates caudal Hox paralogs, to control anteroposterior patterning, nephrogenesis, skeletal, and anorectal development... - Cardiac valve annulus manual segmentation using computer assisted visual feedback in three-dimensional image dataRamon Casero
Computational Biology Group, Computing Laboratory, University of Oxford, Wolfson Building, Parks Rd, OX1 3QD, UK
Conf Proc IEEE Eng Med Biol Soc 2010:738-41. 2010..The Spline Tool was tested successfully on 14 rat hearts, on all four valves... - Three-dimensional models of individual cardiac histoanatomy: tools and challengesRebecca A B Burton
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK
Ann N Y Acad Sci 1080:301-19. 2006..It provides an overview of the tools used in this quest and outlines challenges posed by the approach in the light of applications that may benefit from the availability of such data and tools...