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Genomes and Genes
Saccharomyces cerevisiae S288c
University of Newcastle
Wells G, Weichmann F, COLVIN D, Sloan K, Kudla G, Tollervey D,
. The PIN domain endonuclease Utp24 cleaves pre-ribosomal RNA at two coupled sites in yeast and humans. Nucleic Acids Res. 2016;44:5399-409
..We propose that Utp24 cleaves sites A1/1 and A2/2a in yeast and human cells. ..
Schneider C, Kudla G, Wlotzka W, Tuck A, Tollervey D. Transcriptome-wide analysis of exosome targets. Mol Cell. 2012;48:422-33
..Rrp6 was preferentially associated with structured targets, which frequently did not associate with the core exosome indicating that substrates follow multiple pathways to the nucleases. ..
Schneider C, Tollervey D. Threading the barrel of the RNA exosome. Trends Biochem Sci. 2013;38:485-93
..They also revealed surprisingly high degradation rates for newly synthesized RNAs, particularly RNA polymerase III transcripts. ..
Experts and Doctors on saccharomyces cerevisiae in Newcastle upon Tyne, England, United Kingdom
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Experts and Doctors on humans in Newcastle upon Tyne, England, United Kingdom
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last updated: January 02, 2019