- Threading the barrel of the RNA exosomeClaudia Schneider
Institute for Cell and Molecular Biosciences ICaMB, Newcastle University, Newcastle upon Tyne, UK Electronic address
Trends Biochem Sci 38:485-93. 2013..They also revealed surprisingly high degradation rates for newly synthesized RNAs, particularly RNA polymerase III transcripts. ..
- Transcriptome-wide analysis of exosome targetsClaudia Schneider
Wellcome Trust Centre for Cell Biology, The University of Edinburgh, Edinburgh UK
Mol Cell 48:422-33. 2012..Rrp6 was preferentially associated with structured targets, which frequently did not associate with the core exosome indicating that substrates follow multiple pathways to the nucleases...
- Proofreading of pre-40S ribosome maturation by a translation initiation factor and 60S subunitsSimon Lebaron
Wellcome Trust Centre for Cell Biology, The University of Edinburgh, Edinburgh, Scotland, UK
Nat Struct Mol Biol 19:744-53. 2012..We propose that recruitment of 60S subunits promotes GTP hydrolysis by Fun12, leading to structural rearrangements within the pre-40S particle that bring Nob1 and the pre-rRNA cleavage site together...
- Comparison of the yeast and human nuclear exosome complexesKatherine E Sloan
Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, UK
Biochem Soc Trans 40:850-5. 2012..In the present paper, we provide an overview of the exosome and its role in RNA processing/degradation and discuss important new insights into exosome composition and function in human cells...