K Schallreuter

Summary

Affiliation: University of Bradford
Country: UK

Publications

  1. ncbi request reprint Vitix--a new treatment for vitiligo?
    Karin U Schallreuter
    Int J Dermatol 44:969-70. 2005
  2. doi request reprint From basic research to the bedside: efficacy of topical treatment with pseudocatalase PC-KUS in 71 children with vitiligo
    Karin U Schallreuter
    Department of Biomedical Sciences, University of Bradford, Bradford, UK
    Int J Dermatol 47:743-53. 2008
  3. ncbi request reprint Calcium-activated butyrylcholinesterase in human skin protects acetylcholinesterase against suicide inhibition by neurotoxic organophosphates
    Karin U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, Bradford BD7 1DP, West Yorkshire, UK
    Biochem Biophys Res Commun 355:1069-74. 2007
  4. doi request reprint [Vitiligo. What is new?]
    K U Schallreuter
    Institut für Pigmentationsstörungen e V in Assoziation mit Biotechnikum, Ernst Moritz Arndt Universitat Greifswald, Biotechnikum, W Rahenaustr 46a, 17489, Greifswald, Deutschland
    Hautarzt 61:578-85. 2010
  5. doi request reprint Basic evidence for epidermal H2O2/ONOO(-)-mediated oxidation/nitration in segmental vitiligo is supported by repigmentation of skin and eyelashes after reduction of epidermal H2O2 with topical NB-UVB-activated pseudocatalase PC-KUS
    Karin U Schallreuter
    Institute for Pigmentary Disorders, E M Arndt University, Greifswald, Germany
    FASEB J 27:3113-22. 2013
  6. doi request reprint Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 2: Epidermal H2O2/ONOO(-)-mediated stress in vitiligo hampers indoleamine 2,3-dioxygenase and aryl hydrocarbon receptor-mediated imm
    Karin U Schallreuter
    Institute for Pigmentary Disorders, E M Arndt University, Greifswald, Germany
    FASEB J 26:2471-85. 2012
  7. doi request reprint Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 1: Epidermal H2O2/ONOO(-)-mediated stress abrogates tryptophan hydroxylase and dopa decarboxylase activities, leading to low seroton
    Karin U Schallreuter
    Institute for Pigmentary Disorders, E M Arndt University, Greifswald, Germany
    FASEB J 26:2457-70. 2012
  8. ncbi request reprint Structural and functional alterations in the beta2-adrenoceptor are caused by a point mutation in patients with atopic eczema
    Karin U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, Bradford, UK
    Exp Dermatol 16:807-13. 2007
  9. ncbi request reprint Butyrylcholinesterase is present in the human epidermis and is regulated by H2O2: more evidence for oxidative stress in vitiligo
    Karin U Schallreuter
    Clinical and Experimental Dermatology Department of Biomedical Sciences, University of Bradford, Bradford BD7 1DP, UK
    Biochem Biophys Res Commun 349:931-8. 2006
  10. ncbi request reprint Functioning methionine-S-sulfoxide reductases A and B are present in human skin
    Karin U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, Bradford BD7 1DP, UK
    J Invest Dermatol 126:947-9. 2006

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Vitix--a new treatment for vitiligo?
    Karin U Schallreuter
    Int J Dermatol 44:969-70. 2005
  2. doi request reprint From basic research to the bedside: efficacy of topical treatment with pseudocatalase PC-KUS in 71 children with vitiligo
    Karin U Schallreuter
    Department of Biomedical Sciences, University of Bradford, Bradford, UK
    Int J Dermatol 47:743-53. 2008
    ..The epidermal accumulation of hydrogen peroxide (H(2)O(2)) has been documented in vitiligo...
  3. ncbi request reprint Calcium-activated butyrylcholinesterase in human skin protects acetylcholinesterase against suicide inhibition by neurotoxic organophosphates
    Karin U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, Bradford BD7 1DP, West Yorkshire, UK
    Biochem Biophys Res Commun 355:1069-74. 2007
    ..8m(2) surface area with its calcium gradient in the 10(-3)M range, our results implicate calcium-activated BuchE as a major protective mechanism against suicide inhibition of AchE by organophosphates in this non-neuronal tissue...
  4. doi request reprint [Vitiligo. What is new?]
    K U Schallreuter
    Institut für Pigmentationsstörungen e V in Assoziation mit Biotechnikum, Ernst Moritz Arndt Universitat Greifswald, Biotechnikum, W Rahenaustr 46a, 17489, Greifswald, Deutschland
    Hautarzt 61:578-85. 2010
    ..In addition a review of recent and novel treatment modalities including the role of oxidative stress reduction and combined climatotherapy at the Dead Sea in a group are discussed...
  5. doi request reprint Basic evidence for epidermal H2O2/ONOO(-)-mediated oxidation/nitration in segmental vitiligo is supported by repigmentation of skin and eyelashes after reduction of epidermal H2O2 with topical NB-UVB-activated pseudocatalase PC-KUS
    Karin U Schallreuter
    Institute for Pigmentary Disorders, E M Arndt University, Greifswald, Germany
    FASEB J 27:3113-22. 2013
    ..Taken together, our contribution strongly supports H2O2/ONOO-mediated stress in the pathogenesis of SSV. Our findings offer new treatment intervention for lost skin and hair color...
  6. doi request reprint Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 2: Epidermal H2O2/ONOO(-)-mediated stress in vitiligo hampers indoleamine 2,3-dioxygenase and aryl hydrocarbon receptor-mediated imm
    Karin U Schallreuter
    Institute for Pigmentary Disorders, E M Arndt University, Greifswald, Germany
    FASEB J 26:2471-85. 2012
    ..Taken together, our data support a long-expressed role for in loco redox balance and a distinct immune response. These insights could open novel treatment strategies for this disease...
  7. doi request reprint Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 1: Epidermal H2O2/ONOO(-)-mediated stress abrogates tryptophan hydroxylase and dopa decarboxylase activities, leading to low seroton
    Karin U Schallreuter
    Institute for Pigmentary Disorders, E M Arndt University, Greifswald, Germany
    FASEB J 26:2457-70. 2012
    ..Taken together, our data point to depletion of epidermal Trp by Fenton chemistry and exclude melatonin as a relevant contributor to epidermal redox balance and immune response in vitiligo...
  8. ncbi request reprint Structural and functional alterations in the beta2-adrenoceptor are caused by a point mutation in patients with atopic eczema
    Karin U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, Bradford, UK
    Exp Dermatol 16:807-13. 2007
    ..In summary, the results indicate that atopic eczema is associated with a single point mutation in the beta2-adrenoceptor gene leading to an impaired adrenergic response in the epidermis of these patients...
  9. ncbi request reprint Butyrylcholinesterase is present in the human epidermis and is regulated by H2O2: more evidence for oxidative stress in vitiligo
    Karin U Schallreuter
    Clinical and Experimental Dermatology Department of Biomedical Sciences, University of Bradford, Bradford BD7 1DP, UK
    Biochem Biophys Res Commun 349:931-8. 2006
    ..Based on our results we conclude that H(2)O(2) is a major player in the regulation of the cholinergic signal via both AchE and BchE and this signal is severely affected in the epidermis of patients with active vitiligo...
  10. ncbi request reprint Functioning methionine-S-sulfoxide reductases A and B are present in human skin
    Karin U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, Bradford BD7 1DP, UK
    J Invest Dermatol 126:947-9. 2006
    ..This commentary shows that both diastereomers of methionine sulfoxide (R and S) can be repaired in the human epidermis by methionine sulfoxide reductases A and B, respectively...
  11. ncbi request reprint Estrogens can contribute to hydrogen peroxide generation and quinone-mediated DNA damage in peripheral blood lymphocytes from patients with vitiligo
    Karin U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, Bradford BD7 1DP, UK
    J Invest Dermatol 126:1036-42. 2006
    ..This effect was not abolished by catalase pointing to direct quinone-mediated DNA damage by estrogens in peripheral blood lymphocytes in vitiligo...
  12. ncbi request reprint Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus
    Karin U Schallreuter
    Clinical and Experimental Dermatology Department of Biomedical Sciences, University of Bradford, UK
    Biochem Biophys Res Commun 342:145-52. 2006
    ....
  13. ncbi request reprint Decreased phenylalanine uptake and turnover in patients with vitiligo
    Karin U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, UK
    Mol Genet Metab 86:S27-33. 2005
    ..Based on our observation, we would like to propose that phenylalanine uptake/turnover is under tight control by calcium which in turn could offer an additional novel mechanism in the aetiology of HPA...
  14. ncbi request reprint Hydrogen peroxide regulates the cholinergic signal in a concentration dependent manner
    Karin U Schallreuter
    Clinical and Experimental Dermatology Department of Biomedical Sciences, University of Bradford, Bradford, BD7 1DP, UK
    Life Sci 80:2221-6. 2007
    ..This process is reversible with a narrowband UVB activated pseudocatalase PC-KUS leading to recovery of epidermal and systemic enzyme activities as well as restoration of the lost skin colour...
  15. ncbi request reprint Basic research confirms coexistence of acquired Blaschkolinear Vitiligo and acrofacial Vitiligo
    Karin U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, Bradford BD7 1DP, UK
    Arch Dermatol Res 299:225-30. 2007
    ..This observation raises the question whether besides H(2)O(2)-mediated stress in association with genomic mosaicism could play a role in some cases with vitiligo...
  16. ncbi request reprint Hydrogen peroxide-mediated oxidative stress disrupts calcium binding on calmodulin: more evidence for oxidative stress in vitiligo
    K U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, Bradford BD7 1DP, UK
    Biochem Biophys Res Commun 360:70-5. 2007
    ..Taken together H(2)O(2)-mediated oxidation affects calcium binding in calmodulin leading to perturbed calcium homeostasis and perturbed l-phenylalanine-uptake in the epidermis of acute vitiligo...
  17. ncbi request reprint Advances in melanocyte basic science research
    Karin U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, Bradford BD7 1DP, West Yorkshire, UK
    Dermatol Clin 25:283-91, vii. 2007
    ..The main message of this article is that the intracellular H(2)O(2)- redox-equilibrium controls melanocyte function in a concentration-dependent manner...
  18. ncbi request reprint Methionine sulfoxide reductases A and B are deactivated by hydrogen peroxide (H2O2) in the epidermis of patients with vitiligo
    Karin U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, Bradford, UK
    J Invest Dermatol 128:808-15. 2008
    ..Taken together, our results confirm that very important anti-oxidant enzymes are seriously affected in acute vitiligo...
  19. ncbi request reprint Quinones are reduced by 6-tetrahydrobiopterin in human keratinocytes, melanocytes, and melanoma cells
    Karin U Schallreuter
    Department of Biomedical Sciences, University of Bradford, Bradford, BD7 1DP, UK
    Free Radic Biol Med 44:538-46. 2008
    ..Therefore we conclude that both mechanisms are major players in the prevention of quinone-mediated oxidative stress and DNA damage...
  20. doi request reprint Regulation of melanogenesis--controversies and new concepts
    Karin U Schallreuter
    Clinical and Experimental Dermatology Department of Biomedical Sciences, University of Bradford, Bradford, UK
    Exp Dermatol 17:395-404. 2008
    ..Finally, we propose a novel mechanism involving H2O2 in the regulation of tyrosinase via p53 through transcription of hepatocyte nuclear factor 1alpha which in turn can also affect the POMC response...
  21. doi request reprint Cholesterol regulates melanogenesis in human epidermal melanocytes and melanoma cells
    Karin U Schallreuter
    Clinical and Experimental Dermatology, Division of Biomedical Sciences, School of Life Sciences, University of Bradford, Bradford BD7 1DP, UK
    Exp Dermatol 18:680-8. 2009
    ..Taken together, we show that human epidermal melanocytes have the capacity of cholesterol signalling via LDL/Apo-B100/LDL receptor and that cholesterol under in vitro conditions increases melanogenesis...
  22. doi request reprint The redox--biochemistry of human hair pigmentation
    Karin U Schallreuter
    Institute for Pigmentary Disorders in Association with EM Arndt University Greifswald, Biotechnikum, Greifswald, Germany
    Pigment Cell Melanoma Res 24:51-62. 2011
    ....
  23. ncbi request reprint Human phenylalanine hydroxylase is activated by H2O2: a novel mechanism for increasing the L-tyrosine supply for melanogenesis in melanocytes
    Karin U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, West Yorkshire BD7 1DP, UK
    Biochem Biophys Res Commun 322:88-92. 2004
    ..Hence, generation of H(2)O(2) by UVB can activate epidermal PAH leading to an increased L-tyrosine pool for melanogenesis...
  24. ncbi request reprint Activation/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligo
    Karin U Schallreuter
    Department of Biomedical Sciences, Clinical and Experimental Dermatology, University of Bradford, Bradford, West Yorkshire BD7 1DP, UK
    Biochem Biophys Res Commun 315:502-8. 2004
    ..To our knowledge these results identified for the first time H2O2 regulation of AchE. Moreover, it was shown that H2O2-mediated oxidation of AchE contributes significantly to the well-established oxidative stress in vitiligo...
  25. ncbi request reprint Molecular evidence that halo in Sutton's naevus is not vitiligo
    K U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, BD7 1DP, Bradford, West Yorkshire, UK
    Arch Dermatol Res 295:223-8. 2003
    ..Therefore, it can be concluded that both leucodermas exercise distinct concentration-dependent H2O2 signalling in their pathomechanisms...
  26. ncbi request reprint Increased epidermal functioning wild-type p53 expression in vitiligo
    Karin U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, West Yorkshire, UK
    Exp Dermatol 12:268-77. 2003
    ..Based on our results we hypothesize that the low incidence for actinic damage, basal cell and squamous cell carcinoma as documented in vitiligo could well reside in a protective function of up-regulated wild-type p53...
  27. ncbi request reprint Altered catecholamine synthesis and degradation in the epidermis of patients with atopic eczema
    K U Schallreuter
    Clinical and Experimental Dermatology Department of Biomedical Sciences, University of Bradford, UK
    Arch Dermatol Res 289:663-6. 1997
    ..Taken together, these results support earlier observations of a defective catecholamine/adrenoceptor signal in patients with atopic eczema...
  28. ncbi request reprint A review of recent advances on the regulation of pigmentation in the human epidermis
    K U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, West Yorkshire, UK
    Cell Mol Biol (Noisy-le-grand) 45:943-9. 1999
    ..These recent findings are based on detailed investigations of the depigmentation disorder vitiligo and Hermanský-Pudlák syndrome...
  29. ncbi request reprint alpha-MSH can control the essential cofactor 6-tetrahydrobiopterin in melanogenesis
    K U Schallreuter
    Clinical and Experimental Dermatology Department of Biomedical Sciences, University of Bradford, United Kingdom
    Ann N Y Acad Sci 885:329-41. 1999
    ..In conclusion, alpha-MSH can control (1) intracellular L-tyrosine formation from L-phenylalanine in both melanocytes and keratinocytes, and (2) tyrosinase activity, directly, in melanocytes...
  30. ncbi request reprint Epidermal H(2)O(2) accumulation alters tetrahydrobiopterin (6BH4) recycling in vitiligo: identification of a general mechanism in regulation of all 6BH4-dependent processes?
    K U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, West Yorkshire, UK
    J Invest Dermatol 116:167-74. 2001
    ..Based on this observation, we suggest that H(2)O(2) derived from various sources could be a general mechanism in the regulation of all 6BH(4)-dependent processes...
  31. ncbi request reprint In situ and in vitro evidence for DCoH/HNF-1 alpha transcription of tyrosinase in human skin melanocytes
    Karin U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, Bradford, West Yorkshire BD7 1DP, UK
    Biochem Biophys Res Commun 301:610-6. 2003
    ..Specific binding of DCoH/HNF-1 complex to the human tyrosinase promoter was confirmed by gel shift analysis. These results provide a novel mechanism in the regulation of skin pigmentation...
  32. ncbi request reprint Rapid initiation of repigmentation in vitiligo with Dead Sea climatotherapy in combination with pseudocatalase (PC-KUS)
    Karen U Schallreuter
    Department of Biomedical Sciences, Clinical and Experimental Dermatology, University of Bradford, West Yorkshire, BD7 1DP, UK
    Int J Dermatol 41:482-7. 2002
    ..Mn/EDTA-bicarbonate complex, patent No. EPO 58471 1 A), yielding initiation of repigmentation. Dead Sea climatotherapy is another successful treatment modality for vitiligo, but the mode of action has escaped definition so far...
  33. ncbi request reprint Decreased photodamage and low incidence of non-melanoma skin cancer in 136 sun-exposed caucasian patients with vitiligo
    Karin U Schallreuter
    Institute for Pigmentary Disorders, Greifswald, Germany
    Dermatology 204:194-201. 2002
    ..However, scattered reports on low patient numbers documented no increased risk for sun-induced skin cancers in this disease...
  34. ncbi request reprint In vivo and in vitro evidence for hydrogen peroxide (H2O2) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase
    K U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, UK
    J Investig Dermatol Symp Proc 4:91-6. 1999
    ..In conclusion, there are several lines of evidence that the entire epidermis of patients with vitiligo is involved in the disease process and that correction of the epidermal redox status is mandatory for repigmentation...
  35. ncbi request reprint Thioredoxin reductase - its role in epidermal redox status
    K U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, West Yorkshire, UK
    J Photochem Photobiol B 64:179-84. 2001
    ..This cascade of events is observed in the depigmentation disorder vitiligo, where millimolar levels of H(2)O(2) can accumulate in the epidermis of affected individuals, consequently leading to cellular vacuolation in this compartment...
  36. ncbi request reprint 6-Tetrahydrobiopterin functions as a UVB-light switch for de novo melanogenesis
    K U Schallreuter
    Department of Biomedical Sciences, University of Bradford, West Yorks, UK
    Biochim Biophys Acta 1382:339-44. 1998
    ..Taken together, our results indicate that the photo-oxidation of the tetrahydrobiopterins by UVB may represent a photo-switch in the regulation of tyrosinase activity to promote de novo melanogenesis...
  37. ncbi request reprint The importance of L-phenylalanine transport and its autocrine turnover to L-tyrosine for melanogenesis in human epidermal melanocytes
    K U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, Bradford, United Kingdom
    Biochem Biophys Res Commun 262:423-8. 1999
    ..Taken together, our results identified for the first time the importance of autocrine calcium-dependent active l-phenylalanine uptake/turnover in melanocytes as a major pathway for melanogenesis...
  38. ncbi request reprint What controls melanogenesis?
    K Schallreuter
    Dept of Biomedical Sciences, University of Bradford, UK
    Exp Dermatol 7:143-50. 1998
    ..For decades, this has been the object of much controversy, the salient features of which are delineated in the following contributions...
  39. ncbi request reprint Successful treatment of oxidative stress in vitiligo
    K U Schallreuter
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, UK
    Skin Pharmacol Appl Skin Physiol 12:132-8. 1999
    ..A topical substitution with a UVB-activated pseudocatalase can successfully remove epidermal H2O2 in vitiligo. This approach leads to recovery of the oxidative damage in the epidermis and remarkable repigmentation in this disorder...
  40. ncbi request reprint Oxidative stress via hydrogen peroxide affects proopiomelanocortin peptides directly in the epidermis of patients with vitiligo
    Jennifer D Spencer
    Clinical and Experimental Dermatology Department of Biomedical Sciences, University of Bradford, Bradford, UK
    J Invest Dermatol 127:411-20. 2007
    ..Thus, using vitiligo, we demonstrate that H2O2 can affect pigmentation via epidermal POMC peptide redox homeostasis...
  41. ncbi request reprint Perturbed 6-tetrahydrobiopterin recycling via decreased dihydropteridine reductase in vitiligo: more evidence for H2O2 stress
    Sybille Hasse
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, West Yorkshire, UK
    J Invest Dermatol 122:307-13. 2004
    ..Taken together, these new data add more evidence to a systemic involvement of H2O2 in the pathomechanism of vitiligo...
  42. ncbi request reprint Oxidative stress in vitiligo: photo-oxidation of pterins produces H(2)O(2) and pterin-6-carboxylic acid
    Hartmut Rokos
    Institute for Pigmentary Disorders in Association with Ernst Moritz Arndt University, Greifswald, Germany
    Biochem Biophys Res Commun 292:805-11. 2002
    ....
  43. doi request reprint Presence of epidermal allantoin further supports oxidative stress in vitiligo
    Mohammad Shalbaf
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, Bradford, UK
    Exp Dermatol 17:761-70. 2008
    ..Taken together, our results provide evidence that epidermal XO contributes to H(2)O(2)-mediated oxidative stress in vitiligo via H(2)O(2)-production and allantoin formation in the epidermal compartment...
  44. doi request reprint Enhanced DNA binding capacity on up-regulated epidermal wild-type p53 in vitiligo by H2O2-mediated oxidation: a possible repair mechanism for DNA damage
    Mohamed M A E L Salem
    Clinical and Experimental Dermatology, Department of Biomedical Sciences Centre for Skin Sciences, School of Life Sciences, University of Bradford, Bradford, UK
    FASEB J 23:3790-807. 2009
    ..Moreover, we propose up-regulated wild-type p53 together with p76(MDM2) as major players in the control of DNA damage/repair and prevention of photodamage and nonmelanoma skin cancer in vitiligo...
  45. ncbi request reprint Regulation of tyrosinase by tetrahydropteridines and H2O2
    John M Wood
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, West Yorkshire BD7 1DP, UK
    Biochem Biophys Res Commun 325:1412-7. 2004
    ..3 x 10(-3)M), but deactivated at concentrations in the range 0.5-5.0 x 10(-3)M. In summary, our results confirm a major role for 6BH(4) in the regulation of human pigmentation...
  46. ncbi request reprint A novel mechanism in control of human pigmentation by {beta}-melanocyte-stimulating hormone and 7-tetrahydrobiopterin
    Jennifer D Spencer
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, Bradford BD7 1DP, UK
    J Endocrinol 187:293-302. 2005
    ..Based on these results, we propose a new receptor-independent mechanism in the control of tyrosinase/melanogenesis by beta-MSH and the pterin 7BH(4)...
  47. ncbi request reprint A plaidoyer for cutaneous enzymology: our view of some important unanswered questions on the contributions of selected key enzymes to epidermal homeostasis
    John M Wood
    Department of Biomedical Sciences, Clinical and Experimental Dermatology, School of Life Sciences, University of Bradford, Bradford, UK
    Exp Dermatol 17:569-78. 2008
    ..Last but not least the bench work is only useful for the welfare of our patients if we can apply our basic knowledge...
  48. doi request reprint Computer simulation of heterogeneous single nucleotide polymorphisms in the catalase gene indicates structural changes in the enzyme active site, NADPH-binding and tetramerization domains: a genetic predisposition for an altered catalase in patients with
    John M Wood
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, Bradford, UK
    Exp Dermatol 17:366-71. 2008
    ..Taken together, the work presented herein together with the earlier results on SNPs in the cat gene suggests a genetic predisposition for an altered catalase in patients with vitiligo...
  49. ncbi request reprint Autocrine catecholamine biosynthesis and the beta-adrenoceptor signal promote pigmentation in human epidermal melanocytes
    Johanna M Gillbro
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, West Yorkshire, UK
    J Invest Dermatol 123:346-53. 2004
    ..Moreover, the discovery of this catecholaminergic cAMP response in melanocytes adds a new source for this important second messenger in melanogenesis...
  50. ncbi request reprint Tyrosine hydroxylase isoenzyme I is present in human melanosomes: a possible novel function in pigmentation
    Lee K Marles
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, West Yorkshire, BD7 1DP, UK
    Exp Dermatol 12:61-70. 2003
    ..Our results support a direct function for tyrosine hydroxylase in the melanosome via a concerted action with tyrosinase to promote pigmentation...
  51. ncbi request reprint GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes
    Bhaven Chavan
    Clinical and Experimental Dermatology Department of Biomedical Sciences University of Bradford, Bradford, UK
    J Invest Dermatol 126:2481-9. 2006
    ..Moreover, GFRP expression and GTPCHI activities have been found in the nucleus of both cell types. The significance of this result warrants further investigation...
  52. ncbi request reprint Regulation of human epidermal melanocyte biology by beta-endorphin
    Sobia Kauser
    Department of Biomedical Sciences, University of Bradford, West Yorkshire, UK
    J Invest Dermatol 120:1073-80. 2003
    ..In the absence of any data showing cross-talk between the mu-opiate receptor and the melanocortin-1 receptor, we conclude that the beta-endorphin/mu-opiate receptor system participates in the regulation of skin pigmentation...
  53. ncbi request reprint UVA-irradiated pheomelanin alters the structure of catalase and decreases its activity in human skin
    John M Wood
    Clinical and Experimental Dermatology Department of Biomedical Sciences, University of Bradford, Bradford, UK
    J Invest Dermatol 126:13-4. 2006
    ..Here we support the results of Maresca et al. and expand on them by using structural modeling of native catalase and its photo-oxidation product, where both methionine and tryptophan residues are oxidized, yielding a deactivated enzyme...
  54. ncbi request reprint beta-Endorphin as a regulator of human hair follicle melanocyte biology
    Sobia Kauser
    Department of Biomedical Sciences, University of Bradford, West Yorkshire, UK
    J Invest Dermatol 123:184-95. 2004
    ..These findings suggest a new regulatory role for beta-END in human HFM biology, providing a new research direction into the fundamental regulation of human hair pigmentation...
  55. ncbi request reprint The vesicular acetylcholine transporter is present in melanocytes and keratinocytes in the human epidermis
    Souna M A Elwary
    Clinical and Experimental Dermatology Department of Biomedical Sciences, University of Bradford, Bradford, UK
    J Invest Dermatol 126:1879-84. 2006
    ..These results underline that ACh/choline transport in the non-neuronal epidermis is no different from the neuronal pathway. However, the function of VAChT in the nucleus remains to be shown...
  56. ncbi request reprint Computer simulation of native epidermal enzyme structures in the presence and absence of hydrogen peroxide (H2O2): potential and pitfalls
    Nicholas C J Gibbons
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, Bradford, UK
    J Invest Dermatol 126:2576-82. 2006
    ..Computer modelling coupled with classical biochemical techniques offers a new powerful tool in cutaneous biology to explore oxidative stress-mediated metabolic changes in the skin...
  57. ncbi request reprint A fully functional proopiomelanocortin/melanocortin-1 receptor system regulates the differentiation of human scalp hair follicle melanocytes
    Sobia Kauser
    Department of Biomedical Sciences, University of Bradford, Bradford, West Yorkshire BD7 1DP, United Kingdom
    Endocrinology 146:532-43. 2005
    ..Thus, these findings suggest a role for these POMC peptides in regulating human hair follicle melanocyte differentiation...
  58. ncbi request reprint Regulation of tyrosinase by tetrahydropteridines--what is real? A critical reanalysis of H. Wojtasek's view
    John M Wood
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, West Yorkshire BD7 1DP, UK
    Biochem Biophys Res Commun 331:891-3. 2005
  59. ncbi request reprint Turmeric (curcumin): a widely used curry ingredient, can contribute to oxidative stress in Asian patients with acute vitiligo
    Karin U Schallreuter
    Indian J Dermatol Venereol Leprol 72:57-9. 2006
  60. ncbi request reprint Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo
    Angel L Pey
    Department of Biomedicine, University of Bergen, Bergen, Norway
    FASEB J 20:2130-2. 2006
    ..Taken together, our results identified structural determinants for the specific regulation of PAH and TH by 7(S)BH4, which in turn aid in the understanding of primapterinuria and acute vitiligo...
  61. ncbi request reprint Adrenergic and cholinergic control in the biology of epidermis: physiological and clinical significance
    Sergei A Grando
    Department of Dermatology, University of California, Davis, 95817, USA
    J Invest Dermatol 126:1948-65. 2006
    ..A detailed understanding of the physiology and pathophysiology of the adrenergic/cholinergic network in the skin could offer the development of specific drugs for novel treatment modalities...
  62. pmc Hair follicle pigmentation
    Andrzej Slominski
    Department of Pathology, University of Tennessee, Memphis, Tennessee 38163, USA
    J Invest Dermatol 124:13-21. 2005
    ..Melanin itself has a wide range of bioactivities that extend far beyond its determination of hair color...
  63. ncbi request reprint Novel aspects in cutaneous biology of acetylcholine synthesis and acetylcholine receptors
    Hjalmar Kurzen
    Department of Dermatology, University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    Exp Dermatol 13:27-30. 2004
    ..However, recently, the presence of both different nACh-R and mACh-R in myoepithelial and acinar cells of eccrine sweat glands has been documented, indicating a more complex regulation of sweat production and expulsion...