Pauline Schaap

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. pmc Evolution of size and pattern in the social amoebas
    Pauline Schaap
    College of Life Sciences, University of Dundee, MSI WTB JBC Complex, Dow Street, Dundee DD1 5EH, UK
    Bioessays 29:635-44. 2007
  2. ncbi request reprint Guanylyl cyclases across the tree of life
    Pauline Schaap
    School of Life Sciences, University of Dundee, UK
    Front Biosci 10:1485-98. 2005
  3. ncbi request reprint Non-metazoan class III nucleotidyl cyclases: novel forms and functions
    Pauline Schaap
    School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    IUBMB Life 56:527-8. 2004
  4. doi request reprint Evolution of developmental cyclic adenosine monophosphate signaling in the Dictyostelia from an amoebozoan stress response
    Pauline Schaap
    College of Life Sciences, University of Dundee, MSI WTB JBC Complex, Dow Street, Dundee DD15EH, UK
    Dev Growth Differ 53:452-62. 2011
  5. pmc Evolutionary crossroads in developmental biology: Dictyostelium discoideum
    Pauline Schaap
    College of Life Sciences, University of Dundee, Dundee, UK
    Development 138:387-96. 2011
  6. pmc From drought sensing to developmental control: evolution of cyclic AMP signaling in social amoebas
    Allyson V Ritchie
    College of Life Sciences, University of Dundee, Dundee, Angus, UK
    Mol Biol Evol 25:2109-18. 2008
  7. pmc cAMP production by adenylyl cyclase G induces prespore differentiation in Dictyostelium slugs
    Elisa Alvarez-Curto
    Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, Angus DD1 5EH, UK
    Development 134:959-66. 2007
  8. pmc Vectors for expression of proteins with single or combinatorial fluorescent protein and tandem affinity purification tags in Dictyostelium
    Marcel E Meima
    School of Life Sciences, University of Dundee, MSI WTB JBC Complex, Dow Street, Dundee DD15EH, UK
    Protein Expr Purif 53:283-8. 2007
  9. pmc Analysis of phenotypic evolution in Dictyostelia highlights developmental plasticity as a likely consequence of colonial multicellularity
    Maria Romeralo
    College of Life Sciences, University of Dundee, Dundee, UK
    Proc Biol Sci 280:20130976. 2013
  10. pmc Evolution of self-organisation in Dictyostelia by adaptation of a non-selective phosphodiesterase and a matrix component for regulated cAMP degradation
    Yoshinori Kawabe
    College of Life Sciences, University of Dundee, Dundee, UK
    Development 139:1336-45. 2012

Collaborators

Detail Information

Publications27

  1. pmc Evolution of size and pattern in the social amoebas
    Pauline Schaap
    College of Life Sciences, University of Dundee, MSI WTB JBC Complex, Dow Street, Dundee DD1 5EH, UK
    Bioessays 29:635-44. 2007
    ..The genotypic changes that caused this innovation and the role of dynamic cAMP signaling in defining fruiting body size and pattern throughout social amoeba evolution are discussed...
  2. ncbi request reprint Guanylyl cyclases across the tree of life
    Pauline Schaap
    School of Life Sciences, University of Dundee, UK
    Front Biosci 10:1485-98. 2005
    ..This and the close similarity of many guanylyl cyclases to adenylyl cyclases suggests a paraphyletic origin for the eukaryote enzymes with multiple events of conversion of substrate specificity...
  3. ncbi request reprint Non-metazoan class III nucleotidyl cyclases: novel forms and functions
    Pauline Schaap
    School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    IUBMB Life 56:527-8. 2004
    ..This series of reviews highlights both unique and highly conserved aspects of the activation mechanisms of these enzymes, as compared to those of their mammalian descendants...
  4. doi request reprint Evolution of developmental cyclic adenosine monophosphate signaling in the Dictyostelia from an amoebozoan stress response
    Pauline Schaap
    College of Life Sciences, University of Dundee, MSI WTB JBC Complex, Dow Street, Dundee DD15EH, UK
    Dev Growth Differ 53:452-62. 2011
    ..In this review, I present an overview of the different roles of cAMP in the model D. discoideum and I summarize studies aimed to resolve how these roles emerged during Dictyostelid evolution...
  5. pmc Evolutionary crossroads in developmental biology: Dictyostelium discoideum
    Pauline Schaap
    College of Life Sciences, University of Dundee, Dundee, UK
    Development 138:387-96. 2011
    ..In this Primer, I discuss the mechanisms that control multicellular development in Dictyostelium discoideum and reconstruct how some of these mechanisms evolved from a stress response in the unicellular ancestor...
  6. pmc From drought sensing to developmental control: evolution of cyclic AMP signaling in social amoebas
    Allyson V Ritchie
    College of Life Sciences, University of Dundee, Dundee, Angus, UK
    Mol Biol Evol 25:2109-18. 2008
    ..We propose that high osmolality signals drought in soil amoebas and that developmental cAMP signaling in the Dictyostelia has evolved from this stress response...
  7. pmc cAMP production by adenylyl cyclase G induces prespore differentiation in Dictyostelium slugs
    Elisa Alvarez-Curto
    Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, Angus DD1 5EH, UK
    Development 134:959-66. 2007
    ..These data show that ACG induces prespore differentiation in wild-type cells, with ACB capable of partially taking over this function in its absence...
  8. pmc Vectors for expression of proteins with single or combinatorial fluorescent protein and tandem affinity purification tags in Dictyostelium
    Marcel E Meima
    School of Life Sciences, University of Dundee, MSI WTB JBC Complex, Dow Street, Dundee DD15EH, UK
    Protein Expr Purif 53:283-8. 2007
    ..After denaturation and SDS-PAGE separation of the pArc-34 associated proteins all members of the Arp2/3 complex could be identified...
  9. pmc Analysis of phenotypic evolution in Dictyostelia highlights developmental plasticity as a likely consequence of colonial multicellularity
    Maria Romeralo
    College of Life Sciences, University of Dundee, Dundee, UK
    Proc Biol Sci 280:20130976. 2013
    ..This probably reflects constraints placed by colonial life on developmental control mechanisms, which, depending on local cell density, need to direct from 10 to a million cells into forming a functional fructification...
  10. pmc Evolution of self-organisation in Dictyostelia by adaptation of a non-selective phosphodiesterase and a matrix component for regulated cAMP degradation
    Yoshinori Kawabe
    College of Life Sciences, University of Dundee, Dundee, UK
    Development 139:1336-45. 2012
    ..We conclude that efficient cAMP-mediated aggregation in group 4 evolved by recruitment and adaptation of a non-selective phosphodiesterase and a matrix component into a system for regulated cAMP degradation...
  11. pmc Evolutionary origin of cAMP-based chemoattraction in the social amoebae
    Elisa Alvarez-Curto
    School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Proc Natl Acad Sci U S A 102:6385-90. 2005
    ..This most likely occurred by addition of distal cis-regulatory regions to existing cAMP signaling genes...
  12. pmc Molecular phylogeny and evolution of morphology in the social amoebas
    Pauline Schaap
    School of Life Sciences, University of Dundee, DD15EH Dundee, UK
    Science 314:661-3. 2006
    ..Thus, the latter may be controlled by only a few genes, making their underlying mechanisms relatively easy to unravel...
  13. pmc Functional dissection of adenylate cyclase R, an inducer of spore encapsulation
    Zhi Hui Chen
    College of Life Sciences, University of Dundee, Dundee DD15EH, Scotland, United Kingdom
    J Biol Chem 285:41724-31. 2010
    ..Combined with the observation that the isolated AC domain was inactive, the dominant-negative effect of ΔCRA strongly suggests that the defunct phosphoacceptor domain acquired a novel role in enforcing dimerization of the AC domain...
  14. doi request reprint The Amoebozoa
    Christina Schilde
    College of Life Sciences, University of Dundee, Dundee, UK
    Methods Mol Biol 983:1-15. 2013
    ..The chapter closes with a scenario for the evolution of Dictyostelid multicellularity from an Amoebozoan stress response...
  15. doi request reprint The prokaryote messenger c-di-GMP triggers stalk cell differentiation in Dictyostelium
    Zhi Hui Chen
    College of Life Sciences, University of Dundee, Dundee DD15EH, UK
    Nature 488:680-3. 2012
    ..Apart from identifying the long-elusive stalk-inducing morphogen, our work also identifies a role for c-di-GMP in eukaryotes...
  16. pmc Pharmacological profiling of the Dictyostelium adenylate cyclases ACA, ACB and ACG
    Elisa Alvarez-Curto
    School of Life Sciences, University of Dundee, Dundee, Scotland, UK
    Biochem J 401:309-16. 2007
    ..Both compounds acted directly on enzyme activity assayed in cell lysates, but only SQ22536 was also a specific inhibitor when added to intact cells...
  17. ncbi request reprint cAMP signaling in Dictyostelium. Complexity of cAMP synthesis, degradation and detection
    Shweta Saran
    School of Life Sciences, University of Dundee, MSI WTB complex, Dundee DD1 5EH, UK
    J Muscle Res Cell Motil 23:793-802. 2002
    ..We also briefly discuss the two modes of detection of cAMP...
  18. pmc Activated cAMP receptors switch encystation into sporulation
    Yoshinori Kawabe
    College of Life Sciences, University of Dundee, Dundee, Angus, DD15EH, United Kingdom
    Proc Natl Acad Sci U S A 106:7089-94. 2009
    ..cAMP-mediated aggregation was the most recent innovation...
  19. pmc Adenylyl cyclase G is activated by an intramolecular osmosensor
    Shweta Saran
    School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Biol Cell 15:1479-86. 2004
    ..This strongly suggests that the ACG osmosensor is intramolecular, which would define ACG as the first characterized primary osmosensor in eukaryotes...
  20. ncbi request reprint Contrasting activities of the aggregative and late PDSA promoters in Dictyostelium development
    Karin E Weening
    School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    Dev Biol 255:373-82. 2003
    ..Further 5' deletions abolished all promoter activity. This result also indicates that the induction by DIF and cAMP as seen in cell suspensions is not essential for PdL activity in normal development...
  21. doi request reprint The cyclic AMP phosphodiesterase RegA critically regulates encystation in social and pathogenic amoebas
    Qingyou Du
    College of Life Sciences, University of Dundee, Dundee DD15EH, UK
    Cell Signal 26:453-9. 2014
    ..Our results show that RegA critically regulates Amoebozoan encystation and that components of the cAMP signalling pathway could be effective targets for therapeutic intervention with encystation. ..
  22. ncbi request reprint A STAT-regulated, stress-induced signalling pathway in Dictyostelium
    Tsuyoshi Araki
    School of Life Sciences, University of Dundee, Wellcome Trust Biocentre, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 116:2907-15. 2003
    ..These data show that Dd-STATc functions as a transcriptional activator in a stress-response pathway and the pharmacological evidence, at least, is consistent with cGMP acting as a second messenger...
  23. ncbi request reprint Characterization of a cAMP-stimulated cAMP phosphodiesterase in Dictyostelium discoideum
    Marcel E Meima
    School of Life Sciences, University of Dundee, MSI WTB complex, Dow Street, United Kingdom
    J Biol Chem 278:14356-62. 2003
    ..cGMP is degraded at a 6-fold lower rate than cAMP. Neither cGMP nor 8-Br-cAMP are efficient activators of PdeE activity...
  24. pmc Identification of a novel type of cGMP phosphodiesterase that is defective in the chemotactic stmF mutants
    Marcel E Meima
    School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Biol Cell 13:3870-7. 2002
    ..When purified by immunoprecipitation, the PdeD-YFP fusion protein displayed cGMP-PDE activity, which was retained in a truncated construct that contained only the metallo-beta-lactamase domain...
  25. ncbi request reprint Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum
    David K Muhia
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom
    J Biol Chem 278:22014-22. 2003
    ....
  26. ncbi request reprint Multiple signalling pathways connect chemoattractant receptors and calcium channels in Dictyostelium
    Thomas Nebl
    Department of Microbiology, La Trobe University, Bundoora, Victoria 3083, Australia
    J Muscle Res Cell Motil 23:853-65. 2002
    ....
  27. ncbi request reprint Expression of a family of expansin-like proteins during the development of Dictyostelium discoideum
    Catherine P Darley
    FEBS Lett 546:416-8. 2003