Research Topics
| Glenis K ScaddingSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Comparison of medical and surgical treatment of nasal polyposisGlenis K Scadding
The Royal National Throat, Nose and Ear Hospital, Gray s Inn Road, London WC1 X 8DA, UK
Curr Allergy Asthma Rep 2:494-9. 2002..No cost-benefit analysis has been undertaken in this area, although medical therapy is probably cheaper and involves less work/school absence than sinonasal surgery, even when the latter is performed with an endoscope...- Recent advances in the treatment of rhinitis and rhinosinusitisG K Scadding
Royal National TNE Hospital, Grays Inn Road, London WC1 X8D, UK
Int J Pediatr Otorhinolaryngol 67:S201-4. 2003..The role of antihistamines, topical corticosteroids and anti-leukotrienes is discussed... - Intranasal lysine-aspirin in aspirin-sensitive nasal polyposis: a controlled trialAbhi A Parikh
St Mary s Hospital, Praed Street, London W2 1NY, UK
Laryngoscope 115:1385-90. 2005..However, the studies are limited in number, and their design is open to criticisms. Thus, we conducted a controlled trial to study the clinical effectiveness of topical lysine-aspirin in patients with aspirin-sensitive nasal polyposis... - Optimal management of nasal congestion caused by allergic rhinitis in children: safety and efficacy of medical treatmentsGlenis Scadding
Royal National Throat Nose and Ear Hospital, London, UK
Paediatr Drugs 10:151-62. 2008..Other treatments, such as a nasal antihistamine, decongestants, and immunotherapy, present varying levels of safety and tolerability issues in children... - The burden of allergic rhinitis as reported by UK patients compared with their doctorsGlenis K Scadding
Royal National Throat, Nose and Ear Hospital, London, UK
Rhinology 46:99-106. 2008..Overall, there was a poor correlation between patients and physicians in the reporting of disease severity... 
Poor asthma control?--then look up the nose. The importance of co-morbid rhinitis in patients with asthmaGlenis Scadding
The Royal National Throat, Nose and Ear Hospital, London, UK
Prim Care Respir J 21:222-8. 2012..This article reviews briefly the evidence for the link between asthma and rhinitis, advocates looking for rhinitis when patients present with poorly controlled asthma, and provides guidance for the diagnosis and treatment of rhinitis...- Nitric oxide in the airwaysGlenis Scadding
Royal National TNE Hospital, London, UK
Curr Opin Otolaryngol Head Neck Surg 15:258-63. 2007..This review briefly explains the basic facts about nitric oxide, which is entering clinical practice as a measure of lower airways inflammation and is likely also to be employed in otorhinolaryngological practice... - Patient and physician perspectives on the impact and management of perennial and seasonal allergic rhinitisG K Scadding
Royal National Throat Nose and Ear Hospital, London and Respiratory Therapeutic Development and Global Health Outcomes Research, GlaxoWellcome plc, Uxbridge, UK
Clin Otolaryngol Allied Sci 25:551-7. 2000..Adherence to current guidelines on the management of rhinitis could lead to an effective, structured treatment plan for patients... - Fluticasone furoate nasal spray consistently and significantly improves both the nasal and ocular symptoms of seasonal allergic rhinitis: a review of the clinical dataGlenis K Scadding
Royal National Throat, Nose and Ear Hospital, Rhinology Department, 330 Grey s Inn Road, London WC1X 8DA, UK
Expert Opin Pharmacother 9:2707-15. 2008..Until recently, efficacy against the ocular symptoms of AR has been inconsistent for any single intranasal corticosteroid (INS). Fluticasone furoate is an enhanced-affinity glucocorticoid with potent anti-inflammatory activity... - Pediatric allergy medications: review of currently available formulationsGlenis Scadding
Royal National Throat Nose and Ear Hospital, London WC1X 8DA, UK
Curr Med Res Opin 25:2069-79. 2009..Allergic rhinitis (AR), one form of allergy, causes considerable impairment in quality of life, including disruption of sleep and, in children, interference with school attendance and performance... - Update on the use of nitric oxide as a noninvasive measure of airways inflammationGuy Scadding
Department of Allergy and Clinical Immunology, Royal Brompton Hospital, London, United Kingdom
Rhinology 47:115-20. 2009..Further research is aimed at investigating the role of nitric oxide in allergic rhinitis and nasal congestion. Measuring both bronchial and nasal nitric oxide may assist the combined management of upper and lower airways... - Audit of nasal steroid use and effectiveness in a rhinitis clinicGlenis Scadding
Royal National Throat, Nose and Ear Hospital, Gray s Inn Road, London, UK
Expert Rev Pharmacoecon Outcomes Res 10:87-90. 2010..The effectiveness of intranasal steroids in the real world has not been assessed... - Non-surgical treatment of adenoidal hypertrophy: the role of treating IgE-mediated inflammationGlenis Scadding
Royal National Throat Nose and Ear Hospital, London, UK
Pediatr Allergy Immunol 21:1095-106. 2010..Current treatment options are briefly considered with discussion on the rationale and evidence for the use of INS... - Further marches: allergic and non-allergicG K Scadding
RNTNE Hospital, London, UK
Clin Exp Allergy 37:485-7. 2007 - Medical management of chronic rhinosinusitisGlenis K Scadding
Royal National Throat, Nose and Ear Hospital, Grays Inn Road, London WC1X 8DA, UK
Immunol Allergy Clin North Am 24:103-18. 2004 - Non-allergic rhinitis: diagnosis and managementG K Scadding
Clinical Immunology and Rhinology, Royal National Throat, Nose and Ear Hospital, London, UK
Curr Opin Allergy Clin Immunol 1:15-20. 2001..A complex inter-relationship between allergic and infectious rhinitis is becoming apparent... - SQ-standardized sublingual grass immunotherapy: confirmation of disease modification 2 years after 3 years of treatment in a randomized trialStephen R Durham
Section of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London, United Kingdom
J Allergy Clin Immunol 129:717-725.e5. 2012..The main aim of specific immunotherapy is sustained effect due to changes in the immune system that can be demonstrated only in long-term trials... - Recent advances in antileukotriene therapyGuy W Scadding
Department of Allergy and Clinical Immunology, Imperial College, London, UK
Curr Opin Allergy Clin Immunol 10:370-6. 2010..This review discusses recent advances concerning the molecular mechanisms of antileukotrienes as well as their efficacy in various clinical scenarios and patient groups... - Allergic rhinitis: background, symptoms, diagnosis and treatment optionsGlenis K Scadding
Royal National Throat, Nose and Ear Hospital, London
Nurs Times 105:24-7. 2009..This one-part unit outlines the symptoms, diagnosis and various treatment options for allergic rhinitis. It also highlights nurses' roles in the management of this common condition... - Topical corticosteroids in chronic rhinosinusitis: a randomized, double-blind, placebo-controlled trial using fluticasone propionate aqueous nasal sprayA Parikh
Royal National Throat, Nose, and Ear Hospital, London, UK
Rhinology 39:75-9. 2001..There is compelling evidence that topical corticosteroids down-regulate cytokine expression, and it is likely that a larger, and longer multi-centre trial may prove their efficacy in CRS... - Should intranasal corticosteroids be used for the treatment of ocular symptoms of allergic rhinoconjunctivitis? A review of their efficacy and safety profileSue Lightman
Institute of Ophthalmology, University College London, and Moorfields Eye Hospital, London, UK
Int Arch Allergy Immunol 158:317-25. 2012..There are limited data on ocular safety with INSs. However, the literature supports the use of INSs over several months as there appears to be no considerable increase in the risk of ocular hypertension or glaucoma... - Atopic myelitis in a European woman residing in JapanJeremy D Isaacs
National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
J Neurol Neurosurg Psychiatry 82:1022-4. 2011..Further studies are required to fully elucidate the relationship between atopy and the incidence and severity of CNS inflammatory disorders... - An open audit of montelukast, a leukotriene receptor antagonist, in nasal polyposis associated with asthmaS Ragab
Royal National Throat, Nose and Ear Hospital, London, UK
Clin Exp Allergy 31:1385-91. 2001..It can be difficult to treat effectively, even with surgery and regular topical intranasal corticosteroids many patients are still symptomatic... - BSACI guidelines for the management of rhinosinusitis and nasal polyposisG K Scadding
The Royal National Throat Nose and Ear Hospital, Gray s Inn Road, London, UK
Clin Exp Allergy 38:260-75. 2008..Further well conducted trials in clearly defined patient groups are needed to improve management... - Introduction: allergic rhinitisG K Scadding
Royal National Throat, Nose and Ear Hospital, London, UK
Allergy 62:3-5. 2007 - Corticosteroids in the treatment of pediatric allergic rhinitisG K Scadding
Royal National Throat, Nose and Ear Hospital, London, United Kingdom
J Allergy Clin Immunol 108:S59-64. 2001..Intranasal MF is available with once-daily dosing, which has the potential to decrease systemic side effects... - High levels of nitric oxide synthase activity are associated with nasal polyp tissue from aspirin-sensitive asthmaticsA Parikh
Royal National Throat, Nose, and Ear Hospital, London, UK
Acta Otolaryngol 122:302-5. 2002..004; one-way ANOVA). This finding does not correlate simply with disease severity or with the occurrence of asthma and could indicate another important facet of aspirin-induced airways disease... - BSACI guidelines for the management of allergic and non-allergic rhinitisG K Scadding
The Royal National Throat Nose and Ear Hospital, Gray s Inn Road, London, UK
Clin Exp Allergy 38:19-42. 2008..There are also special sections for children, co-morbid associations and pregnancy. Finally, we have made recommendations for potential areas of future research... - Allergic rhinitis: helping doctors to make better decisions?Glenis K Scadding
Prim Care Respir J 16:261. 2007 - A community based questionnaire study on the association between symptoms suggestive of otitis media with effusion, rhinitis and asthma in primary school childrenDolores Umapathy
Audiological Medicine, Bolton PCT NHS Trust, Halliwell Child Development Centre, Aylesford Walk, Bolton BL1 3SQ, United Kingdom
Int J Pediatr Otorhinolaryngol 71:705-12. 2007.... - Amphotericin B nasal lavages: not a solution for patients with chronic rhinosinusitisFenna A Ebbens
Department of Otorhinolaryngology, Head and Neck Surgery, Academic Medical Center, Amsterdam, The Netherlands
J Allergy Clin Immunol 118:1149-56. 2006..On the basis of this hypothesis, intranasal treatment with amphotericin B should benefit patients with CRS. Data from 2 uncontrolled and 2 controlled trials are conflicting, however... - Peak nasal inspiratory flow; normal range in adult populationGiancarlo Ottaviano
Department of Otolaryngology, Head and Neck Surgery, University of Padua, Padua, Italy
Rhinology 44:32-5. 2006..The study provides normative data for a Caucasian population. Further variables need to be explored to predict expected PNIF values more accurately...