Avan Aihie Sayer

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. pmc New horizons in the pathogenesis, diagnosis and management of sarcopenia
    Avan Aihie Sayer
    Academic Geriatric Medicine, University of Southampton, Southampton, UK
    Age Ageing 42:145-50. 2013
  2. doi Is grip strength a good marker of physical performance among community-dwelling older people?
    P J Stevens
    Academic Geriatric Medicine, School of Medicine, University of Southampton, UK
    J Nutr Health Aging 16:769-74. 2012
  3. pmc Randomized controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial
    Francis M Finucane
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    BMC Endocr Disord 9:15. 2009
  4. ncbi Do all systems age together?
    A Aihie Sayer
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Gerontology 45:83-6. 1999
  5. ncbi Fetal programming of body composition and musculoskeletal development
    Avan Aihie Sayer
    Geriatric Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK
    Early Hum Dev 81:735-44. 2005
  6. ncbi Type 2 diabetes, muscle strength, and impaired physical function: the tip of the iceberg?
    Avan Aihie Sayer
    Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton, UK
    Diabetes Care 28:2541-2. 2005
  7. pmc The developmental origins of sarcopenia: using peripheral quantitative computed tomography to assess muscle size in older people
    Avan Aihie Sayer
    MRC Epidemiology Resource Centre, Southampton General Hospital, Southampton, United Kingdom
    J Gerontol A Biol Sci Med Sci 63:835-40. 2008
  8. ncbi Is grip strength associated with health-related quality of life? Findings from the Hertfordshire Cohort Study
    Avan Aihie Sayer
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK
    Age Ageing 35:409-15. 2006
  9. pmc Falls, sarcopenia, and growth in early life: findings from the Hertfordshire cohort study
    Avan Aihie Sayer
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, United Kingdom
    Am J Epidemiol 164:665-71. 2006
  10. ncbi Early life effects on aging
    Avan Aihie Sayer
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Nestle Nutr Workshop Ser Clin Perform Programme 6:33-44; discussion 44-8. 2002

Collaborators

Detail Information

Publications56

  1. pmc New horizons in the pathogenesis, diagnosis and management of sarcopenia
    Avan Aihie Sayer
    Academic Geriatric Medicine, University of Southampton, Southampton, UK
    Age Ageing 42:145-50. 2013
    ....
  2. doi Is grip strength a good marker of physical performance among community-dwelling older people?
    P J Stevens
    Academic Geriatric Medicine, School of Medicine, University of Southampton, UK
    J Nutr Health Aging 16:769-74. 2012
    ..As muscle strength is central to physical performance, we explored whether grip strength could be used as a marker of the Short Physical Performance Battery...
  3. pmc Randomized controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial
    Francis M Finucane
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    BMC Endocr Disord 9:15. 2009
    ..TRIAL REGISTRATION: Current Controlled Trials: ISRCTN60986572...
  4. ncbi Do all systems age together?
    A Aihie Sayer
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Gerontology 45:83-6. 1999
    ..Aging changes in different body system are well described, but few studies have considered the relationship between them...
  5. ncbi Fetal programming of body composition and musculoskeletal development
    Avan Aihie Sayer
    Geriatric Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK
    Early Hum Dev 81:735-44. 2005
    ..The next stage is translation of these findings into testable preventive strategies to maintain optimum body composition and minimize the risk of obesity, sarcopenia and osteoporosis in later life...
  6. ncbi Type 2 diabetes, muscle strength, and impaired physical function: the tip of the iceberg?
    Avan Aihie Sayer
    Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton, UK
    Diabetes Care 28:2541-2. 2005
  7. pmc The developmental origins of sarcopenia: using peripheral quantitative computed tomography to assess muscle size in older people
    Avan Aihie Sayer
    MRC Epidemiology Resource Centre, Southampton General Hospital, Southampton, United Kingdom
    J Gerontol A Biol Sci Med Sci 63:835-40. 2008
    ..A number of studies have shown strong graded positive relationships between size at birth, grip strength, and estimates of muscle mass in older people. However no studies to date have included direct measures of muscle size...
  8. ncbi Is grip strength associated with health-related quality of life? Findings from the Hertfordshire Cohort Study
    Avan Aihie Sayer
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK
    Age Ageing 35:409-15. 2006
    ..to investigate the relationship between grip strength and health-related quality of life (HRQoL)...
  9. pmc Falls, sarcopenia, and growth in early life: findings from the Hertfordshire cohort study
    Avan Aihie Sayer
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, United Kingdom
    Am J Epidemiol 164:665-71. 2006
    ..The lack of a relation with birth weight suggests that postnatal rather than prenatal influences on muscle growth and development may be important regarding the risk of falls in later life...
  10. ncbi Early life effects on aging
    Avan Aihie Sayer
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Nestle Nutr Workshop Ser Clin Perform Programme 6:33-44; discussion 44-8. 2002
  11. ncbi Does sarcopenia originate in early life? Findings from the Hertfordshire cohort study
    Avan Aihie Sayer
    MRC Environmental Epidemiology Unit, University of Southampton, UK
    J Gerontol A Biol Sci Med Sci 59:M930-4. 2004
    ..Our objective was to investigate the relationship between birth weight, infant growth, and the development of sarcopenia...
  12. ncbi Birth weight, weight at 1 y of age, and body composition in older men: findings from the Hertfordshire Cohort Study
    Avan Aihie Sayer
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southamption, United Kingdom
    Am J Clin Nutr 80:199-203. 2004
    ..However, body mass index also reflects fat-free mass, and few studies have examined the relation between size in early life and direct measures of body composition in older people...
  13. ncbi Prenatal exposure to a maternal low protein diet shortens life span in rats
    A Aihie Sayer
    MRC Environmental Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton General Hospital, Southampton, UK
    Gerontology 47:9-14. 2001
    ..It remains unclear whether life span is similarly adversely affected by early diet restriction...
  14. ncbi Early diet and growth: impact on ageing
    A Aihie Sayer
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Proc Nutr Soc 61:79-85. 2002
    ..A new cohort of subjects aged between 60 and 70 years is being established to investigate how genetic factors interact with growth and nutritional influences to programme musculo-skeletal ageing in later life...
  15. pmc Grip strength and the metabolic syndrome: findings from the Hertfordshire Cohort Study
    A A Sayer
    MRC Epidemiology Resource Centre, University of Southampton, Southampton SO16 6YD, UK
    QJM 100:707-13. 2007
    ..Sarcopenia, the loss of muscle mass and strength with age, is significantly associated with type 2 diabetes in older people...
  16. ncbi Polymorphism of the IGF2 gene, birth weight and grip strength in adult men
    Avan Aihie Sayer
    MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton SO16 6YD, UK
    Age Ageing 31:468-70. 2002
    ..IGF II has proliferative effects in adult muscle and is one of the major determinants of fetal growth; polymorphism in the IGF2 gene could therefore link early growth to adult grip strength...
  17. ncbi Are rates of ageing determined in utero?
    A A Sayer
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton S016 6YD, UK
    Age Ageing 27:579-83. 1998
    ..The long-term effects of poor early nutrition on ageing have been demonstrated in animals but not studied in man...
  18. ncbi Weight from birth to 53 years: a longitudinal study of the influence on clinical hand osteoarthritis
    A Aihie Sayer
    University of Southampton, UK
    Arthritis Rheum 48:1030-3. 2003
    ..To determine the influence of body weight throughout the life course on the development of clinical hand osteoarthritis (OA)...
  19. pmc Diet and its relationship with grip strength in community-dwelling older men and women: the Hertfordshire cohort study
    Sian M Robinson
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, United Kingdom
    J Am Geriatr Soc 56:84-90. 2008
    ..To examine relationships between diet and grip strength in older men and women and to determine whether prenatal growth modifies these relationships...
  20. pmc Social inequalities in osteoporosis and fracture among community-dwelling older men and women: findings from the Hertfordshire Cohort Study
    Holly E Syddall
    MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton SO16 6YD, UK
    Arch Osteoporos 7:37-48. 2012
    ..Public health strategies for prevention of osteoporosis should focus on the whole population...
  21. pmc Type of milk feeding in infancy and health behaviours in adult life: findings from the Hertfordshire Cohort Study
    Sian Robinson
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Br J Nutr 109:1114-22. 2013
    ..009), such that higher scores were associated with having been breastfed. These data support experimental findings which suggest that early dietary exposures can have lifelong influences on food choice...
  22. doi Social inequalities in grip strength, physical function, and falls among community dwelling older men and women: findings from the Hertfordshire Cohort Study
    Holly Syddall
    Epidemiology Resource Centre, University of Southampton, Southhampton General Hospital, Southhampton SO16 6YD, UK
    J Aging Health 21:913-39. 2009
    ..01). Discussion. There are social inequalities in grip strength, PF, and falls among older people. Interventions should consider the contribution of social inequalities to the problem...
  23. ncbi Combined effects of dietary fat and birth weight on serum cholesterol concentrations: the Hertfordshire Cohort Study
    Sian M Robinson
    Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Am J Clin Nutr 84:237-44. 2006
    ....
  24. doi A study of relationships between single nucleotide polymorphisms from the growth hormone-insulin-like growth factor axis and bone mass: the Hertfordshire cohort study
    Elaine M Dennison
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, England, UK
    J Rheumatol 36:1520-6. 2009
    ....
  25. doi A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach
    Helen C Roberts
    Academic Geriatric Medicine, University of Southampton, UK
    Age Ageing 40:423-9. 2011
    ..Grip strength is recommended as a good simple measure of muscle strength when 'measured in standard conditions'. However, standard conditions remain to be defined...
  26. doi Muscle strength in older community-dwelling men is related to type of milk feeding in infancy
    Sian M Robinson
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    J Gerontol A Biol Sci Med Sci 67:990-6. 2012
    ..Muscle growth in the neonatal period may be very sensitive to variations in early nutrition, but little is known about long-term effects of infant feeding on muscle strength...
  27. ncbi Grip strength, body composition, and mortality
    Catharine R Gale
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
    Int J Epidemiol 36:228-35. 2007
    ..We investigated the relation between grip strength, body composition, and cause-specific and total mortality in 800 men and women aged 65 and over...
  28. pmc Symptoms of anxiety or depression and risk of fracture in older people: the Hertfordshire Cohort Study
    Catharine R Gale
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK
    Arch Osteoporos 7:59-65. 2012
    ..Results showed that men, but not women, with probable anxiety at baseline had an increased risk of fracture...
  29. doi Current patterns of diet in community-dwelling older men and women: results from the Hertfordshire Cohort Study
    Sian Robinson
    The MRC Epidemiology Resource Centre, University of Southampton, MRC Epidemiology Resource Centre, Southampton General Hospital Mailpoint 95, Southampton SO16 6YD, UK
    Age Ageing 38:594-9. 2009
    ..Little is known about the dietary patterns of older adults in the UK...
  30. ncbi Null mutation in human ciliary neurotrophic factor gene confers higher body mass index in males
    Sandra D O'Dell
    Division of Human Genetics, University of Southampton School of Medicine, Duthie Building MP 808, Southampton General Hospital, Tremona Road, Southampton S016 6YD, UK
    Eur J Hum Genet 10:749-52. 2002
    ..03, 2 df) and 3 kg/m(2) greater BMI (P=0.02, 2 df). There was no effect in women. The CNTF G>A null mutation therefore confers a moderate effect on obesity in males of A/A genotype, who represent 1% of the general population...
  31. ncbi Specific associations of insulin resistance with impaired health-related quality of life in the Hertfordshire Cohort Study
    Wolff Schlotz
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Qual Life Res 16:429-36. 2007
    ..The results indicate that insulin resistance is associated with poor HRQoL in domains of physical health, but not in domains of mental health...
  32. pmc Growth in early life predicts bone strength in late adulthood: the Hertfordshire Cohort Study
    Helen Oliver
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Bone 41:400-5. 2007
    ..008), and trabecular (p=0.0001) BMD. We have shown that growth in early life is associated with bone size and strength in a UK population aged 65-73 years. Lifestyle factors were associated with volumetric bone density in this population...
  33. pmc Hertfordshire sarcopenia study: design and methods
    Harnish P Patel
    Academic Geriatric Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    BMC Geriatr 10:43. 2010
    ....
  34. ncbi Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster
    Ian N M Day
    Human Genetics Division, Duthie Building Mp808, Tremona Road, School of Medicine, Southampton University Hospital, Southampton, United Kingdom SO16 6YD
    J Clin Endocrinol Metab 89:5569-76. 2004
    ..GH-CSH genotype adds substantially to, but does not account for, the associations between low body weight, at birth and in infancy, and the metabolic syndrome...
  35. ncbi Age-associated changes in hand grip and quadriceps muscle strength ratios in healthy adults
    Dinesh Samuel
    Faculty of Health Sciences, University of Southampton, Highfield, UK
    Aging Clin Exp Res 24:245-50. 2012
    ..This information is difficult to capture through a single measure. The present study therefore aimed to characterize the relative changes in handgrip and lower limb muscle strength with aging by expressing them as a ratio...
  36. pmc Associations between grip strength of parents and their 4-year-old children: findings from the Southampton Women's Survey
    Hazel Inskip
    MRC Lifecourse Epidemiology Unit, University of Southampton, UK
    Paediatr Perinat Epidemiol 26:27-33. 2012
    ..This contributes to our understanding of the role of heritable and environmental factors on early muscle growth and development, which are important for muscle function across the life course...
  37. doi Neighbourhood environment and positive mental health in older people: the Hertfordshire Cohort Study
    Catharine R Gale
    MRC Lifecourse Epidemiology Unit, University of Southampton, UK
    Health Place 17:867-74. 2011
    ..How older people feel about their neighbourhood may be important for positive mental health in later life...
  38. ncbi Patterns of interphalangeal hand joint involvement of osteoarthritis among men and women: a British cohort study
    Jason Poole
    Southampton General Hospital, University of Southampton, Southampton, UK
    Arthritis Rheum 48:3371-6. 2003
    ..To characterize the pattern of involvement of osteoarthritis (OA) of the hand among men and women of the same age...
  39. doi The structure of the Hospital Anxiety and Depression Scale in four cohorts of community-based, healthy older people: the HALCyon program
    Catharine R Gale
    MRC Epidemiology Resource Centre, University of Southampton, Southampton SO16 6YD, UK
    Int Psychogeriatr 22:559-71. 2010
    ..The Hospital Anxiety and Depression Scale (HADS) is widely used but evaluation of its psychometric properties has produced equivocal results. Little is known about its structure in non-clinical samples of older people...
  40. pmc Lower maternal body condition during pregnancy affects skeletal muscle structure and glut-4 protein levels but not glucose tolerance in mature adult sheep
    Paula M Costello
    Institute of Developmental Sciences, University of Southampton, Southampton, UK
    Reprod Sci 20:1144-55. 2013
    ..However, such adaptations may lead to complications in metabolic control in an overabundant postnatal nutrient environment. ..
  41. doi Markers of inflammatory status are associated with hearing threshold in older people: findings from the Hertfordshire Ageing Study
    Carl Anton Verschuur
    Hearing and Balance Centre, Institute of Sound and Vibration Research, University of Southampton, Highfield, Southampton SO17 1BJ, UK
    Age Ageing 41:92-7. 2012
    ..Age-related hearing loss is a common disabling condition but its causes are not well understood and the role of inflammation as an influencing factor has received little consideration in the literature...
  42. pmc Readiness of elders to use assistive devices to maintain their independence in the home
    Helen Pain
    MRC Epidemiology Resource Centre, Southampton General Hospital, Southampton SO16 6YD, UK
    Age Ageing 36:465-7. 2007
  43. pmc Maternal antenatal vitamin D status and offspring muscle development: findings from the Southampton Women's Survey
    Nicholas C Harvey
    Medical Research Council Lifecourse Epidemiology Unit N C H, R J M, A A S, G N, S M R, K M G, H M I, C C, University of Southampton, Southampton SO16 6YD, United Kingdom National Institute for Health Research Southampton Biomedical Research Centre N C H, K M G, C C, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton SO16 6YD, United Kingdom Paediatric Endocrinology R J M, J H D, University Hospital Southampton National Health Service Foundation Trust, Southampton SO16 6YD, United Kingdom and National Institute for Health Research Musculoskeletal Biomedical Research Unit M K J, C C, University of Oxford, Nuffield Orthopedic Centre, Headington, Oxford OX3 7HE, United Kingdom
    J Clin Endocrinol Metab 99:330-7. 2014
    ..Vitamin D has also been implicated in postnatal muscle function, but little is known about a role for antenatal 25(OH)D exposure in programming muscle development...
  44. pmc Muscle size, strength, and physical performance and their associations with bone structure in the Hertfordshire Cohort Study
    Mark H Edwards
    MRC Lifecourse Epidemiology Unit, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
    J Bone Miner Res 28:2295-304. 2013
    ....
  45. ncbi The feasibility and acceptability of muscle biopsy in epidemiological studies: findings from the Hertfordshire Sarcopenia Study (HSS)
    Harnish Patel
    Academic Geriatric Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    J Nutr Health Aging 15:10-5. 2011
    ..Our aim was to ascertain the feasibility and acceptability of obtaining muscle tissue from healthy older people in order to ultimately identify cellular mechanisms underlying life course influences on sarcopenia...
  46. ncbi A study of mitochondrial DNA mutations in peripheral lymphocytes in an aging cohort
    B Zhang
    Human Genetics Division, School of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, U K
    Biochem Soc Trans 31:444-6. 2003
    ..Implications for tissue and population prevalence are discussed. The mitochondrial long-PCR DNA banks established will be useful for a wide range of studies of somatic mutation and of germline haplotypes in relation to aging...
  47. doi Grip strength and its determinants among older people in different healthcare settings
    Helen C Roberts
    Academic Geriatric Medicine, University of Southampton, Mailpoint 807 Southampton General Hospital Tremona Road, Shirley, Southampton, Hants SO16 6YD, UK
    Age Ageing 43:241-6. 2014
    ..It is well described in community-dwelling older people, but the epidemiology of grip strength of older people in rehabilitation or long-term care has been little explored...
  48. pmc Inflammatory markers and incident frailty in men and women: the English Longitudinal Study of Ageing
    Catharine R Gale
    MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton, SO16 6YD, UK
    Age (Dordr) 35:2493-501. 2013
    ..High concentrations of the inflammatory markers CRP and fibrinogen are more strongly predictive of incident frailty in women than in men. Further research is needed to understand the mechanisms underlying this sex difference...
  49. pmc Southampton Mealtime Assistance Study: design and methods
    Helen C Roberts
    Academic Geriatric Medicine, University of Southampton, Southampton General Hospital, Southampton, Hampshire, UK
    BMC Geriatr 13:5. 2013
    ..This study aims to evaluate the effectiveness of using trained volunteer mealtime assistants to help patients on an acute medical ward for older people at mealtimes...
  50. doi A systematic review of the use of volunteers to improve mealtime care of adult patients or residents in institutional settings
    Sue M Green
    School of Health Sciences, University of Southampton, Southampton, UK
    J Clin Nurs 20:1810-23. 2011
    ..The objective of this review was to locate and assess the evidence obtained from articles reporting empirical research that volunteers improve mealtime care of adults in institutional settings...
  51. pmc Peri-implantation and late gestation maternal undernutrition differentially affect fetal sheep skeletal muscle development
    Paula M Costello
    Institute of Developmental Sciences, Developmental Origins of Health and Disease Division, MP 887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    J Physiol 586:2371-9. 2008
    ..However, together these adaptations may influence the risk of later metabolic disease and thus our findings have implications for future strategies aimed at improving maternal diet...
  52. ncbi Nurse-led implementation of the single assessment process in primary care: a descriptive feasibility study
    Helen C Roberts
    University of Southampton, Elderly Care Research Unit, University Department of Geriatric Medicine, Southampton, UK
    Age Ageing 35:394-8. 2006
    ..to determine the resources required to carry out the single assessment process in primary care...
  53. ncbi Prevalence and functionality of paucimorphic and private MC4R mutations in a large, unselected European British population, scanned by meltMADGE
    Khalid K Alharbi
    Human Genetics Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Hum Mutat 28:294-302. 2007
    ....
  54. pmc Association of diarrhoea in childhood with blood pressure and coronary heart disease in older age: analyses of two UK cohort studies
    G David Batty
    MRC Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK
    Int J Epidemiol 36:1349-55. 2007
    ..We examined if episodes of diarrhoea in childhood, a recognized proxy for acute dehydration, were related to measured blood pressure and coronary heart disease in older adults...
  55. ncbi Developmental origins of midlife physical performance: evidence from a British birth cohort
    Diana Kuh
    Medical Research Council National Survey of Health and Development, Department of Epidemiology and Public Health, Royal Free and University College London Medical School, UK
    Am J Epidemiol 164:110-21. 2006
    ..This study is the first to show that childhood growth and development affect midlife performance; prevention of disability and frailty in later life may need to start early...
  56. ncbi Insulin-like growth factor-I genotype and birthweight
    Ian N M Day
    Lancet 360:945; author reply 945-6. 2002