Mark K Saville

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi request reprint Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo
    Mark K Saville
    Cancer Research UK, Cell Transformation Research Group, Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    J Biol Chem 279:42169-81. 2004
  2. pmc The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2
    Lauren F Stevenson
    CR UK Cell Transformation Research Group, Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    EMBO J 26:976-86. 2007
  3. pmc Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53
    Saurabh Dayal
    CR UK Cell Transformation Research Group, Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland
    J Biol Chem 284:5030-41. 2009
  4. ncbi request reprint Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity
    Dimitris P Xirodimas
    University of Dundee, Ninewells Hospital and Medical School, Department of Surgery and Molecular Oncology, Dundee DD1 9SY, UK
    Cell 118:83-97. 2004
  5. pmc p53 isoforms can regulate p53 transcriptional activity
    Jean Christophe Bourdon
    Department of Surgery, Cancer Research UK Cell Transformation Research Group, University of Dundee, Ninewells Hospital, Scotland, UK
    Genes Dev 19:2122-37. 2005
  6. ncbi request reprint p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase
    Yvonne L Woods
    CR UK Cell Transformation Research Group, Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, Ninewells Avenue, Dundee DD1 9SY, UK
    J Biol Chem 279:50157-66. 2004
  7. doi request reprint Targeting the ubiquitin-proteasome system to activate wild-type p53 for cancer therapy
    Nerea Allende-Vega
    CR UK Cell Transformation Research Group, Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom
    Semin Cancer Biol 20:29-39. 2010
  8. ncbi request reprint B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107
    Manel Joaquin
    Ludwig Institute for Cancer Research, Section of Virology and Cell Biology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Norfolk Place, London W2 1PG, UK
    Oncogene 21:7923-32. 2002
  9. pmc Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules
    Lidia M Duncan
    Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, UK
    EMBO J 25:1635-45. 2006

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo
    Mark K Saville
    Cancer Research UK, Cell Transformation Research Group, Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    J Biol Chem 279:42169-81. 2004
    ....
  2. pmc The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2
    Lauren F Stevenson
    CR UK Cell Transformation Research Group, Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    EMBO J 26:976-86. 2007
    ..Our data identify the deubiquitinating enzyme USP2a as a novel regulator of the p53 pathway that acts through its ability to selectively target Mdm2...
  3. pmc Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53
    Saurabh Dayal
    CR UK Cell Transformation Research Group, Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland
    J Biol Chem 284:5030-41. 2009
    ..These differences could be exploited therapeutically. Our study reveals a novel mechanism for regulation of p53 and identifies USP5 as a potential target for p53 activating therapeutic agents for the treatment of cancer...
  4. ncbi request reprint Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity
    Dimitris P Xirodimas
    University of Dundee, Ninewells Hospital and Medical School, Department of Surgery and Molecular Oncology, Dundee DD1 9SY, UK
    Cell 118:83-97. 2004
    ....
  5. pmc p53 isoforms can regulate p53 transcriptional activity
    Jean Christophe Bourdon
    Department of Surgery, Cancer Research UK Cell Transformation Research Group, University of Dundee, Ninewells Hospital, Scotland, UK
    Genes Dev 19:2122-37. 2005
    ..The differential expression of the p53 isoforms in human tumors may explain the difficulties in linking p53 status to the biological properties and drug sensitivity of human cancer...
  6. ncbi request reprint p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase
    Yvonne L Woods
    CR UK Cell Transformation Research Group, Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, Ninewells Avenue, Dundee DD1 9SY, UK
    J Biol Chem 279:50157-66. 2004
    ..We establish that the ability to promote SUMO conjugation is a general property of the p14 Arf tumor suppressor...
  7. doi request reprint Targeting the ubiquitin-proteasome system to activate wild-type p53 for cancer therapy
    Nerea Allende-Vega
    CR UK Cell Transformation Research Group, Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom
    Semin Cancer Biol 20:29-39. 2010
    ..Here we give an overview of the role of components of the ubiquitin-proteasome system in the regulation of p53 and review progress in targeting these proteins to activate wild-type p53 for the treatment of cancer...
  8. ncbi request reprint B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107
    Manel Joaquin
    Ludwig Institute for Cancer Research, Section of Virology and Cell Biology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Norfolk Place, London W2 1PG, UK
    Oncogene 21:7923-32. 2002
    ..This study defines a novel function of B-Myb and further suggests that the p107 N-terminus provides an interaction domain for transcription factors involved in cell cycle control...
  9. pmc Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules
    Lidia M Duncan
    Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, UK
    EMBO J 25:1635-45. 2006
    ....