John Savill

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint Cell biology. Eat me or die
    John Savill
    MRC Centre for Inflammation Research, University of Edinburgh College of Medicine and Veterinary Medicine, Edinburgh EH8 9AG, UK
    Science 302:1516-7. 2003
  2. ncbi request reprint Corpse clearance defines the meaning of cell death
    J Savill
    University of Edinburgh Medical Research Council Centre for Inflammation Research, Department of Clinical and Surgical Sciences, Internal Medicine, Royal Infirmary, UK
    Nature 407:784-8. 2000
  3. pmc Academic paediatrics: Easter Island or Easter Sunday?
    J Savill
    University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Arch Dis Child 90:441. 2005
  4. ncbi request reprint Regulation of glomerular cell number by apoptosis
    J Savill
    Division of Renal and Inflammatory Disease, School of Medical and Surgical Sciences, University of Nottingham, University Hospital, England, United Kingdom
    Kidney Int 56:1216-22. 1999
  5. ncbi request reprint A blast from the past: clearance of apoptotic cells regulates immune responses
    John Savill
    MRC University of Edinburgh Centre for Inflammation Research, Department of Clinical and Surgical Sciences Internal Medicine, Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW, UK
    Nat Rev Immunol 2:965-75. 2002
  6. ncbi request reprint CD31 delays phagocyte membrane repolarization to promote efficient binding of apoptotic cells
    Elizabeth F Vernon-Wilson
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, UK
    J Leukoc Biol 82:1278-88. 2007
  7. ncbi request reprint Apoptotic PS to phagocyte TIM-4: eat me
    John Savill
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Immunity 27:830-2. 2007
  8. ncbi request reprint Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturation
    Lynda M Stuart
    Medical Research Council Center for Inflammation Research, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    J Immunol 168:1627-35. 2002
  9. ncbi request reprint Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment
    Simon Brown
    Inflammation Repair Group, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, UK
    Nature 418:200-3. 2002
  10. pmc Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells
    M Gray
    Medical Research Council Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Proc Natl Acad Sci U S A 104:14080-5. 2007

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Cell biology. Eat me or die
    John Savill
    MRC Centre for Inflammation Research, University of Edinburgh College of Medicine and Veterinary Medicine, Edinburgh EH8 9AG, UK
    Science 302:1516-7. 2003
  2. ncbi request reprint Corpse clearance defines the meaning of cell death
    J Savill
    University of Edinburgh Medical Research Council Centre for Inflammation Research, Department of Clinical and Surgical Sciences, Internal Medicine, Royal Infirmary, UK
    Nature 407:784-8. 2000
    ..Far from being the end of the story, these clearance events allow scavenger cells to confer meaning upon cell death. But if the phagocytic 'spin doctors' receive or transmit the wrong messages, trouble ensues...
  3. pmc Academic paediatrics: Easter Island or Easter Sunday?
    J Savill
    University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Arch Dis Child 90:441. 2005
  4. ncbi request reprint Regulation of glomerular cell number by apoptosis
    J Savill
    Division of Renal and Inflammatory Disease, School of Medical and Surgical Sciences, University of Nottingham, University Hospital, England, United Kingdom
    Kidney Int 56:1216-22. 1999
    ..This brief review looks at the potentially counterbalancing influences that cause glomerular cells to survive, undergo mitosis, differentiate or die...
  5. ncbi request reprint A blast from the past: clearance of apoptotic cells regulates immune responses
    John Savill
    MRC University of Edinburgh Centre for Inflammation Research, Department of Clinical and Surgical Sciences Internal Medicine, Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW, UK
    Nat Rev Immunol 2:965-75. 2002
    ..Therefore, dead cells, which are a reflection of an organism's immediate past, can control its immunological future...
  6. ncbi request reprint CD31 delays phagocyte membrane repolarization to promote efficient binding of apoptotic cells
    Elizabeth F Vernon-Wilson
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, UK
    J Leukoc Biol 82:1278-88. 2007
    ..Our results identify ERG as a downstream effector of CD31 in the regulation of integrin-dependent binding of apoptotic cells by macrophages...
  7. ncbi request reprint Apoptotic PS to phagocyte TIM-4: eat me
    John Savill
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Immunity 27:830-2. 2007
    ..Now cell and structural studies (Kobayashi et al. [2007] and Santiago et al. [2007] in this issue of Immunity) implicate the type I molecule TIM-4...
  8. ncbi request reprint Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturation
    Lynda M Stuart
    Medical Research Council Center for Inflammation Research, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    J Immunol 168:1627-35. 2002
    ....
  9. ncbi request reprint Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment
    Simon Brown
    Inflammation Repair Group, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, UK
    Nature 418:200-3. 2002
    ....
  10. pmc Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells
    M Gray
    Medical Research Council Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Proc Natl Acad Sci U S A 104:14080-5. 2007
    ..These data demonstrate that AC exert a profound influence on an adaptive immune response through the generation of CD19(+) regulatory B cells, which in turn are able to influence the cytokine profile of antigen-specific effector T cells...
  11. ncbi request reprint Proinflammatory cytokines potentiate thrombospondin-mediated phagocytosis of neutrophils undergoing apoptosis
    Y Ren
    Department of Medicine, University Hospital, Nottingham, UK
    J Immunol 154:2366-74. 1995
    ..Thus, M phi phagocytosis of apoptotic neutrophils can be potentiated by proinflammatory cytokines, suggesting a mechanism for negative feedback control of neutrophil number at inflamed sites...
  12. ncbi request reprint Human glomerular mesangial cell phagocytosis of apoptotic neutrophils: mediation by a novel CD36-independent vitronectin receptor/thrombospondin recognition mechanism that is uncoupled from chemokine secretion
    J Hughes
    Department of Medicine, University Hospital, Nottingham, United Kingdom
    J Immunol 158:4389-97. 1997
    ....
  13. pmc Suppression by apoptotic cells defines tumor necrosis factor-mediated induction of glomerular mesangial cell apoptosis by activated macrophages
    J S Duffield
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    Am J Pathol 159:1397-404. 2001
    ....
  14. ncbi request reprint Phagocytosis triggers macrophage release of Fas ligand and induces apoptosis of bystander leukocytes
    S B Brown
    Division of Renal and Inflammatory Disease, University Hospital, Nottingham, United Kingdom
    J Immunol 162:480-5. 1999
    ....
  15. ncbi request reprint Constitutive death of platelets leading to scavenger receptor-mediated phagocytosis. A caspase-independent cell clearance program
    S B Brown
    Centre for Inflammation Research, Department of Clinical Sciences, Royal Infirmary, Edinburgh, EH3 9YW
    J Biol Chem 275:5987-96. 2000
    ....
  16. ncbi request reprint Cytokines promote glomerular mesangial cell survival in vitro by stimulus-dependent inhibition of apoptosis
    A Mooney
    Department of Medicine, University Hospital, Nottingham, United Kingdom
    J Immunol 159:3949-60. 1997
    ..Finally, the data show that Fas ligation can override cytokine survival signaling, emphasizing a candidate role for this molecule in the undesirable apoptotic loss of mesangial cells during the progression of glomerular scarring...
  17. pmc Resident pleural macrophages are key orchestrators of neutrophil recruitment in pleural inflammation
    Jean Francois Cailhier
    Phagocyte Laboratory, MRC Center for Inflammation Research, University of Edinburgh, Teviot Place, Edinburgh, UK, EH8 9AG
    Am J Respir Crit Care Med 173:540-7. 2006
    ..The role played by resident pleural macrophages in the initiation of pleural inflammation is currently unclear...
  18. ncbi request reprint Apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretion
    Mark Lucas
    University of Edinburgh MRC Center for Inflammation Research, University of Edinburgh, College of Medicine and Veterinary Medicine, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    J Immunol 171:2610-5. 2003
    ....
  19. pmc Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death
    Murray C H Clarke
    Centre for Inflammation Research, Department of Clinical and Surgical Sciences Internal Medicine, Royal Infirmary Edinburgh, Edinburgh EH3 9YW, UK
    J Cell Biol 160:577-87. 2003
    ..Thus, progenitor cell death by apoptosis can result in birth of multiple functional anucleate daughter cells...
  20. ncbi request reprint Requirements for apoptotic cell contact in regulation of macrophage responses
    Mark Lucas
    Medical Research Council University of Edinburgh Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Immunol 177:4047-54. 2006
    ..We conclude that the profound suppression of LPS-driven TNF-alpha release by macrophage populations requires hitherto obscure contact-dependent licensing of macrophage responsiveness to TGF-beta by apoptotic cells...
  21. ncbi request reprint Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo
    Siobhan Mitchell
    Centre for Molecular Inflammation and Vascular Research, Mater Misericordiae Hospital and Department of Medicine and Therapeutics, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
    J Am Soc Nephrol 13:2497-507. 2002
    ....
  22. ncbi request reprint Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype
    Lynda M Stuart
    Laboratory of Developmental Immunology, Harvard Department of Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USA
    J Immunol 174:3220-6. 2005
    ..Moreover, it demonstrates that failure of apoptotic cell clearance can be dissociated from autoimmunity...
  23. ncbi request reprint Phagocytotic removal of apoptotic, inflammatory lymphocytes in the central nervous system by microglia and its functional implications
    Tim Magnus
    Department of Neurology, Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Julius Maximilians University, D 97080, Wurzburg, Germany
    J Neuroimmunol 130:1-9. 2002
    ..In this review, we focus on the mechanisms for removal of apoptotic inflammatory cells by microglia in the central nervous system and their functional consequences...
  24. ncbi request reprint Apoptotic cells protect mice against lipopolysaccharide-induced shock
    Yi Ren
    Department of Surgery, University of Hong Kong, Hong Kong, China
    J Immunol 180:4978-85. 2008
    ..Apoptotic cells may therefore have therapeutic potential for the treatment of septic shock...
  25. ncbi request reprint Resolution of inflammation: the beginning programs the end
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 6:1191-7. 2005
    ..Understanding these and further details of the mechanism required for inflammation resolution may underpin the development of drugs that can resolve inflammatory processes in directed and controlled ways...
  26. ncbi request reprint Apoptosis and glomerulonephritis
    Simon Watson
    Queen s Medical Research Institute, University of Edinburgh MRC Center for Inflammation Research, Edinburgh, UK
    Curr Dir Autoimmun 9:188-204. 2006
    ..Nevertheless, there is strong promise for novel therapies based on new knowledge of apoptosis in GN, especially in regulation of leucocyte clearance from the inflamed glomerulus...
  27. ncbi request reprint The death of human platelets during incubation in citrated plasma involves shedding of CD42b and aggregation of dead platelets
    Paul S Hartley
    MRC Human Genetics Unit, Edinburgh EH4 2XU, UK
    Thromb Haemost 95:100-6. 2006
    ....
  28. pmc Nitric oxide is an important mediator of renal tubular epithelial cell death in vitro and in murine experimental hydronephrosis
    Tiina Kipari
    Phagocyte Laboratory, Medical Research Council Centre for Inflammation Research, The Queen s Medical Research Institute, Edinburgh, Scotland
    Am J Pathol 169:388-99. 2006
    ..These data indicate that nitric oxide is a key mediator of macrophage-directed tubular cell apoptosis in vitro and in vivo and also modulates tubulointerstitial fibrosis...
  29. ncbi request reprint Conditional macrophage ablation demonstrates that resident macrophages initiate acute peritoneal inflammation
    Jean Francois Cailhier
    Phagocyte Laboratory, Medical Research Council Center for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 174:2336-42. 2005
    ..These studies indicate a key role for resident peritoneal Mphi in sensing perturbation to the peritoneal microenvironment and regulating PMN infiltration...
  30. ncbi request reprint Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death
    Joseph H McCarty
    Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17 227, Cambridge, MA 02139, USA
    Development 132:165-76. 2005
    ....