Research Topics
Species | John SavillSummaryAffiliation: University of Edinburgh Country: UK Publications
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Detail Information
Publications
Cell biology. Eat me or dieJohn Savill
MRC Centre for Inflammation Research, University of Edinburgh College of Medicine and Veterinary Medicine, Edinburgh EH8 9AG, UK
Science 302:1516-7. 2003- Corpse clearance defines the meaning of cell deathJ Savill
University of Edinburgh Medical Research Council Centre for Inflammation Research, Department of Clinical and Surgical Sciences, Internal Medicine, Royal Infirmary, UK
Nature 407:784-8. 2000..Far from being the end of the story, these clearance events allow scavenger cells to confer meaning upon cell death. But if the phagocytic 'spin doctors' receive or transmit the wrong messages, trouble ensues... 
Academic paediatrics: Easter Island or Easter Sunday?J Savill
University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
Arch Dis Child 90:441. 2005- Regulation of glomerular cell number by apoptosisJ Savill
Division of Renal and Inflammatory Disease, School of Medical and Surgical Sciences, University of Nottingham, University Hospital, England, United Kingdom
Kidney Int 56:1216-22. 1999..This brief review looks at the potentially counterbalancing influences that cause glomerular cells to survive, undergo mitosis, differentiate or die... - A blast from the past: clearance of apoptotic cells regulates immune responsesJohn Savill
MRC University of Edinburgh Centre for Inflammation Research, Department of Clinical and Surgical Sciences Internal Medicine, Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW, UK
Nat Rev Immunol 2:965-75. 2002..Therefore, dead cells, which are a reflection of an organism's immediate past, can control its immunological future... - CD31 delays phagocyte membrane repolarization to promote efficient binding of apoptotic cellsElizabeth F Vernon Wilson
MRC Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, UK
J Leukoc Biol 82:1278-88. 2007..Our results identify ERG as a downstream effector of CD31 in the regulation of integrin-dependent binding of apoptotic cells by macrophages... - Apoptotic PS to phagocyte TIM-4: eat meJohn Savill
MRC Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
Immunity 27:830-2. 2007..Now cell and structural studies (Kobayashi et al. [2007] and Santiago et al. [2007] in this issue of Immunity) implicate the type I molecule TIM-4... - Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturationLynda M Stuart
Medical Research Council Center for Inflammation Research, University of Edinburgh, Edinburgh, Scotland, United Kingdom
J Immunol 168:1627-35. 2002.... - Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfmentSimon Brown
Inflammation Repair Group, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, UK
Nature 418:200-3. 2002.... - Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cellsM Gray
Medical Research Council Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
Proc Natl Acad Sci U S A 104:14080-5. 2007..These data demonstrate that AC exert a profound influence on an adaptive immune response through the generation of CD19(+) regulatory B cells, which in turn are able to influence the cytokine profile of antigen-specific effector T cells... - Proinflammatory cytokines potentiate thrombospondin-mediated phagocytosis of neutrophils undergoing apoptosisY Ren
Department of Medicine, University Hospital, Nottingham, UK
J Immunol 154:2366-74. 1995..Thus, M phi phagocytosis of apoptotic neutrophils can be potentiated by proinflammatory cytokines, suggesting a mechanism for negative feedback control of neutrophil number at inflamed sites... - Human glomerular mesangial cell phagocytosis of apoptotic neutrophils: mediation by a novel CD36-independent vitronectin receptor/thrombospondin recognition mechanism that is uncoupled from chemokine secretionJ Hughes
Department of Medicine, University Hospital, Nottingham, United Kingdom
J Immunol 158:4389-97. 1997.... - Suppression by apoptotic cells defines tumor necrosis factor-mediated induction of glomerular mesangial cell apoptosis by activated macrophagesJ S Duffield
Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
Am J Pathol 159:1397-404. 2001.... - Phagocytosis triggers macrophage release of Fas ligand and induces apoptosis of bystander leukocytesS B Brown
Division of Renal and Inflammatory Disease, University Hospital, Nottingham, United Kingdom
J Immunol 162:480-5. 1999.... - Constitutive death of platelets leading to scavenger receptor-mediated phagocytosis. A caspase-independent cell clearance programS B Brown
Centre for Inflammation Research, Department of Clinical Sciences, Royal Infirmary, Edinburgh, EH3 9YW
J Biol Chem 275:5987-96. 2000.... - Cytokines promote glomerular mesangial cell survival in vitro by stimulus-dependent inhibition of apoptosisA Mooney
Department of Medicine, University Hospital, Nottingham, United Kingdom
J Immunol 159:3949-60. 1997..Finally, the data show that Fas ligation can override cytokine survival signaling, emphasizing a candidate role for this molecule in the undesirable apoptotic loss of mesangial cells during the progression of glomerular scarring... - Resident pleural macrophages are key orchestrators of neutrophil recruitment in pleural inflammationJean Francois Cailhier
Phagocyte Laboratory, MRC Center for Inflammation Research, University of Edinburgh, Teviot Place, Edinburgh, UK, EH8 9AG
Am J Respir Crit Care Med 173:540-7. 2006..The role played by resident pleural macrophages in the initiation of pleural inflammation is currently unclear... - Apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretionMark Lucas
University of Edinburgh/MRC Center for Inflammation Research, University of Edinburgh, College of Medicine and Veterinary Medicine, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
J Immunol 171:2610-5. 2003.... 
Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent deathMurray C H Clarke
Centre for Inflammation Research, Department of Clinical and Surgical Sciences (Internal Medicine, Royal Infirmary Edinburgh, Edinburgh EH3 9YW, UK
J Cell Biol 160:577-87. 2003..Thus, progenitor cell death by apoptosis can result in birth of multiple functional anucleate daughter cells...- Requirements for apoptotic cell contact in regulation of macrophage responsesMark Lucas
Medical Research Council/University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, United Kingdom
J Immunol 177:4047-54. 2006..We conclude that the profound suppression of LPS-driven TNF-alpha release by macrophage populations requires hitherto obscure contact-dependent licensing of macrophage responsiveness to TGF-beta by apoptotic cells... - Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivoSiobhan Mitchell
Centre for Molecular Inflammation and Vascular Research, Mater Misericordiae Hospital and Department of Medicine and Therapeutics, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
J Am Soc Nephrol 13:2497-507. 2002.... - Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotypeLynda M Stuart
Laboratory of Developmental Immunology, Harvard Department of Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USA
J Immunol 174:3220-6. 2005..Moreover, it demonstrates that failure of apoptotic cell clearance can be dissociated from autoimmunity... - Phagocytotic removal of apoptotic, inflammatory lymphocytes in the central nervous system by microglia and its functional implicationsTim Magnus
Department of Neurology, Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Julius-Maximilians-University, D-97080, , Germany
J Neuroimmunol 130:1-9. 2002..In this review, we focus on the mechanisms for removal of apoptotic inflammatory cells by microglia in the central nervous system and their functional consequences... - Apoptotic cells protect mice against lipopolysaccharide-induced shockYi Ren
Department of Surgery, University of Hong Kong, Hong Kong, China
J Immunol 180:4978-85. 2008..Apoptotic cells may therefore have therapeutic potential for the treatment of septic shock... - Resolution of inflammation: the beginning programs the endCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Immunol 6:1191-7. 2005..Understanding these and further details of the mechanism required for inflammation resolution may underpin the development of drugs that can resolve inflammatory processes in directed and controlled ways... - Apoptosis and glomerulonephritisSimon Watson
Queen's Medical Research Institute, University of Edinburgh/MRC Center for Inflammation Research, Edinburgh, UK
Curr Dir Autoimmun 9:188-204. 2006..Nevertheless, there is strong promise for novel therapies based on new knowledge of apoptosis in GN, especially in regulation of leucocyte clearance from the inflamed glomerulus... - The death of human platelets during incubation in citrated plasma involves shedding of CD42b and aggregation of dead plateletsPaul S Hartley
MRC Human Genetics Unit, Edinburgh EH4 2XU, UK
Thromb Haemost 95:100-6. 2006.... - Nitric oxide is an important mediator of renal tubular epithelial cell death in vitro and in murine experimental hydronephrosisTiina Kipari
Phagocyte Laboratory, Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh, Scotland
Am J Pathol 169:388-99. 2006..These data indicate that nitric oxide is a key mediator of macrophage-directed tubular cell apoptosis in vitro and in vivo and also modulates tubulointerstitial fibrosis... - Conditional macrophage ablation demonstrates that resident macrophages initiate acute peritoneal inflammationJean Francois Cailhier
Phagocyte Laboratory, Medical Research Council Center for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
J Immunol 174:2336-42. 2005..These studies indicate a key role for resident peritoneal Mphi in sensing perturbation to the peritoneal microenvironment and regulating PMN infiltration... - Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature deathJoseph H McCarty
Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17 227, Cambridge, MA 02139, USA
Development 132:165-76. 2005....