Nigel J Savery

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi request reprint The molecular mechanism of transcription-coupled DNA repair
    Nigel J Savery
    DNA Protein Interactions Unit, Department of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
    Trends Microbiol 15:326-33. 2007
  2. pmc The unstructured C-terminal extension of UvrD interacts with UvrB, but is dispensable for nucleotide excision repair
    Laura Manelyte
    DNA Protein Interactions Unit, Department of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
    DNA Repair (Amst) 8:1300-10. 2009
  3. doi request reprint Effects of the bacterial transcription-repair coupling factor during transcription of DNA containing non-bulky lesions
    Abigail J Smith
    DNA Protein Interactions Unit, Department of Biochemistry, University of Bristol, Bristol, UK
    DNA Repair (Amst) 7:1670-9. 2008
  4. pmc Regulation and rate enhancement during transcription-coupled DNA repair
    Laura Manelyte
    DNA Protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
    Mol Cell 40:714-24. 2010
  5. pmc Multipartite control of the DNA translocase, Mfd
    Abigail J Smith
    DNA Protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
    Nucleic Acids Res 40:10408-16. 2012
  6. ncbi request reprint Characterisation of the Escherichia coli mfd promoter
    Louise K Stanley
    Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, BS8 1TD, Bristol, UK
    Arch Microbiol 179:381-5. 2003
  7. pmc Controlling the motor activity of a transcription-repair coupling factor: autoinhibition and the role of RNA polymerase
    Abigail J Smith
    DNA Protein Interactions Unit, Department of Biochemistry, University of Bristol, Bristol, UK
    Nucleic Acids Res 35:1802-11. 2007
  8. pmc Modelling emergence of oscillations in communicating bacteria: a structured approach from one to many cells
    Petros Mina
    Bristol Center for Complexity Sciences, University of Bristol, Bristol, UK
    J R Soc Interface 10:20120612. 2013
  9. pmc DNA cleavage and methylation specificity of the single polypeptide restriction-modification enzyme LlaGI
    Rachel M Smith
    DNA Protein Interactions Unit, Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
    Nucleic Acids Res 37:7206-18. 2009
  10. pmc Determinants of the C-terminal domain of the Escherichia coli RNA polymerase alpha subunit important for transcription at class I cyclic AMP receptor protein-dependent promoters
    Nigel J Savery
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    J Bacteriol 184:2273-80. 2002

Collaborators

Detail Information

Publications12

  1. ncbi request reprint The molecular mechanism of transcription-coupled DNA repair
    Nigel J Savery
    DNA Protein Interactions Unit, Department of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
    Trends Microbiol 15:326-33. 2007
    ..Here I review the key features of this multifunctional protein and discuss how recent mechanistic and structural findings have advanced our understanding of transcription-coupled DNA repair in bacteria...
  2. pmc The unstructured C-terminal extension of UvrD interacts with UvrB, but is dispensable for nucleotide excision repair
    Laura Manelyte
    DNA Protein Interactions Unit, Department of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
    DNA Repair (Amst) 8:1300-10. 2009
    ....
  3. doi request reprint Effects of the bacterial transcription-repair coupling factor during transcription of DNA containing non-bulky lesions
    Abigail J Smith
    DNA Protein Interactions Unit, Department of Biochemistry, University of Bristol, Bristol, UK
    DNA Repair (Amst) 7:1670-9. 2008
    ..Our findings suggest that 8-oxoguanine is unlikely to be directly targeted by the transcription-coupled repair pathway, and identify a potential role for Mfd in reducing the level of transcriptional mutagenesis caused by abasic sites...
  4. pmc Regulation and rate enhancement during transcription-coupled DNA repair
    Laura Manelyte
    DNA Protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
    Mol Cell 40:714-24. 2010
    ....
  5. pmc Multipartite control of the DNA translocase, Mfd
    Abigail J Smith
    DNA Protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
    Nucleic Acids Res 40:10408-16. 2012
    ..Our results indicate that regulation of Mfd occurs through multiple nodes, and that activation of Mfd may be a multi-stage process...
  6. ncbi request reprint Characterisation of the Escherichia coli mfd promoter
    Louise K Stanley
    Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, BS8 1TD, Bristol, UK
    Arch Microbiol 179:381-5. 2003
    ..A canonical sigma(70)-dependent promoter, mfd P1, was responsible for the majority of mfd transcription, and a core region consisting of residues -42 to +5 was sufficient for full activity in rich and minimal media...
  7. pmc Controlling the motor activity of a transcription-repair coupling factor: autoinhibition and the role of RNA polymerase
    Abigail J Smith
    DNA Protein Interactions Unit, Department of Biochemistry, University of Bristol, Bristol, UK
    Nucleic Acids Res 35:1802-11. 2007
    ....
  8. pmc Modelling emergence of oscillations in communicating bacteria: a structured approach from one to many cells
    Petros Mina
    Bristol Center for Complexity Sciences, University of Bristol, Bristol, UK
    J R Soc Interface 10:20120612. 2013
    ..We conclude that population effects in GRN design need to be taken into consideration and be part of the design process. This is important in planning intervention strategies or designing specific cell behaviours...
  9. pmc DNA cleavage and methylation specificity of the single polypeptide restriction-modification enzyme LlaGI
    Rachel M Smith
    DNA Protein Interactions Unit, Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
    Nucleic Acids Res 37:7206-18. 2009
    ....
  10. pmc Determinants of the C-terminal domain of the Escherichia coli RNA polymerase alpha subunit important for transcription at class I cyclic AMP receptor protein-dependent promoters
    Nigel J Savery
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    J Bacteriol 184:2273-80. 2002
    ..We also conclude that the relative contributions of individual residues within the 265 determinant depend on promoter sequence, and we discuss explanations for effects of substitutions in the 261 determinant...
  11. pmc Transcription coupled nucleotide excision repair in Escherichia coli can be affected by changing the arginine at position 529 of the beta subunit of RNA polymerase
    Ann K Ganesan
    Department of Biological Sciences, Stanford University, Stanford, CA 94303 5020, USA
    DNA Repair (Amst) 6:1434-40. 2007
    ..Our results suggest that this interaction may be necessary but not sufficient to facilitate TCR...
  12. ncbi request reprint Structural basis for bacterial transcription-coupled DNA repair
    Alexandra M Deaconescu
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell 124:507-20. 2006
    ..These data, along with a structural model for the interaction of TRCF with the transcription elongation complex, provide mechanistic insights into TRCF function...