David B Savage
Affiliation: University of Cambridge
Agostini M, Schoenmakers E, Beig J, Fairall L, Szatmari I, Rajanayagam O, et al
. A Pharmacogenetic Approach to the Treatment of Patients With PPARG Mutations. Diabetes. 2018;67:1086-1092 pubmed publisher
..These observations indicate that detailed structural and functional classification can be used to inform therapeutic decisions in patients with PPARG mutations. ..
Patel S, Alvarez Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka E, et al
. GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans. Cell Metab. 2019;: pubmed publisher
..Finally, we show that pharmacological GDF15 administration to mice can trigger conditioned taste aversion, suggesting that GDF15 may induce an aversive response to nutritional stress. ..
Girousse A, Virtue S, Hart D, Vidal Puig A, Murgatroyd P, Mouisel E, et al
. Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice. Mol Metab. 2018;13:24-29 pubmed publisher
Savage D. Mouse models of inherited lipodystrophy. Dis Model Mech. 2009;2:554-62 pubmed publisher
Haider A, Wei Y, Lim K, Barbosa A, Liu C, Weber U, et al
. PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress. Dev Cell. 2018;45:481-495.e8 pubmed publisher
..These data suggest an ancient mechanism by which nucleoplasmic PCYT1A senses surface PL packing defects on the inner nuclear membrane to control PC homeostasis. ..
Melvin A, O Rahilly S, Savage D. Genetic syndromes of severe insulin resistance. Curr Opin Genet Dev. 2018;50:60-67 pubmed publisher
Savage D, Semple R, Clatworthy M, Lyons P, Morgan B, Cochran E, et al
. Complement abnormalities in acquired lipodystrophy revisited. J Clin Endocrinol Metab. 2009;94:10-6 pubmed publisher
..Future therapeutic approaches to these disorders may benefit from being tailored to their distinct immunopathogenesis. ..
Finucane F, Luan J, Wareham N, Sharp S, O Rahilly S, Balkau B, et al
. Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals. Diabetologia. 2009;52:2345-2349 pubmed publisher
..Given that variations between fasting and postprandial leptin and adiponectin levels tend to be small, the leptin to adiponectin ratio might also have potential value in assessing insulin sensitivity in the non-fasted state. ..
Rowe E, Mimmack M, Barbosa A, Haider A, Isaac I, Ouberai M, et al
. Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1-3. J Biol Chem. 2016;291:6664-78 pubmed publisher