Naveed Sattar

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial
    David W McCarey
    Centre for Rheumatic Diseases, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK
    Lancet 363:2015-21. 2004
  2. pmc Predictors of development of diabetes in patients with chronic heart failure in the Candesartan in Heart Failure Assessment of Reduction in Mortality and Morbidity (CHARM) program
    David Preiss
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland, UK
    Diabetes Care 32:915-20. 2009
  3. pmc Which circulating antioxidant vitamins are confounded by socioeconomic deprivation? The MIDSPAN family study
    Dinesh Talwar
    Department of Clinical Biochemistry, Glasgow Royal Infirmary, Glasgow, United Kingdom
    PLoS ONE 5:e11312. 2010
  4. pmc Existing maternal obesity guidelines may increase inequalities between ethnic groups: a national epidemiological study of 502,474 births in England
    Nicola Heslehurst
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    BMC Pregnancy Childbirth 12:156. 2012
  5. pmc Recruiting South Asians to a lifestyle intervention trial: experiences and lessons from PODOSA (Prevention of Diabetes & Obesity in South Asians)
    Anne Douglas
    Centre for Population Health Sciences, The University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Trials 12:220. 2011
  6. pmc Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance: a cross-sectional, population-based study
    Chris J Packard
    Glasgow Clinical Research Facility, Tennent Building, 38 Church Street, Western Infirmary, Glasgow G116NT, UK
    BMC Public Health 11:42. 2011
  7. pmc Psychological, social and biological determinants of ill health (pSoBid): study protocol of a population-based study
    Yoga N Velupillai
    Glasgow Centre for Population Health, Level 6, 39 St Vincent Place, Glasgow, G1 2ER, UK
    BMC Public Health 8:126. 2008
  8. ncbi request reprint Explaining how "high-grade" systemic inflammation accelerates vascular risk in rheumatoid arthritis
    Naveed Sattar
    Department of Pathological Biochemistry and Centre for Rheumatic Diseases, North Glasgow Hospitals University NHS Trust, Glasgow Royal Infirmary, Glasgow, Scotland, UK
    Circulation 108:2957-63. 2003
  9. ncbi request reprint Do pregnancy complications and CVD share common antecedents?
    Naveed Sattar
    Department of Vascular Biochemistry, 4th Floor QEB Building, Glasgow Royal Infirmary, University NHS Trust, Glasgow G31 2ER, UK
    Atheroscler Suppl 5:3-7. 2004
  10. ncbi request reprint Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study
    Naveed Sattar
    University Department of Pathological Biochemistry, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, Scotland, UK
    Circulation 108:414-9. 2003

Collaborators

Detail Information

Publications146 found, 100 shown here

  1. ncbi request reprint Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial
    David W McCarey
    Centre for Rheumatic Diseases, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK
    Lancet 363:2015-21. 2004
    ..We postulated that statins might reduce inflammatory factors in rheumatoid arthritis and modify surrogates for vascular risk...
  2. pmc Predictors of development of diabetes in patients with chronic heart failure in the Candesartan in Heart Failure Assessment of Reduction in Mortality and Morbidity (CHARM) program
    David Preiss
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland, UK
    Diabetes Care 32:915-20. 2009
    ....
  3. pmc Which circulating antioxidant vitamins are confounded by socioeconomic deprivation? The MIDSPAN family study
    Dinesh Talwar
    Department of Clinical Biochemistry, Glasgow Royal Infirmary, Glasgow, United Kingdom
    PLoS ONE 5:e11312. 2010
    ..We aimed to compare to what extent a range of antioxidant vitamins and carotenoids are associated with adulthood and childhood markers of socioeconomic deprivation and to adverse lifestyle factors...
  4. pmc Existing maternal obesity guidelines may increase inequalities between ethnic groups: a national epidemiological study of 502,474 births in England
    Nicola Heslehurst
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    BMC Pregnancy Childbirth 12:156. 2012
    ..This study compares incidence of first trimester obesity using Asian-specific and general population BMI criteria...
  5. pmc Recruiting South Asians to a lifestyle intervention trial: experiences and lessons from PODOSA (Prevention of Diabetes & Obesity in South Asians)
    Anne Douglas
    Centre for Population Health Sciences, The University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Trials 12:220. 2011
    ..Despite the growing emphasis on the inclusion of ethnic minority patients in research, there is little published on the recruitment of these populations especially to randomised, community based, lifestyle intervention trials in the UK...
  6. pmc Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance: a cross-sectional, population-based study
    Chris J Packard
    Glasgow Clinical Research Facility, Tennent Building, 38 Church Street, Western Infirmary, Glasgow G116NT, UK
    BMC Public Health 11:42. 2011
    ..The Psychosocial and Biological Determinants of Ill-health (pSoBid) study was designed to uncover novel biomarkers of chronic disease that may help explain pathways between socioeconomic adversity and poorer physical and mental health...
  7. pmc Psychological, social and biological determinants of ill health (pSoBid): study protocol of a population-based study
    Yoga N Velupillai
    Glasgow Centre for Population Health, Level 6, 39 St Vincent Place, Glasgow, G1 2ER, UK
    BMC Public Health 8:126. 2008
    ....
  8. ncbi request reprint Explaining how "high-grade" systemic inflammation accelerates vascular risk in rheumatoid arthritis
    Naveed Sattar
    Department of Pathological Biochemistry and Centre for Rheumatic Diseases, North Glasgow Hospitals University NHS Trust, Glasgow Royal Infirmary, Glasgow, Scotland, UK
    Circulation 108:2957-63. 2003
    ..Unraveling such complex relationships in which exaggerated inflammation-risk factor interactions are prevalent may elicit novel insights to effector mechanisms in vascular disease generally...
  9. ncbi request reprint Do pregnancy complications and CVD share common antecedents?
    Naveed Sattar
    Department of Vascular Biochemistry, 4th Floor QEB Building, Glasgow Royal Infirmary, University NHS Trust, Glasgow G31 2ER, UK
    Atheroscler Suppl 5:3-7. 2004
    ..This paper reviews the emerging evidence to support this fascinating concept, addresses potential mechanisms and discusses potential clinical implications...
  10. ncbi request reprint Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study
    Naveed Sattar
    University Department of Pathological Biochemistry, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, Scotland, UK
    Circulation 108:414-9. 2003
    ..Information on the prospective association of this definition for coronary heart disease (CHD) and type 2 diabetes is currently limited...
  11. ncbi request reprint NT-proBNP is associated with coronary heart disease risk in healthy older women but fails to enhance prediction beyond established risk factors: results from the British Women's Heart and Health Study
    Naveed Sattar
    Division of Cardiovascular and Medical Sciences, BHF Cardiovascular Research Building, Faculty of Medicine, University of Glasgow, 126 University Place, Scotland, UK
    Atherosclerosis 209:295-9. 2010
    ..Limited evidence suggests NT-proBNP improves prediction of coronary heart disease (CHD) events but further data are needed, especially in people without pre-existing CHD and in women...
  12. ncbi request reprint Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the west of Scotland coronary prevention study
    Naveed Sattar
    Division of Cardiovascular and Medical Sciences, Universityof Glasgow, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, UK
    Diabetes 53:2855-60. 2004
    ..The simplicity of ALT measurement and its availability in routine clinical practice suggest that this enzyme activity could be included in future diabetes prediction algorithms...
  13. ncbi request reprint Inflammation and endothelial dysfunction: intimate companions in the pathogenesis of vascular disease?
    Naveed Sattar
    Department of Vascular Biochemistry, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, UK
    Clin Sci (Lond) 106:443-5. 2004
    ..In this issue of Clinical Science, Fichtlscherer and co-workers describe a link between endothelial function and sPLA(2) (secretory non-pancreatic type II phospholipase A(2)) serum activity...
  14. pmc Are markers of inflammation more strongly associated with risk for fatal than for nonfatal vascular events?
    Naveed Sattar
    Division of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, Scotland, UK
    PLoS Med 6:e1000099. 2009
    ..We tested whether interleukin (IL)-6, C-reactive protein (CRP), and fibrinogen more strongly associate with fatal compared to nonfatal myocardial infarction (MI) and stroke...
  15. ncbi request reprint Inverse association between birth weight and C-reactive protein concentrations in the MIDSPAN Family Study
    Naveed Sattar
    University Department of Pathological Biochemistry, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, UK
    Arterioscler Thromb Vasc Biol 24:583-7. 2004
    ..However, potential associations between the low-grade inflammatory response as represented by C-reactive protein (CRP) concentrations and low birth weight have been sparsely examined...
  16. ncbi request reprint Effects of tumor necrosis factor blockade on cardiovascular risk factors in psoriatic arthritis: a double-blind, placebo-controlled study
    Naveed Sattar
    University of Glasgow, Glasgow, UK
    Arthritis Rheum 56:831-9. 2007
    ....
  17. ncbi request reprint Leptin and coronary heart disease: prospective study and systematic review
    Naveed Sattar
    BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, University of Glasgow, Glasgow, Scotland, UK
    J Am Coll Cardiol 53:167-75. 2009
    ..This study sought to better determine the link between leptin and coronary heart disease (CHD)...
  18. ncbi request reprint Adiponectin and coronary heart disease: a prospective study and meta-analysis
    Naveed Sattar
    University Department of Vascular Biochemistry, Glasgow, Scotland
    Circulation 114:623-9. 2006
    ..We report new data from a prospective study in the context of a meta-analysis of previously published prospective studies...
  19. ncbi request reprint Serial metabolic measurements and conversion to type 2 diabetes in the west of Scotland coronary prevention study: specific elevations in alanine aminotransferase and triglycerides suggest hepatic fat accumulation as a potential contributing factor
    Naveed Sattar
    Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland
    Diabetes 56:984-91. 2007
    ....
  20. ncbi request reprint The metabolic syndrome: should current criteria influence clinical practice?
    Naveed Sattar
    Glasgow Royal Infirmary, Glasgow, Scotland, UK
    Curr Opin Lipidol 17:404-11. 2006
    ..This review critically appraises this evidence and also evaluates the data linking metabolic syndrome to type 2 diabetes...
  21. ncbi request reprint High sensitivity C-reactive protein and cardiovascular disease: an association built on unstable foundations?
    Naveed Sattar
    Department of Clinical Biochemistry, University of Glasgow, Glasgow Royal Infirmary, Glasgow G31 2ER, UK
    Ann Clin Biochem 43:252-6. 2006
    ..Therefore, the current focus in clinical practice should remain on established risk factors (e.g. smoking, lipids and blood pressure), both to determine coronary heart disease risk and to reduce it...
  22. ncbi request reprint Insulin resistance and the metabolic syndrome as predictors of cardiovascular risk: where are we now?
    N Sattar
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Minerva Endocrinol 30:121-38. 2005
    ..Ongoing clinical trials will further determine the value of lifestyle factors and insulin sensitising agents in reducing risk of vascular and metabolic disease in high risk subjects...
  23. ncbi request reprint High molecular weight adiponectin is not associated with incident coronary heart disease in older women: a nested prospective case-control study
    Naveed Sattar
    British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Clin Endocrinol Metab 93:1846-9. 2008
    ..Adiponectin levels appear weakly linked to incident vascular disease, but the high molecular weight (HMW) fraction may be more relevant...
  24. ncbi request reprint Novel biochemical risk factors for type 2 diabetes: pathogenic insights or prediction possibilities?
    N Sattar
    BHF Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK
    Diabetologia 51:926-40. 2008
    ..g. metabolic syndrome) to identify individuals at risk of both CHD and diabetes...
  25. doi request reprint Why metabolic syndrome criteria have not made prime time: a view from the clinic
    N Sattar
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK
    Int J Obes (Lond) 32:S30-4. 2008
    ..However, it remains unclear whether such criteria help clinical practice. This review will evaluate the usefulness of metabolic syndrome criteria to enhance risk prediction for either cardiovascular disease or diabetes...
  26. ncbi request reprint Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies
    Naveed Sattar
    Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Lancet 371:1927-35. 2008
    ..We investigated to what extent metabolic syndrome and its individual components were related to risk for these two diseases in elderly populations...
  27. ncbi request reprint Vascular comorbidity in rheumatoid arthritis: potential mechanisms and solutions
    Naveed Sattar
    Section of Vascular Biochemistry, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow Royal Infirmary, Scotland, UK
    Curr Opin Rheumatol 17:286-92. 2005
    ..To summarise recent evidence for elevated risk of coronary heart disease (CHD) in rheumatoid arthritis (RA) and explore explanatory mechanisms and modalities that may lessen such risk...
  28. ncbi request reprint Are elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly
    N Sattar
    Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, University Place, Glasgow G12 8TA, UK
    Diabetologia 52:235-9. 2009
    ....
  29. doi request reprint Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials
    Naveed Sattar
    British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Lancet 375:735-42. 2010
    ..We aimed to establish by a meta-analysis of published and unpublished data whether any relation exists between statin use and development of diabetes...
  30. ncbi request reprint Lipid and lipoprotein concentrations in pregnancies complicated by intrauterine growth restriction
    N Sattar
    Department of Pathological Biochemistry, Royal Infirmary University NHS Trust, Glasgow, United Kingdom
    J Clin Endocrinol Metab 84:128-30. 1999
    ....
  31. ncbi request reprint The atherogenic lipoprotein phenotype and vascular endothelial dysfunction
    N Sattar
    Department of Clinical Biochemistry, Glasgow Royal Infirmary University NHS Trust, UK
    Atherosclerosis 138:229-35. 1998
    ..Finally, there is recent strong evidence to suggest that increased postprandial circulating concentrations of triglyceride-rich particles and remnant particles may be deleterious to the endothelium...
  32. ncbi request reprint Antenatal waist circumference and hypertension risk
    N Sattar
    Department of Pathological Biochemistry, Glasgow Royal Infirmary University NHS Trust, Glasgow, Scotland, United Kingdom
    Obstet Gynecol 97:268-71. 2001
    ..To assess whether waist circumference at the first antenatal visit predicts risk of developing hypertension later in pregnancy...
  33. ncbi request reprint C-reactive protein and prediction of coronary heart disease and global vascular events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)
    Naveed Sattar
    Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland, UK
    Circulation 115:981-9. 2007
    ..The role of C-reactive protein (CRP) in predicting vascular events and response to statin therapy remains uncertain. Additional large prospective studies are required...
  34. pmc Pregnancy complications and maternal cardiovascular risk: opportunities for intervention and screening?
    Naveed Sattar
    Glasgow Royal Infirmary University NHS Trust, Glasgow G31 2ER
    BMJ 325:157-60. 2002
  35. ncbi request reprint Microvascular function, metabolic syndrome, and novel risk factor status in women with cardiac syndrome X
    Sachin T Jadhav
    The Glasgow Royal Infirmary, Glasgow, Scotland, United Kingdom
    Am J Cardiol 97:1727-31. 2006
    ..They also have significantly impaired skin microvascular function as assessed by laser Doppler imaging, consistent with generalized vascular dysfunction, a finding with potential diagnostic implications...
  36. ncbi request reprint Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice
    Ashley M Miller
    Division of Immunology, Infection and Inflammation, GBRC, University of Glasgow, Glasgow, United Kingdom
    Circ Res 107:650-8. 2010
    ..The cytokine interleukin (IL)-33 and its receptor ST2 are expressed in adipose tissue, but their role in adipose tissue inflammation during obesity is unclear...
  37. ncbi request reprint Maternal obesity is associated with dysregulation of metabolic, vascular, and inflammatory pathways
    Jane E Ramsay
    University Department of Obstetrics and Gynaecology, Glasgow Royal Infirmary, Scotland, G31 2ER, United Kingdom
    J Clin Endocrinol Metab 87:4231-7. 2002
    ..Clearly, these data provide further rationale to examine the potential benefits of preconceptual weight loss and antenatal exercise...
  38. doi request reprint Circulating interleukin-10 and risk of cardiovascular events: a prospective study in the elderly at risk
    Paul Welsh
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Scotland
    Arterioscler Thromb Vasc Biol 31:2338-44. 2011
    ..The goal of this study was to examine the association of the antiinflammatory interleukin-10 (IL-10) with risk of cardiovascular disease (CVD)...
  39. doi request reprint Socioeconomic deprivation and cortical morphology: psychological, social, and biological determinants of ill health study
    Rajeev Krishnadas
    Sackler Institute of Psychobiological Research, Southern General Hospital, Glasgow, Scotland, UK
    Psychosom Med 75:616-23. 2013
    ..The aim of this study was to examine the association between neighborhood-level deprivation and the morphology of cortical regions associated with language and executive control in adults...
  40. ncbi request reprint Effects of HRT on liver enzyme levels in women with type 2 diabetes: a randomized placebo-controlled trial
    Joyce McKenzie
    Department of Medicine, Glasgow Royal Infirmary University NHS Trust, Glasgow, Scotland, UK
    Clin Endocrinol (Oxf) 65:40-4. 2006
    ..g. nonalcoholic fatty liver disease (NAFLD)]. Recent data indicating that hormone replacement therapy (HRT) may lessen diabetes risk is intriguing but explanatory mechanisms are unclear...
  41. ncbi request reprint Metabolic, inflammatory and haemostatic effects of a low-dose continuous combined HRT in women with type 2 diabetes: potentially safer with respect to vascular risk?
    Joyce McKenzie
    Diabetes Centre, Glasgow Royal Infirmary University NHS Trust, Glasgow, UK
    Clin Endocrinol (Oxf) 59:682-9. 2003
    ....
  42. doi request reprint Vascular dysfunction and alteration of novel and classic cardiovascular risk factors in mothers of growth restricted offspring
    Malini G Kanagalingam
    Reproductive and Maternal Medicine, University of Glasgow, Glasgow, United Kingdom
    Atherosclerosis 205:244-50. 2009
    ..However, whether established or putative novel cardiovascular risk factors including vascular and metabolic function are disrupted in women who delivered small for gestational age (SGA) offspring is unknown...
  43. ncbi request reprint Effects of prior moderate exercise on postprandial metabolism and vascular function in lean and centrally obese men
    Jason M R Gill
    Department of Vascular Biochemistry, University of Glasgow, Glasgow Royal Infirmary, Glasgow G12 8QQ, Scotland, UK
    J Am Coll Cardiol 44:2375-82. 2004
    ..We investigated whether a session of prior exercise could ameliorate postprandial endothelial dysfunction...
  44. pmc Leptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly population
    Paul Welsh
    Faculty of Medicine, University of Glasgow, Scotland, UK
    Diabetes Care 32:308-10. 2009
    ..To clarify the association of circulating levels of leptin with risk for cardiovascular disease (CVD) events and new-onset diabetes in men and women...
  45. ncbi request reprint Effects of low-dose continuous combined HRT on vascular function in women with type 2 diabetes
    Andrew F B Kernohan
    Division of Cardiovascular and Medical Sciences, University of Glasgow, 36 Church St, Glasgow, G11 6NT, UK
    Diab Vasc Dis Res 1:82-8. 2004
    ..Women with type 2 diabetes (T2DM) are at increased cardiovascular risk and have impaired endothelial function. Any benefits of HRT on endothelial function in this group are of particular interest...
  46. pmc Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases?
    David W McCarey
    Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow, UK
    Arthritis Res Ther 7:55-61. 2005
    ..Together with their known vasculoprotective effects, this growing body of evidence provides compelling support for longer-term trials of statin therapy in human disease such as rheumatoid arthritis...
  47. doi request reprint 25-Hydroxyvitamin D is lower in deprived groups, but is not associated with carotid intima media thickness or plaques: results from pSoBid
    Susan Knox
    Department of Clinical Biochemistry, Glasgow Royal Infirmary, Glasgow G31 2ER, UK
    Atherosclerosis 223:437-41. 2012
    ..The association of the circulating serum vitamin D metabolite 25-hydroxyvitamin D (25OHD) with atherosclerotic burden is unclear, with previous studies reporting disparate results...
  48. pmc Programming of adiposity in offspring of mothers with type 1 diabetes at age 7 years
    Robert S Lindsay
    Faculty of Medicine, University of Glasgow, Glasgow, UK
    Diabetes Care 33:1080-5. 2010
    ....
  49. ncbi request reprint Inflammation and endothelial activation is evident at birth in offspring of mothers with type 1 diabetes
    Scott M Nelson
    Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 2ER, UK
    Diabetes 56:2697-704. 2007
    ..We examined whether these biomarkers were elevated at birth in offspring of type 1 diabetic mothers (OT1DM)...
  50. ncbi request reprint Short- and long-term changes in plasma inflammatory markers associated with preeclampsia
    Dilys J Freeman
    Division of Developmental Medicine, University of Glasgow, Glasgow, United Kingdom
    Hypertension 44:708-14. 2004
    ..In conclusion, preeclampsia is associated with short- and long-term changes in inflammatory status...
  51. pmc N-terminal pro-B-type natriuretic peptide and the prediction of primary cardiovascular events: results from 15-year follow-up of WOSCOPS
    Paul Welsh
    College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
    Eur Heart J 34:443-50. 2013
    ..To test whether N-terminal pro-B-type natriuretic peptide (NT-proBNP) was independently associated with, and improved the prediction of, cardiovascular disease (CVD) in a primary prevention cohort...
  52. doi request reprint The inverse relationship between alanine aminotransferase in the normal range and adverse cardiovascular and non-cardiovascular outcomes
    Ian Ford
    From the Robertson Centre for Biostatistics, University of Glasgow, Glasgow, Scotland
    Int J Epidemiol 40:1530-8. 2011
    ..High serum alanine aminotransferase (ALT) levels have been associated with increased risk of diabetes and with increased mortality, but associations of variations of ALT in the normal range with outcomes have been less well studied...
  53. ncbi request reprint Effect of prior moderate exercise on postprandial metabolism in men with type 2 diabetes: heterogeneity of responses
    Jason M R Gill
    Department of Vascular Biochemistry, University of Glasgow, United Kingdom
    Atherosclerosis 194:134-43. 2007
    ..On the afternoon before one test, participants performed a 90-min treadmill walk (Exercise); no exercise was performed before the CONTROL test. Exercise significantly reduced fasting glucose (..
  54. ncbi request reprint Socioeconomic status and the cerebellar grey matter volume. Data from a well-characterised population sample
    Jonathan Cavanagh
    Sackler Institute of Psychobiological Research, Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, UK
    Cerebellum 12:882-91. 2013
    ..These findings provide data on the relationship between socioeconomic deprivation and a brain region highly sensitive to environmental factors. ..
  55. pmc Personality, socio-economic status and inflammation: cross-sectional, population-based study
    Keith Millar
    College of Medical, Veterinary and Life Sciences, Institute of Mental Health and Wellbeing, University of Glasgow, Glasgow, Scotland
    PLoS ONE 8:e58256. 2013
    ....
  56. ncbi request reprint Effects of a moderate exercise session on postprandial lipoproteins, apolipoproteins and lipoprotein remnants in middle-aged men
    Jason M R Gill
    Department of Vascular Biochemistry, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK
    Atherosclerosis 185:87-96. 2006
    ....
  57. ncbi request reprint IGF-1 and leptin associate with fetal HDL cholesterol at birth: examination in offspring of mothers with type 1 diabetes
    Scott M Nelson
    Department of Reproductive and Maternal Medicine, Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 ER, UK
    Diabetes 56:2705-9. 2007
    ..We examined the influence of maternal diabetes on cord lipids at birth and relationship to body composition, cord insulin, leptin, and other hormonal measures...
  58. ncbi request reprint Cardiovascular risk parameters in men with ankylosing spondylitis in comparison with non-inflammatory control subjects: relevance of systemic inflammation
    Hiren Divecha
    Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Scotland, UK
    Clin Sci (Lond) 109:171-6. 2005
    ..In conclusion, men with AS have perturbances in several CHD risk factors, which appear to be driven principally by systemic inflammatory mediators. Inflammation-driven atherogenesis potentially contributes to the excess CHD risk in AS...
  59. ncbi request reprint Divergent metabolic and vascular phenotypes in pre-eclampsia and intrauterine growth restriction: relevance of adiposity
    Jane E Ramsay
    University Department of Obstetrics and Gynaecology, Glasgow Royal Infirmary, Scotland, UK
    J Hypertens 22:2177-83. 2004
    ..Pre-eclampsia (PE) and intrauterine growth restriction (IUGR) may both arise secondary to inadequate trophoblast invasion. Maternal vascular disease is evident only in PE. Little mechanistic evidence exists to explain this dichotomy...
  60. doi request reprint Obesity is associated with fatal coronary heart disease independently of traditional risk factors and deprivation
    Jennifer Logue
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Heart 97:564-8. 2011
    ..However, there is now evidence of a differential effect of risk factors on fatal and non-fatal CHD events, with markers of inflammation more strongly associated with fatal than non-fatal events...
  61. ncbi request reprint Adipocytokines and risk of stroke in older people: a nested case-control study
    David J Stott
    Division of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Scotland, UK
    Int J Epidemiol 38:253-61. 2009
    ..Inflammation may play an important role in atherothrombosis and in promoting cerebral damage after stroke. We hypothesized that plasma adipocytokine concentrations would be associated with risk of stroke in older people...
  62. pmc Reduced glomerular filtration rate and its association with clinical outcome in older patients at risk of vascular events: secondary analysis
    Ian Ford
    Robertson Centre for Biostatistics, University of Glasgow, Glasgow, Scotland
    PLoS Med 6:e16. 2009
    ..We aimed to determine the predictive value of the GFR for mortality and morbidity using data from the 5,804 participants randomized in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)...
  63. pmc Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach
    Paul Welsh
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Clin Endocrinol Metab 95:93-9. 2010
    ..Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven...
  64. pmc Soluble ST2 associates with diabetes but not established cardiovascular risk factors: a new inflammatory pathway of relevance to diabetes?
    Ashley M Miller
    Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    PLoS ONE 7:e47830. 2012
    ..Further mechanistic studies determining how sST2 is linked to diabetes pathways may offer new insights into the inflammatory paradigm for type 2 diabetes...
  65. doi request reprint Circulating 25OHD, dietary vitamin D, PTH, and calcium associations with incident cardiovascular disease and mortality: the MIDSPAN Family Study
    Paul Welsh
    Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom
    J Clin Endocrinol Metab 97:4578-87. 2012
    ..Observational studies relating circulating 25-hydroxyvitamin D (25OHD) and dietary vitamin D intake to cardiovascular disease (CVD) have reported conflicting results...
  66. doi request reprint Role for TNF in atherosclerosis? Lessons from autoimmune disease
    Gayle E McKellar
    Center for Rheumatic Diseases, Glasgow, Royal Infirmary, Glasgow, UK
    Nat Rev Cardiol 6:410-7. 2009
    ..Moreover, such data obtained in chronic inflammatory diseases likely have relevance to primary atherosclerosis...
  67. ncbi request reprint Reproducibility and repeatability of peripheral microvascular assessment using iontophoresis in conjunction with laser Doppler imaging
    Sachin Jadhav
    Divisions of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow Royal Infirmary, Glasgow, Scotland, UK
    J Cardiovasc Pharmacol 50:343-9. 2007
    ..LDI can be used to assess peripheral vascular response with good repeatability as long as measurements are corrected for skin resistance, which affects drug delivery. This has important implications for the future use of LDI...
  68. doi request reprint The incidence and risk factors for new onset atrial fibrillation in the PROSPER study
    Peter W Macfarlane
    Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Europace 13:634-9. 2011
    ..We aimed to determine retrospectively whether pravastatin reduces the incidence of AF and whether any electrocardiographic measures or clinical conditions might be risk factors for its development...
  69. ncbi request reprint Metformin or antiandrogen in the treatment of hirsutism in polycystic ovary syndrome
    Lyndal Harborne
    University Department of Obstetrics and Gynecology, Royal Infirmary, Glasgow, Scotland, United Kingdom G31 2ER
    J Clin Endocrinol Metab 88:4116-23. 2003
    ..However, metformin did reduce markers of insulin resistance. The data suggest that hirsutism may be effectively treated by reducing hyperinsulinemia...
  70. ncbi request reprint Enhancement of endothelial function by pregnancy: inadequate response in women with type 1 diabetes
    Jane E Ramsay
    University Department of Obstetrics and Gynaecology, Glasgow Royal Infirmary, Scotland, UK
    Diabetes Care 26:475-9. 2003
    ..Our aim was to study vascular function and metabolic and inflammatory risk factors during the antenatal and postpartum periods in women with type 1 diabetes compared with healthy control subjects...
  71. pmc Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohort
    Paul G Shiels
    Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland
    PLoS ONE 6:e22521. 2011
    ....
  72. pmc Fasting plasma glucose in non-diabetic participants and the risk for incident cardiovascular events, diabetes, and mortality: results from WOSCOPS 15-year follow-up
    David Preiss
    Faculty of Medicine, University of Glasgow, Glasgow, UK
    Eur Heart J 31:1230-6. 2010
    ..The evidence base for fasting plasma glucose (FPG) in the non-diabetic range as a risk factor for cardiovascular disease (CVD) is inconclusive. We investigated this question in the West of Scotland Coronary Prevention Study (WOSCOPS)...
  73. doi request reprint Intergenerational change and familial aggregation of body mass index
    Paul C D Johnson
    Robertson Centre for Biostatistics, Boyd Orr Building, University of Glasgow, Glasgow, UK
    Eur J Epidemiol 27:53-61. 2012
    ..Familial influences on BMI among middle-aged women appear significantly stronger from mothers than fathers...
  74. ncbi request reprint Serum C-reactive protein and lipids in ultra-Marathon runners
    Maciej Tomaszewski
    British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, and Department of Pathological Biochemistry, University of Glasgow, Glasgow, United Kingdom
    Am J Cardiol 94:125-6. 2004
    ..This exercise-induced reduction in low-density lipoprotein cholesterol was independent of the decrease in C-reactive protein levels...
  75. ncbi request reprint Apolipoprotein E-deficient mice are resistant to the development of collagen-induced arthritis
    Darren L Asquith
    University of Glasgow, Glasgow, UK
    Arthritis Rheum 62:472-7. 2010
    ..To determine whether elevated serum lipid levels resulting from feeding animals a high-fat diet can affect the inflammatory process in C57BL/6 (B6) wild-type (WT) and B6 ApoE(-/-) mouse models of collagen-induced arthritis (CIA)...
  76. ncbi request reprint Inflammatory suppression rapidly attenuates microvascular dysfunction in rheumatoid arthritis
    Deepankar Datta
    Centre for Rheumatic Diseases, Royal Infirmary, Glasgow, United Kingdom
    Atherosclerosis 192:391-5. 2007
    ..Assessment of cutaneous vascular function may be a useful, non-invasive surrogate indicator of vascular risk in RA, inclusive of myocardial microvascular abnormalities...
  77. ncbi request reprint C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study
    Dilys J Freeman
    Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow, UK
    Diabetes 51:1596-600. 2002
    ..They also add to the notion that low-grade inflammation is important in the pathogenesis of type 2 diabetes...
  78. doi request reprint Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial
    Scott W Muir
    Division of Cardiovascular and Medical Sciences, Acute Stroke Unit, University of Glasgow, Western Infirmary, Glasgow, UK
    Stroke 39:3303-7. 2008
    ..We sought to investigate whether allopurinol alters expression of inflammatory markers after acute ischemic stroke...
  79. ncbi request reprint Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS)
    A M Wallace
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, University of Glasgow, Glasgow, Scotland
    Circulation 104:3052-6. 2001
    ..18; 95% CI, 1.00 to 1.39; P=0.05) at the expense of C-reactive protein. CONCLUSIONS: We show, for the first time, in a large prospective study that leptin is a novel, independent risk factor for coronary heart disease...
  80. ncbi request reprint The effects of transdermal estradiol in combination with oral norethisterone on lipoproteins, coagulation, and endothelial markers in postmenopausal women with type 2 diabetes: a randomized, placebo-controlled study
    M Perera
    Diabetes Center, West Glasgow Hospitals National Health Service Trust, University of Glasgow, Scotland
    J Clin Endocrinol Metab 86:1140-3. 2001
    ..In addition, a reduction in von Willebrand factor antigen is consistent with an improvement in endothelial function. We suggest that the regimen used in this study may have the potential to reduce CHD risk in women with type 2 diabetes...
  81. ncbi request reprint Classic and novel risk factor parameters in women with a history of preeclampsia
    Naveed Sattar
    Department of Pathological Biochemistry, Glasgow Royal Infirmary University NHS Trust, Glasgow G31 2ER UK
    Hypertension 42:39-42. 2003
    ..Rather markedly elevated ICAM-1 concentrations and specific but subtle features of the metabolic syndrome (glucose, blood pressure) are likely to be involved...
  82. ncbi request reprint Growth hormone replacement reduces C-reactive protein and large-artery stiffness but does not alter endothelial function in patients with adult growth hormone deficiency
    Roland W McCallum
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary, Glasgow G11 6NT, UK
    Clin Endocrinol (Oxf) 62:473-9. 2005
    ..GH replacement may lead to differentially altered production of vasorelaxant agents from the endothelium of large and small arteries. Reduction in vascular inflammation may be associated with reduced vascular risk...
  83. ncbi request reprint Low triglyceride, not low cholesterol concentration, independently predicts poor outcome following acute stroke
    Christopher J Weir
    Acute Stroke Unit, University Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, UK
    Cerebrovasc Dis 16:76-82. 2003
    ..Such information may yield further mechanistic information on the relationship between lipids and stroke outcome...
  84. ncbi request reprint Increase in serum adiponectin concentration in patients with heart failure and cachexia: relationship with leptin, other cytokines, and B-type natriuretic peptide
    Margaret B McEntegart
    BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland, UK
    Eur Heart J 28:829-35. 2007
    ..Adiponectin concentration is inversely related to body weight and, in animals, causes weight loss. We, therefore, measured adiponectin concentration in patients with heart failure (HF) and cachexia...
  85. ncbi request reprint Lipids and lipoprotein subfractions in women with PCOS: relationship to metabolic and endocrine parameters
    I R Pirwany
    Department of Obstetrics and Gynaecology, Glasgow Royal Infirmary University NHS Trust, Glasgow, UK
    Clin Endocrinol (Oxf) 54:447-53. 2001
    ....
  86. ncbi request reprint Lower concentrations of carotenoids in the critically ill patient are related to a systemic inflammatory response and increased lipid peroxidation
    T Quasim
    University Department of Surgery, Royal Infirmary, Glasgow, UK
    Clin Nutr 22:459-62. 2003
    ..Critically-ill patients have low circulating concentrations of vitamin antioxidants. The functional significance of such reductions is not clear...
  87. pmc Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring
    Eleanor Jarvie
    Reproductive and Maternal Medicine, Faculty of Medicine, University of Glasgow, Glasgow, U K
    Clin Sci (Lond) 119:123-9. 2010
    ..The combination of excess/altered lipid nutrient supply, suboptimal in utero metabolic environment and alterations in placental gene expression, inflammation and metabolism may also induce obesity in the offspring...
  88. ncbi request reprint Microvascular dysfunction: a link between pre-eclampsia and maternal coronary heart disease
    Jane E Ramsay
    Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary University NHS Trust, UK
    BJOG 110:1029-31. 2003
    ..Pregnancies complicated by pre-eclampsia may identify women at risk of vascular disease in later life and may provide the opportunity for lifestyle and risk factor modification to alter maternal vascular disease risk...
  89. ncbi request reprint Supraphysiological concentrations of estradiol in menopausal women given repeated implant therapy do not adversely affect lipid profiles
    Imran R Pirwany
    Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow, UK
    Hum Reprod 17:825-9. 2002
    ..We examined metabolic parameters in cohorts of women with and without subcutaneous estrogen therapy with concomitant supra-normal concentrations of estradiol (SE)...
  90. ncbi request reprint Factors critical to iontophoretic assessment of vascular reactivity: implications for clinical studies of endothelial dysfunction
    Jane Elizabeth Ramsay
    Department of Obstetrics and Gynaecology, Royal Infirmary, Glasgow, Scotland, UK
    J Cardiovasc Pharmacol 39:9-17. 2002
    ..These findings have implications for clinical studies that use the iontophoresis technique for assessing vascular function...
  91. ncbi request reprint Genetic determinants of metabolic syndrome components in the stroke-prone spontaneously hypertensive rat
    Pamela Strahorn
    BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    J Hypertens 23:2179-86. 2005
    ..Animal models may facilitate genetic analysis of complex phenotypes by allowing complete control of environmental conditions and the ability to produce designer strains...
  92. ncbi request reprint Hormone replacement therapy can augment vascular relaxation in post-menopausal women with type 2 diabetes
    M Perera
    Department of Obstetrics and Gynaecology, University of Glasgow, G3 8SJ, UK
    Hum Reprod 17:497-502. 2002
    ..Observational studies have suggested that estrogens may provide cardioprotection by regulating endothelial nitric oxide synthase...
  93. ncbi request reprint A comparison of glycaemic and metabolic control over time among South Asian and European patients with Type 2 diabetes: results from follow-up in a routine diabetes clinic
    B Mukhopadhyay
    Department of Diabetes, Glasgow Royal Infirmary, Glasgow, UK
    Diabet Med 23:94-8. 2006
    ..We therefore wished to determine whether South Asians with diabetes had similar or greater year-on-year deterioration in metabolic parameters compared with Europeans...
  94. ncbi request reprint Inflammation and ischaemic stroke
    Keith W Muir
    Division of Medicine and Neurosciences, University of Manchester, Hope Hospital, Salford, UK
    Curr Opin Neurol 20:334-42. 2007
    ..Each aspect is reviewed...
  95. ncbi request reprint Strikingly low circulating CRP concentrations in ultramarathon runners independent of markers of adiposity: how low can you go?
    Maciej Tomaszewski
    British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, UK
    Arterioscler Thromb Vasc Biol 23:1640-4. 2003
    ....
  96. doi request reprint Does low to moderate alcohol intake protect against cognitive decline in older people?
    David J Stott
    Faculty of Medicine, Academic Section of Geriatric Medicine, University of Glasgow, Glasgow, United Kingdom
    J Am Geriatr Soc 56:2217-24. 2008
    ..To determine whether low to moderate alcohol intake is protective against cognitive decline in older people...
  97. ncbi request reprint Novel antecedent plasma biomarkers of cardiovascular disease: improved evaluation methods and comparator benchmarks raise the bar
    Paul Welsh
    Division of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Scotland, UK
    Curr Opin Lipidol 19:563-71. 2008
    ..To assess recent advances in cardiovascular disease biomarkers, focusing on past failings, current promise, and areas for future work...
  98. ncbi request reprint Metformin reduces serum mullerian-inhibiting substance levels in women with polycystic ovary syndrome after protracted treatment
    Richard Fleming
    University Department of Obstetrics and Gynaecology, Royal Infirmary, Glasgow, United Kingdom
    Fertil Steril 83:130-6. 2005
    ..Assessment of ovarian responses to metformin treatment in obese women with polycystic ovary syndrome (PCOS)...
  99. ncbi request reprint Comparison of the associations of apolipoprotein B and non-high-density lipoprotein cholesterol with other cardiovascular risk factors in patients with the metabolic syndrome in the Insulin Resistance Atherosclerosis Study
    Naveed Sattar
    Section of Vascular Biochemistry, North Glasgow Hospitals University NHS Trust, Glasgow Royal Infirmary, Glasgow, UK
    Circulation 110:2687-93. 2004
    ..Both apolipoprotein (apo)B and non-HDL cholesterol (NHDLC) have been proposed as an additional indicator to identify patients at higher risk in MetS patients...
  100. ncbi request reprint Non-esterified fatty acids impair endothelium-dependent vasodilation in rat mesenteric resistance vessels
    Christopher A R Sainsbury
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Clin Sci (Lond) 107:625-9. 2004
    ..There was no impairment of vasodilation to SNAP following NEFA incubation. We conclude that NEFAs directly impair endothelial function in rat resistance arteries via an increase in oxidative stress at the vascular endothelium...