Timothy J Sargeant

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Characterization of inducible models of Tay-Sachs and related disease
    Timothy J Sargeant
    Department of Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 8:e1002943. 2012
  2. doi request reprint Adeno-associated virus-mediated expression of β-hexosaminidase prevents neuronal loss in the Sandhoff mouse brain
    Timothy J Sargeant
    Department of Medicine, University of Cambridge, Level 5 Addenbrooke s Hospital, Box 157, Hills Road, Cambridge CB2 0QQ, UK
    Hum Mol Genet 20:4371-80. 2011

Detail Information

Publications2

  1. pmc Characterization of inducible models of Tay-Sachs and related disease
    Timothy J Sargeant
    Department of Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 8:e1002943. 2012
    ..As in germline Hexb-/- mice, these neurodegenerative manifestations advanced rapidly, indicating that the pathogenesis and progression of GM2 gangliosidosis is not influenced by developmental events in the maturing nervous system...
  2. doi request reprint Adeno-associated virus-mediated expression of β-hexosaminidase prevents neuronal loss in the Sandhoff mouse brain
    Timothy J Sargeant
    Department of Medicine, University of Cambridge, Level 5 Addenbrooke s Hospital, Box 157, Hills Road, Cambridge CB2 0QQ, UK
    Hum Mol Genet 20:4371-80. 2011
    ..Loss of neurons was localized to only a few regions in the Sandhoff brain and was prevented by rAAV-mediated transfer of β-hexosaminidase gene function at considerable distances from the site of vector administration...