M S Sansom

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Molecular simulations and lipid-protein interactions: potassium channels and other membrane proteins
    M S P Sansom
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
    Biochem Soc Trans 33:916-20. 2005
  2. pmc A7DB: a relational database for mutational, physiological and pharmacological data related to the alpha7 nicotinic acetylcholine receptor
    Steven D Buckingham
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    BMC Neurosci 6:2. 2005
  3. pmc Water in channel-like cavities: structure and dynamics
    M S Sansom
    Laboratory of Molecular Biophysics, University of Oxford, United Kingdom
    Biophys J 70:693-702. 1996
  4. ncbi request reprint Potassium channels: structures, models, simulations
    Mark S P Sansom
    Laboratory of Molecular Biophysics, Department of Biochemistry, The University of Oxford, The Rex Richards Building, South Parks Road, Oxford, UK
    Biochim Biophys Acta 1565:294-307. 2002
  5. ncbi request reprint Ion channels: frozen motion
    Mark S P Sansom
    Laboratory of Molecular Biophysics, Department of Biochemistry, The University of Oxford, The Rex Richards Building, South Parks Road, OX1 3QU, Oxford, UK
    Curr Biol 12:R65-7. 2002
  6. ncbi request reprint Membrane proteins: Aquaporins--channels without ions
    M S Sansom
    Laboratory of Molecular Biophysics, Department of Biochemistry, The University of Oxford, The Rex Richards Building, South Parks Road, OX1 3QU, Oxford, UK
    Curr Biol 11:R71-3. 2001
  7. ncbi request reprint Hinges, swivels and switches: the role of prolines in signalling via transmembrane alpha-helices
    M S Sansom
    Department of Biochemistry, University of Oxford, UK
    Trends Pharmacol Sci 21:445-51. 2000
  8. ncbi request reprint Potassium channels: watching a voltage-sensor tilt and twist
    M S Sansom
    Laboratory of Molecular Biophysics, Department of Biochemistry, The University of Oxford, Oxford, OX1 3QU, UK
    Curr Biol 10:R206-9. 2000
  9. ncbi request reprint Putting the parts together
    M S Sansom
    Laboratory of Molecular Biophysics Department of Biochemistry The University of Oxford The Rex Richards Building South Parks Road, Oxford, OX1 3QU, UK
    Curr Biol 9:R738-41. 1999
  10. ncbi request reprint Effective diffusion coefficients of K+ and Cl- ions in ion channel models
    G R Smith
    Department of Biochemistry, University of Oxford, UK
    Biophys Chem 79:129-51. 1999

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Molecular simulations and lipid-protein interactions: potassium channels and other membrane proteins
    M S P Sansom
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
    Biochem Soc Trans 33:916-20. 2005
    ..A combination of molecular modelling and simulation reveals a potential phosphatidylinositol 4,5-bisphosphate-binding site on the surface of Kir6.2...
  2. pmc A7DB: a relational database for mutational, physiological and pharmacological data related to the alpha7 nicotinic acetylcholine receptor
    Steven D Buckingham
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    BMC Neurosci 6:2. 2005
    ..The growing amount of structural, pharmacological and physiological data for these receptors indicates the need for a dedicated and accurate database to provide a means to access this information in a coherent manner...
  3. pmc Water in channel-like cavities: structure and dynamics
    M S Sansom
    Laboratory of Molecular Biophysics, University of Oxford, United Kingdom
    Biophys J 70:693-702. 1996
    ..In particular the reduction of rotational reorientation rate is expected to alter the local dielectric constant within a transbilayer pore...
  4. ncbi request reprint Potassium channels: structures, models, simulations
    Mark S P Sansom
    Laboratory of Molecular Biophysics, Department of Biochemistry, The University of Oxford, The Rex Richards Building, South Parks Road, Oxford, UK
    Biochim Biophys Acta 1565:294-307. 2002
    ..Progress in this area is explored via two examples: inward rectifier (Kir) and voltage-gated (Kv) potassium channels. A brief account of structural studies of ancillary domains and subunits of K channels is provided...
  5. ncbi request reprint Ion channels: frozen motion
    Mark S P Sansom
    Laboratory of Molecular Biophysics, Department of Biochemistry, The University of Oxford, The Rex Richards Building, South Parks Road, OX1 3QU, Oxford, UK
    Curr Biol 12:R65-7. 2002
    ..New structural studies, together with computer simulations, have provided profound insights into ion conduction mechanisms...
  6. ncbi request reprint Membrane proteins: Aquaporins--channels without ions
    M S Sansom
    Laboratory of Molecular Biophysics, Department of Biochemistry, The University of Oxford, The Rex Richards Building, South Parks Road, OX1 3QU, Oxford, UK
    Curr Biol 11:R71-3. 2001
    ..Recently determined structures have shed new light on the way that aquaporins act as passive, but selective, pores for the transport of small molecules--such as water or glycerol--across membranes...
  7. ncbi request reprint Hinges, swivels and switches: the role of prolines in signalling via transmembrane alpha-helices
    M S Sansom
    Department of Biochemistry, University of Oxford, UK
    Trends Pharmacol Sci 21:445-51. 2000
    ..This helix lines the pore and plays a key role in the gating of this channel...
  8. ncbi request reprint Potassium channels: watching a voltage-sensor tilt and twist
    M S Sansom
    Laboratory of Molecular Biophysics, Department of Biochemistry, The University of Oxford, Oxford, OX1 3QU, UK
    Curr Biol 10:R206-9. 2000
    ..Recent studies have used fluorescence resonance energy transfer as a spectroscopic ruler to determine the nature and magnitude of the voltage-induced movement of S4 that leads to channel opening...
  9. ncbi request reprint Putting the parts together
    M S Sansom
    Laboratory of Molecular Biophysics Department of Biochemistry The University of Oxford The Rex Richards Building South Parks Road, Oxford, OX1 3QU, UK
    Curr Biol 9:R738-41. 1999
    ..The structures of several different domains and subunits of potassium channels have recently been solved. Reassembling these fragments into a working model of an intact voltage-gated channel will be a major challenge...
  10. ncbi request reprint Effective diffusion coefficients of K+ and Cl- ions in ion channel models
    G R Smith
    Department of Biochemistry, University of Oxford, UK
    Biophys Chem 79:129-51. 1999
    ..These results are broadly in line with a previous similar study of Na+ ions, and may be useful in Poisson-Nernst-Planck, Eyring rate theory or Brownian dynamics calculations of channel conductance...
  11. pmc The dielectric properties of water within model transbilayer pores
    M S Sansom
    Laboratory of Molecular Biophysics, University of Oxford, England
    Biophys J 73:2404-15. 1997
    ....
  12. ncbi request reprint Membrane proteins: A tale of barrels and corks
    M S Sansom
    Laboratory of Molecular Biophysics, Department of Biochemistry, The University of Oxford, The Rex Richards Building, South Parks Road, Oxford, OX1 3QU, UK
    Curr Biol 9:R254-7. 1999
    ..Analysis of ligand-induced changes in the structure of FhuA has provided our first structural insights into an active transport mechanism for a complex solute...
  13. ncbi request reprint Modelling and simulation of ion channels: applications to the nicotinic acetylcholine receptor
    M S Sansom
    Laboratory of Molecular Biophysics, University of Oxford, United Kingdom
    J Struct Biol 121:246-62. 1998
    ..A simplified model of the remainder of the channel protein when added to the M2 helix bundle plays a significant role in enhancing the ion selectivity of the channel...
  14. ncbi request reprint The influenza A virus M2 channel: a molecular modeling and simulation study
    M S Sansom
    Laboratory of Molecular Biophysics, University of Oxford, United Kingdom
    Virology 233:163-73. 1997
    ..A switch from the closed to the open form of the channel occurs if H37 is protonated midway through a simulation. The open channel is suggested to contain a wire of H-bonded water molecules which enables proton permeability...
  15. ncbi request reprint Ion channels: structure of a molecular brake
    M S Sansom
    Laboratory of Molecular Biophysics, Department of Biochemistry, The University of Oxford, The Rex Richards Building, South Parks Road, Oxford OX1 3QU, UK
    Curr Biol 9:R173-5. 1999
    ....
  16. ncbi request reprint Channels formed by the transmembrane helix of phospholamban: a simulation study
    M S Sansom
    Laboratory of Molecular Biophysics, University of Oxford, UK
    Biophys Chem 69:269-81. 1997
    ..Pore radius profiles were used to predict a channel conductance of 50 to 70 ps in 0.2 M KCl, which compares well with an experimental value of 100 ps...
  17. ncbi request reprint Viral ion channels: molecular modeling and simulation
    M S Sansom
    Department of Biochemistry, University of Oxford, UK
    Bioessays 20:992-1000. 1998
    ..Simulations based on channel models may yield insights into possible ion conduction and selectivity mechanisms...
  18. ncbi request reprint Transmembrane peptide NB of influenza B: a simulation, structure, and conductance study
    W B Fischer
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U K
    Biochemistry 39:12708-16. 2000
    ..1997) Biophys. J. 72, 1109-1126)] of ca. 20, 60, and 90 pS, respectively, suggested that the multiple conductance levels seen experimentally must correspond to different degrees of oligomerization of the peptide to form channels...
  19. ncbi request reprint Transmembrane domains of viral ion channel proteins: a molecular dynamics simulation study
    W B Fischer
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Rex Richards Building, South Parks Road, Oxford, OX1 3QU, UK
    Biopolymers 53:529-38. 2000
    ..Hydrogen bonding of polar side-chains with the peptide backbone and with one another occurs when such residues are present within the bilayer core, thus minimizing the energetic cost of burying such side-chains...
  20. ncbi request reprint Electrostatics studies and molecular dynamics simulations of a homology model of the Shaker K+ channel pore
    K M Ranatunga
    Department of Biochemistry, University of Oxford, UK
    Eur Biophys J 30:295-303. 2001
    ..This is more consistent with the high cation flux exhibited by the channel in its conductance value of 19 pS...
  21. pmc Voltage-dependent insertion of alamethicin at phospholipid/water and octane/water interfaces
    D P Tieleman
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, The Rex Richards Building, South Parks Road, Oxford OX1 3QU, United Kingdom
    Biophys J 80:331-46. 2001
    ..Our findings give new insight into the mechanism of channel formation by alamethicin and the structure and dynamics of membrane-associated helices...
  22. pmc Structure and dynamics of K channel pore-lining helices: a comparative simulation study
    I H Shrivastava
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    Biophys J 78:79-92. 2000
    ..Aromatic residues at the extremities of the helices underwent complex motions on both short (<10 ps) and long (>100 ps) time scales...
  23. ncbi request reprint Proline-induced hinges in transmembrane helices: possible roles in ion channel gating
    D P Tieleman
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    Proteins 44:63-72. 2001
    ..In conclusion, our simulations suggest a model in which hinge-bending motions of TM helices may play a functional role in the gating mechanisms of several different families of ion channels...
  24. ncbi request reprint Potassium and sodium ions in a potassium channel studied by molecular dynamics simulations
    P C Biggin
    Department of Biochemistry, University of Oxford, UK
    Biochim Biophys Acta 1510:1-9. 2001
    ..This suggests that the key to the ion selectivity of KcsA is the greater dehydration energy of Na(+) ions, and helps to explain the block of KcsA by internal Na(+) ions...
  25. ncbi request reprint Amantadine blocks channel activity of the transmembrane segment of the NB protein from influenza B
    W B Fischer
    Department of Biochemistry, University of Oxford, UK
    Eur Biophys J 30:416-20. 2001
    ..Channel behaviour of the peptide in the presence of amantadine is in accordance with findings for the intact channel. Thus, the synthetic transmembrane peptide captures the ion channel activity of the intact NB protein...
  26. ncbi request reprint Simulation of the packing of idealized transmembrane alpha-helix bundles
    H S Son
    Laboratory of Molecular Biophysics, Rex Richards Building, University of Oxford, Oxford OX1 3QU, UK
    Eur Biophys J 28:489-98. 1999
    ..The results suggest that seven and 12 transmembrane helix bundles resembling those observed experimentally (e.g., bacteriorhodopsin, rhodopsin and cytochrome c oxidase subunit I) may be generated by simulations using simple potentials...
  27. ncbi request reprint Simulation studies on bacteriorhodopsin alpha-helices
    H S Son
    Laboratory of Molecular Biophysics, The Rex Richards Building, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Eur Biophys J 28:674-82. 2000
    ..The results obtained from the simulations may be used for further simulation studies and analysis in investigating transmembrane helix packing...
  28. ncbi request reprint Channel gating: twist to open
    P C Biggin
    Laboratory of Molecular Biophysics, Department of Biochemistry, The University of Oxford, The Rex Richards Building, South Parks Road, OX1 3QU, Oxford, UK
    Curr Biol 11:R364-6. 2001
    ..Recent studies of the bacterial mechanosensitive channel MscL have combined a number of different approaches to come up with a model for the channel gating mechanism...
  29. ncbi request reprint The structure of the HIV-1 Vpu ion channel: modelling and simulation studies
    F S Cordes
    Laboratory of Molecular Biophysics, Department of Biochemistry, Oxford University, UK
    Biochim Biophys Acta 1512:291-8. 2001
    ..The latter model adopts a very stable structure during the 2 ns of simulation. The stability of the models with W facing the pore depends on the starting structure. A possible gating mechanism is outlined...
  30. ncbi request reprint Ion channels: a first view of K+ channels in atomic glory
    M S Sansom
    Laboratory of Molecular Biophysics, University of Oxford, UK
    Curr Biol 8:R450-2. 1998
    ..These provide our first real structural insights into possible mechanisms of ion selectivity and permeation for K+ channels...
  31. ncbi request reprint Amino acid distributions in integral membrane protein structures
    M B Ulmschneider
    Laboratory of Molecular Biophysics, Rex Richards Building, Department of Biochemistry, University of Oxford, South Parks Road, OX1 3QU, Oxford, UK
    Biochim Biophys Acta 1512:1-14. 2001
    ..This suggests that there may be subtle differences in the factors stabilising beta-barrels in bacterial outer membranes and alpha-helix bundles in all other membranes...
  32. pmc Side-chain ionization states in a potassium channel
    K M Ranatunga
    Biophysics Section, Blackett Laboratory, Imperial College of Science, Technology, and Medicine, London SW7 2BZ, United Kingdom
    Biophys J 80:1210-9. 2001
    ....