Manjinder S Sandhu

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer
    Manjinder S Sandhu
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    J Natl Cancer Inst 94:972-80. 2002
  2. ncbi request reprint Association between insulin-like growth factor-I: insulin-like growth factor-binding protein-1 ratio and metabolic and anthropometric factors in men and women
    Manjinder S Sandhu
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    Cancer Epidemiol Biomarkers Prev 13:166-70. 2004
  3. doi request reprint The association between circulating lipoprotein(a) and type 2 diabetes: is it causal?
    Zheng Ye
    MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, U K
    Diabetes 63:332-42. 2014
  4. pmc Socioeconomic position and risk of short-term weight gain: prospective study of 14,619 middle-aged men and women
    Lisa R Purslow
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    BMC Public Health 8:112. 2008
  5. ncbi request reprint INS VNTR class genotype and indexes of body size and obesity: population-based studies of 7,999 middle-aged men and women
    Manjinder S Sandhu
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge, UK
    Diabetes 54:2812-5. 2005
  6. doi request reprint Lipoprotein(a) and risk of coronary, cerebrovascular, and peripheral artery disease: the EPIC-Norfolk prospective population study
    Deepti Gurdasani
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    Arterioscler Thromb Vasc Biol 32:3058-65. 2012
  7. ncbi request reprint No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults
    Paul G Surtees
    Strangeways Research Laboratory and University of Cambridge, Department of Public Health and Primary Care, Worts Causeway, Cambridge CB1 8RN, UK
    J Psychiatr Res 41:404-9. 2007
  8. doi request reprint Genetic determinants of lipid homeostasis
    Elizabeth H Young
    Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Best Pract Res Clin Endocrinol Metab 26:203-9. 2012
  9. pmc Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer
    Yoko Ito
    Department of Oncology, University of Cambridge, CRUK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Hum Mol Genet 17:2633-43. 2008
  10. pmc Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies
    Nadeem Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, UK
    Lancet 375:1634-9. 2010

Detail Information

Publications36

  1. ncbi request reprint Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer
    Manjinder S Sandhu
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    J Natl Cancer Inst 94:972-80. 2002
    ..This new evidence for biologic interactions among insulin, IGF-I, and IGFBPs in the context of colorectal carcinogenesis provides a potential mechanism through which diet and associated factors may increase the risk of this cancer...
  2. ncbi request reprint Association between insulin-like growth factor-I: insulin-like growth factor-binding protein-1 ratio and metabolic and anthropometric factors in men and women
    Manjinder S Sandhu
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    Cancer Epidemiol Biomarkers Prev 13:166-70. 2004
    ....
  3. doi request reprint The association between circulating lipoprotein(a) and type 2 diabetes: is it causal?
    Zheng Ye
    MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, U K
    Diabetes 63:332-42. 2014
    ..However, a genetic variant that elevated Lp(a) levels was not associated with risk of T2D, suggesting that elevated Lp(a) levels are not causally associated with a lower risk of T2D. ..
  4. pmc Socioeconomic position and risk of short-term weight gain: prospective study of 14,619 middle-aged men and women
    Lisa R Purslow
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    BMC Public Health 8:112. 2008
    ..The association between socioeconomic position in middle age and risk of subsequent, short-term weight gain is unknown. We therefore assessed this association in a prospective population based cohort study in Norfolk, UK...
  5. ncbi request reprint INS VNTR class genotype and indexes of body size and obesity: population-based studies of 7,999 middle-aged men and women
    Manjinder S Sandhu
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge, UK
    Diabetes 54:2812-5. 2005
    ..These data suggest that INS VNTR class is not an important determinant of size and body weight regulation in middle-aged men and women...
  6. doi request reprint Lipoprotein(a) and risk of coronary, cerebrovascular, and peripheral artery disease: the EPIC-Norfolk prospective population study
    Deepti Gurdasani
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    Arterioscler Thromb Vasc Biol 32:3058-65. 2012
    ..To contextualize these findings, we also examined the association between Lp(a) levels and risk of stroke and CAD and studied the role of low-density lipoprotein as an effect modifier of Lp(a)-associated cardiovascular risk...
  7. ncbi request reprint No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults
    Paul G Surtees
    Strangeways Research Laboratory and University of Cambridge, Department of Public Health and Primary Care, Worts Causeway, Cambridge CB1 8RN, UK
    J Psychiatr Res 41:404-9. 2007
    ..A total of 1214 (16.4%) participants reported lifetime MDD and 355 (4.8%) reported lifetime GAD. In this population based study we found no evidence to support an association between the BDNF gene Val66Met polymorphism and mood status...
  8. doi request reprint Genetic determinants of lipid homeostasis
    Elizabeth H Young
    Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Best Pract Res Clin Endocrinol Metab 26:203-9. 2012
    ..Better functional validation of lipid loci is required to clarify the biological role of proteins encoded by specific genomic regions and understand how they influence lipid metabolism and confer disease risk...
  9. pmc Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer
    Yoko Ito
    Department of Oncology, University of Cambridge, CRUK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Hum Mol Genet 17:2633-43. 2008
    ..These results indicate that IGF2 DMR0 hypomethylation has diagnostic potential for colon cancer rather than value as a surrogate biomarker for constitutive LOI...
  10. pmc Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies
    Nadeem Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, UK
    Lancet 375:1634-9. 2010
    ..Whether triglyceride-mediated pathways are causally relevant to coronary heart disease is uncertain. We studied a genetic variant that regulates triglyceride concentration to help judge likelihood of causality...
  11. ncbi request reprint Low circulating IGF-II concentrations predict weight gain and obesity in humans
    Manjinder S Sandhu
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, U K
    Diabetes 52:1403-8. 2003
    ..006). Our data suggest that circulating IGF-II levels may play a role in body weight regulation and development of obesity in men and women with normal glucose tolerance...
  12. pmc Common variants in WFS1 confer risk of type 2 diabetes
    Manjinder S Sandhu
    UK Medical Research Council MRC Epidemiology Unit, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Nat Genet 39:951-3. 2007
    ..Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes...
  13. ncbi request reprint Lipoprotein(a) Levels, Genotype, and Incident Aortic Valve Stenosis: A Prospective Mendelian Randomization Study and Replication in a Case-Control Cohort
    Benoit J Arsenault
    From the Montreal Heart Institute Research Center, Montreal, Quebec, Canada B J A, M P D, E R, J C T Department of Medicine, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada B J A, M P D, E R, J C T Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands S M B MRC Epidemiology Unit N J W and Department of Public Health and Primary Care K T K, M S S, University of Cambridge, Cambridge, United Kingdom and Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, United Kingdom M S S
    Circ Cardiovasc Genet 7:304-10. 2014
    ..Our objective was to determine whether lipoprotein(a) levels and a common genetic variant that is strongly associated with lipoprotein(a) levels are associated with an increased risk of developing AVS...
  14. pmc Association of HIV and ART with cardiometabolic traits in sub-Saharan Africa: a systematic review and meta-analysis
    David G Dillon
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK, Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda, Division of Diabetic Medicine and Endocrinology, Department of Medicine, University of Cape Town, Cape Town, South Africa Chronic Diseases Initiative in Africa, Department of Chemical Pathology, National Health Laboratory Service, University of the Witwatersrand Medical School, Johannesburg, South Africa, Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi, Department of Physiology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania, Department of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania, Royal Victoria Teaching Hospital, School of Medicine, University of The Gambia, Banjul, The Gambia, Department of Medicine, Obafemi Awolowo University, Ile Ife, Nigeria, Women s Equity in Access to Care and Treatment, Kigali, Rwanda, HIV 1 Immunopathogenesis Laboratory, Wistar Institute, Germany
    Int J Epidemiol 42:1754-71. 2013
    ....
  15. pmc LDL-cholesterol concentrations: a genome-wide association study
    Manjinder S Sandhu
    Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK
    Lancet 371:483-91. 2008
    ..We therefore did a genome-wide association study of LDL-cholesterol concentrations...
  16. ncbi request reprint IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer
    Ali Al-Zahrani
    CR UK Department of Oncology, Cambridge, UK
    Hum Mol Genet 15:1-10. 2006
    ..More specifically and consistent with experimental models, our data suggest that higher IGF1 levels may increase the risk of breast cancer but higher IGFBP3 levels may be protective...
  17. pmc The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis
    Hebe N Gouda
    Department of Public Health and Primary Care, University ofCambridge, Cambridge CB2 0SR, UK
    Am J Epidemiol 171:645-55. 2010
    ..Work on PPARG Pro12Ala should now focus on the observed heterogeneity in the magnitude of the association between populations. Further investigations into gene-gene and gene-environment interactions may prove enlightening...
  18. pmc A systematic review of definitions of extreme phenotypes of HIV control and progression
    Deepti Gurdasani
    aWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton bStrangeways Research Laboratory, Department of Public Health and Primary Care, University of Cambridge, Wort s Causeway, Cambridge cMedical Research Council, Clinical Trials Unit, Aviation House, London, UK dCentre for the AIDS Programme of Research in South Africa CAPRISA, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa eWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford fImperial College Healthcare NHS Trust, London gCambridge University Hospitals NHS Foundation Trust, Department of Infectious Diseases, Addenbrooke s Hospital, Cambridge hKing s College London, Weston Education Centre iDivision of Infection and Immunity, University College London, London, UK
    AIDS 28:149-62. 2014
    ..In this context, we were able to identify common components in existing definitions that may provide a framework for developing consensus definitions for these phenotypes in HIV infection. ..
  19. ncbi request reprint Sociodemographic distribution of non-communicable disease risk factors in rural Uganda: a cross-sectional study
    Georgina Av Murphy
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, Wellcome Trust Sanger Institute, Hinxton, UK, Medical Research Council Uganda Virus Research Institute MRC UVRI, Uganda Research Unit on AIDS, Entebbe, Uganda, London School of Hygiene and Tropical Medicine, London, UK and School of International Development, University of East Anglia, Norwich, UK
    Int J Epidemiol 42:1740-53. 2013
    ..In contrast to high-income countries, the sociodemographic distribution, including socioeconomic inequalities, of NCDs and their risk factors is unclear in sub-Saharan Africa, particularly among rural populations...
  20. ncbi request reprint Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study
    Manjinder S Sandhu
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    Lancet 359:1740-5. 2002
    ..We therefore prospectively examined the associations between circulating concentrations of IGF-I and IGFBP-1 and development of glucose tolerance...
  21. ncbi request reprint Self-reported birth weight and subsequent risk of colorectal cancer
    Manjinder S Sandhu
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge CB2 2SR, United Kingdom
    Cancer Epidemiol Biomarkers Prev 11:935-8. 2002
    ..There is a J-shape relation between self-reported birth weight and subsequent risk of colorectal cancer. Babies born with macrosomia appear to have the greatest risk...
  22. ncbi request reprint Insulin-like growth factor-I and risk of type 2 diabetes and coronary heart disease: molecular epidemiology
    Manjinder S Sandhu
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Endocr Dev 9:44-54. 2005
    ....
  23. ncbi request reprint PGC-1alpha genotype modifies the association of volitional energy expenditure with [OV0312]O2max
    Paul W Franks
    Institute of Public Health, University of Cambridge, United Kingdom
    Med Sci Sports Exerc 35:1998-2004. 2003
    ..Other murine studies demonstrate that exercise increases PGC-1alpha mRNA expression...
  24. pmc Study of association between common variation in the insulin-like growth factor 2 gene and indices of obesity and body size in middle-aged men and women
    Barbara Heude
    Medical Research Council Epidemiology Unit, Strangeways Research Laboratory, Cambridge CB1 8RN, United Kingdom
    J Clin Endocrinol Metab 92:2734-8. 2007
    ..Previous studies have reported that polymorphisms in IGF2 are associated with body weight and body mass index (BMI), but the results have been inconsistent...
  25. ncbi request reprint The impact of abnormalities in IGF and inflammatory systems on the metabolic syndrome
    Kalpana Kaushal
    Department of Diabetes and Endocrinology, Hope Hospital, Stott Lane, Salford, UK
    Diabetes Care 27:2682-8. 2004
    ....
  26. ncbi request reprint Serum levels of type II secretory phospholipase A2 and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 25:839-46. 2005
    ..To study the prospective relationship between serum levels of type II secretory phospholipase A2 (sPLA2) and the risk of future coronary artery disease (CAD) in apparently healthy men and women...
  27. ncbi request reprint C-reactive protein levels and coronary artery disease incidence and mortality in apparently healthy men and women: the EPIC-Norfolk prospective population study 1993-2003
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Atherosclerosis 187:415-22. 2006
    ..Measurement of C-reactive protein (CRP) levels has been proposed as a useful marker to improve the prediction of future coronary artery disease (CAD) risk, but this notion has been challenged recently...
  28. ncbi request reprint Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study
    Stefan F C Vaessen
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Lipid Res 47:2064-70. 2006
    ..The positive correlation of apoA-V levels with TG levels, negative correlation with LPL levels, and lack of association with CAD risk highlight the need for further human studies to clarify the role of apoA-V...
  29. ncbi request reprint The brain-derived neurotrophic factor Val66Met polymorphism is associated with sense of coherence in a non-clinical community sample of 7335 adults
    Paul G Surtees
    J Psychiatr Res 41:707-10. 2007
  30. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  31. pmc Genome-wide association analysis identifies 20 loci that influence adult height
    Michael N Weedon
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
    Nat Genet 40:575-83. 2008
    ..Finally, our results provide insights into the genetic architecture of a classic quantitative trait...
  32. ncbi request reprint Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations
    Aline Meirhaeghe
    INSERM, U744, Lille, Institut Pasteur de Lille, Lille, Universite de Lille 2, UMR 5744, Lille, France
    Hum Mol Genet 16:1343-50. 2007
    ..015, n = 634) and higher BNP promoter activity in reporter gene assays. Collectively, these data suggest that relatively high BNP expression may protect against type 2 diabetes in humans...
  33. ncbi request reprint Energy intake at breakfast and weight change: prospective study of 6,764 middle-aged men and women
    Lisa R Purslow
    MRC Epidemiology Unit, Institute of Medical Science, Addenbrooke s Hospital, Cambridge, United Kingdom
    Am J Epidemiol 167:188-92. 2008
    ..Redistribution of daily energy intake, so that more energy is consumed at breakfast and less energy is consumed later in the day, may help to reduce weight gain in middle-aged adults...
  34. ncbi request reprint A new sensitive and specific enzyme-linked immunosorbent assay for IgD
    David E Mosedale
    Translational Research Unit, Papworth Hospital NHS Trust, Papworth Everard, Cambridge Cambs CB3 8RE, UK
    J Immunol Methods 313:74-80. 2006
    ..These results highlight the care that needs to be taken to control for age, sex and cigarette smoking when examining levels of circulating IgD in future studies...
  35. ncbi request reprint Physical activity, C-reactive protein levels and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands
    Eur J Cardiovasc Prev Rehabil 13:970-6. 2006
    ..Whether this relationship is in part mediated by lower levels of systemic inflammation, as indicated by C-reactive protein concentrations, is unknown...
  36. ncbi request reprint Role of the apolipoprotein B-apolipoprotein A-I ratio in cardiovascular risk assessment: a case-control analysis in EPIC-Norfolk
    Wim A van der Steeg
    Academic Medical Center, Amsterdam, The Netherlands
    Ann Intern Med 146:640-8. 2007
    ..It is not known whether this ratio is better than traditional lipid values for risk assessment and prediction and whether it adds predictive value to the Framingham risk score...