Peter Sandercock

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial
    Peter Sandercock
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Lancet 379:2352-63. 2012
  2. pmc Update on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited
    Peter Sandercock
    The IST 3 Co ordinating Centre, Neurosciences Trial Unit, Bramwell Dott Building, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Trials 12:252. 2011
  3. doi request reprint Negative results: why do they need to be published?
    Peter Sandercock
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Bramwell Dott Building, Edinburgh EH4 2XU, UK
    Int J Stroke 7:32-3. 2012
  4. pmc A systematic review of clinical trials of pharmacological interventions for acute ischaemic stroke (1955-2008) that were completed, but not published in full
    Lorna M Gibson
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Trials 11:43. 2010
  5. doi request reprint The authors say: 'The data are not so robust because of heterogeneity' - so, how should I deal with this systematic review? Meta-analysis and the clinician
    Peter Sandercock
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Cerebrovasc Dis 31:615-20. 2011
  6. pmc The International Stroke Trial database
    Peter A G Sandercock
    Department of Clinical Neurosciences, University of Edinburgh, Department of Clinical Neurosciences, Western General Hospital, Edinburgh EH4 2XU, UK
    Trials 12:101. 2011
  7. doi request reprint Stroke: Carotid stenosis--surgery or stenting to prevent stroke?
    Peter Sandercock
    Department of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh, UK
    Nat Rev Neurol 6:647-8. 2010
  8. doi request reprint 'Where are we now with intravenous thrombolysis for acute ischaemic stroke'?
    Peter Sandercock
    University of Edinburgh, Edinburgh, UK
    Int J Stroke 5:381-2. 2010
  9. ncbi request reprint Targeting recombinant tissue-type plasminogen activator in acute ischemic stroke based on risk of intracranial hemorrhage or poor functional outcome: an analysis of the third international stroke trial
    William N Whiteley
    From the Divisions of Clinical Neurosciences W N W, G C, P S and Neuroimaging Sciences J W, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom Edinburgh MRC Hub for Trials Methodology Research, Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom D T, G M and Neurological and Mental Health Division, The George Institute for Global Health, University of Sydney, Sydney, Australia R I L
    Stroke 45:1000-6. 2014
  10. doi request reprint The use of blood biomarkers to predict poor outcome after acute transient ischemic attack or ischemic stroke
    William Whiteley
    Division of Clinical Neurosciences, General Hospital, University of Edinburgh, Edinburgh, UK
    Stroke 43:86-91. 2012

Detail Information

Publications41

  1. pmc The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial
    Peter Sandercock
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Lancet 379:2352-63. 2012
    ..The third International Stroke Trial (IST-3) sought to determine whether a wider range of patients might benefit up to 6 h from stroke onset...
  2. pmc Update on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited
    Peter Sandercock
    The IST 3 Co ordinating Centre, Neurosciences Trial Unit, Bramwell Dott Building, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Trials 12:252. 2011
    ..IST-3 sought to improve the external validity and precision of the estimates of the overall treatment effects (efficacy and safety) of rtPA in acute ischaemic stroke, and to determine whether a wider range of patients might benefit...
  3. doi request reprint Negative results: why do they need to be published?
    Peter Sandercock
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Bramwell Dott Building, Edinburgh EH4 2XU, UK
    Int J Stroke 7:32-3. 2012
    ..This short narrative review article defines 'negative results' and cites several ethical and scientific reasons why such studies should be made publicly available...
  4. pmc A systematic review of clinical trials of pharmacological interventions for acute ischaemic stroke (1955-2008) that were completed, but not published in full
    Lorna M Gibson
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Trials 11:43. 2010
    ....
  5. doi request reprint The authors say: 'The data are not so robust because of heterogeneity' - so, how should I deal with this systematic review? Meta-analysis and the clinician
    Peter Sandercock
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Cerebrovasc Dis 31:615-20. 2011
    ....
  6. pmc The International Stroke Trial database
    Peter A G Sandercock
    Department of Clinical Neurosciences, University of Edinburgh, Department of Clinical Neurosciences, Western General Hospital, Edinburgh EH4 2XU, UK
    Trials 12:101. 2011
    ....
  7. doi request reprint Stroke: Carotid stenosis--surgery or stenting to prevent stroke?
    Peter Sandercock
    Department of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh, UK
    Nat Rev Neurol 6:647-8. 2010
    ..In appropriately selected patients, plaque removal by carotid endarterectomy is of substantial net benefit. Endovascular stenting appears less "invasive" than endarterectomy,but is the former as safe and effective as the latter?..
  8. doi request reprint 'Where are we now with intravenous thrombolysis for acute ischaemic stroke'?
    Peter Sandercock
    University of Edinburgh, Edinburgh, UK
    Int J Stroke 5:381-2. 2010
    ....
  9. ncbi request reprint Targeting recombinant tissue-type plasminogen activator in acute ischemic stroke based on risk of intracranial hemorrhage or poor functional outcome: an analysis of the third international stroke trial
    William N Whiteley
    From the Divisions of Clinical Neurosciences W N W, G C, P S and Neuroimaging Sciences J W, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom Edinburgh MRC Hub for Trials Methodology Research, Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom D T, G M and Neurological and Mental Health Division, The George Institute for Global Health, University of Sydney, Sydney, Australia R I L
    Stroke 45:1000-6. 2014
    ..We tested if predictive models could identify patients least likely to be harmed by sICH or those who gained no net benefit...
  10. doi request reprint The use of blood biomarkers to predict poor outcome after acute transient ischemic attack or ischemic stroke
    William Whiteley
    Division of Clinical Neurosciences, General Hospital, University of Edinburgh, Edinburgh, UK
    Stroke 43:86-91. 2012
    ..We investigated whether such measurements improved the classification of patients into 4 categories of predicted risk of poor outcome: very high, intermediate high, intermediate low, and very low...
  11. pmc Association of circulating inflammatory markers with recurrent vascular events after stroke: a prospective cohort study
    William Whiteley
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh, EH4 2XU, UK
    Stroke 42:10-6. 2011
    ....
  12. ncbi request reprint Cost-effectiveness of thrombolysis with recombinant tissue plasminogen activator for acute ischemic stroke assessed by a model based on UK NHS costs
    Peter Sandercock
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Stroke 35:1490-7. 2004
    ..We aimed to model the health economic impact of limited use of thrombolytic therapy and to assess whether it was likely to be cost-effective when used more widely in the UK National Health Service (NHS)...
  13. pmc Does intermittent pneumatic compression reduce the risk of post stroke deep vein thrombosis? The CLOTS 3 trial: statistical analysis plan
    Martin Dennis
    Division of Clinical Neurosciences, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Trials 14:66. 2013
    ..The CLOTS 3 trial aims to determine whether, compared with best medical care, best medical care plus intermittent pneumatic compression (IPC) in immobile stroke patients reduces the risk of proximal deep vein thrombosis (DVT)...
  14. doi request reprint The effect of graduated compression stockings on long-term outcomes after stroke: the CLOTS trials 1 and 2
    Martin Dennis
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, UK
    Stroke 44:1075-9. 2013
    ..We aimed to estimate the effects of graduated compression stockings on venous thromboembolism events, survival, and functional status at 6 months after stroke...
  15. pmc Does intermittent pneumatic compression reduce the risk of post stroke deep vein thrombosis? The CLOTS 3 trial: study protocol for a randomized controlled trial
    Martin Dennis
    Division of Clinical Neurosciences, University of Edinburgh Western General Hospital, Edinburgh EH4 2XU, UK
    Trials 13:26. 2012
    ..The CLOTS trial 3 aims to determine whether, compared with best medical care, best medical care plus intermittent pneumatic compression in immobile stroke patients reduces the risk of proximal deep vein thrombosis...
  16. pmc Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis
    Joanna M Wardlaw
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Lancet 379:2364-72. 2012
    ..The IST-3 trial adds substantial new data. We therefore assessed all the evidence from randomised trials for rt-PA in acute ischaemic stroke in an updated systematic review and meta-analysis...
  17. ncbi request reprint Immediate computed tomography scanning of acute stroke is cost-effective and improves quality of life
    Joanna M Wardlaw
    Division of Clinical Neurosciences, Western General Hospital, Crewe Rd, Edinburgh, EH4 2XY, UK
    Stroke 35:2477-83. 2004
    ..We determined whether, and in what circumstances, CT is cost-effective in acute stroke...
  18. doi request reprint Can clinical features distinguish between immobile patients with stroke at high and low risk of deep vein thrombosis? Statistical modelling based on the CLOTS trials cohorts
    Martin Dennis
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    J Neurol Neurosurg Psychiatry 82:1067-73. 2011
    ..Guidelines recommend that DVT prophylaxis should be guided by an assessment of the individual patient's risk. The authors aimed to develop and test models to predict DVT risk...
  19. ncbi request reprint Impact of stroke syndrome and stroke severity on the process of consent in the Third International Stroke Trial
    Ingrid Kane
    Division of Clinical Neurosciences, Western General Hospital, Edinburgh, UK, and Western Clinical School, University of Sydney, Australia
    Cerebrovasc Dis 21:348-52. 2006
    ..We sought to assess the process of consent and to evaluate the influence of the patient's neurological deficit on the method used to obtain consent in the first 300 patients recruited into the Third International Stroke Trial (IST-3)...
  20. doi request reprint Third international stroke trial
    William Whiteley
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
    Int J Stroke 1:172-6. 2006
  21. ncbi request reprint Blood biomarkers for the diagnosis of acute cerebrovascular diseases: a prospective cohort study
    William Whiteley
    Division of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Crewe Road, Edinburgh, UK william whiteley ed ac uk
    Cerebrovasc Dis 32:141-7. 2011
    ..The diagnosis of stroke or TIA in the emergency department is difficult, though important for early treatment. Circulating biomarkers might improve upon clinical assessment at admission...
  22. pmc Inflammatory markers and poor outcome after stroke: a prospective cohort study and systematic review of interleukin-6
    William Whiteley
    Division of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Med 6:e1000145. 2009
    ....
  23. doi request reprint Risk factors for intracranial hemorrhage in acute ischemic stroke patients treated with recombinant tissue plasminogen activator: a systematic review and meta-analysis of 55 studies
    William N Whiteley
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK
    Stroke 43:2904-9. 2012
    ..We sought to identify the risk factors for ICH with a systematic review of the published literature...
  24. ncbi request reprint Systematic reviews of animal experiments
    Peter Sandercock
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh EH4 2XU, UK
    Lancet 360:586. 2002
  25. doi request reprint Blood biomarkers in the diagnosis of ischemic stroke: a systematic review
    William Whiteley
    Division of Clinical Neurosciences, University of Edinburgh, UK
    Stroke 39:2902-9. 2008
    ..CT may be normal in the early stages of ischemic stroke or in patients with minor symptoms and MR is not always possible. Many blood markers have been proposed for the diagnosis of stroke in the acute setting...
  26. ncbi request reprint An assessment of the cost-effectiveness of magnetic resonance, including diffusion-weighted imaging, in patients with transient ischaemic attack and minor stroke: a systematic review, meta-analysis and economic evaluation
    Joanna Wardlaw
    Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
    Health Technol Assess 18:1-368. 2014
    ..Patients with transient ischaemic attack (TIA) or minor stroke need rapid treatment of risk factors to prevent recurrent stroke. ABCD2 score or magnetic resonance diffusion-weighted brain imaging (MR DWI) may help assessment and treatment...
  27. ncbi request reprint Stroke
    Charles Warlow
    Division of Clinical Neurosciences, Western General Hospital, EH4 2XU, Edinburgh, UK
    Lancet 362:1211-24. 2003
    ..However, stroke management will only be most effective when delivered in the context of an organised, expert, educated, and enthusiastic stroke service that can react quickly to the needs of patients at all stages from onset to recovery...
  28. ncbi request reprint Effects of introducing an integrated care pathway in an acute stroke unit
    Joseph Kwan
    Western General Hospital, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK
    Age Ageing 33:362-7. 2004
    ..We sought to evaluate the effects of introducing an integrated care pathway for acute stroke...
  29. doi request reprint Hoover's sign for the diagnosis of functional weakness: a prospective unblinded cohort study in patients with suspected stroke
    Laura McWhirter
    Division of Clinical Neurosciences, Bramwell Dott Building, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    J Psychosom Res 71:384-6. 2011
    ..However, little is known about the performance of this sign in clinical practice...
  30. doi request reprint Blood markers for the prognosis of ischemic stroke: a systematic review
    William Whiteley
    Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
    Stroke 40:e380-9. 2009
    ..The performance of validated prognostic clinical models in acute ischemic stroke might be improved by addition of data on blood biomarkers...
  31. ncbi request reprint Comparison of 10 different magnetic resonance perfusion imaging processing methods in acute ischemic stroke: effect on lesion size, proportion of patients with diffusion/perfusion mismatch, clinical scores, and radiologic outcomes
    Ingrid Kane
    Division of Clinical Neurosciences, Bramwell Dott Building, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland
    Stroke 38:3158-64. 2007
    ..Several methods are available to assess the magnetic resonance perfusion lesion in acute ischemic stroke. We tested 10 of these to compare perfusion lesion sizes and to assess the relation to clinical scores and final infarct extent...
  32. doi request reprint A telephone hotline for transient ischaemic attack and stroke: prospective audit of a model to improve rapid access to specialist stroke care
    Enda Kerr
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh
    BMJ 341:c3265. 2010
    ..The challenge with such patients is to minimise delays and ensure that treatment is appropriate, and to provide this care with the available resources...
  33. ncbi request reprint Full heparin anticoagulation should not be used in acute ischemic stroke
    Peter Sandercock
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
    Stroke 34:231-2. 2003
  34. doi request reprint The NeuroGrid stroke exemplar clinical trial protocol
    J M Wardlaw
    Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
    Int J Stroke 2:63-9. 2007
    ..However, multicentre trials use many different scanners in different hospitals and present complex problems for image data collection, interpretation and analysis and long-term secure archiving...
  35. pmc Low dose aspirin and cognitive function in middle aged to elderly adults: randomised controlled trial
    Jackie F Price
    Division of Community Health Sciences and Centre for Public Health and Primary Care Research, University of Edinburgh, Edinburgh
    BMJ 337:a1198. 2008
    ..To determine the effects of low dose aspirin on cognitive function in middle aged to elderly men and women at moderately increased cardiovascular risk...
  36. ncbi request reprint Third International Stroke Trial 3: an update
    Antonio Arauz
    aStroke Clinic, National Institute of Neurology and Neurosurgery, Mexico City, Mexico bDepartment of Internal Medicine, Oslo University Hospital, Oslo, Norway cDivision of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Curr Opin Neurol 27:8-12. 2014
    ..It sought to determine whether a wider variety of patients might benefit from treatment than were eligible under the prevailing European Union approval for the drug, especially among those aged over 80 years...
  37. ncbi request reprint Contents of the Cochrane library on the organisation of stroke services
    Peter Sandercock
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
    Cerebrovasc Dis 15:2-4. 2003
    ..This paper briefly summarises the output of the Cochrane Stroke Group in relation to evaluating different forms of the organisation of services for patients with stroke...
  38. pmc "Can it read my mind?" - What do the public and experts think of the current (mis)uses of neuroimaging?
    Joanna M Wardlaw
    Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e25829. 2011
    ..The present study also emphasizes the need for better frameworks for scientific engagement with media and public education...
  39. ncbi request reprint Immediate anticoagulation for acute stroke in atrial fibrillation: no
    Peter Sandercock
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh EH4 2XU, UK
    Stroke 37:3054-5. 2006
  40. ncbi request reprint Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke
    Emily Sena
    Clinical Neurosciences, University of Edinburgh, Edinburgh, Scotland, UK
    Stroke 38:388-94. 2007
    ..Here we use systematic review and meta-analysis to describe the characteristics and limits to the neuroprotective action of tirilazad in animal models of stroke...