Affiliation: University of Warwick
Sampath K, Ephrussi A. CncRNAs: RNAs with both coding and non-coding roles in development. Development. 2016;143:1234-41 pubmed publisher
..Here, we discuss key examples of cncRNAs and review their roles, regulation and mechanisms of action during development. ..
Vrljicak P, Tao S, Varshney G, Quach H, Joshi A, LaFave M, et al
. Genome-Wide Analysis of Transposon and Retroviral Insertions Reveals Preferential Integrations in Regions of DNA Flexibility. G3 (Bethesda). 2016;6:805-17 pubmed publisher
..Our findings show that structural features influence the integration of heterologous DNA in genomes, and have implications for targeted genome engineering. ..
Zaucker A, Kumari P, Sampath K. Zebrafish embryogenesis - A framework to study regulatory RNA elements in development and disease. Dev Biol. 2019;: pubmed publisher
..We also highlight the potential of zebrafish to model human diseases and for drug discovery. ..
Sampath K, Robertson E. Keeping a lid on nodal: transcriptional and translational repression of nodal signalling. Open Biol. 2016;6:150200 pubmed publisher
..Here, we discuss recent evidence from sea urchins, frogs, fish, mice and humans that show a role for transcriptional and translational repression of Nodal signalling during early development. ..
Quach H, Tao S, Vrljicak P, Joshi A, Ruan H, Sukumaran R, et al
. A Multifunctional Mutagenesis System for Analysis of Gene Function in Zebrafish. G3 (Bethesda). 2015;5:1283-99 pubmed publisher
..warwick.ac.uk/). Our approach complements other efforts using zebrafish to facilitate functional genomic studies in this model of human development and disease. ..
Kumari P, Sampath K. cncRNAs: Bi-functional RNAs with protein coding and non-coding functions. Semin Cell Dev Biol. 2015;47-48:40-51 pubmed publisher
..Because the functions of many RNAs across genomes remains unclear, we propose that RNAs be classified as coding, non-coding or both only after careful analysis of their functions. ..