N J Samani

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. pmc Novel loci associated with increased risk of sudden cardiac death in the context of coronary artery disease
    Adriana Huertas-Vazquez
    The Heart Institute, Cedars Sinai Medical Center, Los Angeles, California, United States of America
    PLoS ONE 8:e59905. 2013
  2. pmc Comparative in silico analysis identifies bona fide MyoD binding sites within the Myocyte stress 1 gene promoter
    Samir Ounzain
    Cardiology Group, Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, LE3 9QP, UK
    BMC Mol Biol 9:50. 2008
  3. doi request reprint Coronary artery disease-associated locus on chromosome 9p21 and early markers of atherosclerosis
    Nilesh J Samani
    Department of Cardiovascular Sciences, University of Leicester, UK
    Arterioscler Thromb Vasc Biol 28:1679-83. 2008
  4. pmc Genomewide association analysis of coronary artery disease
    Nilesh J Samani
    University of Leicester, Leicester, United Kingdom
    N Engl J Med 357:443-53. 2007
  5. pmc Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester, UK
    Hypertension 56:1069-76. 2010
  6. doi request reprint The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol
    Nilesh J Samani
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK
    J Mol Med (Berl) 86:1233-41. 2008
  7. pmc A genomewide linkage study of 1,933 families affected by premature coronary artery disease: The British Heart Foundation (BHF) Family Heart Study
    Nilesh J Samani
    Department of Cardiovascular Sciences, University of Leicester, UK
    Am J Hum Genet 77:1011-20. 2005
  8. ncbi request reprint Genetic analysis of the SA and Na+/K+-ATPase alpha1 genes in the Milan hypertensive rat
    D Lodwick
    Department of Medicine and Therapeutics, University of Leicester, UK
    J Hypertens 16:139-44. 1998
  9. ncbi request reprint Successful isolation of a rat chromosome 1 blood pressure quantitative trait locus in reciprocal congenic strains
    S A Frantz
    Departments of Cardiology and Ophthalmology, University of Leicester, Leicester, UK
    Hypertension 32:639-46. 1998
  10. doi request reprint Is there an association between angiotensin converting enzyme (ACE) genotypes and abdominal aortic aneurysm?
    B Obukofe
    Department of Cardiovascular Sciences, University of Leicester, UK
    Eur J Vasc Endovasc Surg 40:457-60. 2010

Detail Information

Publications94

  1. pmc Novel loci associated with increased risk of sudden cardiac death in the context of coronary artery disease
    Adriana Huertas-Vazquez
    The Heart Institute, Cedars Sinai Medical Center, Los Angeles, California, United States of America
    PLoS ONE 8:e59905. 2013
    ..The objective of this study was to identify novel DNA variation associated with SCD in the context of coronary artery disease (CAD)...
  2. pmc Comparative in silico analysis identifies bona fide MyoD binding sites within the Myocyte stress 1 gene promoter
    Samir Ounzain
    Cardiology Group, Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, LE3 9QP, UK
    BMC Mol Biol 9:50. 2008
    ..In this study we employed a comparative in silico analysis coupled with an experimental promoter characterisation to delineate these mechanisms...
  3. doi request reprint Coronary artery disease-associated locus on chromosome 9p21 and early markers of atherosclerosis
    Nilesh J Samani
    Department of Cardiovascular Sciences, University of Leicester, UK
    Arterioscler Thromb Vasc Biol 28:1679-83. 2008
    ..The effect of the locus on early markers of atherosclerosis is unknown. We examined its association with carotid intima-media thickness (CIMT) and brachial flow-mediated dilatation (FMD)...
  4. pmc Genomewide association analysis of coronary artery disease
    Nilesh J Samani
    University of Leicester, Leicester, United Kingdom
    N Engl J Med 357:443-53. 2007
    ..Modern genotyping platforms permit a systematic search for inherited components of complex diseases. We performed a joint analysis of two genomewide association studies of coronary artery disease...
  5. pmc Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester, UK
    Hypertension 56:1069-76. 2010
    ....
  6. doi request reprint The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol
    Nilesh J Samani
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK
    J Mol Med (Berl) 86:1233-41. 2008
    ..The findings support further investigation of the role of these genes in cholesterol metabolism and coronary risk...
  7. pmc A genomewide linkage study of 1,933 families affected by premature coronary artery disease: The British Heart Foundation (BHF) Family Heart Study
    Nilesh J Samani
    Department of Cardiovascular Sciences, University of Leicester, UK
    Am J Hum Genet 77:1011-20. 2005
    ..The exclusion of a common locus that increases risk of CAD to siblings by >50% has important implications for strategies for further defining the genetic basis of CAD...
  8. ncbi request reprint Genetic analysis of the SA and Na+/K+-ATPase alpha1 genes in the Milan hypertensive rat
    D Lodwick
    Department of Medicine and Therapeutics, University of Leicester, UK
    J Hypertens 16:139-44. 1998
    ..To study whether the SA gene locus (on rat chromosome 1) and the sodium potassium ATPase alpha1 gene locus (on rat chromosome 2) contribute to the elevated blood pressure in the Milan hypertensive rat...
  9. ncbi request reprint Successful isolation of a rat chromosome 1 blood pressure quantitative trait locus in reciprocal congenic strains
    S A Frantz
    Departments of Cardiology and Ophthalmology, University of Leicester, Leicester, UK
    Hypertension 32:639-46. 1998
    ....
  10. doi request reprint Is there an association between angiotensin converting enzyme (ACE) genotypes and abdominal aortic aneurysm?
    B Obukofe
    Department of Cardiovascular Sciences, University of Leicester, UK
    Eur J Vasc Endovasc Surg 40:457-60. 2010
    ..This study aimed to investigate the possible association between the ACE insertion/deletion polymorphism and abdominal aortic aneurysm (AAA) in order to replicate the findings of other authors...
  11. pmc Genetic dissection of a blood pressure quantitative trait locus on rat chromosome 1 and gene expression analysis identifies SPON1 as a novel candidate hypertension gene
    Jenny Rebecca Clemitson
    Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK
    Circ Res 100:992-9. 2007
    ..Spon1 belongs to a family of genes with antiangiogenic properties. These findings justify further investigation of this novel positional candidate gene in BP control in hypertensive rat models and humans...
  12. ncbi request reprint A myocardial perfusion reserve index in humans using first-pass contrast-enhanced magnetic resonance imaging
    J H Cullen
    Department of Medicine and Therapeutics, University of Leicester, England, United Kingdom
    J Am Coll Cardiol 33:1386-94. 1999
    ....
  13. ncbi request reprint Genetic dissection of region around the Sa gene on rat chromosome 1: evidence for multiple loci affecting blood pressure
    S Frantz
    Department of Cardiology, University of Leicester, Leicester, United Kingdom
    Hypertension 38:216-21. 2001
    ..Our observations serve to illustrate the complexity of QTL dissection and the care needed to interpret findings from congenic studies...
  14. ncbi request reprint ms1, a novel stress-responsive, muscle-specific gene that is up-regulated in the early stages of pressure overload-induced left ventricular hypertrophy
    Harin Mahadeva
    Division of Cardiology, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, UK
    FEBS Lett 521:100-4. 2002
    ..These findings suggest that ms1 may be important in striated muscle biology and the development of pressure-induced left ventricular hypertrophy...
  15. ncbi request reprint Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population
    Martin D Tobin
    Department of Health Sciences, University of Leicester, Leicester, England
    Circulation 112:3423-9. 2005
    ..Mutations in the WNK1 and WNK4 genes cause a rare monogenic hypertensive syndrome, pseudohypoaldosteronism type II. We investigated whether polymorphisms in these WNK genes influence BP in the general population...
  16. doi request reprint Arachidonate 5-lipoxygenase (5-LO) promoter genotype and risk of myocardial infarction: a case-control study
    Annette Maznyczka
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Atherosclerosis 199:328-32. 2008
    ..Elevated CIMT is a risk factor for coronary events. In this study we investigated whether carriage of two variants alleles for the 5-lipoxygenase promoter polymorphism is associated with increased risk of myocardial infarction (MI)...
  17. doi request reprint A regulatory SNP of the BICD1 gene contributes to telomere length variation in humans
    Massimo Mangino
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Hum Mol Genet 17:2518-23. 2008
    ..004). BICD1 is involved in Golgi-to-endoplasmic reticulum vacuolar transport. Previous studies have implicated vacuolar genes in telomere length homeostasis in yeast. Our study indicates that BICD1 plays a similar role in humans...
  18. doi request reprint The canonical E-box motif: a target for glucocorticoid action that drives rhythmic mouse Pai-1 transcription in vitro
    Joanne H Singletary
    Cardiology Group, Department of Cardiovascular Sciences, Glenfield General Hospital, Clinical Sciences Wing, University of Leicester, Leicester LE3 9QP, UK
    Gene 420:42-7. 2008
    ..The mechanism described has global impact on diverse dynamic biological processes governed by the neuroendocrine axis and the circadian clockwork to control complex coordination of gene cascades and biology...
  19. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  20. ncbi request reprint Coronary artery disease: combined stress MR imaging protocol-one-stop evaluation of myocardial perfusion and function
    P R Sensky
    Department of Cardiology, Glenfield Hospital, Groby Rd, Leicester LE3 9QP, United Kingdom
    Radiology 215:608-14. 2000
    ..This protocol offers a one-stop assessment of patients with coronary artery disease with use of a clinical MR imager...
  21. doi request reprint Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations
    Martin D Tobin
    Department of Health Sciences, University of Leicester, UK
    Int J Epidemiol 37:1132-41. 2008
    ..We investigated the association between rs10494366 in NOS1AP and QTc, and assessed gender-specific NOS1AP associations with QTc during rest and after exercise...
  22. doi request reprint Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population
    Martin D Tobin
    Department of Health Sciences and Genetics, University of Leicester, UK
    Hypertension 51:1658-64. 2008
    ..Notably, variants in KCNJ1, which causes Bartter syndrome type 2, were strongly associated, potentially providing a novel target for intervention...
  23. doi request reprint A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways
    Chris I Jones
    Department of Cardiovascular Science, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester, United Kingdom
    Blood 114:1405-16. 2009
    ..004). Furthermore the minor allele of the intronic SNP rs17786144 in ITPR1 modified Ca(2+) levels after activation with ADP (P < .004). These data provide novel insights into key hubs within platelet signaling networks...
  24. ncbi request reprint Genotypes and haplotypes predisposing to myocardial infarction: a multilocus case-control study
    Martin D Tobin
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, UK
    Eur Heart J 25:459-67. 2004
    ..To identify polymorphisms and haplotypes in candidate genes that predispose to myocardial infarction (MI) using a multilocus approach...
  25. ncbi request reprint White cell telomere length and risk of premature myocardial infarction
    Scott Brouilette
    Division of Cardiology, Department of Medicine, University of Leicester, United Kingdom
    Arterioscler Thromb Vasc Biol 23:842-6. 2003
    ..Mean telomeres lengths provide an assessment of biological age with shorter telomeres, indicating increased biological age. We investigated whether subjects with premature myocardial infarction (MI) had shorter leukocyte telomeres...
  26. ncbi request reprint Influence of non-invasive measurements of arterial blood pressure in frequency and time-domain estimates of cardiac baroreflex sensitivity
    Stephen Matthew Smith
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    J Hypertens 26:76-82. 2008
    ....
  27. ncbi request reprint Analysis of quantitative trait loci for blood pressure on rat chromosomes 2 and 13. Age-related differences in effect
    N J Samani
    Department of Medicine, University of Leicester, UK
    Hypertension 28:1118-22. 1996
    ....
  28. ncbi request reprint Psychological morbidity and illness appraisals of patients with cardiac and non-cardiac chest pain attending a rapid access chest pain clinic: a longitudinal cohort study
    N Robertson
    School of Psychology, University of Leicester, UK
    Heart 94:e12. 2008
    ..To assess the psychological morbidity and illness beliefs in newly referred patients with chest pain, and to compare the psychological morbidity of patients with pain of cardiac origin with that of patients with pain of non-cardiac origin...
  29. ncbi request reprint Cerebral critical closing pressure estimation from Finapres and arterial blood pressure measurements in the aorta
    R B Panerai
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Physiol Meas 27:1387-402. 2006
    ....
  30. ncbi request reprint LGALS2 functional variant rs7291467 is not associated with susceptibility to myocardial infarction in Caucasians
    Massimo Mangino
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Atherosclerosis 194:112-5. 2007
    ..Despite this, we found no significant association of allele frequency with risk of MI. Stratification for age, gender and other cardiovascular risk factors also failed to reveal an association of this polymorphism with MI...
  31. ncbi request reprint Association analysis of IL-12B and IL-23R polymorphisms in myocardial infarction
    Massimo Mangino
    Department of Cardiovascular Sciences, Clinical Sciences Wing, Glenfield Hospital, University of Leicester, Leicester, UK
    J Mol Med (Berl) 86:99-103. 2008
    ..These results indicate that unlike other chronic inflammatory diseases, the examined variants are unlikely to be major contributors to the pathogenesis of MI...
  32. ncbi request reprint The interleukin-10-1082 'A' allele and abdominal aortic aneurysms
    Matthew J Bown
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    J Vasc Surg 46:687-93. 2007
    ..The aim of this study was to determine whether this polymorphism is associated with AAA and also examine its effect on the growth of small AAA...
  33. ncbi request reprint Transient drifts between Finapres and continuous intra-aortic measurements of blood pressure
    Ronney B Panerai
    Department of Cardiovascular Sciences, University of Leicester, UK
    Blood Press Monit 12:369-76. 2007
    ..We tested the hypothesis that continuous beat-to-beat differences are not random and aimed to describe the temporal pattern of any transient drifts...
  34. ncbi request reprint Beyond "misunderstanding": written information and decisions about taking part in a genetic epidemiology study
    Mary Dixon-Woods
    University of Leicester, Leicester, UK
    Soc Sci Med 65:2212-22. 2007
    ..These questions need to be addressed through engagement and dialogue between the research, research participants, social science, and ethics communities...
  35. ncbi request reprint Ischemic preconditioning of the whole heart confers protection on subsequently isolated ventricular myocytes
    Glenn C Rodrigo
    Department of Cardiovascular Sciences, University of Leicester, Glenfield General Hospital, Leicester, UK
    Am J Physiol Heart Circ Physiol 294:H524-31. 2008
    ..The model should allow future studies in isolated cells of the protective mechanisms induced by true ischemia...
  36. doi request reprint Saturated fatty acids do not directly stimulate Toll-like receptor signaling
    Clett Erridge
    Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK
    Arterioscler Thromb Vasc Biol 29:1944-9. 2009
    ....
  37. pmc Association between lipid profile and circulating concentrations of estrogens in young men
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Atherosclerosis 203:257-62. 2009
    ..Unlike androgens, estrogens were not extensively investigated in relation to cardiovascular phenotypes in men...
  38. doi request reprint Common variation in the WNK1 gene and blood pressure in childhood: the Avon Longitudinal Study of Parents and Children
    Martin D Tobin
    Departments of Health Sciences and Genetics, Genetic Epidemiology Group, University of Leicester, Leicester, United Kingdom
    Hypertension 52:974-9. 2008
    ..Our study suggests that previously reported effects of WNK1 variants on blood pressure are mediated via effects on the gradient of blood pressure change with age...
  39. pmc Inverse associations between androgens and renal function: the Young Men Cardiovascular Association (YMCA) study
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Am J Hypertens 22:100-5. 2009
    ..Men exhibit higher risk of nondiabetic renal diseases than women. This male susceptibility to renal disease may be mediated by gender-specific factors such as sex hormones...
  40. pmc A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester, LE3 9QP, UK
    Arterioscler Thromb Vasc Biol 29:1316-21. 2009
    ..We hypothesized that common variants in LRP6 could predispose subjects to elevated LDL-cholesterol (LDL-C)...
  41. doi request reprint Association between the coronary artery disease risk locus on chromosome 9p21.3 and abdominal aortic aneurysm
    Matthew J Bown
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Circ Cardiovasc Genet 1:39-42. 2008
    ..3 and coronary artery disease. We performed a case-control study to investigate the association between this locus and abdominal aortic aneurysm (AAA)...
  42. pmc Common variants near TERC are associated with mean telomere length
    Veryan Codd
    Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK
    Nat Genet 42:197-9. 2010
    ..Each copy of the minor allele of rs12696304 was associated with an approximately 75-base-pair reduction in mean telomere length, equivalent to approximately 3.6 years of age-related telomere-length attrition...
  43. pmc Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function
    Alison H Goodall
    Department of Cardiovascular Science, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester, UK
    Blood 116:4646-56. 2010
    ..Taken together, these data reveal novel proteins regulating the platelet response...
  44. pmc Pathway analysis shows association between FGFBP1 and hypertension
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester LE3 9QP, UK
    J Am Soc Nephrol 22:947-55. 2011
    ..Taken together, these data suggest that FGFBP1 associates with hypertension and that systematic analysis of signaling pathways can identify previously undescribed genetic associations...
  45. pmc A genome-wide survey demonstrates widespread non-linear mRNA in expressed sequences from multiple species
    Richard J Dixon
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester LE3 9QP, UK
    Nucleic Acids Res 33:5904-13. 2005
    ..These findings imply that RREO affects a significant subset of genes within a genome and suggests that non-linear information encoded within the genomes of complex organisms could contribute to phenotypic variation...
  46. ncbi request reprint Galectin 1 inhibits incorporation of vitronectin and chondroitin sulfate B into the extracellular matrix of human vascular smooth muscle cells
    Elena P Moiseeva
    Division of Cardiology, Department of Medicine, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester LE3 9QP, UK
    Biochim Biophys Acta 1619:125-32. 2003
    ..These results suggest that galectin-1 is likely to be involved in the ECM assembly affecting incorporation of some ECM components important for SMC behaviour...
  47. ncbi request reprint Circadian clock genes cause activation of the human PAI-1 gene promoter with 4G/5G allelic preference
    Nelson W Chong
    Cardiology Group, Department of Cardiovascular Sciences, Glenfield General Hospital, Clinical Sciences Wing, University of Leicester, Leicester LE3 9QP, UK
    FEBS Lett 580:4469-72. 2006
    ..These results identify a potential novel mechanism whereby allele-specific clock genes - mediated modulation of PAI-1 expression may contribute to circadian variation in cardiac risk...
  48. ncbi request reprint Kidney specificity of rat chromosome 1 blood pressure quantitative trait locus region
    Jenny Rebecca Clemitson
    Department of Cardiology, University of Leicester, Leicester, United Kingdom
    Hypertension 40:292-7. 2002
    ....
  49. ncbi request reprint Complementary intron sequence motifs associated with human exon repetition: a role for intragenic, inter-transcript interactions in gene expression
    Richard J Dixon
    Department of Cardiovascular Sciences Leicester, LE3 9Q, UK
    Bioinformatics 23:150-5. 2007
    ..The regulation of this process is not fully understood. We therefore investigated the entire flanking intronic sequences of exons involved in exon repetition for common sequence elements...
  50. pmc Mapping of a major locus that determines telomere length in humans
    Mariuca Vasa-Nicotera
    Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, United Kingdom
    Am J Hum Genet 76:147-51. 2005
    ..Identification of the gene involved and elucidation of its mechanism of action could have important implications for our understanding of chromosomal assembly, telomere biology, and susceptibility to age-related diseases...
  51. ncbi request reprint Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study
    Scott W Brouilette
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Lancet 369:107-14. 2007
    ..Inter-individual differences in biological ageing could affect susceptibility to coronary heart disease. Our aim was to determine whether mean leucocyte telomere length is a predictor of the development of coronary heart disease...
  52. ncbi request reprint Efficacy of transmyocardial laser revascularization and thoracic sympathectomy for the treatment of refractory angina
    Manuel Galinanes
    Department of Integrative Human Cardiovascular Physiology and Cardiac Surgery, Glenfield Hospital, University of Leicester, United Kingdom
    Ann Thorac Surg 78:122-8. 2004
    ..We investigate the efficacy of TMR and thoracic sympathectomy (TS) for relief of angina and whether any clinical benefit is associated with enhanced myocardial perfusion...
  53. ncbi request reprint Coronary heart disease in people of south-Asian origin
    Kamlesh Khunti
    Department of Health Sciences, University of Leicester, Leicester LE5 4PW, UK
    Lancet 364:2077-8. 2004
  54. doi request reprint Short leukocyte telomere length is associated with abdominal aortic aneurysm (AAA)
    G Atturu
    Department of Cardiovascular Sciences, Robert Kilpatrick Building, Leicester Royal Infirmary, University of Leicester, Leicester LE2 7LX, United Kingdom
    Eur J Vasc Endovasc Surg 39:559-64. 2010
    ..The aim of this study was to determine the relationship between abdominal aortic aneurysm (AAA) and white cell telomere length...
  55. ncbi request reprint Influence of noninvasive peripheral arterial blood pressure measurements on assessment of dynamic cerebral autoregulation
    Emily L Sammons
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    J Appl Physiol 103:369-75. 2007
    ....
  56. ncbi request reprint Chromosomal assignment of the human SA gene to 16p13.11 and demonstration of its expression in the kidney
    N J Samani
    Department of Medicine, University of Leicester, UK
    Biochem Biophys Res Commun 199:862-8. 1994
    ..Increased expression of the gene in the kidney may be the mechanism through which some allelic variants of the gene raise blood pressure in rodent models. In this study we also demonstrate that the SA gene is expressed in human kidneys...
  57. doi request reprint Are baroreflex events detected by invasive and non-invasive techniques coincident?
    Stephen M Smith
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Clin Physiol Funct Imaging 28:262-9. 2008
    ..Non-invasive, compared with intra-arterial estimates of BRS by sequence analysis are not influenced by coincidence of sequences if acceptance of sequences is based on the correlation coefficient criteria (>0.85)...
  58. ncbi request reprint Galectin-1 interacts with beta-1 subunit of integrin
    Elena P Moiseeva
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, UK
    Biochem Biophys Res Commun 310:1010-6. 2003
    ..Galectin-1 is likely to affect SMC adhesion by interacting with beta1 integrin on the cell surface of SMCs and inducing outside-in signalling...
  59. pmc Exon repetition: a major pathway for processing mRNA of some genes is allele-specific
    Roberto Rigatti
    Department of Biochemistry, University of Leicester, UK
    Nucleic Acids Res 32:441-6. 2004
    ..It is not determined by exonic splicing signals, as had been suggested previously. In heterozygotes, RNA transcribed from the two alleles of an affected gene can have fundamentally different fates...
  60. ncbi request reprint Leukotriene B4 production in healthy subjects carrying variants of the arachidonate 5-lipoxygenase-activating protein gene associated with a risk of myocardial infarction
    Annette Maznyczka
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester, UK
    Clin Sci (Lond) 112:411-6. 2007
    ..The results suggest that knowledge of a patient's haplotype may not provide useful information on the probable clinical response to ALOX5AP inhibitors...
  61. doi request reprint Short- and medium-term survival following coronary artery bypass surgery in British Indo-Asian and white Caucasian individuals: impact of diabetes mellitus
    Leonidas Hadjinikolaou
    University Hospitals of Leicester NHS Trust, Leicester, UK
    Interact Cardiovasc Thorac Surg 10:389-93. 2010
    ..SA diabetics have a significantly higher postoperative mortality and worse overall life expectancy. Ethnicity per se is not an independent predictor of short- or medium-term survival after CABG...
  62. ncbi request reprint Dimorphism in the P2Y1 ADP receptor gene is associated with increased platelet activation response to ADP
    Simon L Hetherington
    Department of Cardiovascular Sciences, University of Leicester, United Kingdom
    Arterioscler Thromb Vasc Biol 25:252-7. 2005
    ..There is marked interindividual variation in platelet response to ADP. We studied whether genetic variants in the P2Y1 or P2Y12 genes affect platelet response to ADP...
  63. doi request reprint Telomere length is shorter in healthy offspring of subjects with coronary artery disease: support for the telomere hypothesis
    S W Brouilette
    Department of Cardiovascular Sciences, University of Leicester, UK
    Heart 94:422-5. 2008
    ..Telomeres are shorter in subjects with coronary artery disease (CAD) and may indicate premature biological ageing. However, whether shorter telomeres are a primary abnormality or secondary to the disease is unclear...
  64. ncbi request reprint Association studies in current cardiovascular genetics - functional variants, tags or both?
    M Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    J Hum Hypertens 21:425-6. 2007
  65. pmc Circulating stromelysin-1 (MMP-3): a novel predictor of LV dysfunction, remodelling and all-cause mortality after acute myocardial infarction
    D Kelly
    Department of Cardiovascular Sciences, University of Leicester, UK
    Eur J Heart Fail 10:133-9. 2008
    ..We investigated the temporal profile of MMP-3 and its relationship to LV dysfunction and prognosis following AMI...
  66. doi request reprint Continuous estimates of dynamic cerebral autoregulation: influence of non-invasive arterial blood pressure measurements
    R B Panerai
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Physiol Meas 29:497-513. 2008
    ....
  67. ncbi request reprint Restoration of myocardial blood flow following percutaneous coronary balloon dilatation and stent implantation: assessment with qualitative and quantitative contrast-enhanced magnetic resonance imaging
    P R Sensky
    Department of Cardiology, University of Leicester, Glenfield Hospital, Leicester, UK
    Clin Radiol 57:593-9. 2002
    ..To examine the serial use of magnetic resonance imaging (MRI) to evaluate regional myocardial perfusion changes following percutaneous coronary angioplasty and stent implantation (PTCA)...
  68. ncbi request reprint Magnetic resonance perfusion imaging in patients with coronary artery disease: a qualitative approach
    Penelope R Sensky
    Department of Cardiology, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QP
    Int J Cardiovasc Imaging 18:373-83; discussion 385-6. 2002
    ..Although contrast-enhanced first pass magnetic resonance imaging (MRI) has potential to quantify blood flow through extensive image post-processing, clinical utility is likely to depend on rapid qualitative analysis...
  69. ncbi request reprint Interpreting regional myocardial magnetic resonance imaging data: a new method for collation with angiographic findings in patients with coronary artery disease
    Penelope R Sensky
    Departments of Cardiology, University of Leicester, Glenfield Hospital, Leicester, UK
    Clin Radiol 57:498-501. 2002
    ..Routine clinical use of this approach is likely to increase the accuracy of MRI data interpretation and to influence both medical and interventional treatment strategies...
  70. ncbi request reprint Analysis of the role of the SA gene in blood pressure regulation by gene targeting
    Vanessa Walsh
    Division of Cardiology, Department of Medicine, University of Leicester, Leicester, UK
    Hypertension 41:1212-8. 2003
    ..SA is not involved in the regulation of either basal or salt related BP, and the lack of differential effect in SA-/- mice is not a consequence of compensatory activation of the renin-angiotensin system...
  71. doi request reprint Evidence for genetic regulation of endothelial progenitor cells and their role as biological markers of atherosclerotic susceptibility
    Andrew Whittaker
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Eur Heart J 29:332-8. 2008
    ..We hypothesized that EPC number and/or function may be genetically regulated and may vary in healthy adult offspring depending on parental history of CAD...
  72. doi request reprint Myocyte stress 1 plays an important role in cellular hypertrophy and protection against apoptosis
    Andrea L Koekemoer
    Department of Cardiovascular Sciences, University of Leicester, Glenfield General Hospital, Leicester, UK
    FEBS Lett 583:2964-7. 2009
    ..These findings suggest the involvement of MS1 in cellular hypertrophy and protection against apoptosis...
  73. pmc Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia
    Chris Wallace
    Clinical Pharmacology and The Genome Centre, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, EC1M 6BQ, UK
    Am J Hum Genet 82:139-49. 2008
    ..This finding provides a potential biological mechanism for the recent association of this same allele of the same SNP with increased risk of coronary disease...
  74. ncbi request reprint Enhanced linkage of a locus on chromosome 2 to premature coronary artery disease in the absence of hypercholesterolemia
    Jeremie Nsengimana
    Genetic Epidemiology Division, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
    Eur J Hum Genet 15:313-9. 2007
    ..Candidate genes include the interleukin 1 cluster and two potential regulators of high-density lipoprotein cholesterol level, PLA2R1 and OSBPL6...
  75. ncbi request reprint Increased support for linkage of a novel locus on chromosome 5q13 for essential hypertension in the British Genetics of Hypertension Study
    Patricia B Munroe
    Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute Barts and the London School of Medicine, Charterhouse Square, London, United Kingdom
    Hypertension 48:105-11. 2006
    ..07). We found increased evidence for linkage and borderline-significant evidence for association for a hypertension susceptibility locus on chromosome 5q13 that is worthy of detailed fine mapping and assessment of candidate genes...
  76. pmc Genome-wide association analysis identifies 20 loci that influence adult height
    Michael N Weedon
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
    Nat Genet 40:575-83. 2008
    ..Finally, our results provide insights into the genetic architecture of a classic quantitative trait...
  77. pmc Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension
    Chris Wallace
    Clinical Pharmacology and The Genome Centre, The William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Am J Hum Genet 79:323-31. 2006
    ..This is the first identity-by-descent regression analysis of hypertension to our knowledge, and it demonstrates the value of this approach for the incorporation of additional phenotypic information in genetic studies of complex traits...
  78. ncbi request reprint Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency
    Marianne Barr
    British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, UK
    Hypertension 49:113-9. 2007
    ..This study strongly suggests that the impaired 11beta-hydroxylase efficiency associated previously with the CYP11B2 -344 and intron conversion variants is because of linkage with these newly identified polymorphisms in CYP11B1...
  79. pmc Plasma matrix metalloproteinase-9 and left ventricular remodelling after acute myocardial infarction in man: a prospective cohort study
    Dominic Kelly
    Department of Vascular Surgery, St George s Hospital Medical School, London, UK
    Eur Heart J 28:711-8. 2007
    ....
  80. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  81. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  82. ncbi request reprint Premature coronary artery disease shows no evidence of linkage to loci encoding for tissue inhibitors of matrix metalloproteinases
    Micha F Dorsch
    Institute for Cardiovascular Research, University of Leeds, Leeds General Infirmary, G Floor, Jubilee Wing, LS2 9JT, Leeds, UK
    J Hum Genet 48:508-13. 2003
    ..Polymorphisms of the tissue inhibitors of MMP genes do not predispose to premature coronary artery disease in an epidemiologically significant way...
  83. pmc Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
    ..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases...
  84. ncbi request reprint The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke
    Anna Helgadottir
    deCODE Genetics, Sturlugata 8, Reykjavik, Iceland
    Nat Genet 36:233-9. 2004
    ..We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall...
  85. doi request reprint Physiological interaction between alpha-adducin and WNK1-NEDD4L pathways on sodium-related blood pressure regulation
    Paolo Manunta
    Division of Nephrology, Dialysis, and Hypertension, University Vita Salute San Raffaele Hospital, Via Olgettina 60, 20132 Milan, Italy
    Hypertension 52:366-72. 2008
    ..Relatively common alleles in the ADD1, WNK1, and NEDD4L genes when present in combination may have significant effects on renal sodium handling, BP, and antihypertensive response to thiazides...
  86. doi request reprint Biological ageing and cardiovascular disease
    Nilesh J Samani
    Heart 94:537-9. 2008
  87. ncbi request reprint A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study
    Dilys J Freeman
    Department of Biological Sciences, University of Durham, Durham, UK
    Eur Heart J 24:1833-42. 2003
    ..Gene-smoking and gene-treatment interactions were investigated...
  88. ncbi request reprint T594M variant of the epithelial sodium channel beta-subunit gene and hypertension in individuals of African ancestry in South Africa
    Benedicta Nkeh
    School of Physiology, Cardiovascular Genomics Research Unit, Johannesburg Hospital, University of the Witwatersrand, Johannesburg, South Africa
    Am J Hypertens 16:847-52. 2003
    ..The T594M variant of the beta-subunit of the sodium epithelial channel (ENaC) gene may contribute to hypertension in individuals of African origin...
  89. pmc Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease
    Heribert Schunkert
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Circulation 117:1675-84. 2008
    ..3 as affecting the risk of coronary artery disease (CAD). We investigated the association of this locus with CAD in 7 case-control studies and undertook a meta-analysis...
  90. ncbi request reprint Angiotensinogen gene promoter region variant modifies body size-ambulatory blood pressure relations in hypertension
    Armindo D Tiago
    Cardiovascular Genomics Research Unit, Department of Physiology, Johannesburg and Chris Hani Baragwanath Hospitals and the University of the Witwatersrand, South Africa
    Circulation 106:1483-7. 2002
    ..As angiotensinogen is expressed in adipose tissue and angiotensinogen (AGT) gene promoter variants influence the production of angiotensinogen, we evaluated the role of AGT gene variants as potential modifiers of body size-BP relations...
  91. ncbi request reprint Genome scans for hypertension and blood pressure regulation
    Nilesh J Samani
    Am J Hypertens 16:167-71. 2003
  92. ncbi request reprint Elevated C-reactive protein in atherosclerosis--chicken or egg?
    Heribert Schunkert
    N Engl J Med 359:1953-5. 2008
  93. ncbi request reprint Chromosome 1 blood pressure QTL region influences renal function curve and salt sensitivity in SHR
    Ming Lo
    Departement de Physiologie et Pharmacologie Clinique, Centre National de la Recherche Scientifique UMR 5014, Faculte de Pharmacie, 69373 Lyon Cedex 08, France
    Physiol Genomics 8:15-21. 2002
    ..These findings suggest that the BP QTL(s) present in this region of chromosome 1 influences BP and salt sensitivity, at least partly, by modulating pressure-natriuresis...