J M Sallenave

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint Antimicrobial activity of antiproteinases
    J M Sallenave
    Rayne Laboratory, MRC Centre for Inflammation Research, Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland, U K
    Biochem Soc Trans 30:111-5. 2002
  2. pmc The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease
    J M Sallenave
    Center for Inflammation Research, Edinburgh Medical School, Edinburgh, Scotland, UK
    Respir Res 1:87-92. 2000
  3. ncbi request reprint Regulation of adenovirus-mediated elafin transgene expression by bacterial lipopolysaccharide
    A J Simpson
    Rayne Laboratory, Respiratory Medicine Unit, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, Scotland, UK
    Hum Gene Ther 12:1395-406. 2001
  4. pmc Regulation of pulmonary and systemic bacterial lipopolysaccharide responses in transgenic mice expressing human elafin
    J M Sallenave
    Rayne Laboratory, Respiratory Medicine Unit, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, Scotland, United Kingdom
    Infect Immun 71:3766-74. 2003
  5. ncbi request reprint Neutrophil-derived elastases and their inhibitors: potential role in the pathogenesis of lung disease
    P T Reid
    Western General Hospital, Edinburgh, UK
    Curr Opin Investig Drugs 2:59-67. 2001
  6. ncbi request reprint Innate immune defences in the human uterus during pregnancy
    A E King
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Placenta 28:1099-106. 2007
  7. ncbi request reprint Endogenous pulmonary antibiotics
    M A Gibbons
    Rayne Laboratory, MRC Centre for Inflammation Research, Edinburgh University Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Scott Med J 51:37-42. 2006
  8. ncbi request reprint Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection
    A J Simpson
    Rayne Laboratory, Respiratory Medicine Unit, Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, Scotland, United Kingdom
    J Immunol 167:1778-86. 2001
  9. ncbi request reprint Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor
    J M Sallenave
    Department of Biochemistry, Edinburgh University Medical School
    Biol Chem Hoppe Seyler 372:13-21. 1991
  10. ncbi request reprint Characterization and gene sequence of the precursor of elafin, an elastase-specific inhibitor in bronchial secretions
    J M Sallenave
    Department of Biochemistry, Edinburgh University Medical School, United Kingdom
    Am J Respir Cell Mol Biol 8:439-45. 1993

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Antimicrobial activity of antiproteinases
    J M Sallenave
    Rayne Laboratory, MRC Centre for Inflammation Research, Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland, U K
    Biochem Soc Trans 30:111-5. 2002
    ..Using viral gene transfer vectors, we are currently investigating the potential of these inhibitors in various models of inflammation in vivo...
  2. pmc The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease
    J M Sallenave
    Center for Inflammation Research, Edinburgh Medical School, Edinburgh, Scotland, UK
    Respir Res 1:87-92. 2000
    ..Because of its natural tropism for the lung, the use of adenovirus-mediated gene transfer is extremely promising in such applications...
  3. ncbi request reprint Regulation of adenovirus-mediated elafin transgene expression by bacterial lipopolysaccharide
    A J Simpson
    Rayne Laboratory, Respiratory Medicine Unit, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, Scotland, UK
    Hum Gene Ther 12:1395-406. 2001
    ....
  4. pmc Regulation of pulmonary and systemic bacterial lipopolysaccharide responses in transgenic mice expressing human elafin
    J M Sallenave
    Rayne Laboratory, Respiratory Medicine Unit, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, Scotland, United Kingdom
    Infect Immun 71:3766-74. 2003
    ..These results indicate that elafin may have a dual function, promoting up-regulation of local lung innate immunity while simultaneously down-regulating potentially unwanted systemic inflammatory responses in the circulation...
  5. ncbi request reprint Neutrophil-derived elastases and their inhibitors: potential role in the pathogenesis of lung disease
    P T Reid
    Western General Hospital, Edinburgh, UK
    Curr Opin Investig Drugs 2:59-67. 2001
    ..Thus the potential for the development as therapeutic tools is likely to become more attractive as improved drug development and delivery mechanisms appear...
  6. ncbi request reprint Innate immune defences in the human uterus during pregnancy
    A E King
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Placenta 28:1099-106. 2007
    ..In particular, upregulation of these molecules by inflammatory molecules present in chorioamnionitis will ensure a robust response to infection...
  7. ncbi request reprint Endogenous pulmonary antibiotics
    M A Gibbons
    Rayne Laboratory, MRC Centre for Inflammation Research, Edinburgh University Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Scott Med J 51:37-42. 2006
    ..The principles discussed in the article apply to innate immune defence throughout the body, but particular emphasis is placed on AMPs in the lung and the potential application to pulmonary infection...
  8. ncbi request reprint Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection
    A J Simpson
    Rayne Laboratory, Respiratory Medicine Unit, Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, Scotland, United Kingdom
    J Immunol 167:1778-86. 2001
    ..Genetic augmentation of elafin therefore has the capacity to protect the lung against the injurious effects of both bacterial pathogens resistant to conventional antibiotics and activated neutrophils...
  9. ncbi request reprint Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor
    J M Sallenave
    Department of Biochemistry, Edinburgh University Medical School
    Biol Chem Hoppe Seyler 372:13-21. 1991
    ..This region could therefore be the reactive site of ESI. The thermodynamic and kinetic constants of the reactions of ESI with human neutrophil elastase and with porcine pancreatic elastase show that ESI is a fast-acting inhibitor...
  10. ncbi request reprint Characterization and gene sequence of the precursor of elafin, an elastase-specific inhibitor in bronchial secretions
    J M Sallenave
    Department of Biochemistry, Edinburgh University Medical School, United Kingdom
    Am J Respir Cell Mol Biol 8:439-45. 1993
    ..The finding of possible cross-linking function for the precursor in addition to its antiproteinase activity indicates a possible role for this molecule as a cross-linker agent in the extracellular matrix...
  11. ncbi request reprint Isolation of elafin and elastase-specific inhibitor (ESI) from bronchial secretions. Evidence of sequence homology and immunological cross-reactivity
    J M Sallenave
    Department of Biochemistry, Edinburgh University Medical School
    Biol Chem Hoppe Seyler 373:27-33. 1992
    ..present in different tissues...