P C Salinas

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neurons
    Anita C Hall
    Department of Biological Sciences, Imperial College of Science, Technology and Medicine, London SW7 2AY
    Mol Cell Neurosci 20:257-70. 2002
  2. ncbi request reprint Retrograde signalling at the synapse: a role for Wnt proteins
    P C Salinas
    Department of Anatomy and Developmental Biology, University College London, University Street, London WC1E 6BT, UK
    Biochem Soc Trans 33:1295-8. 2005
  3. pmc Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release
    Azlina Ahmad-Annuar
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, England, UK
    J Cell Biol 174:127-39. 2006
  4. pmc c-Jun N-terminal kinase (JNK) cooperates with Gsk3beta to regulate Dishevelled-mediated microtubule stability
    Lorenza Ciani
    Department of Anatomy and Developmental Biology, University College London, London, UK
    BMC Cell Biol 8:27. 2007
  5. ncbi request reprint Wnt signaling in neural circuit assembly
    Patricia C Salinas
    Department of Anatomy and Developmental Biology, University College London, London, WC1E 6BT, United Kingdom
    Annu Rev Neurosci 31:339-58. 2008
  6. ncbi request reprint Modulation of the microtubule cytoskeleton: a role for a divergent canonical Wnt pathway
    Patricia C Salinas
    Department of Anatomy and Developmental Biology, University College London, London, UK
    Trends Cell Biol 17:333-42. 2007
  7. ncbi request reprint Signaling at the vertebrate synapse: new roles for embryonic morphogens?
    Patricia C Salinas
    Department of Anatomy and Developmental Biology, University College London, University Street, London WC1E 6BT, United Kingdom
    J Neurobiol 64:435-45. 2005
  8. ncbi request reprint Cadherins and catenins in synapse development
    Patricia C Salinas
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Curr Opin Neurobiol 15:73-80. 2005
  9. ncbi request reprint WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons
    F R Lucas
    Developmental Biology Research Centre, The Randall Institute, King s College London, 26 29 Drury Lane, London, WC2B 5RL, United Kingdom
    Dev Biol 192:31-44. 1997
  10. ncbi request reprint Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development
    Silvana B Rosso
    Department of Anatomy and Developmental Biology, Rockefeller Building, University College London, University Street, London WC1E 6BT, UK
    Nat Neurosci 8:34-42. 2005

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neurons
    Anita C Hall
    Department of Biological Sciences, Imperial College of Science, Technology and Medicine, London SW7 2AY
    Mol Cell Neurosci 20:257-70. 2002
    ..Lithium directly inhibits GSK-3beta in contrast to VPA, which inhibits GSK-3beta indirectly by an as-yet-unknown pathway. These findings may have important implications for the development of new strategies to treat bipolar disorders...
  2. ncbi request reprint Retrograde signalling at the synapse: a role for Wnt proteins
    P C Salinas
    Department of Anatomy and Developmental Biology, University College London, University Street, London WC1E 6BT, UK
    Biochem Soc Trans 33:1295-8. 2005
    ..In this paper I discuss the role of the Wnt-Dvl (Dishevelled protein)-GSK-3beta (glycogen synthase kinase-3beta) signalling pathway in axon remodelling during synapse formation in the central nervous system...
  3. pmc Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release
    Azlina Ahmad-Annuar
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, England, UK
    J Cell Biol 174:127-39. 2006
    ..These findings demonstrate that Wnts signal across the synapse on Dvl-expressing presynaptic terminals to regulate synaptic assembly and suggest a potential novel function for Wnts in neurotransmitter release...
  4. pmc c-Jun N-terminal kinase (JNK) cooperates with Gsk3beta to regulate Dishevelled-mediated microtubule stability
    Lorenza Ciani
    Department of Anatomy and Developmental Biology, University College London, London, UK
    BMC Cell Biol 8:27. 2007
    ..A divergent Wnt-Dvl canonical pathway which bifurcates downstream of Gsk3beta regulates MT dynamics...
  5. ncbi request reprint Wnt signaling in neural circuit assembly
    Patricia C Salinas
    Department of Anatomy and Developmental Biology, University College London, London, WC1E 6BT, United Kingdom
    Annu Rev Neurosci 31:339-58. 2008
    ..This review discusses recent advances on how Wnt signaling influences different aspects of neuronal circuit assembly through changes in gene expression and/or cytoskeletal modulation...
  6. ncbi request reprint Modulation of the microtubule cytoskeleton: a role for a divergent canonical Wnt pathway
    Patricia C Salinas
    Department of Anatomy and Developmental Biology, University College London, London, UK
    Trends Cell Biol 17:333-42. 2007
    ..Here I discuss recent evidence supporting a direct role for canonical Wnt signalling in microtubule regulation, and how this function sheds a new light into the mechanisms that regulate cell-fate determination and polarization...
  7. ncbi request reprint Signaling at the vertebrate synapse: new roles for embryonic morphogens?
    Patricia C Salinas
    Department of Anatomy and Developmental Biology, University College London, University Street, London WC1E 6BT, United Kingdom
    J Neurobiol 64:435-45. 2005
    ..This mode of action raises the provocative idea that these same morphogens might also provide a coordinate system for axons to establish the distance to their targets during axon guidance and synapse formation...
  8. ncbi request reprint Cadherins and catenins in synapse development
    Patricia C Salinas
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Curr Opin Neurobiol 15:73-80. 2005
    ..Recent work has elucidated a pivotal role for these molecules in synaptic assembly, remodelling and plasticity. Far from being mere adhesive scaffolds, cadherins might directly regulate cell signalling to modulate synaptic connectivity...
  9. ncbi request reprint WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons
    F R Lucas
    Developmental Biology Research Centre, The Randall Institute, King s College London, 26 29 Drury Lane, London, WC2B 5RL, United Kingdom
    Dev Biol 192:31-44. 1997
    ..These results suggest a direct effect of WNT-7a in the regulation of neuronal cytoskeleton and synapsin I in granule cell neurons. We propose that WNT proteins have a novel function in the formation of neuronal connections...
  10. ncbi request reprint Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development
    Silvana B Rosso
    Department of Anatomy and Developmental Biology, Rockefeller Building, University College London, University Street, London WC1E 6BT, UK
    Nat Neurosci 8:34-42. 2005
    ..These findings demonstrate a new function for the non-canonical Wnt pathway in dendrite development and identify Dvl as a regulator of Rho GTPases and JNK during dendritic morphogenesis...
  11. pmc Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli
    Silvia A Purro
    Research Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 28:8644-54. 2008
    ..Consistently, short hairpin RNA knockdown of APC mimics Wnt3a function. Together, our findings define APC as a key Wnt signaling target in the regulation of microtubule growth direction...
  12. ncbi request reprint Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells
    U Wagner
    Department of Neuroscience, The Institute of Psychiatry, London, UK
    FEBS Lett 411:369-72. 1997
    ..Tau is hyperphosphorylated in Alzheimer's disease and the possible relevance of these findings to Alzheimer's disease pathogenesis are discussed...
  13. doi request reprint Dual roles for Wnt signalling during the formation of the vertebrate neuromuscular junction
    J P Henriquez
    Departamento de Biologia Celular, Facultad de Ciencias Biologicas, Universidad de Concepcion, Chile
    Acta Physiol (Oxf) 204:128-36. 2012
    ..The dual function of different Wnts might finely modulate the proper apposition of the pre- and post-synaptic terminals during NMJ formation and growth...
  14. ncbi request reprint Synaptogenesis: Wnt and TGF-beta take centre stage
    Patricia C Salinas
    Department of Biological Sciences, Imperial College London, Exhibition Road, SW8 2AZ, London, UK
    Curr Biol 13:R60-2. 2003
    ..Recent studies have identified two signaling molecules, Wnt and TGF-beta, which are required for formation and growth of the neuromuscular synapse...
  15. pmc Wnt signaling promotes AChR aggregation at the neuromuscular synapse in collaboration with agrin
    Juan P Henriquez
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 105:18812-7. 2008
    ..Our data reveal a role for Wnts in post-synaptic assembly at the vertebrate NMJ by enhancing agrin function through Rac1 activation...
  16. doi request reprint From neuronal activity to the actin cytoskeleton: a role for CaMKKs and betaPIX in spine morphogenesis
    Lorenza Ciani
    Department of Anatomy and Developmental Biology, University College London, University Street, London WC1E 6BT, UK
    Neuron 57:3-4. 2008
    ..In this issue of Neuron, Saneyoshi et al. identify a new signaling complex containing CaMKK/CaMKI/betaPIX/Rac that regulates the morphogenesis of spines in an activity-dependent manner...
  17. ncbi request reprint WNTs in the vertebrate nervous system: from patterning to neuronal connectivity
    Lorenza Ciani
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
    Nat Rev Neurosci 6:351-62. 2005
    ..This knowledge provides a framework for the study of the mechanisms by which WNTs regulate diverse neuronal functions. Manipulation of the WNT pathways could provide new strategies for nerve regeneration and neuronal circuit modulation...
  18. ncbi request reprint The morphogen sonic hedgehog collaborates with netrin-1 to guide axons in the spinal cord
    Patricia C Salinas
    Department of Biological Sciences, Imperial College London, Exhibition Road, SW7 2AZ, London, UK
    Trends Neurosci 26:641-3. 2003
    ..This new role for the morphogen Shh raises the possibility that principles similar to those used to establish positional information in embryonic patterning are also employed during axon navigation...
  19. pmc Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis
    Macarena Sahores
    Department of Cell and Developmental Biology, Physiology and Pharmacology, University College London, London WC1E6BT, UK
    Development 137:2215-25. 2010
    ..These findings support a model where neuronal activity and Wnts increase the responsiveness of neurons to Wnt signalling by recruiting Fz5 receptor at synaptic sites...
  20. ncbi request reprint WNT-3, expressed by motoneurons, regulates terminal arborization of neurotrophin-3-responsive spinal sensory neurons
    Olga Krylova
    Department of Biological Sciences, Imperial College of Science, Technology and Medicine, London SW7 AY, United Kingdom
    Neuron 35:1043-56. 2002
    ..This activity is present at limb levels and is blocked by a WNT antagonist. We propose that WNT-3, expressed by MNs, acts as a retrograde signal that controls terminal arborization of muscle afferents...
  21. pmc A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules
    Lorenza Ciani
    Department of Biological Sciences, Imperial College London, London SW7 2AZ, England, UK
    J Cell Biol 164:243-53. 2004
    ..Our data indicate a bifurcation in the so-called canonical WNT-signaling pathway to regulate microtubule stability...
  22. ncbi request reprint Wnt signaling in neural circuit development
    Lee G Fradkin
    Department of Molecular and Cell Biology, Leiden University Medical Center, 2333 AL, Leiden, The Netherlands
    J Neurosci 25:10376-8. 2005
  23. ncbi request reprint Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea
    Alain Dabdoub
    Section on Developmental Neuroscience, NIDCD, National Institutes of Health, Rockville, MD 20850, USA
    Development 130:2375-84. 2003
    ..We propose that Wnt signaling across the region of developing outer hair cells gives rise to planar polarity in the mammalian cochlea...
  24. ncbi request reprint Neurobiology: backchat at the synapse
    Patricia C Salinas
    Nature 425:464-7. 2003