Moin A Saleem

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. pmc Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes
    Rachel Lennon
    Academic and Children s Renal Unit, University of Bristol, Southmead Hospital, Bristol, United Kingdom BS10 5NB
    J Am Soc Nephrol 19:2140-9. 2008
  2. doi request reprint New developments in steroid-resistant nephrotic syndrome
    Moin A Saleem
    Academic Renal Unit, Learning and Research Building, Southmead Hospital, Bristol, UK
    Pediatr Nephrol 28:699-709. 2013
  3. doi request reprint The phenomenon of focal segmental glomerulosclerosis post-transplantation-a one-hit wonder?
    Moin A Saleem
    Children s and Academic Renal Unit, Southmead Hospital University of Bristol, Bristol, BS10 5NB, UK
    Pediatr Nephrol 27:2163-6. 2012
  4. pmc Regulation of Neph3 gene in podocytes--key roles of transcription factors NF-kappaB and Sp1
    Mervi Ristola
    Department of Bacteriology and Immunology, Haartman Institute, P, O, Box 21, 00014 University of Helsinki, Finland
    BMC Mol Biol 10:83. 2009
  5. ncbi request reprint Biology of the human podocyte
    Moin A Saleem
    Academic and Children s Renal Unit, University of Bristol, Southmead Hospital, Bristol, UK
    Nephron Exp Nephrol 95:e87-92. 2003
  6. ncbi request reprint A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression
    Moin A Saleem
    Children s Renal Unit and Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, UK
    J Am Soc Nephrol 13:630-8. 2002
  7. pmc Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation
    Moin A Saleem
    Children s Unit, University of Bristol, Southmead Hospital, Bristol, United Kingdom
    Am J Pathol 161:1459-66. 2002
  8. pmc The molecular and functional phenotype of glomerular podocytes reveals key features of contractile smooth muscle cells
    Moin A Saleem
    Academic and Children s Renal Unit, University of Bristol, Lifeline Bldg, Southmead Hospital, Bristol, BS10 5NB, United Kingdom
    Am J Physiol Renal Physiol 295:F959-70. 2008
  9. ncbi request reprint Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes
    Richard J M Coward
    Academic and Children s Renal Unit, Southmead Hospital, University of Bristol, Bristol, UK
    J Am Soc Nephrol 16:629-37. 2005
  10. doi request reprint Active proteases in nephrotic plasma lead to a podocin-dependent phosphorylation of VASP in podocytes via protease activated receptor-1
    Jessica J Harris
    Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, BS10 5NB, UK
    J Pathol 229:660-71. 2013

Detail Information

Publications51

  1. pmc Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes
    Rachel Lennon
    Academic and Children s Renal Unit, University of Bristol, Southmead Hospital, Bristol, United Kingdom BS10 5NB
    J Am Soc Nephrol 19:2140-9. 2008
    ..In summary, active hemopexin causes nephrin-dependent remodeling of podocytes and affects permeability of the glomerular filtration barrier by degrading the glycocalyx...
  2. doi request reprint New developments in steroid-resistant nephrotic syndrome
    Moin A Saleem
    Academic Renal Unit, Learning and Research Building, Southmead Hospital, Bristol, UK
    Pediatr Nephrol 28:699-709. 2013
    ....
  3. doi request reprint The phenomenon of focal segmental glomerulosclerosis post-transplantation-a one-hit wonder?
    Moin A Saleem
    Children s and Academic Renal Unit, Southmead Hospital University of Bristol, Bristol, BS10 5NB, UK
    Pediatr Nephrol 27:2163-6. 2012
    ....
  4. pmc Regulation of Neph3 gene in podocytes--key roles of transcription factors NF-kappaB and Sp1
    Mervi Ristola
    Department of Bacteriology and Immunology, Haartman Institute, P, O, Box 21, 00014 University of Helsinki, Finland
    BMC Mol Biol 10:83. 2009
    ..In this study we investigated the transcriptional regulation of Neph3 gene by identifying transcription factors that control Neph3 expression...
  5. ncbi request reprint Biology of the human podocyte
    Moin A Saleem
    Academic and Children s Renal Unit, University of Bristol, Southmead Hospital, Bristol, UK
    Nephron Exp Nephrol 95:e87-92. 2003
    ..How this emerging information is shaping our understanding of glomerular biology, and ultimately our understanding of the pathophysiology of glomerular diseases, is outlined here...
  6. ncbi request reprint A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression
    Moin A Saleem
    Children s Renal Unit and Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, UK
    J Am Soc Nephrol 13:630-8. 2002
    ..In conclusion, the development of this cell line provides a new tool in the study of podocyte biology, which will enable accurate assessment of the behavior of these complex cells in health and disease...
  7. pmc Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation
    Moin A Saleem
    Children s Unit, University of Bristol, Southmead Hospital, Bristol, United Kingdom
    Am J Pathol 161:1459-66. 2002
    ..We demonstrate an intimate relationship between nephrin podocin and filamentous actin, and reason that disruption of nephrin/podocin could be a final common pathway leading to foot process effacement in proteinuric diseases...
  8. pmc The molecular and functional phenotype of glomerular podocytes reveals key features of contractile smooth muscle cells
    Moin A Saleem
    Academic and Children s Renal Unit, University of Bristol, Lifeline Bldg, Southmead Hospital, Bristol, BS10 5NB, United Kingdom
    Am J Physiol Renal Physiol 295:F959-70. 2008
    ..We conclude that the mature podocyte in vitro possesses functional apparatus of contractile smooth muscle cells, with potential implications for its in vivo ability to regulate glomerular dynamic and permeability characteristics...
  9. ncbi request reprint Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes
    Richard J M Coward
    Academic and Children s Renal Unit, Southmead Hospital, University of Bristol, Bristol, UK
    J Am Soc Nephrol 16:629-37. 2005
    ..This work demonstrates that nephrotic plasma seems to be deficient in factors that act via the podocyte SD complex, which are essential in maintaining its physiologic function...
  10. doi request reprint Active proteases in nephrotic plasma lead to a podocin-dependent phosphorylation of VASP in podocytes via protease activated receptor-1
    Jessica J Harris
    Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, BS10 5NB, UK
    J Pathol 229:660-71. 2013
    ..These data suggest a specific biomarker for disease activity, as well as revealing a novel and highly specific receptor-mediated signalling pathway to the actin cytoskeleton...
  11. ncbi request reprint Nephrin is critical for the action of insulin on human glomerular podocytes
    Richard J M Coward
    AcademicChildren s Renal Unit, University of Bristol, Bristol, UK
    Diabetes 56:1127-35. 2007
    ..This work demonstrates a previously unsuspected role of nephrin in vesicular docking and insulin responsiveness of podocytes...
  12. ncbi request reprint Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes
    Rebecca R Foster
    Microvascular Research Laboratories, Department of Physiology, University of Bristol, Preclinical Veterinary School, United Kingdom
    Am J Physiol Renal Physiol 284:F1263-73. 2003
    ..These results indicate that one of the functions of VEGF secreted from podocytes may be to act as an autocrine factor on calcium homeostasis and cell survival...
  13. doi request reprint Chronic exposure to laminar shear stress induces Kruppel-like factor 2 in glomerular endothelial cells and modulates interactions with co-cultured podocytes
    Sadie C Slater
    Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, UK
    Int J Biochem Cell Biol 44:1482-90. 2012
    ..These data provide the first direct evidence of glomerular endothelial cell to podocyte cross-talk...
  14. doi request reprint Flufenamic acid is a tool for investigating TRPC6-mediated calcium signalling in human conditionally immortalised podocytes and HEK293 cells
    Rebecca R Foster
    The Academic Renal Unit, University of Bristol, BristolNB, UK
    Cell Calcium 45:384-90. 2009
    ..In conclusion, FFA activates TRPC6 [Ca(2+)](i) signalling in both ciPod and HEK293 cells independently of TRPC3 and TRPC7, and independently of properties of the fenamate family...
  15. doi request reprint Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy
    Rachel Lennon
    Academic and Children s, Renal Unit, Paul O Gorman Lifeline Centre, University of Bristol, Southmead Hospital, Bristol BS10, UK
    Nephrol Dial Transplant 24:3288-96. 2009
    ..In the kidney, glomerular podocytes are novel insulin-sensitive cells that have the ability to rapidly transport glucose. In this study, we tested the hypothesis that palmitate would induce insulin resistance in podocytes...
  16. pmc Functional distinctions in cytosolic calcium regulation between cells of the glomerular filtration barrier
    Rebecca Rachael Foster
    The Academic Renal Unit, Southmead Hospital, University of Bristol, BS10 5NB, UK
    Cell Calcium 48:44-53. 2010
    ..In conclusion, cell activation by FFA in podocytes stimulates the opening of a Ca(2+) channel, probably TRPC6, in a nephrin-dependent manner with a different activation profile to GEnC...
  17. ncbi request reprint Vascular endothelial growth factor and nephrin interact and reduce apoptosis in human podocytes
    Rebecca R Foster
    Microvascular Research Laboratories, Department of Physiology, University of Bristol, Preclinical Veterinary School, Southwell St, Bristol BS2 8EJ, UK
    Am J Physiol Renal Physiol 288:F48-57. 2005
    ..However, the involvement of AKT in this survival response in normal human podocytes is not clear...
  18. pmc Establishment of conditionally immortalized human glomerular mesangial cells in culture, with unique migratory properties
    Ramadan M Sarrab
    Children s Renal Unit and Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, United Kingdom
    Am J Physiol Renal Physiol 301:F1131-8. 2011
    ..This conditionally immortalized human mesangial cell line represents a new tool for the study of human mesangial cell biology in vitro...
  19. pmc Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors
    Dawid G Nowak
    Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK
    J Cell Sci 121:3487-95. 2008
    ....
  20. ncbi request reprint Interferon-beta reduces proteinuria in experimental glomerulonephritis
    Simon C Satchell
    Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, UK
    J Am Soc Nephrol 18:2875-84. 2007
    ..These data indicate that IFN-beta may have potential as a therapeutic agent in proteinuric renal disease...
  21. pmc WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing
    Elianna M Amin
    Centre for Research in Biomedicine, University of the West of England, Bristol, UK
    Cancer Cell 20:768-80. 2011
    ..Altered VEGF splicing was reversed by wild-type WT1, knockdown of SRSF1, or SRPK1 and inhibition of SRPK1, which prevented in vitro and in vivo angiogenesis and associated tumor growth...
  22. doi request reprint Insulin signaling to the glomerular podocyte is critical for normal kidney function
    Gavin I Welsh
    Academic Renal Unit, School of Clinical Sciences, University of Bristol, Bristol BS8 1TH, UK
    Cell Metab 12:329-40. 2010
    ..Collectively, this work reveals the critical importance of podocyte insulin sensitivity for kidney function...
  23. ncbi request reprint Podocytes as a target of insulin
    Richard J M Coward
    Academic and Children s Renal Unit, Southmead Hospital, Bristol, UK
    Curr Diabetes Rev 7:22-7. 2011
    ..This introduces a rationale for therapeutic intervention to improve podocyte insulin sensitivity early in the presentation of DN...
  24. ncbi request reprint The human glomerular podocyte is a novel target for insulin action
    Richard J M Coward
    Academic and Children s Renal Unit, University of Bristol, Southmead Hospital, Bristol, UK BS10 5NB
    Diabetes 54:3095-102. 2005
    ..Insulin responsiveness in this key structural component of the glomerular filtration barrier may have central relevance for understanding of diabetic nephropathy and for the association of albuminuria with states of insulin resistance...
  25. pmc An in vitro model of the glomerular capillary wall using electrospun collagen nanofibres in a bioartificial composite basement membrane
    Sadie C Slater
    Academic Renal Unit, University of Bristol, Bristol, United Kingdom
    PLoS ONE 6:e20802. 2011
    ..These models will advance the study of both the physiology of normal glomerular filtration and of its disruption in glomerular disease...
  26. doi request reprint Nephrin-signature molecule of the glomerular podocyte?
    Gavin I Welsh
    University of Bristol, Children s Renal Unit, Bristol Royal Hospital for Children, UK
    J Pathol 220:328-37. 2010
    ..Thus, it is reasoned that nephrin is a signature molecule required to define distinct podocyte characteristics...
  27. doi request reprint New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes
    Avril A Morrison
    Bristol Genomics Research Institute, Centre for Research in Biomedicine, Faculty of Health and Life Sciences, University of the West of England, Bristol, UK
    Am J Physiol Renal Physiol 295:F12-7. 2008
    ..Recent advances including the development of transgenic mouse models and conditionally immortalized podocyte cell lines are beginning to shed light on WT1's crucial role in podocyte function...
  28. pmc Simultaneous sequencing of 24 genes associated with steroid-resistant nephrotic syndrome
    Hugh J McCarthy
    Academic and Children s Renal Unit, University of Bristol, UK
    Clin J Am Soc Nephrol 8:637-48. 2013
    ..The hypothesis was that the increasing reliability of next generation sequencing allows comprehensive one-step genetic investigation of this group and similar patient groups...
  29. doi request reprint The podocyte cytoskeleton--key to a functioning glomerulus in health and disease
    Gavin I Welsh
    Academic and Children s Renal Unit, School of Clinical Sciences, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol BS10 5NB, UK
    Nat Rev Nephrol 8:14-21. 2012
    ....
  30. doi request reprint Genetics in clinical practice: nephrotic and proteinuric syndromes
    Hugh J McCarthy
    Academic Renal Unit, Learning and Research Building, Southmead Hospital, Bristol, UK
    Nephron Exp Nephrol 118:e1-8. 2011
    ..The next big challenge for clinicians and researchers is to translate the molecular information learnt into the understanding of acquired, non-inherited forms of the disease...
  31. ncbi request reprint Human podocytes express angiopoietin 1, a potential regulator of glomerular vascular endothelial growth factor
    Simon C Satchell
    Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, United Kingdom
    J Am Soc Nephrol 13:544-50. 2002
    ....
  32. ncbi request reprint The bioactivity of plasma factors in focal segmental glomerulosclerosis
    Joanna Marszal
    Academic and Children s Renal Unit, University of Bristol, Southmead Hospital, Bristol, UK
    Nephron Exp Nephrol 104:e1-5. 2006
    ..Putting together this knowledge, with the latest technological advances in protein identification, provides promising avenues towards finally solving the basis of this enigmatic disease...
  33. ncbi request reprint A proteomic investigation of glomerular podocytes from a Denys-Drash syndrome patient with a mutation in the Wilms tumour suppressor gene WT1
    Rebecca L Viney
    Bristol Genomics Research Institute, Centre for Research in Biomedicine, Faculty of Applied Sciences, University of the West of England, Bristol, UK
    Proteomics 7:804-15. 2007
    ..We conclude that one of WT1 functions in podocytes is to regulate the expression of key components and regulators of the cytoskeleton...
  34. doi request reprint Exogenous vascular endothelial growth factor supplementation can restore the podocyte barrier-forming capacity disrupted by sera of preeclamptic women
    Daniel E Henao
    Grupo Reproducción, Universidad de Antioquia, Medellin, Colombia Academic Renal Unit, University of Bristol, Bristol, UK
    J Obstet Gynaecol Res 39:46-52. 2013
    ..To determine whether exogenous vascular endothelial growth factor (VEGF) supplementation to sera from women with preeclampsia can restore the podocyte barrier-forming capacity disrupted after stimulation with sera from these women...
  35. ncbi request reprint Urine--a mirror of the (glomerular) soul?
    Moin A Saleem
    Academic and Children s Renal Unit, Southmead Hospital, Bristol, UK
    Nephron Clin Pract 95:c75-6. 2003
  36. doi request reprint Paediatric non-heart-beating renal transplantation
    Anusha G Edwards
    Department of Surgery, Southmead Hospital, Bristol, BS10 5NB, UK
    Arch Dis Child 95:843-4. 2010
    ..The use of non-heart-beating donor renal transplants has seen a revival in adult practice, with encouraging results. The authors present the first two cases in the UK of paediatric renal transplant from non-heart-beating donors...
  37. ncbi request reprint Expression of CCN1 (CYR61) in developing, normal, and diseased human kidney
    Kazutomo Sawai
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kawahara cho, Sakyo ku, Kyoto, Japan
    Am J Physiol Renal Physiol 293:F1363-72. 2007
    ....
  38. ncbi request reprint Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains
    Tobias B Huber
    Renal Division, University Hospital Freiburg, Germany
    Hum Mol Genet 12:3397-405. 2003
    ..Our findings demonstrate that the failure of mutant podocin to recruit nephrin into lipid rafts may be essential for the pathogenesis of NPHS2...
  39. pmc KIBRA modulates directional migration of podocytes
    Kerstin Duning
    Medizinische Klinik und Poliklinik D, Universitatsklinikum Munster, Munster, Germany
    J Am Soc Nephrol 19:1891-903. 2008
    ..Stable knockdown of KIBRA in immortalized podocytes impaired directed cell migration, suggesting that KIBRA modulates the motility of podocytes by linking polarity proteins and cytoskeleton-associated protein complexes...
  40. ncbi request reprint PPARalpha activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism
    Shuyu Ren
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Biochem Biophys Res Commun 338:1818-24. 2005
    ..These findings may have importance for treatment strategies of renal diseases affecting the expression of nephrin and subsequently the proper action of the glomerular filtration apparatus...
  41. ncbi request reprint Prognosis, treatment and outcome of childhood mesangiocapillary (membranoproliferative) glomerulonephritis
    Janette C Cansick
    Department of Paediatric Nephrology, Birmingham Children s Hospital, Birmingham, UK
    Nephrol Dial Transplant 19:2769-77. 2004
    ..Prognostic factors and outcome are incompletely known in childhood mesangiocapillary glomerulonephritis (MCGN). This study aimed to correlate renal outcome with clinical and histopathological variables...
  42. ncbi request reprint A novel renal perspective of preeclampsia: a look from the podocyte
    Daniel E Henao
    Nephrol Dial Transplant 22:1477. 2007
  43. ncbi request reprint Mechanism of perturbation of integrin-mediated cell-matrix interactions by reactive carbonyl compounds and its implication for pathogenesis of diabetic nephropathy
    Vadim K Pedchenko
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    Diabetes 54:2952-60. 2005
    ..This mechanism may contribute to the development of diabetic nephropathy...
  44. ncbi request reprint Human podocytes possess a stretch-sensitive, Ca2+-activated K+ channel: potential implications for the control of glomerular filtration
    Michael J Morton
    School of Biomedical Sciences, Worsley Building, University of Leeds, Leeds LS2 9NQ, UK
    J Am Soc Nephrol 15:2981-7. 2004
    ..By implication, these results suggest that podocytes may be able to respond to changes in the glomerular capillary pressure and modulate the GFR...
  45. ncbi request reprint Sam68-like mammalian protein 2, identified by digital differential display as expressed by podocytes, is induced in proteinuria and involved in splice site selection of vascular endothelial growth factor
    Clemens D Cohen
    Medizinische Poliklinik, Ludwig Maximilians University, Pettenkoferstrasse 8a, Munich, 80336, Germany
    J Am Soc Nephrol 16:1958-65. 2005
    ..SLM-2-dependent VEGF splicing indicates the importance of mRNA splice site selection for glomerular filtration barrier function...
  46. ncbi request reprint Expression of functional CCR and CXCR chemokine receptors in podocytes
    Tobias Bruno Huber
    Department of Medicine, Division of Nephrology, University of Freiburg, Freiburg, Germany
    J Immunol 168:6244-52. 2002
    ..The release of oxygen radicals that accompanies the activation of CCRs and CXCRs may contribute to podocyte injury and the development of proteinuria during membranous nephropathy...
  47. ncbi request reprint Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1
    Bart Janssen
    Institute of Human Genetics Heidelberg, Heidelberg, Germany
    Diabetes 54:2320-7. 2005
    ..Diabetic patients with the CNDP1 Mannheim variant are less susceptible for nephropathy. Carnosine protects against the adverse effects of high glucose levels on renal cells...
  48. doi request reprint Activation of podocytes by mesangial-derived TNF-alpha: glomerulo-podocytic communication in IgA nephropathy
    Kar Neng Lai
    Dept of Medicine, Rm 411, Professorial Block, Queen Mary Hospital, Univ of Hong Kong, Hong Kong
    Am J Physiol Renal Physiol 294:F945-55. 2008
    ....
  49. pmc Comparative promoter analysis allows de novo identification of specialized cell junction-associated proteins
    Clemens D Cohen
    Medizinische Poliklinik, University of Munich, 80336 Munich, Germany
    Proc Natl Acad Sci U S A 103:5682-7. 2006
    ..Nephrin, ZO-1, and cadherin-5 mRNA showed stringent coexpression across a diverse set of human glomerular diseases. Comparative promoter analysis can identify regulatory pathways at work in tissue homeostasis and disease processes...
  50. ncbi request reprint Redistribution of connexin43 expression in glomerular podocytes predicts poor renal prognosis in patients with type 2 diabetes and overt nephropathy
    Kazutomo Sawai
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Nephrol Dial Transplant 21:2472-7. 2006
    ..In this study, we examined whether alteration of gap junction protein connexin43 (Cx43) expression in podocytes is associated with the progression of overt diabetic nephropathy...
  51. ncbi request reprint Identification of the glomerular podocyte as a target for growth hormone action
    Gaddameedi R Reddy
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109 0718, USA
    Endocrinology 148:2045-55. 2007
    ..These results provide a novel mechanistic link between GH's actions and glomerular dysfunction in disorders such as acromegaly and diabetic glomerulosclerosis...