I Sabroe

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. ncbi request reprint "Dirty little secrets"--endotoxin contamination of recombinant proteins
    Sonia J Wakelin
    MRC Centre for Inflammation Research, University of Edinburgh, UK
    Immunol Lett 106:1-7. 2006
  2. ncbi request reprint Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses
    Gavin E Morris
    Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, Sheffield, S10 2JF, UK
    FASEB J 20:2153-5. 2006
  3. pmc Diesel exhaust particle exposure in vitro alters monocyte differentiation and function
    Nazia Chaudhuri
    Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United Kingdom
    PLoS ONE 7:e51107. 2012
  4. pmc Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines
    Alexander Basran
    Department of Infection and Immunity, Faculty of Medicine, Dentistry and Health, University of Sheffield, Beech Hill Rd, Sheffield, UK
    J Leukoc Biol 93:7-19. 2013
  5. pmc Regulation of human neutrophil chemokine receptor expression and function by activation of Toll-like receptors 2 and 4
    Ian Sabroe
    Academic Units of Respiratory Medicine, Section of Functional Genomics, Division of Genomic Medicine, University of Sheffield, Sheffield, UK
    Immunology 115:90-8. 2005
  6. ncbi request reprint Toll-like receptors in health and disease: complex questions remain
    Ian Sabroe
    Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield, United Kingdom
    J Immunol 171:1630-5. 2003
  7. doi request reprint Ex vivo-expanded bone marrow CD34+ derived neutrophils have limited bactericidal ability
    Emily Patricia Dick
    Academic Unit of Respiratory Medicine, Section of Infection, Inflammation and Immunity, School of Medicine and Biomedical Sciences, Royal Hallamshire Hospital, Sheffield, United Kingdom
    Stem Cells 26:2552-63. 2008
  8. ncbi request reprint Toll-like receptor (TLR)-based networks regulate neutrophilic inflammation in respiratory disease
    I Sabroe
    Academic Unit of Respiratory Medicine, Section of Infection, Inflammation and Immunity, School of Medicine and Biomedical Sciences, Royal Hallamshire Hospital, University of Sheffield, Sheffield S10 2JF, U K
    Biochem Soc Trans 35:1492-5. 2007
  9. ncbi request reprint Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease
    Ian Sabroe
    Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, L Floor, Royal Hallamshire Hospital, Sheffield, UK
    Am J Respir Crit Care Med 175:306-11. 2007
  10. ncbi request reprint Toll-like receptors: their role in allergy and non-allergic inflammatory disease
    I Sabroe
    Section of Functional Genomics, Division of Genomic Medicine, University of Sheffield, Sheffield, UK
    Clin Exp Allergy 32:984-9. 2002

Collaborators

Detail Information

Publications60

  1. ncbi request reprint "Dirty little secrets"--endotoxin contamination of recombinant proteins
    Sonia J Wakelin
    MRC Centre for Inflammation Research, University of Edinburgh, UK
    Immunol Lett 106:1-7. 2006
    ..We propose that considerable caution is needed in the investigation of TLR4 agonists, particularly when using proteins produced in a bacterium that also houses the most ideal TLR4 agonist, LPS...
  2. ncbi request reprint Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses
    Gavin E Morris
    Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, Sheffield, S10 2JF, UK
    FASEB J 20:2153-5. 2006
    ..Thus, inflammatory responses to pathogens are regulated by networks in which patterns of TLR expression and colocalization of tissue cells and leukocytes are critical...
  3. pmc Diesel exhaust particle exposure in vitro alters monocyte differentiation and function
    Nazia Chaudhuri
    Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United Kingdom
    PLoS ONE 7:e51107. 2012
    ....
  4. pmc Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines
    Alexander Basran
    Department of Infection and Immunity, Faculty of Medicine, Dentistry and Health, University of Sheffield, Beech Hill Rd, Sheffield, UK
    J Leukoc Biol 93:7-19. 2013
    ....
  5. pmc Regulation of human neutrophil chemokine receptor expression and function by activation of Toll-like receptors 2 and 4
    Ian Sabroe
    Academic Units of Respiratory Medicine, Section of Functional Genomics, Division of Genomic Medicine, University of Sheffield, Sheffield, UK
    Immunology 115:90-8. 2005
    ..Thus, although treatment of purified human neutrophils with TLR2 and TLR4 agonists modifies chemokine receptor expression, remaining receptors remain functionally competent...
  6. ncbi request reprint Toll-like receptors in health and disease: complex questions remain
    Ian Sabroe
    Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield, United Kingdom
    J Immunol 171:1630-5. 2003
  7. doi request reprint Ex vivo-expanded bone marrow CD34+ derived neutrophils have limited bactericidal ability
    Emily Patricia Dick
    Academic Unit of Respiratory Medicine, Section of Infection, Inflammation and Immunity, School of Medicine and Biomedical Sciences, Royal Hallamshire Hospital, Sheffield, United Kingdom
    Stem Cells 26:2552-63. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  8. ncbi request reprint Toll-like receptor (TLR)-based networks regulate neutrophilic inflammation in respiratory disease
    I Sabroe
    Academic Unit of Respiratory Medicine, Section of Infection, Inflammation and Immunity, School of Medicine and Biomedical Sciences, Royal Hallamshire Hospital, University of Sheffield, Sheffield S10 2JF, U K
    Biochem Soc Trans 35:1492-5. 2007
    ..The present review describes some of these networks and the resulting potential for their targeting in respiratory disease...
  9. ncbi request reprint Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease
    Ian Sabroe
    Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, L Floor, Royal Hallamshire Hospital, Sheffield, UK
    Am J Respir Crit Care Med 175:306-11. 2007
    ....
  10. ncbi request reprint Toll-like receptors: their role in allergy and non-allergic inflammatory disease
    I Sabroe
    Section of Functional Genomics, Division of Genomic Medicine, University of Sheffield, Sheffield, UK
    Clin Exp Allergy 32:984-9. 2002
    ..The likelihood of adverse consequences of such treatments, though possible, may be minimized by use of conjugated vaccines...
  11. ncbi request reprint Practical and conceptual models of chronic obstructive pulmonary disease
    Ian Sabroe
    Academic Unit of Respiratory Medicine, Section of Infection, Inflammation, and Immunity, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United Kingdom
    Proc Am Thorac Soc 4:606-10. 2007
    ....
  12. ncbi request reprint The role of TLR activation in inflammation
    I Sabroe
    Academic Unit of Respiratory Medicine, Section of Infection, Inflammation and Immunity, School of Medicine and Biomedical Sciences, University of Sheffield, UK
    J Pathol 214:126-35. 2008
    ....
  13. pmc Pathological networking: a new approach to understanding COPD
    Ian Sabroe
    Academic Unit of Respiratory Medicine, L Floor, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Thorax 62:733-8. 2007
    ....
  14. ncbi request reprint Identifying and hurdling obstacles to translational research
    Ian Sabroe
    Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Nat Rev Immunol 7:77-82. 2007
    ..The purpose of this Opinion article is to examine the nature of these hurdles and to provide food for thought on the main obstacles that impede this process...
  15. ncbi request reprint Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span
    Ian Sabroe
    Academic Unit of Respiratory Medicine, Section of Functional Genomics, Division of Genomic Medicine, University of Sheffield, Sheffield, United Kingdom
    J Immunol 170:5268-75. 2003
    ..TLR4 signaling presents itself as a pharmacological target that may allow therapeutic modulation of neutrophil survival by direct and indirect mechanisms at sites of inflammation...
  16. ncbi request reprint What can we learn from highly purified neutrophils?
    I Sabroe
    Division of Genomic Medicine, University of Sheffield, M Floor, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Biochem Soc Trans 32:468-9. 2004
    ....
  17. ncbi request reprint Toll-like receptors and chronic lung disease
    Nazia Chaudhuri
    Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, M Floor, Royal Hallamshire Hospital, Sheffield, UK
    Clin Sci (Lond) 109:125-33. 2005
    ..This review will explore TLR history, molecular signalling and the potential roles of TLRs in chronic lung disease...
  18. pmc The role of interleukin-1beta in direct and toll-like receptor 4-mediated neutrophil activation and survival
    Lynne R Prince
    Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, M Floor, Royal Hallamshire Hospital, Sheffield S10 2JF, United Kingdom
    Am J Pathol 165:1819-26. 2004
    ..Thus an important paradigm of neutrophil regulation needs to be viewed in the context of a cellular network in which actions of IL-1beta on neutrophils are indirect and mediated by other cells...
  19. ncbi request reprint The CC chemokine eotaxin (CCL11) is a partial agonist of CC chemokine receptor 2b
    R Martinelli
    Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College of Science, Technology, and Medicine, South Kensington, London SW7 2AZ, United Kingdom
    J Biol Chem 276:42957-64. 2001
    ....
  20. pmc Translational mini-review series on Toll-like receptors: networks regulated by Toll-like receptors mediate innate and adaptive immunity
    L C Parker
    Academic Unit of Respiratory Medicine, School of Medicine and Biological Sciences, University of Sheffield, UK
    Clin Exp Immunol 147:199-207. 2007
    ....
  21. pmc Chemokines, innate and adaptive immunity, and respiratory disease
    I Sabroe
    Division of Genomic Medicine, University of Sheffield, UK
    Eur Respir J 19:350-5. 2002
    ..Chemokines are fundamental regulators of leukocyte homeostasis and inflammation, and their antagonism by small molecule chemokine receptor antagonists may be of enormous importance in the future treatment of human respiratory disease...
  22. ncbi request reprint Toll-like receptor (TLR)2 and TLR4 agonists regulate CCR expression in human monocytic cells
    Lisa C Parker
    Section of Functional Genomics, Division of Genomic Medicine, University of Sheffield, Sheffield, United Kingdom
    J Immunol 172:4977-86. 2004
    ..This work provides further insights into the mechanisms that regulate leukocyte recruitment and trafficking during TLR-induced inflammatory responses...
  23. ncbi request reprint Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses
    Ian Sabroe
    Section of Functional Genomics, Division of Genomic Medicine, University of Sheffield, Sheffield, United Kingdom
    J Immunol 168:4701-10. 2002
    ..We conclude that LPS has little role in the regulation of peripheral blood eosinophil and basophil function, and that, even in neutrophils, monocytes orchestrate many previously observed leukocyte LPS response patterns...
  24. pmc Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
    Sarah R Walmsley
    Academic Unit of Respiratory Medicine, The Medical School, University of Sheffield, Sheffield, United Kingdom
    J Clin Invest 121:1053-63. 2011
    ..These data support what we believe to be a novel function for PHD3 in regulating neutrophil survival in hypoxia and may enable the development of new therapeutics for inflammatory disease...
  25. ncbi request reprint The expression and roles of Toll-like receptors in the biology of the human neutrophil
    Lisa C Parker
    Academic Units of Respiratory, Medicine and Cell Biology, Section of Functional Genomics, Division of Genomic Medicine, University of Sheffield, UK
    J Leukoc Biol 77:886-92. 2005
    ....
  26. doi request reprint Basic science of the innate immune system and the lung
    Nazia Chaudhuri
    Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, UK
    Paediatr Respir Rev 9:236-42. 2008
    ..In chronic disease, dysregulated inflammation maintains these systems in a state of constant activation, potentially resulting in tissue damage and progressive disease...
  27. ncbi request reprint Endotoxin tolerance induces selective alterations in neutrophil function
    Lisa C Parker
    Division of Genomic Medicine, University of Sheffield, M Floor, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK
    J Leukoc Biol 78:1301-5. 2005
    ..Induction of tolerance was associated with a loss of TLR4 surface expression. Tolerance, therefore, induces a selective reprogramming of neutrophil function, but cells retain a predominantly proinflammatory phenotype...
  28. pmc Translational mini-review series on immunology of vascular disease: inflammation, infections and Toll-like receptors in cardiovascular disease
    J R Ward
    Cardiovascular Research Unit, The University of Sheffield, Sheffield, UK
    Clin Exp Immunol 156:386-94. 2009
    ....
  29. pmc The rise and rise of Staphylococcus aureus: laughing in the face of granulocytes
    S Anwar
    Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Clin Exp Immunol 157:216-24. 2009
    ..Unravelling the biology of these interactions is a challenging task, but one which may yield new strategies to address this, as yet, defiant organism...
  30. pmc A central role for monocytes in Toll-like receptor-mediated activation of the vasculature
    Jon R Ward
    Cardiovascular Research Unit, School of Medicine and Biomedical Sciences, The University of Sheffield, Sheffield, UK
    Immunology 128:58-68. 2009
    ....
  31. ncbi request reprint Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes
    Gavin E Morris
    Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, M Floor, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK
    Am J Respir Crit Care Med 171:814-22. 2005
    ..They have an established role in the activation of leukocytes, endothelial cells, and some smooth muscle cell types, but their roles in airway smooth muscle are uncertain...
  32. doi request reprint Rhinoviral infection and asthma: the detection and management of rhinoviruses by airway epithelial cells
    L C Parker
    Academic Unit of Respiratory Medicine, Department of Infection and Immunity, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK
    Clin Exp Allergy 44:20-8. 2014
    ....
  33. doi request reprint Muckle-Wells syndrome without mutation in exon 3 of the NLRP3 gene, identified by evidence of excessive monocyte production of functional interleukin 1β and rapid response to anakinra
    R A Sabroe
    Department of Dermatology, Royal Hallamshire Hospital, Sheffield, UK
    Clin Exp Dermatol 38:874-7. 2013
    ..We propose that this patient has Muckle-Wells syndrome without deafness, occurring de novo. Functional screening for IL-1 production could aid diagnosis in future similar cases...
  34. ncbi request reprint Monocyte and macrophage dysfunction as a cause of HIV-1 induced dysfunction of innate immunity
    P Collini
    Department of Infection and Immunity, University of Sheffield, Sheffield, UK
    Curr Mol Med 10:727-40. 2010
    ..Future research should focus on refining experimental models and on elucidating the physiological mechanisms of monocyte/ Mϕ dysfunction during HIV 1 infection...
  35. ncbi request reprint Reducing the toll of inflammatory lung disease
    Nazia Chaudhuri
    Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, L Floor, Royal Hallamshire Hospital, Sheffield, UK
    Chest 131:1550-6. 2007
    ..Our growing knowledge in this field will have a significant impact on the understanding of the pathogenesis of inflammatory diseases, and TLR-based therapies are already in early clinical trials to modify atopic disease severity...
  36. doi request reprint The generation of highly purified primary human neutrophils and assessment of apoptosis in response to Toll-like receptor ligands
    Lisa C Parker
    School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield S10 2JF, UK
    Methods Mol Biol 517:191-204. 2009
    ..A variety of methods are available to study neutrophil function: purification of human neutrophils and analysis of their lifespan are described here...
  37. ncbi request reprint The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis
    Ian Sabroe
    Division of Genomic Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    Clin Infect Dis 41:S421-6. 2005
    ....
  38. pmc Pathways regulating lipopolysaccharide-induced neutrophil survival revealed by lentiviral transduction of primary human neutrophils
    Emily P Dick
    University of Sheffield, UK
    Immunology 127:249-55. 2009
    ....
  39. ncbi request reprint Potentiation of TLR4 signalling by plasmin activity
    Jon R Ward
    Division of Genomic Medicine, University of Sheffield Medical School, University of Sheffield, Sheffield S10 2JF, UK
    Biochem Biophys Res Commun 341:299-303. 2006
    ..These studies link fibrinolysis and TLR signalling, identifying further mechanisms potentially involved in activation of innate immunity...
  40. pmc A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains
    Lisa C Parker
    Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United Kingdom
    J Immunol 181:5606-17. 2008
    ....
  41. pmc Differential and cell-type specific regulation of responses to Toll-like receptor agonists by ISO-1
    Peter W West
    Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    Immunology 125:101-10. 2008
    ..ISO-1 is a promising parent molecule which inhibits TLR-induced ERK activation and inflammatory cytokine production in monocytes, whose role may be complicated by cell-type specificity...
  42. pmc A Bayesian approach to copy-number-polymorphism analysis in nuclear pedigrees
    Konstantina Kosta
    School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    Am J Hum Genet 81:808-12. 2007
    ..We have implemented the basic model for use with nuclear families, and we illustrate its application through an analysis of the CNP located in gene CCL3L1 in 201 families with asthma...
  43. ncbi request reprint Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor
    Jon R Ward
    Section of Functional Genomics, University of Sheffield, UK
    Thromb Haemost 94:831-8. 2005
    ....
  44. ncbi request reprint Granulocyte apoptosis in the pathogenesis and resolution of lung disease
    Stephen M Bianchi
    Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, M Floor, Royal Hallamshire Hospital, Sheffield S10 2JF, U K
    Clin Sci (Lond) 110:293-304. 2006
    ..This review will explore the physiological roles of granulocyte apoptosis and their importance in infectious and non-infectious lung disease...
  45. pmc Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor
    Kathryn R Vaughan
    Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, UK
    J Immunol 179:8544-53. 2007
    ..Specific targeting of P2Y11 could retain key immune functions of neutrophils but reduce the injurious effects of increased neutrophil longevity during inflammation...
  46. pmc Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin
    Lynne R Prince
    Academic Unit of Respiratory Medicine, University of Sheffield, Sheffield, UK
    J Immunol 180:3502-11. 2008
    ..This may be a pathological pathway of cell death to which neutrophils are particularly susceptible, and could be therapeutically targeted to limit neutrophil death and preserve host responses...
  47. ncbi request reprint Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa
    Stephen M Bianchi
    Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield S10 2JF, UK
    Am J Respir Crit Care Med 177:35-43. 2008
    ..Whether these metabolites, particularly pyocyanin, can also modulate apoptotic cell engulfment is unknown...
  48. pmc CCR4 blockade does not inhibit allergic airways inflammation
    Dolores M Conroy
    Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College, London, United Kingdom
    J Leukoc Biol 74:558-63. 2003
    ..This study casts doubts on the validity of CCR4 as a therapeutic target in the treatment of asthma...
  49. ncbi request reprint CCR4 in human allergen-induced late responses in the skin and lung
    Kayhan T Nouri-Aria
    Upper Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, GB
    Eur J Immunol 32:1933-8. 2002
    ..CCR4 may be important in the recruitment of T lymphocytes at sites of allergic inflammation, in a non-organ-specific manner...
  50. ncbi request reprint Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers
    Andrew Menzies-Gow
    Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Immunol 169:2712-8. 2002
    ..Thus, intradermal injection of eotaxin and eotaxin-2 in humans induced infiltration of eosinophils and other inflammatory cells as well as changes consistent with CC chemokine-induced mast cell degranulation...
  51. ncbi request reprint The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy
    James E Pease
    Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, South Kensington, London SW7 2AZ, UK
    Am J Respir Med 1:19-25. 2002
    ..Clinical trials of such compounds will ultimately provide crucial information currently lacking and will define whether or not IL-8 blockade provides future therapy in pulmonary disease...
  52. ncbi request reprint The carboxyl terminus of the chemokine receptor CCR3 contains distinct domains which regulate chemotactic signaling and receptor down-regulation in a ligand-dependent manner
    Ian Sabroe
    Leukocyte Biology Section, Biomedical Sciences Division, Imperial College London, UK
    Eur J Immunol 35:1301-10. 2005
    ..Thus, the CCR3 C terminus contains distinct domains responsible for the regulation of receptor desensitization and for coupling to chemotactic responses...
  53. ncbi request reprint Incapacitating the immune system in cystic fibrosis
    Ian Sabroe
    Nat Med 13:1417-8. 2007
  54. ncbi request reprint The identification, characterization, and distribution of guinea pig CCR4 and epitope mapping of a blocking antibody
    Louise A Jopling
    Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Exhibition Road, London SW7 2AZ, United Kingdom
    J Biol Chem 277:6864-73. 2002
    ..Subsequent analysis of chimeric chemokine receptors indicated that 10E4, a functional inhibitor of gpCCR4 responses, recognized the amino terminus of CCR4...
  55. ncbi request reprint Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease
    Andrei E Medvedev
    Department of Microbiology and Immunology, University of Maryland, Baltimore UMB, Baltimore, Maryland 21201, USA
    J Endotoxin Res 12:133-50. 2006
    ..In this review, we present current theories of the molecular mechanisms that underlie induction and maintenance of 'microbial tolerance', and discuss the possible relevance of tolerance to several infectious and non-infectious diseases...
  56. ncbi request reprint Variations in eosinophil chemokine responses: an investigation of CCR1 and CCR3 function, expression in atopy, and identification of a functional CCR1 promoter
    Rhian M Phillips
    Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Immunol 170:6190-201. 2003
    ..Identification of a functional CCR1 promoter will facilitate the study of possible genetic determinants underlying this potentially important clinical phenotype...
  57. ncbi request reprint CXCR1+CD4+ T cells in human allergic disease
    James N Francis
    Upper Respiratory Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, United Kingdom
    J Immunol 172:268-73. 2004
    ..Phenotypic analysis reveals that IFN-gamma expression was lower in the CXCR1+CD4+ cells. The identification of CXCR1 as a marker of allergic rhinitis reveals a possible target for therapeutic intervention in atopic disease...
  58. ncbi request reprint Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists
    Shannon A Bryan
    National Heart and Lung Institute, and Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College School of Medicine, London, United Kingdom
    Am J Respir Crit Care Med 165:1602-9. 2002
    ..Such whole blood methods may also be employed in the investigation of other small molecule chemokine receptor antagonists...
  59. ncbi request reprint Indomethacin causes prostaglandin D(2)-like and eotaxin-like selective responses in eosinophils and basophils
    Victoria E L Stubbs
    Leukocyte Biology Section, Biomedical Sciences Division, Imperial College Faculty of Medicine, Imperial College of Science, Technology and Medicine, South Kensington, London SW7 2AZ, United Kingdom
    J Biol Chem 277:26012-20. 2002
    ..Indomethacin and its analogues may therefore provide a structural basis from which selective PGD(2) receptor small molecule antagonists may be designed and which may have utility in the treatment of allergic inflammatory disease...
  60. ncbi request reprint Delta 12-prostaglandin J2, a plasma metabolite of prostaglandin D2, causes eosinophil mobilization from the bone marrow and primes eosinophils for chemotaxis
    Akos Heinemann
    Department of Experimental and Clinical Pharmacology, Karl Franzens University, Graz, Austria
    J Immunol 170:4752-8. 2003
    ....