Caroline A Sabin

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Conventional cardiovascular risk factors in HIV infection: how conventional are they?
    Caroline A Sabin
    HIV Epidemiology and Biostatistics Unit, Department of Primary Care and Population Sciences, Royal Free and UC Medical School, London NW32PF, UK
    Curr Opin HIV AIDS 3:214-9. 2008
  2. ncbi Long-term follow-up of antiretroviral-naive HIV-positive patients treated with nevirapine
    C A Sabin
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    J Acquir Immune Defic Syndr 26:462-5. 2001
  3. ncbi CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK
    Mark Bower
    Research Department of Infection and Population Health, Division of Population Health, UCL Medical School, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK
    Haematologica 94:875-80. 2009
  4. ncbi The changing clinical epidemiology of AIDS in the highly active antiretroviral therapy era
    Caroline A Sabin
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    AIDS 16:S61-8. 2002
  5. ncbi Deaths in the era of HAART: contribution of late presentation, treatment exposure, resistance and abnormal laboratory markers
    Caroline A Sabin
    Department of Primary Care and Population Sciences, Royal Free and UC Medical School, Pond St, London, UK
    AIDS 20:67-71. 2006
  6. ncbi An audit of antiretroviral treatment use in HIV-infected patients in a London clinic: the limitations of observational databases when auditing antiretroviral treatment use
    C A Sabin
    Royal Free Centre for HIV Medicine, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London, UK
    HIV Med 4:87-93. 2003
  7. ncbi Early antiretroviral therapy: the role of cohorts
    Caroline A Sabin
    Research Department of Infection and Population Health, Division of Population Health, UCL Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    Curr Opin HIV AIDS 4:200-5. 2009
  8. ncbi AIDS events among individuals initiating HAART: do some patients experience a greater benefit from HAART than others?
    C Sabine
    Department of Primary Care and Population Sciences, Royal Free and UC Medical School, London, UK
    AIDS 19:1995-2000. 2005
  9. ncbi Twenty five years of HIV infection in haemophilic men in Britain: an observational study
    Caroline A Sabin
    Department of Primary Care and Population Sciences, Royal Free and UC Medical School, London NW3 2PF
    BMJ 331:997-8. 2005
  10. ncbi Cohort studies: to what extent can they inform treatment guidelines?
    Caroline A Sabin
    UCL Medical School, London, UK
    Curr Opin Infect Dis 23:15-20. 2010

Collaborators

Detail Information

Publications95

  1. ncbi Conventional cardiovascular risk factors in HIV infection: how conventional are they?
    Caroline A Sabin
    HIV Epidemiology and Biostatistics Unit, Department of Primary Care and Population Sciences, Royal Free and UC Medical School, London NW32PF, UK
    Curr Opin HIV AIDS 3:214-9. 2008
    ..To describe the prevalence of traditional cardiovascular disease risk factors in HIV-infected individuals and to describe the impact of these factors outcomes...
  2. ncbi Long-term follow-up of antiretroviral-naive HIV-positive patients treated with nevirapine
    C A Sabin
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    J Acquir Immune Defic Syndr 26:462-5. 2001
    ..RNA levels rebounded >500 copies/ml in 37 of these patients, on average 2 years after initial response. In conclusion, in ARV-naive patients, NVP is generally well tolerated and long-term response rates are good...
  3. ncbi CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK
    Mark Bower
    Research Department of Infection and Population Health, Division of Population Health, UCL Medical School, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK
    Haematologica 94:875-80. 2009
    ..Earlier highly active anti-retroviral therapy initiation and wider access to HIV testing is advocated to reduce the risk of systemic non-Hodgkin's lymphoma...
  4. ncbi The changing clinical epidemiology of AIDS in the highly active antiretroviral therapy era
    Caroline A Sabin
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    AIDS 16:S61-8. 2002
  5. ncbi Deaths in the era of HAART: contribution of late presentation, treatment exposure, resistance and abnormal laboratory markers
    Caroline A Sabin
    Department of Primary Care and Population Sciences, Royal Free and UC Medical School, Pond St, London, UK
    AIDS 20:67-71. 2006
    ..To describe the characteristics of deaths that occur among HIV-positive individuals in the HAART era...
  6. ncbi An audit of antiretroviral treatment use in HIV-infected patients in a London clinic: the limitations of observational databases when auditing antiretroviral treatment use
    C A Sabin
    Royal Free Centre for HIV Medicine, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London, UK
    HIV Med 4:87-93. 2003
    ..To audit the use of antiretroviral (ARV) treatment in a large treatment clinic in the UK against the British HIV Association (BHIVA) ARV treatment guidelines...
  7. ncbi Early antiretroviral therapy: the role of cohorts
    Caroline A Sabin
    Research Department of Infection and Population Health, Division of Population Health, UCL Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    Curr Opin HIV AIDS 4:200-5. 2009
    ..To review the data that contribute to the debate on the optimal time to initiate highly active antiretroviral therapy in HIV-infected individuals, with a focus on the information that is available from cohort studies...
  8. ncbi AIDS events among individuals initiating HAART: do some patients experience a greater benefit from HAART than others?
    C Sabine
    Department of Primary Care and Population Sciences, Royal Free and UC Medical School, London, UK
    AIDS 19:1995-2000. 2005
    ..To describe the rate of new AIDS events over the first year of HAART in patients with different characteristics and to describe the decrease in incidence of AIDS between the first and second 6 months of the year in these patients...
  9. ncbi Twenty five years of HIV infection in haemophilic men in Britain: an observational study
    Caroline A Sabin
    Department of Primary Care and Population Sciences, Royal Free and UC Medical School, London NW3 2PF
    BMJ 331:997-8. 2005
  10. ncbi Cohort studies: to what extent can they inform treatment guidelines?
    Caroline A Sabin
    UCL Medical School, London, UK
    Curr Opin Infect Dis 23:15-20. 2010
    ..This review examines situations in which information from cohort studies has proved to be useful for the development of treatment guidelines...
  11. ncbi Treatment exhaustion of highly active antiretroviral therapy (HAART) among individuals infected with HIV in the United Kingdom: multicentre cohort study
    Caroline A Sabin
    Department of Primary Care and Population Sciences, Royal Free and UC Medical School, London NW3 2PF
    BMJ 330:695. 2005
    ....
  12. ncbi Pitfalls of assessing hepatotoxicity in trials and observational cohorts
    Caroline A Sabin
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Clin Infect Dis 38:S56-64. 2004
    ..I describe some of the benefits and limitations of RCTs and observational data sets when drawing conclusions about the relationship between antiretroviral therapy and the development of hepatic abnormalities...
  13. ncbi Late presenters in the era of highly active antiretroviral therapy: uptake of and responses to antiretroviral therapy
    Caroline A Sabin
    Royal Free and University College Medical School, Royal Free NHS Trust, London, UK
    AIDS 18:2145-51. 2004
    ..To investigate the characteristics and clinical, immunological and virological outcomes for individuals presenting for care with low CD4 cell counts...
  14. ncbi Markers of HIV-1 disease progression in individuals with haemophilia coinfected with hepatitis C virus: a longitudinal study
    Caroline A Sabin
    Department of Primary Care and Population Sciences, Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, London, UK
    Lancet 360:1546-51. 2002
    ..We aimed to assess the relation between markers of liver function and progression to AIDS and death in individuals with haemophilia infected with HIV-1 and hepatitis C virus...
  15. ncbi Should HIV therapy be started at a CD4 cell count above 350 cells/microl in asymptomatic HIV-1-infected patients?
    Caroline A Sabin
    Research Department of Infection and Population Health, Division of Population Health, UCL Medical School, University College London, Royal Free Campus, Rowland Hill Street, London, UK
    Curr Opin Infect Dis 22:191-7. 2009
    ..The aim is to review the available data that contribute to the debate on the optimal time to initiate highly active antiretroviral therapy (HAART) in HIV-infected individuals with a CD4 cell count more than 350 cells/microl...
  16. ncbi Relationships among the detection of p24 antigen, human immunodeficiency virus (HIV) RNA level, CD4 cell count, and disease progression in HIV-infected individuals with hemophilia
    C A Sabin
    Department of Primary Care and Population Sciences, Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, Rowland Hill St, London NW3 2PF, United Kingdom
    J Infect Dis 184:511-4. 2001
    ..85; P=.06) after adjusting for CD4 cell counts and HIV RNA levels during follow-up, age, and calendar year. A significant relationship between p24 antigenemia and death was nonsignificant after adjusting for CD4 cell count...
  17. ncbi The associations between age and the development of laboratory abnormalities and treatment discontinuation for reasons other than virological failure in the first year of highly active antiretroviral therapy
    C A Sabin
    Department of Primary Care and Population Science, Royal Free and UC Medical School, London, UK
    HIV Med 10:35-43. 2009
    ....
  18. ncbi Long-term patterns of hepatitis C virus RNA concentrations in a cohort of HIV seronegative men with bleeding disorders
    Caroline A Sabin
    Haemophilia Centre and Haemostasis Unit and Department of Primary Care and Population Sciences, Royal Free and University Medical School, London, United Kingdom
    J Med Virol 68:68-75. 2002
    ....
  19. ncbi Changes over time in risk factors for cardiovascular disease and use of lipid-lowering drugs in HIV-infected individuals and impact on myocardial infarction
    C A Sabin
    Dept of Primary Care and Population Sciences, Royal Free and UC Medical School, Rowland Hill St, London, NW3 2PF, United Kingdom
    Clin Infect Dis 46:1101-10. 2008
    ..We evaluated changes in risk factors for CVD and the use of lipid-lowering therapy in HIV-infected individuals and assessed the impact of any changes on the incidence of myocardial infarction...
  20. ncbi Are previous treatment interruptions associated with higher viral rebound rates in patients with viral suppression?
    Loveleen K Bansi
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Hampstead Campus, Rowland Hill Street, London, NW3 2PF, UK
    AIDS 22:349-56. 2008
    ..We investigated whether previous treatment interruptions are associated with a raised risk of viral rebound in individuals who have attained virological suppression...
  21. ncbi Hepatitis B virus pre-S deletion mutations are a risk factor for hepatocellular carcinoma: a matched nested case-control study
    Zhong Liao Fang
    Department of Medicine, UCL Medical School, London W1T 4JF, UK
    J Gen Virol 89:2882-90. 2008
    ..The 5' terminus of pre-S2 is the favoured site for the deletion mutations, especially in HCC cases. Further prospective studies are required to confirm the role of these mutations in the development of HCC...
  22. ncbi Stability of antiretroviral regimens in patients with viral suppression
    Rebecca K Lodwick
    Research Department of Infection and Population Health, Division of Population Health, Royal Free and University College Medical School, London, UK
    AIDS 22:1039-46. 2008
    ..To study the rate of treatment change due to toxicities in patients who achieved viral suppression within 6 months of starting antiretroviral therapy and who have never experienced virological failure...
  23. ncbi The effect of highly active antiretroviral therapy for HIV on the anti-HCV specific humoral immune response
    Esteban Herrero-Martinez
    Department of Virology, Royal Free and University College Medical School, London, United Kingdom
    J Med Virol 72:187-93. 2004
    ..The relationship disappeared or was obscured after therapy (R = 0.24, P = 0.30 and R = 0.16, P = 0.50, respectively). Thus, we show that HAART affects the HCV specific humoral immune responses without affecting the HCV RNA level...
  24. ncbi Factors influencing increases in CD4 cell counts of HIV-positive persons receiving long-term highly active antiretroviral therapy
    Colette J Smith
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom
    J Infect Dis 190:1860-8. 2004
    ..We sought to investigate the factors associated with increases in CD4 cell count among human immunodeficiency virus (HIV)-positive antiretroviral-naive patients starting HAART...
  25. ncbi Changes in outcome of persons initiating highly active antiretroviral therapy at a CD4 count less than 50 Cells/mm3
    Kholoud Porter
    Medical Research Council Clinical Trials Unit, London, United Kingdom
    J Acquir Immune Defic Syndr 47:202-5. 2008
    ....
  26. ncbi Risk of extensive virological failure to the three original antiretroviral drug classes over long-term follow-up from the start of therapy in patients with HIV infection: an observational cohort study
    Andrew N Phillips
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Lancet 370:1923-8. 2007
    ..We estimated the proportion of patients who had extensive triple-class failure during long-term follow-up and examined characteristics associated with an increased rate of failure...
  27. ncbi Increased duration of viral suppression is associated with lower viral rebound rates in patients with previous treatment failures
    Andrew A Benzie
    St Mary s Hospital, London, UK
    AIDS 21:1423-30. 2007
    ....
  28. ncbi Transgenic human CRP is not pro-atherogenic, pro-atherothrombotic or pro-inflammatory in apoE-/- mice
    Glenys A Tennent
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, University College London, UK
    Atherosclerosis 196:248-55. 2008
    ..Thus, there was no evidence in this 18 month study of apoE(-/-), and control apoE(+/+) mice, that transgenic human CRP was pro-atherogenic, pro-inflammatory or pro-atherothrombotic...
  29. ncbi Outcomes in the first year after initiation of first-line HAART among heterosexual men and women in the UK CHIC Study
    Tristan J Barber
    St Stephen s AIDS Trust Clinical Trials Unit, Chelsea and Westminster NHS Foundation Trust, London, UK
    Antivir Ther 16:805-14. 2011
    ..We analysed the influence of gender on use and outcomes of first-line HAART in a UK cohort...
  30. ncbi Using two on-going HIV studies to obtain clinical data from before, during and after pregnancy for HIV-positive women
    Susie E Huntington
    Research Department of Infection and Population Health, University College London, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK
    BMC Med Res Methodol 12:110. 2012
    ..A methodology was developed to find and match records for women reported to both studies thereby obtaining clinical and treatment data on pregnant HIV-positive women not available from either dataset alone...
  31. ncbi Late diagnosis in the HAART era: proposed common definitions and associations with mortality
    Caroline A Sabin
    Research Department of Infection and Population Health, UCL Medical School, London, UK
    AIDS 24:723-7. 2010
    ....
  32. ncbi The rate of viral rebound after attainment of an HIV load <50 copies/mL according to specific antiretroviral drugs in use: results from a multicenter cohort study
    Colette J Smith
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    J Infect Dis 192:1387-97. 2005
    ....
  33. ncbi Human immunodeficiency virus rebound after suppression to <400 copies/mL during initial highly active antiretroviral therapy regimens, according to prior nucleoside experience and duration of suppression
    Andrew N Phillips
    Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, United Kingdom
    J Infect Dis 186:1086-91. 2002
    ..95; P=.009). It appears that only a small period of pre-HAART nucleoside therapy is sufficient to confer a disadvantage, in terms of risk of virus rebound, that persists for several years...
  34. ncbi Virological suppression at 6 months is related to choice of initial regimen in antiretroviral-naive patients: a cohort study
    Gail V Matthews
    Department of HIV Medicine, Chelsea Hospital, London, UK
    AIDS 16:53-61. 2002
    ..Clinical trial data is required to confirm these findings...
  35. ncbi A complex hepatitis B virus (X/C) recombinant is common in Long An county, Guangxi and may have originated in southern China
    Zhong Liao Fang
    Division of Medicine, UCL Medical School, London, UK
    J Gen Virol 92:402-11. 2011
    ..The exception, isolate QL523, has a greater proportion of genotype C parent. Phylogeographic analysis reveals that these recombinants probably arose in southern China and spread later to Vietnam and Laos...
  36. ncbi The prognostic value of a single hepatitis C virus RNA load measurement taken early after human immunodeficiency virus seroconversion
    Esteban Herrero-Martinez
    Department of Virology, Royal Free and University College Medical School, Royal Free Hospital, London, United Kingdom
    J Infect Dis 186:470-6. 2002
    ..25; P=.01). Adjusting for HIV RNA levels, CD4 cell counts, and the age effect, HCV RNA load >5.90 log(10) copies/mL was predictive of progression to AIDS and all-cause mortality over a period of at least 15 years...
  37. ncbi Response to efavirenz-containing regimens in previously antiretroviral-naive HIV-positive patients: the role of gender
    Colette J Smith
    HIV Biostatistics and Epidemiology Group and Department of Primary Care and Population Science, Royal Free and University College Medical School, London, United Kingdom
    J Acquir Immune Defic Syndr 46:62-7. 2007
    ..We investigated the role of gender on response to efavirenz (EFV)-containing regimens in previously antiretroviral-naive patients...
  38. ncbi The potential for CD4 cell increases in HIV-positive individuals who control viraemia with highly active antiretroviral therapy
    Colette J Smith
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, London, UK
    AIDS 17:963-9. 2003
    ..To study the long-term CD4 cell responses to highly active antiretroviral therapy (HAART) in treatment-naive patients whose viral loads remained below 500 copies/ml for prolonged periods...
  39. ncbi Death rates in HIV-positive antiretroviral-naive patients with CD4 count greater than 350 cells per microL in Europe and North America: a pooled cohort observational study
    Rebecca K Lodwick
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, Royal Free Campus, London, UK
    Lancet 376:340-5. 2010
    ..We aimed to examine this by analysis of pooled data from industrialised countries...
  40. ncbi HBV A1762T, G1764A mutations are a valuable biomarker for identifying a subset of male HBsAg carriers at extremely high risk of hepatocellular carcinoma: a prospective study
    Zhong Liao Fang
    Department of Medicine, Royal Free and University College Medical School, University College London, London, United Kingdom
    Am J Gastroenterol 103:2254-62. 2008
    ..It is likely to be extremely beneficial in terms of cost and resources if a significant number of tumors can be detected early by screening this selected population. Our aim is to test this hypothesis...
  41. ncbi Viral breakthrough after suppression with highly active antiretroviral therapy: experience from 233 individuals with viral loads of less than 50 copies/ml followed for up to 4 years
    Fiona C Lampe
    Royal Free Centre for HIV Medicine, London, UK
    AIDS 17:768-70. 2003
  42. ncbi Use of viral load measured after 4 weeks of highly active antiretroviral therapy to predict virologic outcome at 24 weeks for HIV-1-positive individuals
    Colette J Smith
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom
    J Acquir Immune Defic Syndr 37:1155-9. 2004
    ..We suggest that this group of patients should be particularly closely monitored...
  43. ncbi Recent epidemic of acute hepatitis C virus in HIV-positive men who have sex with men linked to high-risk sexual behaviours
    Mark Danta
    UCL Institute of Hepatology, London, UK
    AIDS 21:983-91. 2007
    ..To characterize the mode of hepatitis C virus (HCV) transmission in a recent epidemic of acute HCV in HIV-infected individuals using linked molecular and clinical epidemiological studies...
  44. ncbi Success of clinical care for human immunodeficiency virus infection according to demographic group among sexually infected patients in a routine clinic population, 1999 to 2004
    Fiona C Lampe
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Hospital, Rowland Hill Street, London, England
    Arch Intern Med 167:692-700. 2007
    ..The success of clinical care for human immunodeficiency virus infection may vary across demographic groups, because of patient- and health care-related factors...
  45. ncbi Rapid reconstitution of humoral immunity against cytomegalovirus but not HIV following highly active antiretroviral therapy
    Jane R Deayton
    Department of Virology, Royal Free Hampstead NHS Trust and Royal Free and University College School of Medicine, London, UK
    AIDS 16:2129-35. 2002
    ..CONCLUSIONS: In patients with HCMV DNAaemia, reconstitution of humoral immunity to HCMV gB occurs rapidly following the initiation of HAART. These changes contrast with the patterns observed for anti-HIV humoral immune responses...
  46. ncbi Predictors of pregnancy and changes in pregnancy incidence among HIV-positive women accessing HIV clinical care
    Susie E Huntington
    Medical Research Council MRC Centre of Epidemiology for Child Health, Institute of Child Health, University College London, London, UK
    AIDS 27:95-103. 2013
    ..To describe predictors of pregnancy and changes in pregnancy incidence among HIV-positive women accessing HIV clinical care...
  47. ncbi Can linear regression modeling help clinicians in the interpretation of genotypic resistance data? An application to derive a lopinavir-score
    Alessandro Cozzi-Lepri
    Department of Infection and Population Health, Division of Population Health, UCL Medical School, Royal Free Campus, London, United Kingdom
    PLoS ONE 6:e25665. 2011
    ....
  48. ncbi HIV-associated central nervous system diseases in the recent combination antiretroviral therapy era
    Lucy Garvey
    Clinical Trials Centre, Winston Churchill Wing, St Mary s Hospital, London, W2 1NY, UK
    Eur J Neurol 18:527-34. 2011
    ..Data describing the incidence and survival of HIV-related central nervous system diseases (CNS-D) in recent years are sparse...
  49. ncbi CD4 cell count changes in individuals with counts above 500 cells/mm and viral loads below 50 copies/ml on antiretroviral therapy
    Andrew N Phillips
    Royal Free Centre for HIV Medicine, London, UK
    AIDS 16:1073-5. 2002
  50. ncbi A randomized comparative trial of tenofovir DF or abacavir as replacement for a thymidine analogue in persons with lipoatrophy
    Graeme J Moyle
    Chelsea and Westminster Hospital, London, UK
    AIDS 20:2043-50. 2006
    ..Peripheral fat loss, lipoatrophy, appears most associated with prolonged therapy with thymidine nucleoside analogues...
  51. ncbi Differential effects of prednisolone and azathioprine on the development of human cytomegalovirus replication post liver transplantation
    Gaia Nebbia
    Department of Infection, Royal Free and University College Medical School, London, UK
    Transplantation 84:605-10. 2007
    ..We sought to investigate the impact of different immunosuppressive regimens on human cytomegalovirus (HCMV) incidence and replication dynamics in a cohort of 256 patients after liver transplantation...
  52. ncbi The relationship between CD4 cell count nadirs and the toxicity profiles of antiretroviral regimens
    J Smith Colette
    Centre for HIV Medicine, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Hospital, London, UK
    Antivir Ther 10:459-67. 2005
    ..We investigated the relationship between the pre-HAART CD4 count nadir, HAART and the occurrence of laboratory-defined toxicities...
  53. ncbi Proinflammatory effects of bacterial recombinant human C-reactive protein are caused by contamination with bacterial products, not by C-reactive protein itself
    Mark B Pepys
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London, UK
    Circ Res 97:e97-103. 2005
    ....
  54. ncbi Theoretical rationale for the use of sequential single-drug antiretroviral therapy for treatment of HIV infection
    Andrew N Phillips
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    AIDS 17:1009-16. 2003
    ..We aimed to explore the use of sequential monotherapy regimens using a mathematical model of quasi-species dynamics, to see if these could take advantage of the poor replicative capacity of highly resistant virus...
  55. ncbi Response to antiviral therapy in patients with genotype 3 chronic hepatitis C: fibrosis but not race encourages relapse
    Dania Shoeb
    The Liver Unit, Blizard Institute for Cellular and Molecular Science, Queen Mary University of London, London, UK
    Eur J Gastroenterol Hepatol 23:747-53. 2011
    ..We completed a retrospective analysis of patients with genotype 3 hepatitis C virus (HCV) undergoing therapy in four UK centres with large populations of patients from the Indian subcontinent...
  56. ncbi Drug resistance genotypes predict response to amprenavir-containing regimens in highly drug-experienced HIV-1-infected patients
    Caroline A Sabin
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Antivir Ther 8:301-8. 2003
    ..New formulations of amprenavir, together with boosted regimens, may enhance the activity in the presence of protease inhibitor-resistant virus...
  57. ncbi Drug resistance is uncommon in pregnant women with low viral loads taking zidovudine monotherapy to prevent perinatal HIV transmission
    Nick Larbalestier
    Department of Genitourinary Medicine, Virology Section, Guys, Kings and St Thomas' School of Medicine, London, UK
    AIDS 17:2665-7. 2003
    ....
  58. ncbi Treatment switches during pregnancy among HIV-positive women on antiretroviral therapy at conception
    Susie E Huntington
    UCL Medical School, Royal Free Campus, UK
    AIDS 25:1647-55. 2011
    ....
  59. ncbi Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice
    Gideon M Hirschfield
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London NW3 2PF, United Kingdom
    Proc Natl Acad Sci U S A 102:8309-14. 2005
    ..Nevertheless, the present results do not suggest that human CRP is either proatherogenic or atheroprotective in vivo...
  60. ncbi Targeting C-reactive protein for the treatment of cardiovascular disease
    Mark B Pepys
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, University College London, Rowland Hill Street, London NW3 2PF, UK
    Nature 440:1217-21. 2006
    ....
  61. ncbi Risk factors associated with early hepatic artery thrombosis after orthotopic liver transplantation - univariable and multivariable analysis
    Parveen Warner
    Liver Transplantation and Hepatobiliary Unit, University Department of Surgery, University College London and Royal Free Hospital, London, UK
    Transpl Int 24:401-8. 2011
    ..Early recognition of these factors, strict surveillance protocols with arterial Doppler and selective anticoagulation for patients at risk need to be evaluated prospectively...
  62. ncbi Gender and clinical outcomes after starting highly active antiretroviral treatment: a cohort study
    Antonia L Moore
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Hampstead, London, UK
    J Acquir Immune Defic Syndr 29:197-202. 2002
    ..To examine gender differences in clinical response to highly active antiretroviral treatment (HAART)...
  63. ncbi The problems faced when assessing the prevalence and incidence of antiretroviral-related toxicities
    Colette J Smith
    Department of Primary Care and Population Sciences and Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, London, UK
    Antivir Ther 9:865-78. 2004
    ..We investigated the possible explanations for the differences in the incidence and prevalence rates of HAART-related toxicities between studies, focussing on metabolic and hepatotoxic disorders...
  64. ncbi Prevalence of hepatitis C-related cirrhosis in elderly Asian patients infected in childhood
    Michael J Glynn
    Hepatobiliary Group, Department of Adult and Pediatric Gastroenterology, Barts and The London, Queen Mary's School of Medicine and Dentistry, London, United Kingdom
    Clin Gastroenterol Hepatol 3:910-7. 2005
    ....
  65. ncbi Late HIV presentation: epidemiology, clinical implications and management
    Laura Waters
    St Stephens Research, St Stephens Centre, Chelsea and Westminster Hospital, 369 Fulham Road, London, UK
    Expert Rev Anti Infect Ther 9:877-89. 2011
    ..Finally, strategies to increase HIV testing uptake to reduce late presentation will be summarized...
  66. ncbi Highly active antiretroviral therapy and cervical intraepithelial neoplasia
    Antonia L Moore
    Center for HIV Medicine, Royal Free Hospital, London, UK
    AIDS 16:927-9. 2002
    ..Such studies will provide the basis for guidelines for monitoring CIN in HIV-positive women in the HAART era...
  67. ncbi Emergence of the H208Y mutation in the reverse transcriptase (RT) of HIV-1 in association with nucleoside RT inhibitor therapy
    G Nebbia
    Department of Virology, Royal Free and University College Medical School, Rowland Hill Street, NW3 2PF London, UK
    J Antimicrob Chemother 59:1013-6. 2007
    ..The aim of the study was to determine whether mutations at RT codon 208 are associated with nucleoside RT inhibitor (NRTI) exposure, NRTI resistance patterns and HIV-1 subtype...
  68. ncbi Factors associated with specific causes of death amongst HIV-positive individuals in the D:A:D Study
    Colette Smith
    Research Department of Infection and Population Health, UCL, Royal Free Campus, London, UK
    AIDS 24:1537-48. 2010
    ..To investigate any emerging trends in causes of death amongst HIV-positive individuals in the current cART era, and to investigate the factors associated with each specific cause of death...
  69. ncbi Autoimmunity and glomerulonephritis in mice with targeted deletion of the serum amyloid P component gene: SAP deficiency or strain combination?
    Julian D Gillmore
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London, UK
    Immunology 112:255-64. 2004
    ..Alternatively, the autoimmunity may be independent of SAP deficiency and caused by expression of 129/Sv chromosome 1 genes in the C57BL/6 background...
  70. ncbi Immunosuppression and donor age with respect to severity of HCV recurrence after liver transplantation
    Dimitrios N Samonakis
    Royal Free Hospital, Liver Transplantation and Hepatobiliary Unit, London, UK
    Liver Transpl 11:386-95. 2005
    ..Maintenance azathioprine gave survival advantage...
  71. ncbi The association of HBV core promoter double mutations (A1762T and G1764A) with viral load differs between HBeAg positive and anti-HBe positive individuals: a longitudinal analysis
    Zhong Liao Fang
    Division of Medicine, UCL Medical School, Windeyer Building, Cleveland Street, London W1T 4JF, UK
    J Hepatol 50:273-80. 2009
    ..We aim to determine the association after controlling for HBeAg - a strong confounding factor...
  72. ncbi The late diagnosis and consequent short-term mortality of HIV-infected heterosexuals (England and Wales, 2000-2004)
    Timothy R Chadborn
    HIV and STI Department, Health Protection Agency Centre for Infections, London, UK
    AIDS 20:2371-9. 2006
    ..To describe the proportion of HIV-infected heterosexual individuals diagnosed late and estimate how much mortality could have been prevented by earlier diagnosis...
  73. ncbi Impact of the insect biting nuisance on a British youth expedition to Alaska
    Fiona J Cooke
    Academic Centre for Travel Medicine and Vaccines, Royal Free and University College Medical School, London, United Kingdom
    J Travel Med 9:76-81. 2002
    ..Thus, it is recommended that expeditions and independent travelers to this area do not need to increase time spent in the field to compensate for expedition man days lost due to problems associated with the insect biting nuisance...
  74. ncbi Valacyclovir provides optimum acyclovir exposure for prevention of cytomegalovirus and related outcomes after organ transplantation
    Paul Fiddian
    Royal Free and University College Medical School Royal Free Campus, London NW3 2PF, United Kingdom
    J Infect Dis 186:S110-5. 2002
    ..Increasing acyclovir exposure to that achieved with valacyclovir extends benefits of prophylaxis to include impact on graft rejection and opportunistic infections...
  75. ncbi Natural history and outcome in systemic AA amyloidosis
    Helen J Lachmann
    National Amyloidosis Centre and Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London
    N Engl J Med 356:2361-71. 2007
    ..Little is known about the natural history of AA amyloidosis or its response to treatment...
  76. ncbi von Willebrand disease in women with menorrhagia: a systematic review
    Meena Shankar
    Department of Obstetrics and Gynaecology, Royal Free Hospital, London, UK
    BJOG 111:734-40. 2004
    ..Testing for this disorder should be considered when investigating women with menorrhagia, especially those of Caucasian origin, those with no obvious pelvic pathology or with additional bleeding symptoms...
  77. ncbi Cardiovascular disease risk factors in HIV patients--association with antiretroviral therapy. Results from the DAD study
    Nina Friis-Møller
    DAD Coordinating Centre, Copenhagen HIV Programme, Hvidovre University Hospital, Copenhagen, Denmark
    AIDS 17:1179-93. 2003
    ..To determine the prevalence of risk factors for cardiovascular disease (CVD) among HIV-infected persons, and to investigate any association between such risk factors, stage of HIV disease, and use of antiretroviral therapies...
  78. ncbi Immunological changes during treatment interruptions: risk factors and clinical sequelae
    Mary B Poulton
    Brighton Health Care NHS Trust, Royal Sussex County Hospital, Brighton, East Sussex BN2 5BE, UK
    AIDS 17:126-8. 2003
  79. ncbi When should antiretroviral therapy be started for HIV infection? Interpreting the evidence from observational studies
    Andrew N Phillips
    AIDS 17:1863-9. 2003
  80. ncbi Combination antiretroviral therapy and the risk of myocardial infarction
    Nina Friis-Møller
    N Engl J Med 349:1993-2003. 2003
    ..It remains controversial whether exposure to combination antiretroviral treatment increases the risk of myocardial infarction...
  81. ncbi Cost-utility analysis of primary prophylaxis versus treatment on-demand for individuals with severe haemophilia
    Alexander H Miners
    Health Economics Research Group, Brunel University, Uxbridge, United Kingdom
    Pharmacoeconomics 20:759-74. 2002
    ..To assess the cost effectiveness of primary prophylaxis with clotting factor instead of treatment following a bleed (on-demand) for individuals with severe haemophilia...
  82. ncbi The impact of HIV on mortality rates in the complete UK haemophilia population
    Sarah C Darby
    AIDS 18:525-33. 2004
    ..From 1997, after the introduction of effective treatment, substantial reductions occurred, although mortality from liver disease remained high...
  83. ncbi Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies
    Matthias Egger
    Department of Social and Preventive Medicine, University of Bern, CH 3012 Bern, Switzerland
    Lancet 360:119-29. 2002
    ..The ART Cohort Collaboration, which includes 13 cohort studies from Europe and North America, was established to fill this knowledge gap...
  84. ncbi Sexual transmission of hepatitis C in MSM may not be confined to those with HIV infection
    Daniel Richardson
    J Infect Dis 197:1213-4, author reply 1214-5. 2008
  85. ncbi HIV/HCV coinfection, HAART, and liver-related mortality
    Caroline A Sabin
    Lancet 364:757-8; author reply 758. 2004
  86. ncbi Predictors of hypertension and changes of blood pressure in HIV-infected patients
    Rodolphe Thiebaut
    INSERM E0338 epsilont U593, ISPED, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Antivir Ther 10:811-23. 2005
    ..We assessed predictors of changes in systolic (SBP) and diastolic (DBP) blood pressure during follow-up and of the development of hypertension in HIV-infected individuals...
  87. ncbi HIV-1 drug resistance in HIV-1-infected children in the United Kingdom from 1998 to 2004
    Rana Chakraborty
    Paediatric Infectious Diseases Unit, St George s Hospital, London
    Pediatr Infect Dis J 27:457-9. 2008
    ..Three-class resistance was noted in 42 samples (14.1%). Our study also highlighted underutilization of testing and the need for prompt genotyping after drug discontinuation which may have lead to an underestimation of HIV-1 resistance...
  88. ncbi Incidence and risk factors for new-onset diabetes in HIV-infected patients: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study
    Stephane De Wit
    Centre Hospitalier Universitaire Saint Pierre, Brussels, Belgium
    Diabetes Care 31:1224-9. 2008
    ....
  89. ncbi Late diagnosis of HIV infection: epidemiological features, consequences and strategies to encourage earlier testing
    Enrico Girardi
    UOC Epidemiologia Clinica, Istituto Nazionale per le Malattie Infettive L Spallanzani IRCCS, Rome, Italy
    J Acquir Immune Defic Syndr 46:S3-8. 2007
    ..This review summarizes recent evidence on the epidemiology of late presentation and its impact on clinical progression, and describes several key strategies that may encourage earlier diagnosis...
  90. ncbi The changing incidence of AIDS events in patients receiving highly active antiretroviral therapy
    Caroline A Sabin
    ICONA, Institute of Infectious and Tropical Diseases, University of Milan, Italy
    Arch Intern Med 165:416-23. 2005
    ..CONCLUSION: Although the incidence of all AIDS-defining events decreased substantially after starting HAART, the pattern of decline was most pronounced for events with a viral etiology...
  91. ncbi Class of antiretroviral drugs and the risk of myocardial infarction
    Nina Friis Møller
    University of Copenhagen, Copenhagen, Denmark
    N Engl J Med 356:1723-35. 2007
    ..We conducted a study to investigate the association of cumulative exposure to protease inhibitors and nonnucleoside reverse-transcriptase inhibitors with the risk of myocardial infarction...
  92. ncbi Liver-related deaths in persons infected with the human immunodeficiency virus: the D:A:D study
    Rainer Weber
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital, CH 809a Zurich, Switzerland
    Arch Intern Med 166:1632-41. 2006
    ..An increasing proportion of deaths among human immunodeficiency virus (HIV)-infected persons with access to combination antiretroviral therapy (cART) are due to complications of liver diseases...
  93. ncbi HIV treatment response and prognosis in Europe and North America in the first decade of highly active antiretroviral therapy: a collaborative analysis
    Margaret T May
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Lancet 368:451-8. 2006
    ..We aimed to examine trends in the characteristics of patients starting HAART in Europe and North America, and their treatment response and short-term prognosis...
  94. ncbi No time to wait: how many HIV-infected homosexual men are diagnosed late and consequently die? (England and Wales, 1993-2002)
    Timothy R Chadborn
    HIV STI Department, Communicable Disease Surveillance Centre, Health Protection Agency s, Centre for Infections London, London NW9 5EQ UK
    AIDS 19:513-20. 2005
    ..To determine separately risk factors for late diagnosis and short-term mortality...
  95. ncbi Epidemiological evidence for cardiovascular disease in HIV-infected patients and relationship to highly active antiretroviral therapy
    Judith S Currier
    Circulation 118:e29-35. 2008