Natalie S Ryan
Affiliation: University College London
- Motor features in posterior cortical atrophy and their imaging correlatesNatalie S Ryan
Dementia Research Centre, Department of Neurodegenerative Disease, University College London UCL Institute of Neurology, Queen Square, London, UK Electronic address
Neurobiol Aging 35:2845-57. 2014..Our data suggest that PCA patients with motor features have greater atrophy of contralateral sensorimotor areas but are still likely to have underlying Alzheimer's disease. ..
- Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer's diseaseNatalie S Ryan
Dementia Research Centre, Box 16 National Hospital for Neurology and Neurosugery, Queen Square, London WC1N 3BG, UK
Brain 136:1399-414. 2013..It may be owing to their dense connectivity that imaging changes are seen first in the thalamus and striatum, which then progress to involve other regions in a vulnerable neuronal network...
- Defining and describing the pre-dementia stages of familial Alzheimer's diseaseNatalie S Ryan
Dementia Research Centre, Department of Neurodegenerative Diseases, Box 16, National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
Alzheimers Res Ther 3:29. 2011..Furthermore, the study highlights some of the challenges of defining pre-dementia clinical stages in familial Alzheimer's disease and the need for the field to develop a consistent terminology...
- An unbiased longitudinal analysis framework for tracking white matter changes using diffusion tensor imaging with application to Alzheimer's diseaseShiva Keihaninejad
Dementia Research Centre, UCL Institute of Neurology, London, UK Centre for Medical Image Computing CMIC, University College London, UK
Neuroimage 72:153-63. 2013..Tensor-based registration for longitudinal processing of DTI data in clinical studies may be of particular value in studies assessing disease progression...
- The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from the DIAN studyDavid M Cash
From the Dementia Research Centre D M C, Y L, N S R, K M K, T Y, I B M, M N R, S O, N C F and Wellcome Trust Centre for Neuroimaging G R R, UCL Institute of Neurology, London, UK Washington University School of Medicine T L S B, N J C, D S M, C X, R J B, J C M, St Louis, MO Mayo Clinic C R J, Rochester, MN Imaging Genetics Center P M T, Laboratory of Neuroimaging, Department of Neurology and Psychiatry, UCLA School of Medicine, Los Angeles, CA Indiana University School of Medicine B F G, A J S, Indianapolis Mental Health Research Institute C L M, The University of Melbourne, Victoria, Australia Mary S Easton Center for Alzheimer s Disease J M R, UCLA Department of Neurology, Los Angeles, CA Butler Hospital S P S, Providence, RI Neuroscience Research Australia P R S, Sydney and the Center for Alzheimer Research and Treatment R A S, Japan
Neurology 81:1425-33. 2013..To assess regional patterns of gray and white matter atrophy in familial Alzheimer disease (FAD) mutation carriers...
- Genetic influences on atrophy patterns in familial Alzheimer's disease: a comparison of APP and PSEN1 mutationsRachael I Scahill
Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, London, UK
J Alzheimers Dis 35:199-212. 2013..We conclude that the mechanisms by which APP and PSEN1 mutations cause neuronal loss may differ which furthers our understanding of the neuropathology underlying AD and may inform future therapeutic strategies and trial designs...
- White matter tract signatures of the progressive aphasiasColin J Mahoney
Dementia Research Centre, UCL Institute of Neurology, London, UK
Neurobiol Aging 34:1687-99. 2013..These WM signatures of PPA syndromes illustrate the selective vulnerability of brain language networks in these diseases and might have some pathologic specificity...
- Global gray matter changes in posterior cortical atrophy: a serial imaging studyManja Lehmann
Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
Alzheimers Dement 8:502-12. 2012..However, differential longitudinal atrophy patterns are not well understood...
- The importance of group-wise registration in tract based spatial statistics study of neurodegeneration: a simulation study in Alzheimer's diseaseShiva Keihaninejad
Dementia Research Centre, University College London Institute of Neurology, London, United Kingdom
PLoS ONE 7:e45996. 2012..Using a group-wise average atlas as the reference outperformed other references in the TBSS pipeline in all evaluations...
- Shining a light on posterior cortical atrophySebastian J Crutch
Dementia Research Centre, UCL Institute of Neurology, London, UK
Alzheimers Dement 9:463-5. 2013....
- Imaging the onset and progression of Alzheimer's disease: implications for prevention trialsYuying Liang
Dementia Research Centre, University College London Institute of Neurology, London, UK
J Alzheimers Dis 33:S305-12. 2013....
- Carbon-11-Pittsburgh compound B positron emission tomography imaging of amyloid deposition in presenilin 1 mutation carriersWilliam D Knight
Department of Neurodegeneration, UCL Institute of Neurology, University College London, Dementia Research Centre, Queen Square, London WC1N 3BG, UK
Brain 134:293-300. 2011..A few individuals with presenilin 1 mutations showed increased cerebellar (11)Carbon-Pittsburgh compound B retention suggesting that this region may not be as suitable a reference region in familial Alzheimer's disease...
- Posterior cerebral atrophy in the absence of medial temporal lobe atrophy in pathologically-confirmed Alzheimer's diseaseManja Lehmann
Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
Neurobiol Aging 33:627.e1-627.e12. 2012..These results underline the importance of considering PA in AD diagnosis, particularly in younger patients where medial temporal atrophy may be less conspicuous...
- Imaging biomarkers in Alzheimer's diseaseNatalie S Ryan
University College London, Institute of Neurology, Queen Square, London WC1N 3BG, UK
Ann N Y Acad Sci 1180:20-7. 2009..A multimodal approach, where imaging markers are combined, may be required to maximize the potential of imaging to enhance our understanding of Alzheimer's disease and to help find effective therapies...
- Correlating familial Alzheimer's disease gene mutations with clinical phenotypeNatalie S Ryan
Dementia Research Centre, Department of Neurodegenerative Diseases, University College London, Institute of Neurology, London, UK
Biomark Med 4:99-112. 2010..Exploring the genetic and pathological basis of this phenotypic heterogeneity can illuminate aspects of the underlying disease mechanism, and is likely to inform our understanding and treatment of AD in the future...