Natalie S Ryan

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Correlating familial Alzheimer's disease gene mutations with clinical phenotype
    Natalie S Ryan
    Dementia Research Centre, Department of Neurodegenerative Diseases, University College London, Institute of Neurology, London, UK
    Biomark Med 4:99-112. 2010
  2. doi request reprint An unbiased longitudinal analysis framework for tracking white matter changes using diffusion tensor imaging with application to Alzheimer's disease
    Shiva Keihaninejad
    Dementia Research Centre, UCL Institute of Neurology, London, UK Centre for Medical Image Computing CMIC, University College London, UK
    Neuroimage 72:153-63. 2013
  3. doi request reprint Genetic influences on atrophy patterns in familial Alzheimer's disease: a comparison of APP and PSEN1 mutations
    Rachael I Scahill
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, London, UK
    J Alzheimers Dis 35:199-212. 2013
  4. pmc White matter tract signatures of the progressive aphasias
    Colin J Mahoney
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Neurobiol Aging 34:1687-99. 2013
  5. pmc Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer's disease
    Natalie S Ryan
    Dementia Research Centre, Box 16 National Hospital for Neurology and Neurosugery, Queen Square, London WC1N 3BG, UK
    Brain 136:1399-414. 2013
  6. pmc Global gray matter changes in posterior cortical atrophy: a serial imaging study
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Alzheimers Dement 8:502-12. 2012
  7. pmc Motor features in posterior cortical atrophy and their imaging correlates
    Natalie S Ryan
    Dementia Research Centre, Department of Neurodegenerative Disease, University College London UCL Institute of Neurology, Queen Square, London, UK Electronic address
    Neurobiol Aging 35:2845-57. 2014
  8. doi request reprint Shining a light on posterior cortical atrophy
    Sebastian J Crutch
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Alzheimers Dement 9:463-5. 2013
  9. doi request reprint Imaging the onset and progression of Alzheimer's disease: implications for prevention trials
    Yuying Liang
    Dementia Research Centre, University College London Institute of Neurology, London, UK
    J Alzheimers Dis 33:S305-12. 2013
  10. pmc The importance of group-wise registration in tract based spatial statistics study of neurodegeneration: a simulation study in Alzheimer's disease
    Shiva Keihaninejad
    Dementia Research Centre, University College London Institute of Neurology, London, United Kingdom
    PLoS ONE 7:e45996. 2012

Detail Information

Publications16

  1. pmc Correlating familial Alzheimer's disease gene mutations with clinical phenotype
    Natalie S Ryan
    Dementia Research Centre, Department of Neurodegenerative Diseases, University College London, Institute of Neurology, London, UK
    Biomark Med 4:99-112. 2010
    ..Exploring the genetic and pathological basis of this phenotypic heterogeneity can illuminate aspects of the underlying disease mechanism, and is likely to inform our understanding and treatment of AD in the future...
  2. doi request reprint An unbiased longitudinal analysis framework for tracking white matter changes using diffusion tensor imaging with application to Alzheimer's disease
    Shiva Keihaninejad
    Dementia Research Centre, UCL Institute of Neurology, London, UK Centre for Medical Image Computing CMIC, University College London, UK
    Neuroimage 72:153-63. 2013
    ..Tensor-based registration for longitudinal processing of DTI data in clinical studies may be of particular value in studies assessing disease progression...
  3. doi request reprint Genetic influences on atrophy patterns in familial Alzheimer's disease: a comparison of APP and PSEN1 mutations
    Rachael I Scahill
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, London, UK
    J Alzheimers Dis 35:199-212. 2013
    ..We conclude that the mechanisms by which APP and PSEN1 mutations cause neuronal loss may differ which furthers our understanding of the neuropathology underlying AD and may inform future therapeutic strategies and trial designs...
  4. pmc White matter tract signatures of the progressive aphasias
    Colin J Mahoney
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Neurobiol Aging 34:1687-99. 2013
    ..These WM signatures of PPA syndromes illustrate the selective vulnerability of brain language networks in these diseases and might have some pathologic specificity...
  5. pmc Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer's disease
    Natalie S Ryan
    Dementia Research Centre, Box 16 National Hospital for Neurology and Neurosugery, Queen Square, London WC1N 3BG, UK
    Brain 136:1399-414. 2013
    ..It may be owing to their dense connectivity that imaging changes are seen first in the thalamus and striatum, which then progress to involve other regions in a vulnerable neuronal network...
  6. pmc Global gray matter changes in posterior cortical atrophy: a serial imaging study
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Alzheimers Dement 8:502-12. 2012
    ..However, differential longitudinal atrophy patterns are not well understood...
  7. pmc Motor features in posterior cortical atrophy and their imaging correlates
    Natalie S Ryan
    Dementia Research Centre, Department of Neurodegenerative Disease, University College London UCL Institute of Neurology, Queen Square, London, UK Electronic address
    Neurobiol Aging 35:2845-57. 2014
    ..Our data suggest that PCA patients with motor features have greater atrophy of contralateral sensorimotor areas but are still likely to have underlying Alzheimer's disease. ..
  8. doi request reprint Shining a light on posterior cortical atrophy
    Sebastian J Crutch
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Alzheimers Dement 9:463-5. 2013
    ....
  9. doi request reprint Imaging the onset and progression of Alzheimer's disease: implications for prevention trials
    Yuying Liang
    Dementia Research Centre, University College London Institute of Neurology, London, UK
    J Alzheimers Dis 33:S305-12. 2013
    ....
  10. pmc The importance of group-wise registration in tract based spatial statistics study of neurodegeneration: a simulation study in Alzheimer's disease
    Shiva Keihaninejad
    Dementia Research Centre, University College London Institute of Neurology, London, United Kingdom
    PLoS ONE 7:e45996. 2012
    ..Using a group-wise average atlas as the reference outperformed other references in the TBSS pipeline in all evaluations...
  11. pmc Abnormalities of fixation, saccade and pursuit in posterior cortical atrophy
    Timothy J Shakespeare
    1 Dementia Research Centre, Department of Neurodegenerative Disease, Institute of Neurology, University College London, London, UK
    Brain 138:1976-91. 2015
    ....
  12. pmc Posterior cerebral atrophy in the absence of medial temporal lobe atrophy in pathologically-confirmed Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 33:627.e1-627.e12. 2012
    ..These results underline the importance of considering PA in AD diagnosis, particularly in younger patients where medial temporal atrophy may be less conspicuous...
  13. doi request reprint Imaging biomarkers in Alzheimer's disease
    Natalie S Ryan
    University College London, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Ann N Y Acad Sci 1180:20-7. 2009
    ..A multimodal approach, where imaging markers are combined, may be required to maximize the potential of imaging to enhance our understanding of Alzheimer's disease and to help find effective therapies...
  14. doi request reprint Spontaneous ARIA (amyloid-related imaging abnormalities) and cerebral amyloid angiopathy related inflammation in presenilin 1-associated familial Alzheimer's disease
    Natalie S Ryan
    Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, Queen Square, London, UK
    J Alzheimers Dis 44:1069-74. 2015
    ..Recognition that ARIA may arise spontaneously during FAD and of the potential risk factors for its development are important observations given the recent launch of amyloid-modifying therapy trials for FAD. ..
  15. pmc Defining and describing the pre-dementia stages of familial Alzheimer's disease
    Natalie S Ryan
    Dementia Research Centre, Department of Neurodegenerative Diseases, Box 16, National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Alzheimers Res Ther 3:29. 2011
    ..Furthermore, the study highlights some of the challenges of defining pre-dementia clinical stages in familial Alzheimer's disease and the need for the field to develop a consistent terminology...
  16. doi request reprint Carbon-11-Pittsburgh compound B positron emission tomography imaging of amyloid deposition in presenilin 1 mutation carriers
    William D Knight
    Department of Neurodegeneration, UCL Institute of Neurology, University College London, Dementia Research Centre, Queen Square, London WC1N 3BG, UK
    Brain 134:293-300. 2011
    ..A few individuals with presenilin 1 mutations showed increased cerebellar (11)Carbon-Pittsburgh compound B retention suggesting that this region may not be as suitable a reference region in familial Alzheimer's disease...