D A Rusakov

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc The role of perisynaptic glial sheaths in glutamate spillover and extracellular Ca(2+) depletion
    D A Rusakov
    Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    Biophys J 81:1947-59. 2001
  2. pmc CaMKII translocation requires local NMDA receptor-mediated Ca2+ signaling
    Agnes Thalhammer
    Department of Pharmacology, Laboratory for Molecular Pharmacology, University College London, Gower Street, London, UK
    EMBO J 25:5873-83. 2006
  3. pmc Shaping the synaptic signal: molecular mobility inside and outside the cleft
    Dmitri A Rusakov
    Institute of Neurology, University College London, Queen Square, London WC1 3BG, UK
    Trends Neurosci 34:359-69. 2011
  4. pmc Long-term potentiation depends on release of D-serine from astrocytes
    Christian Henneberger
    UCL Institute of Neurology, University College London, London WC1N 3BG, UK
    Nature 463:232-6. 2010
  5. pmc Ca2+-dependent mechanisms of presynaptic control at central synapses
    Dmitri A Rusakov
    Institute of Neurology, University College London, London, UK
    Neuroscientist 12:317-26. 2006
  6. pmc Astrocytes as regulators of synaptic function: a quest for the Ca2+ master key
    Dmitri A Rusakov
    UCL Institute of Neurology, University College London, London, UK
    Neuroscientist 17:513-23. 2011
  7. pmc Modulation of presynaptic Ca2+ entry by AMPA receptors at individual GABAergic synapses in the cerebellum
    Dmitri A Rusakov
    Molecular Neurobiology Laboratory, Mitsubishi Kagaku Institute of Life Sciences, and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo 194 8511, Japan
    J Neurosci 25:4930-40. 2005
  8. pmc Comment on "Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity"
    Dmitri A Rusakov
    Institute of Neurology, University College LondonQueen SquareLondon WC1N 2BG, UK
    Science 305:1912; author reply. 2004
  9. ncbi request reprint Perisynaptic asymmetry of glia: new insights into glutamate signalling
    Dmitri A Rusakov
    Institute of Neurology, University College London, Queen Square, UK
    Trends Neurosci 25:492-4. 2002
  10. pmc Heterogeneity and specificity of presynaptic Ca2+ current modulation by mGluRs at individual hippocampal synapses
    Dmitri A Rusakov
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Cereb Cortex 14:748-58. 2004

Collaborators

Detail Information

Publications27

  1. pmc The role of perisynaptic glial sheaths in glutamate spillover and extracellular Ca(2+) depletion
    D A Rusakov
    Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    Biophys J 81:1947-59. 2001
    ..The results provide a quantitative guidance for interpretation of physiological experiments that address fast transients of neurotransmitters and small ions in the brain tissue...
  2. pmc CaMKII translocation requires local NMDA receptor-mediated Ca2+ signaling
    Agnes Thalhammer
    Department of Pharmacology, Laboratory for Molecular Pharmacology, University College London, Gower Street, London, UK
    EMBO J 25:5873-83. 2006
    ..Together with the requirement for activated, possibly ligand-bound, NMDARs as CaMKII binding partners, this suggests that synaptic CaMKII accumulation is an input-specific signaling event...
  3. pmc Shaping the synaptic signal: molecular mobility inside and outside the cleft
    Dmitri A Rusakov
    Institute of Neurology, University College London, Queen Square, London WC1 3BG, UK
    Trends Neurosci 34:359-69. 2011
    ....
  4. pmc Long-term potentiation depends on release of D-serine from astrocytes
    Christian Henneberger
    UCL Institute of Neurology, University College London, London WC1N 3BG, UK
    Nature 463:232-6. 2010
    ..We therefore demonstrate that Ca(2+)-dependent release of D-serine from an astrocyte controls NMDAR-dependent plasticity in many thousands of excitatory synapses nearby...
  5. pmc Ca2+-dependent mechanisms of presynaptic control at central synapses
    Dmitri A Rusakov
    Institute of Neurology, University College London, London, UK
    Neuroscientist 12:317-26. 2006
    ..Here we present an overview of major players involved in Ca2+-dependent presynaptic regulation of neurotransmitter release and discuss the relationships arising between their actions...
  6. pmc Astrocytes as regulators of synaptic function: a quest for the Ca2+ master key
    Dmitri A Rusakov
    UCL Institute of Neurology, University College London, London, UK
    Neuroscientist 17:513-23. 2011
    ..This review highlights limitations and potential advantages of such approaches from the current methodological perspective...
  7. pmc Modulation of presynaptic Ca2+ entry by AMPA receptors at individual GABAergic synapses in the cerebellum
    Dmitri A Rusakov
    Molecular Neurobiology Laboratory, Mitsubishi Kagaku Institute of Life Sciences, and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo 194 8511, Japan
    J Neurosci 25:4930-40. 2005
    ..The results provide the first quantitative description of presynaptic Ca2+ kinetics and its modulation by AMPA receptor activation (most likely via a glutamate spillover-mediated mechanism) at identified GABAergic synapses...
  8. pmc Comment on "Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity"
    Dmitri A Rusakov
    Institute of Neurology, University College LondonQueen SquareLondon WC1N 2BG, UK
    Science 305:1912; author reply. 2004
  9. ncbi request reprint Perisynaptic asymmetry of glia: new insights into glutamate signalling
    Dmitri A Rusakov
    Institute of Neurology, University College London, Queen Square, UK
    Trends Neurosci 25:492-4. 2002
    ..This asymmetry favours activation of axonal, as opposed to dendritic, extrasynaptic glutamate receptors, thus imposing rule on information processing in the brain...
  10. pmc Heterogeneity and specificity of presynaptic Ca2+ current modulation by mGluRs at individual hippocampal synapses
    Dmitri A Rusakov
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Cereb Cortex 14:748-58. 2004
    ..Glutamatergic modulation of GABA release from individual synapses thus depends on the co-occurrence of presynaptic N-type Ca2+ channels and the target cell-dependent expression of group III mGluRs...
  11. pmc NR2B-containing receptors mediate cross talk among hippocampal synapses
    Annalisa Scimemi
    Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 24:4767-77. 2004
    ..These NMDAR isoforms thus play complementary roles in sensing global and local glutamate signals, respectively...
  12. pmc The optimal height of the synaptic cleft
    Leonid P Savtchenko
    Institute of Neurology, University College London, Queen Square, London, United Kingdom
    Proc Natl Acad Sci U S A 104:1823-8. 2007
    ..Therefore, our results suggest that a simple fundamental principle may underlie the synaptic cleft architecture: to maximize synaptic strength...
  13. pmc Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit
    Karri P Lamsa
    Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Science 315:1262-6. 2007
    ..Anti-Hebbian LTP may occur in interneurons that are silent during periods of intense pyramidal cell firing, such as sharp waves, and lead to their altered activation during theta activity...
  14. pmc Electric fields due to synaptic currents sharpen excitatory transmission
    Sergiy Sylantyev
    Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Science 319:1845-9. 2008
    ..Voltage-dependent temporal tuning of excitatory synaptic responses may thus contribute to signal integration in neural circuits...
  15. pmc GABA(B) receptor modulation of feedforward inhibition through hippocampal neurogliaform cells
    Christopher J Price
    Medical Research Council Anatomical Neuropharmacology Unit, Oxford OX1 3TH, United Kingdom
    J Neurosci 28:6974-82. 2008
    ..The NGFC-CA1 pyramidal cell connection therefore provides a unique and subtle mechanism to shape the integration time domain for signals arriving via a major excitatory input to CA1 pyramidal cells...
  16. pmc Analog modulation of mossy fiber transmission is uncoupled from changes in presynaptic Ca2+
    Ricardo Scott
    Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 28:7765-73. 2008
    ..We conclude that depolarization-dependent modulation of transmission at these boutons does not rely on changes in presynaptic Ca2+...
  17. pmc Asymmetry of glia near central synapses favors presynaptically directed glutamate escape
    Knut Petter Lehre
    Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom
    Biophys J 83:125-34. 2002
    ..Our data suggest that the perisynaptic environment of these common central synapses favors fast presynaptic feedback in the information flow while preserving the specificity of the postsynaptic input...
  18. pmc Presynaptic fluctuations and release-independent depression
    Kirill E Volynski
    Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Nat Neurosci 9:1091-3. 2006
    ..The relationship between this apparent depression and the interstimulus interval provides a window on the kinetics of state transitions of the release apparatus...
  19. pmc GABAA receptors at hippocampal mossy fibers
    Arnaud Ruiz
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom
    Neuron 39:961-73. 2003
    ..Antibodies against the alpha2 subunit of GABAA receptors stain mossy fibers. Axonal GABAA receptors thus play a potentially important role in tonic and activity-dependent heterosynaptic modulation of information flow to the hippocampus...
  20. pmc Main determinants of presynaptic Ca2+ dynamics at individual mossy fiber-CA3 pyramidal cell synapses
    Ricardo Scott
    Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 26:7071-81. 2006
    ..Rapid Ca2+ release from stores represents up to 20% of the presynaptic Ca2+ transient evoked by a brief train of action potentials. The results identify the main components of presynaptic Ca2+ dynamics at this important cortical synapse...
  21. pmc Matrix metalloproteinase-7 disrupts dendritic spines in hippocampal neurons through NMDA receptor activation
    Tina V Bilousova
    Division of Biomedical Sciences, University of California Riverside, California 92521 0121, USA
    J Neurochem 97:44-56. 2006
    ..These findings are the first direct evidence that MMPs can influence the morphology of mature dendritic spines, and hence synaptic stability...
  22. ncbi request reprint Electric fields of synaptic currents could influence diffusion of charged neurotransmitter molecules
    Leonid P Savtchenko
    Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Synapse 51:270-8. 2004
    ..This previously unrecognized mechanism should affect the kinetics of synaptic receptor currents, thus contributing to fast synaptic signaling in the brain...
  23. pmc Glutamate transporter studies reveal the pruning of metabotropic glutamate receptors and absence of AMPA receptor desensitization at mature calyx of held synapses
    Robert Renden
    The Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 25:8482-97. 2005
    ..In the more mature calyx, there is a far smaller diffusional barrier attributable to the highly fenestrated synaptic terminal morphology, so AMPA receptor desensitization is avoided and mGluR-mediated inhibition is not necessary...
  24. ncbi request reprint Extracellular diffusivity determines contribution of high-versus low-affinity receptors to neural signaling
    Leonid P Savtchenko
    Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 25:101-11. 2005
    ..The results suggest that variations in extracellular diffusivity could reflect an altered contribution of higher- versus lower-affinity receptor types to the network activity of synaptic circuits...
  25. pmc Expression of long-term potentiation in aged rats involves perforated synapses but dendritic spine branching results from high-frequency stimulation alone
    Tiruchinapalli M Dhanrajan
    Department of Biological Sciences, The Open University, Milton Keynes, United Kingdom
    Hippocampus 14:255-64. 2004
    ..In contrast, an increase in the number of branched spines appears to result from high-frequency stimulation alone. These data shed light on the current controversy about the expression mechanism of LTP...
  26. ncbi request reprint Glutamate escape from a tortuous synaptic cleft of the hippocampal mossy fibre synapse
    Leonid P Savtchenko
    DCEE, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neurochem Int 45:479-84. 2004
    ..The results predict that, in the absence of neuronal glutamate transporters, it should take approximately 10 ms for 50% and 60-70 ms for 90% of glutamate molecules to escape the MF synapse...
  27. pmc Characterization of AMPA receptors targeted by the climbing fiber transmitter mediating presynaptic inhibition of GABAergic transmission at cerebellar interneuron-Purkinje cell synapses
    Shin ichiro Satake
    National Institute for Physiological Sciences, Okazaki 444 8787, Japan
    J Neurosci 26:2278-89. 2006
    ..These findings demonstrate that the CF transmitter directly inhibits GABA release from interneurons to the PC, relying on extrasynaptic diffusion and local heterogeneity in AMPAR subunit compositions...