Christiana Ruhrberg


Affiliation: University College London
Country: UK


  1. Liyanage S, Fantin A, Villacampa P, Lange C, Denti L, Cristante E, et al. Myeloid-Derived Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor Are Dispensable for Ocular Neovascularization--Brief Report. Arterioscler Thromb Vasc Biol. 2016;36:19-24 pubmed publisher
    ..The finding that myeloid cells are not a significant local source of VEGF in these rodent models of ONV suggests that myeloid function in neovascular eye disease differs from skin wound healing and other neovascular pathologies. ..
  2. Fantin A, Lampropoulou A, Senatore V, Brash J, Prahst C, Lange C, et al. VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation. J Exp Med. 2017;214:1049-1064 pubmed publisher
    ..These findings raise the possibility that targeting NRP1 or its NCD interactors may be a useful therapeutic strategy in neovascular disease to reduce VEGF165-induced edema without compromising vessel growth. ..
  3. Plein A, Fantin A, Denti L, Pollard J, Ruhrberg C. Erythro-myeloid progenitors contribute endothelial cells to blood vessels. Nature. 2018;562:223-228 pubmed publisher
  4. Brash J, Ruhrberg C, Fantin A. Evaluating Vascular Hyperpermeability-inducing Agents in the Skin with the Miles Assay. J Vis Exp. 2018;: pubmed publisher
  5. Tillo M, Erskine L, Cariboni A, Fantin A, Joyce A, Denti L, et al. VEGF189 binds NRP1 and is sufficient for VEGF/NRP1-dependent neuronal patterning in the developing brain. Development. 2015;142:314-9 pubmed publisher
    ..Here, we have combined expression studies and in situ ligand-binding assays with the analysis of genetically altered mice and in vitro models to demonstrate that VEGF189 can bind NRP1 and promote NRP1-dependent neuronal responses. ..
  6. Plein A, Fantin A, Ruhrberg C. Neural crest cells in cardiovascular development. Curr Top Dev Biol. 2015;111:183-200 pubmed publisher
    ..We additionally discuss their contribution to the cardiac valves as well as the still contentious role of cardiac NCCs in the development of the myocardium and conductive system of the heart. ..
  7. Tillo M, Schwarz Q, Ruhrberg C. Mouse hindbrain ex vivo culture to study facial branchiomotor neuron migration. J Vis Exp. 2014;: pubmed publisher
  8. Tata M, Ruhrberg C, Fantin A. Vascularisation of the central nervous system. Mech Dev. 2015;138 Pt 1:26-36 pubmed publisher
  9. Raimondi C, Brash J, Fantin A, Ruhrberg C. NRP1 function and targeting in neurovascular development and eye disease. Prog Retin Eye Res. 2016;52:64-83 pubmed publisher
    ..This review will also discuss the potential of NRP1 inhibitors for the treatment for neovascular eye diseases. ..

More Information


  1. Tata M, Wall I, Joyce A, Vieira J, Kessaris N, Ruhrberg C. Regulation of embryonic neurogenesis by germinal zone vasculature. Proc Natl Acad Sci U S A. 2016;113:13414-13419 pubmed
    ..Therefore, germinal zone vascularization sustains NPC proliferation in the prenatal brain. ..
  2. Ruhrberg C, Bautch V. Neurovascular development and links to disease. Cell Mol Life Sci. 2013;70:1675-84 pubmed publisher
    ..Finally, we highlight the significance of these mechanisms for two different types of neurovascular CNS disease. ..
  3. Tata M, Ruhrberg C. The Mouse Hindbrain As a Model for Studying Embryonic Neurogenesis. J Vis Exp. 2018;: pubmed publisher
    ..Here, we present a simple and quick method to use the mouse embryo hindbrain for analyzing mammalian neural progenitor cell (NPC) behavior in wholemount preparations and tissue sections. ..
  4. Fantin A, Lampropoulou A, Gestri G, Raimondi C, Senatore V, Zachary I, et al. NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells. Cell Rep. 2015;11:1577-90 pubmed publisher
    ..We conclude that NRP1 enables ECM-induced filopodia formation for tip cell function during sprouting angiogenesis. ..
  5. Tillo M, Charoy C, Schwarz Q, Maden C, Davidson K, Fantin A, et al. 2- and 6-O-sulfated proteoglycans have distinct and complementary roles in cranial axon guidance and motor neuron migration. Development. 2016;143:1907-13 pubmed publisher
    ..We have also investigated how HS2ST interacts with other signals in the hindbrain and show that fibroblast growth factor (FGF) signalling regulates FBM neuron migration in an HS2ST-dependent manner. ..